Amino acid dipepetide frequency for Streptococcus phage Javan270

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.462AlaAla: 3.462 ± 0.998
0.692AlaCys: 0.692 ± 0.299
4.154AlaAsp: 4.154 ± 0.615
4.55AlaGlu: 4.55 ± 0.687
2.473AlaPhe: 2.473 ± 0.608
3.462AlaGly: 3.462 ± 0.908
0.692AlaHis: 0.692 ± 0.202
5.341AlaIle: 5.341 ± 0.811
5.44AlaLys: 5.44 ± 0.725
7.813AlaLeu: 7.813 ± 1.002
2.077AlaMet: 2.077 ± 0.507
3.758AlaAsn: 3.758 ± 0.572
1.385AlaPro: 1.385 ± 0.366
2.473AlaGln: 2.473 ± 0.692
3.462AlaArg: 3.462 ± 0.627
4.55AlaSer: 4.55 ± 0.68
4.055AlaThr: 4.055 ± 0.718
3.363AlaVal: 3.363 ± 0.803
1.484AlaTrp: 1.484 ± 0.343
1.681AlaTyr: 1.681 ± 0.326
0.0AlaXaa: 0.0 ± 0.0
Cys
0.495CysAla: 0.495 ± 0.232
0.0CysCys: 0.0 ± 0.0
0.396CysAsp: 0.396 ± 0.179
0.297CysGlu: 0.297 ± 0.18
0.099CysPhe: 0.099 ± 0.086
0.297CysGly: 0.297 ± 0.185
0.0CysHis: 0.0 ± 0.0
0.791CysIle: 0.791 ± 0.339
0.495CysLys: 0.495 ± 0.211
0.692CysLeu: 0.692 ± 0.286
0.0CysMet: 0.0 ± 0.0
0.198CysAsn: 0.198 ± 0.14
0.198CysPro: 0.198 ± 0.146
0.297CysGln: 0.297 ± 0.169
0.396CysArg: 0.396 ± 0.179
0.198CysSer: 0.198 ± 0.159
0.0CysThr: 0.0 ± 0.0
0.198CysVal: 0.198 ± 0.121
0.198CysTrp: 0.198 ± 0.132
0.297CysTyr: 0.297 ± 0.144
0.0CysXaa: 0.0 ± 0.0
Asp
3.659AspAla: 3.659 ± 0.747
0.692AspCys: 0.692 ± 0.301
4.253AspAsp: 4.253 ± 0.776
4.945AspGlu: 4.945 ± 0.669
2.868AspPhe: 2.868 ± 0.575
5.143AspGly: 5.143 ± 0.788
0.593AspHis: 0.593 ± 0.235
4.451AspIle: 4.451 ± 0.577
6.725AspLys: 6.725 ± 0.947
5.539AspLeu: 5.539 ± 0.848
1.879AspMet: 1.879 ± 0.38
3.264AspAsn: 3.264 ± 0.567
1.484AspPro: 1.484 ± 0.366
1.484AspGln: 1.484 ± 0.366
2.176AspArg: 2.176 ± 0.707
2.67AspSer: 2.67 ± 0.406
2.67AspThr: 2.67 ± 0.748
6.132AspVal: 6.132 ± 0.949
0.593AspTrp: 0.593 ± 0.234
2.571AspTyr: 2.571 ± 0.554
0.0AspXaa: 0.0 ± 0.0
Glu
5.539GluAla: 5.539 ± 0.75
0.297GluCys: 0.297 ± 0.156
5.143GluAsp: 5.143 ± 0.671
7.022GluGlu: 7.022 ± 0.898
4.352GluPhe: 4.352 ± 0.702
3.363GluGly: 3.363 ± 0.456
0.791GluHis: 0.791 ± 0.302
5.934GluIle: 5.934 ± 0.824
8.209GluLys: 8.209 ± 0.944
7.22GluLeu: 7.22 ± 0.977
2.077GluMet: 2.077 ± 0.496
5.539GluAsn: 5.539 ± 0.92
2.176GluPro: 2.176 ± 0.544
3.363GluGln: 3.363 ± 0.536
2.769GluArg: 2.769 ± 0.642
4.055GluSer: 4.055 ± 0.444
2.868GluThr: 2.868 ± 0.551
5.044GluVal: 5.044 ± 0.646
1.385GluTrp: 1.385 ± 0.4
2.769GluTyr: 2.769 ± 0.505
0.0GluXaa: 0.0 ± 0.0
Phe
3.264PheAla: 3.264 ± 0.58
0.099PheCys: 0.099 ± 0.109
3.264PheAsp: 3.264 ± 0.546
3.857PheGlu: 3.857 ± 0.615
1.78PhePhe: 1.78 ± 0.399
2.571PheGly: 2.571 ± 0.588
0.396PheHis: 0.396 ± 0.186
3.264PheIle: 3.264 ± 0.656
3.264PheLys: 3.264 ± 0.582
3.758PheLeu: 3.758 ± 0.624
1.78PheMet: 1.78 ± 0.46
2.473PheAsn: 2.473 ± 0.521
0.89PhePro: 0.89 ± 0.26
1.978PheGln: 1.978 ± 0.417
1.879PheArg: 1.879 ± 0.444
2.769PheSer: 2.769 ± 0.449
2.571PheThr: 2.571 ± 0.49
2.275PheVal: 2.275 ± 0.506
0.297PheTrp: 0.297 ± 0.144
2.077PheTyr: 2.077 ± 0.652
0.0PheXaa: 0.0 ± 0.0
Gly
2.67GlyAla: 2.67 ± 0.653
0.099GlyCys: 0.099 ± 0.09
4.055GlyAsp: 4.055 ± 0.635
3.659GlyGlu: 3.659 ± 0.533
4.451GlyPhe: 4.451 ± 0.796
3.857GlyGly: 3.857 ± 0.544
0.495GlyHis: 0.495 ± 0.236
3.956GlyIle: 3.956 ± 0.618
5.637GlyLys: 5.637 ± 0.629
6.033GlyLeu: 6.033 ± 1.068
1.187GlyMet: 1.187 ± 0.359
3.264GlyAsn: 3.264 ± 0.752
0.791GlyPro: 0.791 ± 0.222
3.758GlyGln: 3.758 ± 0.593
2.571GlyArg: 2.571 ± 0.536
3.363GlySer: 3.363 ± 0.618
4.253GlyThr: 4.253 ± 0.646
3.264GlyVal: 3.264 ± 0.715
0.989GlyTrp: 0.989 ± 0.377
2.473GlyTyr: 2.473 ± 0.606
0.0GlyXaa: 0.0 ± 0.0
His
1.088HisAla: 1.088 ± 0.27
0.099HisCys: 0.099 ± 0.101
1.187HisAsp: 1.187 ± 0.289
0.593HisGlu: 0.593 ± 0.221
0.692HisPhe: 0.692 ± 0.252
1.286HisGly: 1.286 ± 0.39
0.297HisHis: 0.297 ± 0.174
0.989HisIle: 0.989 ± 0.296
0.495HisLys: 0.495 ± 0.212
1.582HisLeu: 1.582 ± 0.393
0.0HisMet: 0.0 ± 0.0
1.385HisAsn: 1.385 ± 0.336
0.791HisPro: 0.791 ± 0.242
0.495HisGln: 0.495 ± 0.202
0.297HisArg: 0.297 ± 0.164
1.484HisSer: 1.484 ± 0.447
1.286HisThr: 1.286 ± 0.464
0.692HisVal: 0.692 ± 0.309
0.0HisTrp: 0.0 ± 0.0
0.396HisTyr: 0.396 ± 0.197
0.0HisXaa: 0.0 ± 0.0
Ile
5.242IleAla: 5.242 ± 0.921
0.692IleCys: 0.692 ± 0.298
5.044IleAsp: 5.044 ± 0.602
7.22IleGlu: 7.22 ± 0.997
3.165IlePhe: 3.165 ± 0.544
5.044IleGly: 5.044 ± 0.623
1.286IleHis: 1.286 ± 0.27
4.154IleIle: 4.154 ± 0.652
6.033IleLys: 6.033 ± 0.854
4.747IleLeu: 4.747 ± 0.881
1.582IleMet: 1.582 ± 0.391
3.363IleAsn: 3.363 ± 0.503
2.176IlePro: 2.176 ± 0.42
3.066IleGln: 3.066 ± 0.521
3.758IleArg: 3.758 ± 0.535
3.857IleSer: 3.857 ± 0.72
4.253IleThr: 4.253 ± 0.561
2.769IleVal: 2.769 ± 0.421
0.396IleTrp: 0.396 ± 0.209
2.473IleTyr: 2.473 ± 0.404
0.0IleXaa: 0.0 ± 0.0
Lys
5.539LysAla: 5.539 ± 0.833
0.198LysCys: 0.198 ± 0.137
5.44LysAsp: 5.44 ± 0.595
7.714LysGlu: 7.714 ± 0.893
3.758LysPhe: 3.758 ± 0.511
3.956LysGly: 3.956 ± 0.577
2.077LysHis: 2.077 ± 0.457
6.231LysIle: 6.231 ± 1.048
5.539LysLys: 5.539 ± 0.693
7.022LysLeu: 7.022 ± 0.608
2.473LysMet: 2.473 ± 0.494
5.044LysAsn: 5.044 ± 0.59
2.571LysPro: 2.571 ± 0.472
5.143LysGln: 5.143 ± 0.73
4.55LysArg: 4.55 ± 0.785
4.055LysSer: 4.055 ± 0.606
5.44LysThr: 5.44 ± 0.496
4.55LysVal: 4.55 ± 0.534
1.582LysTrp: 1.582 ± 0.436
2.868LysTyr: 2.868 ± 0.526
0.0LysXaa: 0.0 ± 0.0
Leu
5.934LeuAla: 5.934 ± 0.942
0.89LeuCys: 0.89 ± 0.334
5.242LeuAsp: 5.242 ± 0.757
8.802LeuGlu: 8.802 ± 1.034
3.363LeuPhe: 3.363 ± 0.708
5.143LeuGly: 5.143 ± 1.215
0.791LeuHis: 0.791 ± 0.248
5.539LeuIle: 5.539 ± 0.873
8.802LeuLys: 8.802 ± 0.919
7.121LeuLeu: 7.121 ± 0.906
2.077LeuMet: 2.077 ± 0.484
5.341LeuAsn: 5.341 ± 0.625
2.769LeuPro: 2.769 ± 0.473
1.978LeuGln: 1.978 ± 0.51
4.253LeuArg: 4.253 ± 0.64
5.934LeuSer: 5.934 ± 0.686
5.44LeuThr: 5.44 ± 0.998
5.242LeuVal: 5.242 ± 0.6
0.593LeuTrp: 0.593 ± 0.314
3.462LeuTyr: 3.462 ± 0.692
0.0LeuXaa: 0.0 ± 0.0
Met
2.868MetAla: 2.868 ± 0.507
0.0MetCys: 0.0 ± 0.0
1.088MetAsp: 1.088 ± 0.342
1.978MetGlu: 1.978 ± 0.393
1.187MetPhe: 1.187 ± 0.373
1.088MetGly: 1.088 ± 0.308
0.297MetHis: 0.297 ± 0.228
2.176MetIle: 2.176 ± 0.487
2.176MetLys: 2.176 ± 0.509
1.385MetLeu: 1.385 ± 0.309
0.593MetMet: 0.593 ± 0.199
1.286MetAsn: 1.286 ± 0.36
0.495MetPro: 0.495 ± 0.198
0.495MetGln: 0.495 ± 0.228
0.989MetArg: 0.989 ± 0.32
2.67MetSer: 2.67 ± 0.523
1.978MetThr: 1.978 ± 0.415
1.286MetVal: 1.286 ± 0.441
0.198MetTrp: 0.198 ± 0.146
0.89MetTyr: 0.89 ± 0.273
0.0MetXaa: 0.0 ± 0.0
Asn
2.967AsnAla: 2.967 ± 0.546
0.099AsnCys: 0.099 ± 0.101
3.56AsnAsp: 3.56 ± 0.64
4.648AsnGlu: 4.648 ± 0.551
1.879AsnPhe: 1.879 ± 0.309
5.242AsnGly: 5.242 ± 0.721
0.791AsnHis: 0.791 ± 0.242
4.55AsnIle: 4.55 ± 0.66
4.55AsnLys: 4.55 ± 0.706
5.044AsnLeu: 5.044 ± 0.698
0.692AsnMet: 0.692 ± 0.247
3.066AsnAsn: 3.066 ± 0.569
1.879AsnPro: 1.879 ± 0.346
3.066AsnGln: 3.066 ± 0.493
1.978AsnArg: 1.978 ± 0.466
4.253AsnSer: 4.253 ± 0.863
2.868AsnThr: 2.868 ± 0.403
3.165AsnVal: 3.165 ± 0.571
0.989AsnTrp: 0.989 ± 0.284
1.681AsnTyr: 1.681 ± 0.536
0.0AsnXaa: 0.0 ± 0.0
Pro
1.484ProAla: 1.484 ± 0.422
0.099ProCys: 0.099 ± 0.084
2.077ProAsp: 2.077 ± 0.483
1.978ProGlu: 1.978 ± 0.507
0.791ProPhe: 0.791 ± 0.224
1.385ProGly: 1.385 ± 0.276
0.89ProHis: 0.89 ± 0.288
1.681ProIle: 1.681 ± 0.448
2.571ProLys: 2.571 ± 0.59
2.769ProLeu: 2.769 ± 0.445
0.593ProMet: 0.593 ± 0.232
1.088ProAsn: 1.088 ± 0.403
0.396ProPro: 0.396 ± 0.176
0.593ProGln: 0.593 ± 0.32
0.593ProArg: 0.593 ± 0.268
2.077ProSer: 2.077 ± 0.408
1.582ProThr: 1.582 ± 0.371
1.78ProVal: 1.78 ± 0.385
0.297ProTrp: 0.297 ± 0.176
0.989ProTyr: 0.989 ± 0.253
0.0ProXaa: 0.0 ± 0.0
Gln
3.462GlnAla: 3.462 ± 0.824
0.099GlnCys: 0.099 ± 0.101
2.176GlnAsp: 2.176 ± 0.5
3.165GlnGlu: 3.165 ± 0.459
2.473GlnPhe: 2.473 ± 0.502
1.681GlnGly: 1.681 ± 0.402
0.593GlnHis: 0.593 ± 0.241
3.264GlnIle: 3.264 ± 0.573
2.868GlnLys: 2.868 ± 0.433
3.857GlnLeu: 3.857 ± 0.76
0.791GlnMet: 0.791 ± 0.242
2.473GlnAsn: 2.473 ± 0.519
0.89GlnPro: 0.89 ± 0.307
1.088GlnGln: 1.088 ± 0.387
2.176GlnArg: 2.176 ± 0.304
2.67GlnSer: 2.67 ± 0.467
2.176GlnThr: 2.176 ± 0.58
2.868GlnVal: 2.868 ± 0.763
0.099GlnTrp: 0.099 ± 0.086
1.681GlnTyr: 1.681 ± 0.414
0.0GlnXaa: 0.0 ± 0.0
Arg
1.484ArgAla: 1.484 ± 0.36
0.198ArgCys: 0.198 ± 0.136
2.176ArgAsp: 2.176 ± 0.419
2.967ArgGlu: 2.967 ± 0.426
1.978ArgPhe: 1.978 ± 0.369
2.077ArgGly: 2.077 ± 0.412
1.088ArgHis: 1.088 ± 0.28
2.769ArgIle: 2.769 ± 0.645
3.758ArgLys: 3.758 ± 0.851
5.044ArgLeu: 5.044 ± 0.847
1.385ArgMet: 1.385 ± 0.392
3.066ArgAsn: 3.066 ± 0.61
0.791ArgPro: 0.791 ± 0.289
1.78ArgGln: 1.78 ± 0.488
1.681ArgArg: 1.681 ± 0.577
2.67ArgSer: 2.67 ± 0.512
2.571ArgThr: 2.571 ± 0.465
1.681ArgVal: 1.681 ± 0.317
1.187ArgTrp: 1.187 ± 0.357
1.978ArgTyr: 1.978 ± 0.344
0.0ArgXaa: 0.0 ± 0.0
Ser
4.55SerAla: 4.55 ± 0.745
0.396SerCys: 0.396 ± 0.192
4.945SerAsp: 4.945 ± 0.714
4.846SerGlu: 4.846 ± 0.661
2.967SerPhe: 2.967 ± 0.542
4.154SerGly: 4.154 ± 0.499
0.791SerHis: 0.791 ± 0.227
3.659SerIle: 3.659 ± 0.607
4.451SerLys: 4.451 ± 0.667
5.341SerLeu: 5.341 ± 0.708
2.077SerMet: 2.077 ± 0.481
3.56SerAsn: 3.56 ± 0.571
1.681SerPro: 1.681 ± 0.434
2.67SerGln: 2.67 ± 0.58
3.066SerArg: 3.066 ± 0.436
4.154SerSer: 4.154 ± 0.659
3.363SerThr: 3.363 ± 0.563
3.165SerVal: 3.165 ± 0.416
1.088SerTrp: 1.088 ± 0.345
2.571SerTyr: 2.571 ± 0.579
0.0SerXaa: 0.0 ± 0.0
Thr
6.132ThrAla: 6.132 ± 1.259
0.198ThrCys: 0.198 ± 0.133
2.868ThrAsp: 2.868 ± 0.629
2.473ThrGlu: 2.473 ± 0.581
2.176ThrPhe: 2.176 ± 0.406
4.253ThrGly: 4.253 ± 0.509
0.989ThrHis: 0.989 ± 0.294
4.055ThrIle: 4.055 ± 0.73
5.637ThrLys: 5.637 ± 0.677
4.747ThrLeu: 4.747 ± 0.625
1.286ThrMet: 1.286 ± 0.353
3.066ThrAsn: 3.066 ± 0.416
1.286ThrPro: 1.286 ± 0.378
1.978ThrGln: 1.978 ± 0.485
1.385ThrArg: 1.385 ± 0.457
3.956ThrSer: 3.956 ± 0.593
4.055ThrThr: 4.055 ± 0.765
3.857ThrVal: 3.857 ± 0.641
0.396ThrTrp: 0.396 ± 0.175
2.473ThrTyr: 2.473 ± 0.564
0.0ThrXaa: 0.0 ± 0.0
Val
4.154ValAla: 4.154 ± 0.712
0.099ValCys: 0.099 ± 0.09
3.462ValAsp: 3.462 ± 0.526
4.451ValGlu: 4.451 ± 0.645
1.582ValPhe: 1.582 ± 0.388
4.253ValGly: 4.253 ± 0.519
0.692ValHis: 0.692 ± 0.331
3.956ValIle: 3.956 ± 0.619
4.846ValLys: 4.846 ± 0.769
3.857ValLeu: 3.857 ± 0.793
1.484ValMet: 1.484 ± 0.42
3.462ValAsn: 3.462 ± 0.724
1.582ValPro: 1.582 ± 0.423
2.374ValGln: 2.374 ± 0.452
2.473ValArg: 2.473 ± 0.428
5.143ValSer: 5.143 ± 0.835
3.165ValThr: 3.165 ± 0.59
3.758ValVal: 3.758 ± 0.801
0.495ValTrp: 0.495 ± 0.224
1.879ValTyr: 1.879 ± 0.372
0.0ValXaa: 0.0 ± 0.0
Trp
0.396TrpAla: 0.396 ± 0.159
0.198TrpCys: 0.198 ± 0.138
0.692TrpAsp: 0.692 ± 0.22
0.89TrpGlu: 0.89 ± 0.346
0.692TrpPhe: 0.692 ± 0.219
1.187TrpGly: 1.187 ± 0.386
0.198TrpHis: 0.198 ± 0.156
1.484TrpIle: 1.484 ± 0.349
1.088TrpLys: 1.088 ± 0.334
1.187TrpLeu: 1.187 ± 0.294
0.396TrpMet: 0.396 ± 0.238
0.692TrpAsn: 0.692 ± 0.267
0.099TrpPro: 0.099 ± 0.1
0.593TrpGln: 0.593 ± 0.213
0.396TrpArg: 0.396 ± 0.198
0.593TrpSer: 0.593 ± 0.24
0.297TrpThr: 0.297 ± 0.177
0.989TrpVal: 0.989 ± 0.297
0.198TrpTrp: 0.198 ± 0.168
0.692TrpTyr: 0.692 ± 0.415
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.978TyrAla: 1.978 ± 0.374
0.396TyrCys: 0.396 ± 0.177
2.571TyrAsp: 2.571 ± 0.423
3.857TyrGlu: 3.857 ± 0.608
1.78TyrPhe: 1.78 ± 0.463
1.484TyrGly: 1.484 ± 0.359
1.385TyrHis: 1.385 ± 0.392
2.077TyrIle: 2.077 ± 0.431
3.165TyrLys: 3.165 ± 0.521
3.956TyrLeu: 3.956 ± 0.803
0.593TyrMet: 0.593 ± 0.259
1.582TyrAsn: 1.582 ± 0.36
1.385TyrPro: 1.385 ± 0.41
1.879TyrGln: 1.879 ± 0.419
1.484TyrArg: 1.484 ± 0.403
2.374TyrSer: 2.374 ± 0.527
2.374TyrThr: 2.374 ± 0.487
1.088TyrVal: 1.088 ± 0.311
0.495TyrTrp: 0.495 ± 0.208
1.681TyrTyr: 1.681 ± 0.616
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 55 proteins (10112 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski