Amino acid dipepetide frequency for Streptococcus phage Javan443

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.374AlaAla: 2.374 ± 1.156
0.339AlaCys: 0.339 ± 0.15
3.985AlaAsp: 3.985 ± 0.628
5.003AlaGlu: 5.003 ± 0.642
1.441AlaPhe: 1.441 ± 0.294
3.9AlaGly: 3.9 ± 0.881
0.933AlaHis: 0.933 ± 0.246
5.681AlaIle: 5.681 ± 0.624
7.546AlaLys: 7.546 ± 0.94
6.444AlaLeu: 6.444 ± 0.946
2.12AlaMet: 2.12 ± 0.637
4.07AlaAsn: 4.07 ± 0.733
1.441AlaPro: 1.441 ± 0.421
2.12AlaGln: 2.12 ± 0.751
2.883AlaArg: 2.883 ± 0.518
5.511AlaSer: 5.511 ± 1.118
5.003AlaThr: 5.003 ± 1.139
4.579AlaVal: 4.579 ± 0.508
0.848AlaTrp: 0.848 ± 0.255
1.441AlaTyr: 1.441 ± 0.295
0.0AlaXaa: 0.0 ± 0.0
Cys
0.339CysAla: 0.339 ± 0.172
0.254CysCys: 0.254 ± 0.146
0.509CysAsp: 0.509 ± 0.267
0.594CysGlu: 0.594 ± 0.219
0.339CysPhe: 0.339 ± 0.174
0.254CysGly: 0.254 ± 0.137
0.085CysHis: 0.085 ± 0.094
0.085CysIle: 0.085 ± 0.092
0.509CysLys: 0.509 ± 0.171
0.339CysLeu: 0.339 ± 0.175
0.254CysMet: 0.254 ± 0.159
0.085CysAsn: 0.085 ± 0.086
0.085CysPro: 0.085 ± 0.094
0.085CysGln: 0.085 ± 0.083
0.17CysArg: 0.17 ± 0.102
0.254CysSer: 0.254 ± 0.129
0.424CysThr: 0.424 ± 0.182
0.339CysVal: 0.339 ± 0.167
0.085CysTrp: 0.085 ± 0.101
0.254CysTyr: 0.254 ± 0.165
0.0CysXaa: 0.0 ± 0.0
Asp
3.222AspAla: 3.222 ± 0.461
0.509AspCys: 0.509 ± 0.242
3.731AspAsp: 3.731 ± 0.792
4.748AspGlu: 4.748 ± 0.665
4.07AspPhe: 4.07 ± 0.557
4.833AspGly: 4.833 ± 0.74
0.339AspHis: 0.339 ± 0.165
4.833AspIle: 4.833 ± 0.847
6.105AspLys: 6.105 ± 0.775
5.342AspLeu: 5.342 ± 0.683
1.187AspMet: 1.187 ± 0.321
5.172AspAsn: 5.172 ± 0.624
1.187AspPro: 1.187 ± 0.351
1.272AspGln: 1.272 ± 0.314
1.95AspArg: 1.95 ± 0.367
3.9AspSer: 3.9 ± 0.631
3.222AspThr: 3.222 ± 0.571
2.968AspVal: 2.968 ± 0.41
0.848AspTrp: 0.848 ± 0.329
2.459AspTyr: 2.459 ± 0.668
0.0AspXaa: 0.0 ± 0.0
Glu
4.663GluAla: 4.663 ± 0.549
0.17GluCys: 0.17 ± 0.134
3.476GluAsp: 3.476 ± 0.69
5.766GluGlu: 5.766 ± 0.752
2.798GluPhe: 2.798 ± 0.411
2.459GluGly: 2.459 ± 0.527
1.017GluHis: 1.017 ± 0.309
6.868GluIle: 6.868 ± 0.813
7.546GluLys: 7.546 ± 0.827
6.783GluLeu: 6.783 ± 0.878
2.713GluMet: 2.713 ± 0.426
4.07GluAsn: 4.07 ± 0.707
1.272GluPro: 1.272 ± 0.462
3.052GluGln: 3.052 ± 0.622
2.205GluArg: 2.205 ± 0.518
3.561GluSer: 3.561 ± 0.597
4.494GluThr: 4.494 ± 0.609
6.444GluVal: 6.444 ± 0.82
0.848GluTrp: 0.848 ± 0.278
2.459GluTyr: 2.459 ± 0.534
0.0GluXaa: 0.0 ± 0.0
Phe
2.798PheAla: 2.798 ± 0.552
0.085PheCys: 0.085 ± 0.103
3.392PheAsp: 3.392 ± 0.706
3.9PheGlu: 3.9 ± 0.682
1.611PhePhe: 1.611 ± 0.564
3.561PheGly: 3.561 ± 0.489
0.678PheHis: 0.678 ± 0.21
3.137PheIle: 3.137 ± 0.68
3.137PheLys: 3.137 ± 0.544
1.95PheLeu: 1.95 ± 0.364
1.187PheMet: 1.187 ± 0.276
2.12PheAsn: 2.12 ± 0.403
1.526PhePro: 1.526 ± 0.292
0.848PheGln: 0.848 ± 0.288
1.526PheArg: 1.526 ± 0.36
3.985PheSer: 3.985 ± 0.624
2.459PheThr: 2.459 ± 0.414
2.628PheVal: 2.628 ± 0.517
0.509PheTrp: 0.509 ± 0.193
1.526PheTyr: 1.526 ± 0.42
0.0PheXaa: 0.0 ± 0.0
Gly
3.731GlyAla: 3.731 ± 0.65
0.254GlyCys: 0.254 ± 0.13
2.628GlyAsp: 2.628 ± 0.542
3.137GlyGlu: 3.137 ± 0.383
3.222GlyPhe: 3.222 ± 0.49
5.087GlyGly: 5.087 ± 0.836
0.509GlyHis: 0.509 ± 0.279
3.646GlyIle: 3.646 ± 0.555
5.766GlyLys: 5.766 ± 0.617
7.631GlyLeu: 7.631 ± 1.112
1.696GlyMet: 1.696 ± 0.412
3.646GlyAsn: 3.646 ± 0.394
0.848GlyPro: 0.848 ± 0.221
2.883GlyGln: 2.883 ± 0.581
2.628GlyArg: 2.628 ± 0.451
3.392GlySer: 3.392 ± 0.703
4.663GlyThr: 4.663 ± 1.003
4.07GlyVal: 4.07 ± 0.636
1.102GlyTrp: 1.102 ± 0.312
2.544GlyTyr: 2.544 ± 0.52
0.0GlyXaa: 0.0 ± 0.0
His
0.509HisAla: 0.509 ± 0.224
0.085HisCys: 0.085 ± 0.074
0.678HisAsp: 0.678 ± 0.284
0.848HisGlu: 0.848 ± 0.327
0.509HisPhe: 0.509 ± 0.267
0.678HisGly: 0.678 ± 0.238
0.17HisHis: 0.17 ± 0.139
0.678HisIle: 0.678 ± 0.293
1.187HisLys: 1.187 ± 0.464
0.848HisLeu: 0.848 ± 0.257
0.254HisMet: 0.254 ± 0.112
0.594HisAsn: 0.594 ± 0.244
0.254HisPro: 0.254 ± 0.126
0.424HisGln: 0.424 ± 0.194
0.678HisArg: 0.678 ± 0.268
0.933HisSer: 0.933 ± 0.306
1.272HisThr: 1.272 ± 0.368
0.678HisVal: 0.678 ± 0.265
0.254HisTrp: 0.254 ± 0.158
0.509HisTyr: 0.509 ± 0.217
0.0HisXaa: 0.0 ± 0.0
Ile
5.426IleAla: 5.426 ± 0.78
0.424IleCys: 0.424 ± 0.177
6.359IleAsp: 6.359 ± 0.828
5.511IleGlu: 5.511 ± 0.685
2.289IlePhe: 2.289 ± 0.419
3.985IleGly: 3.985 ± 0.702
1.187IleHis: 1.187 ± 0.352
4.494IleIle: 4.494 ± 0.866
6.359IleLys: 6.359 ± 0.806
5.596IleLeu: 5.596 ± 0.725
1.611IleMet: 1.611 ± 0.435
5.087IleAsn: 5.087 ± 0.719
1.611IlePro: 1.611 ± 0.329
1.95IleGln: 1.95 ± 0.374
2.035IleArg: 2.035 ± 0.39
4.324IleSer: 4.324 ± 0.484
5.003IleThr: 5.003 ± 0.835
3.307IleVal: 3.307 ± 0.524
0.424IleTrp: 0.424 ± 0.176
3.137IleTyr: 3.137 ± 0.586
0.0IleXaa: 0.0 ± 0.0
Lys
6.783LysAla: 6.783 ± 0.955
0.17LysCys: 0.17 ± 0.133
5.257LysAsp: 5.257 ± 0.915
8.394LysGlu: 8.394 ± 1.013
3.307LysPhe: 3.307 ± 0.531
5.511LysGly: 5.511 ± 0.557
1.272LysHis: 1.272 ± 0.375
5.426LysIle: 5.426 ± 0.844
6.783LysLys: 6.783 ± 0.768
7.377LysLeu: 7.377 ± 0.883
2.205LysMet: 2.205 ± 0.478
4.833LysAsn: 4.833 ± 0.626
2.12LysPro: 2.12 ± 0.485
3.137LysGln: 3.137 ± 0.475
3.392LysArg: 3.392 ± 0.484
5.257LysSer: 5.257 ± 0.666
7.207LysThr: 7.207 ± 0.615
5.935LysVal: 5.935 ± 0.669
0.678LysTrp: 0.678 ± 0.266
2.883LysTyr: 2.883 ± 0.426
0.0LysXaa: 0.0 ± 0.0
Leu
6.19LeuAla: 6.19 ± 0.986
0.509LeuCys: 0.509 ± 0.239
5.681LeuAsp: 5.681 ± 0.805
6.953LeuGlu: 6.953 ± 0.846
2.883LeuPhe: 2.883 ± 0.628
5.426LeuGly: 5.426 ± 1.025
0.933LeuHis: 0.933 ± 0.363
6.274LeuIle: 6.274 ± 0.606
7.037LeuLys: 7.037 ± 0.569
5.681LeuLeu: 5.681 ± 0.77
1.611LeuMet: 1.611 ± 0.324
4.833LeuAsn: 4.833 ± 0.702
2.459LeuPro: 2.459 ± 0.371
2.713LeuGln: 2.713 ± 0.582
3.561LeuArg: 3.561 ± 0.551
6.19LeuSer: 6.19 ± 0.848
7.801LeuThr: 7.801 ± 1.018
5.257LeuVal: 5.257 ± 0.622
0.424LeuTrp: 0.424 ± 0.192
2.883LeuTyr: 2.883 ± 0.403
0.0LeuXaa: 0.0 ± 0.0
Met
2.205MetAla: 2.205 ± 0.487
0.085MetCys: 0.085 ± 0.086
1.441MetAsp: 1.441 ± 0.426
1.95MetGlu: 1.95 ± 0.366
1.187MetPhe: 1.187 ± 0.298
1.102MetGly: 1.102 ± 0.335
0.085MetHis: 0.085 ± 0.069
2.12MetIle: 2.12 ± 0.437
2.289MetLys: 2.289 ± 0.614
2.035MetLeu: 2.035 ± 0.609
0.509MetMet: 0.509 ± 0.18
1.187MetAsn: 1.187 ± 0.327
0.594MetPro: 0.594 ± 0.186
1.017MetGln: 1.017 ± 0.281
1.187MetArg: 1.187 ± 0.341
2.374MetSer: 2.374 ± 0.578
1.781MetThr: 1.781 ± 0.454
1.272MetVal: 1.272 ± 0.41
0.085MetTrp: 0.085 ± 0.086
0.763MetTyr: 0.763 ± 0.249
0.0MetXaa: 0.0 ± 0.0
Asn
4.663AsnAla: 4.663 ± 1.177
0.339AsnCys: 0.339 ± 0.168
3.985AsnAsp: 3.985 ± 0.453
4.409AsnGlu: 4.409 ± 0.582
1.781AsnPhe: 1.781 ± 0.349
4.833AsnGly: 4.833 ± 0.61
0.848AsnHis: 0.848 ± 0.297
3.561AsnIle: 3.561 ± 0.599
5.342AsnLys: 5.342 ± 0.799
4.239AsnLeu: 4.239 ± 0.621
1.781AsnMet: 1.781 ± 0.397
3.985AsnAsn: 3.985 ± 0.48
1.95AsnPro: 1.95 ± 0.39
3.646AsnGln: 3.646 ± 0.677
1.696AsnArg: 1.696 ± 0.446
4.663AsnSer: 4.663 ± 0.57
3.815AsnThr: 3.815 ± 0.63
3.392AsnVal: 3.392 ± 0.374
0.848AsnTrp: 0.848 ± 0.235
2.205AsnTyr: 2.205 ± 0.512
0.0AsnXaa: 0.0 ± 0.0
Pro
1.865ProAla: 1.865 ± 0.445
0.0ProCys: 0.0 ± 0.0
1.611ProAsp: 1.611 ± 0.358
1.696ProGlu: 1.696 ± 0.419
1.95ProPhe: 1.95 ± 0.414
0.594ProGly: 0.594 ± 0.319
0.424ProHis: 0.424 ± 0.179
1.611ProIle: 1.611 ± 0.371
2.544ProLys: 2.544 ± 0.543
2.374ProLeu: 2.374 ± 0.641
0.509ProMet: 0.509 ± 0.211
1.611ProAsn: 1.611 ± 0.375
0.424ProPro: 0.424 ± 0.168
0.763ProGln: 0.763 ± 0.196
0.933ProArg: 0.933 ± 0.325
1.017ProSer: 1.017 ± 0.327
1.102ProThr: 1.102 ± 0.35
1.865ProVal: 1.865 ± 0.473
0.085ProTrp: 0.085 ± 0.076
1.102ProTyr: 1.102 ± 0.296
0.0ProXaa: 0.0 ± 0.0
Gln
2.883GlnAla: 2.883 ± 0.476
0.254GlnCys: 0.254 ± 0.144
1.611GlnAsp: 1.611 ± 0.328
2.459GlnGlu: 2.459 ± 0.424
1.696GlnPhe: 1.696 ± 0.413
1.95GlnGly: 1.95 ± 0.357
0.17GlnHis: 0.17 ± 0.107
2.713GlnIle: 2.713 ± 0.48
3.561GlnLys: 3.561 ± 0.718
4.324GlnLeu: 4.324 ± 0.505
0.678GlnMet: 0.678 ± 0.239
2.205GlnAsn: 2.205 ± 0.404
0.848GlnPro: 0.848 ± 0.226
1.696GlnGln: 1.696 ± 0.383
1.102GlnArg: 1.102 ± 0.234
3.137GlnSer: 3.137 ± 0.403
3.052GlnThr: 3.052 ± 0.665
1.611GlnVal: 1.611 ± 0.392
0.509GlnTrp: 0.509 ± 0.177
1.526GlnTyr: 1.526 ± 0.325
0.0GlnXaa: 0.0 ± 0.0
Arg
2.798ArgAla: 2.798 ± 0.613
0.17ArgCys: 0.17 ± 0.123
2.628ArgAsp: 2.628 ± 0.464
2.713ArgGlu: 2.713 ± 0.389
1.102ArgPhe: 1.102 ± 0.279
1.865ArgGly: 1.865 ± 0.344
0.763ArgHis: 0.763 ± 0.212
3.052ArgIle: 3.052 ± 0.506
3.137ArgLys: 3.137 ± 0.468
3.392ArgLeu: 3.392 ± 0.628
1.272ArgMet: 1.272 ± 0.346
2.289ArgAsn: 2.289 ± 0.412
0.763ArgPro: 0.763 ± 0.188
1.102ArgGln: 1.102 ± 0.352
1.611ArgArg: 1.611 ± 0.475
1.526ArgSer: 1.526 ± 0.38
2.12ArgThr: 2.12 ± 0.333
1.526ArgVal: 1.526 ± 0.379
0.339ArgTrp: 0.339 ± 0.175
1.781ArgTyr: 1.781 ± 0.264
0.0ArgXaa: 0.0 ± 0.0
Ser
4.494SerAla: 4.494 ± 1.13
0.254SerCys: 0.254 ± 0.153
4.663SerAsp: 4.663 ± 0.535
3.392SerGlu: 3.392 ± 0.441
4.155SerPhe: 4.155 ± 0.597
4.07SerGly: 4.07 ± 0.748
0.763SerHis: 0.763 ± 0.292
4.833SerIle: 4.833 ± 0.706
6.105SerLys: 6.105 ± 0.703
5.172SerLeu: 5.172 ± 0.792
1.102SerMet: 1.102 ± 0.303
4.324SerAsn: 4.324 ± 0.823
1.102SerPro: 1.102 ± 0.379
3.9SerGln: 3.9 ± 0.6
2.544SerArg: 2.544 ± 0.413
4.748SerSer: 4.748 ± 0.812
3.392SerThr: 3.392 ± 0.427
5.172SerVal: 5.172 ± 0.714
0.424SerTrp: 0.424 ± 0.192
3.222SerTyr: 3.222 ± 0.663
0.0SerXaa: 0.0 ± 0.0
Thr
5.342ThrAla: 5.342 ± 1.179
0.339ThrCys: 0.339 ± 0.187
3.222ThrAsp: 3.222 ± 0.573
4.409ThrGlu: 4.409 ± 0.643
3.476ThrPhe: 3.476 ± 0.612
5.766ThrGly: 5.766 ± 0.632
0.763ThrHis: 0.763 ± 0.308
5.172ThrIle: 5.172 ± 0.703
4.748ThrLys: 4.748 ± 0.555
6.359ThrLeu: 6.359 ± 0.638
1.696ThrMet: 1.696 ± 0.439
4.748ThrAsn: 4.748 ± 0.844
2.544ThrPro: 2.544 ± 0.511
2.968ThrGln: 2.968 ± 0.8
1.526ThrArg: 1.526 ± 0.338
4.494ThrSer: 4.494 ± 0.982
5.342ThrThr: 5.342 ± 0.6
3.815ThrVal: 3.815 ± 0.786
0.763ThrTrp: 0.763 ± 0.281
2.12ThrTyr: 2.12 ± 0.515
0.0ThrXaa: 0.0 ± 0.0
Val
4.324ValAla: 4.324 ± 0.833
0.254ValCys: 0.254 ± 0.162
4.324ValAsp: 4.324 ± 0.754
4.494ValGlu: 4.494 ± 0.726
2.798ValPhe: 2.798 ± 0.584
4.324ValGly: 4.324 ± 0.703
0.424ValHis: 0.424 ± 0.233
3.476ValIle: 3.476 ± 0.419
4.748ValLys: 4.748 ± 0.674
6.105ValLeu: 6.105 ± 0.782
1.526ValMet: 1.526 ± 0.399
3.985ValAsn: 3.985 ± 0.524
2.035ValPro: 2.035 ± 0.481
1.696ValGln: 1.696 ± 0.371
1.696ValArg: 1.696 ± 0.342
4.918ValSer: 4.918 ± 0.807
4.155ValThr: 4.155 ± 0.647
4.155ValVal: 4.155 ± 0.655
0.424ValTrp: 0.424 ± 0.226
2.035ValTyr: 2.035 ± 0.531
0.0ValXaa: 0.0 ± 0.0
Trp
0.848TrpAla: 0.848 ± 0.195
0.17TrpCys: 0.17 ± 0.111
0.339TrpAsp: 0.339 ± 0.176
0.678TrpGlu: 0.678 ± 0.266
0.424TrpPhe: 0.424 ± 0.183
0.424TrpGly: 0.424 ± 0.172
0.085TrpHis: 0.085 ± 0.091
0.424TrpIle: 0.424 ± 0.162
0.848TrpLys: 0.848 ± 0.271
0.933TrpLeu: 0.933 ± 0.307
0.594TrpMet: 0.594 ± 0.204
0.678TrpAsn: 0.678 ± 0.234
0.085TrpPro: 0.085 ± 0.086
0.339TrpGln: 0.339 ± 0.161
1.017TrpArg: 1.017 ± 0.346
1.017TrpSer: 1.017 ± 0.272
0.509TrpThr: 0.509 ± 0.219
0.424TrpVal: 0.424 ± 0.194
0.085TrpTrp: 0.085 ± 0.089
0.509TrpTyr: 0.509 ± 0.242
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.205TyrAla: 2.205 ± 0.544
0.678TyrCys: 0.678 ± 0.246
2.374TyrAsp: 2.374 ± 0.562
1.611TyrGlu: 1.611 ± 0.388
1.526TyrPhe: 1.526 ± 0.385
2.544TyrGly: 2.544 ± 0.439
0.594TyrHis: 0.594 ± 0.262
2.035TyrIle: 2.035 ± 0.466
2.628TyrLys: 2.628 ± 0.503
2.374TyrLeu: 2.374 ± 0.683
0.678TyrMet: 0.678 ± 0.226
2.459TyrAsn: 2.459 ± 0.367
0.933TyrPro: 0.933 ± 0.361
2.374TyrGln: 2.374 ± 0.422
1.611TyrArg: 1.611 ± 0.383
2.628TyrSer: 2.628 ± 0.628
2.798TyrThr: 2.798 ± 0.392
2.459TyrVal: 2.459 ± 0.491
0.848TyrTrp: 0.848 ± 0.267
1.017TyrTyr: 1.017 ± 0.371
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 66 proteins (11795 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski