Amino acid dipepetide frequency for Mycoplasma falconis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.004AlaAla: 4.004 ± 0.198
0.392AlaCys: 0.392 ± 0.048
2.961AlaAsp: 2.961 ± 0.144
3.622AlaGlu: 3.622 ± 0.182
2.741AlaPhe: 2.741 ± 0.123
2.809AlaGly: 2.809 ± 0.134
0.724AlaHis: 0.724 ± 0.067
6.089AlaIle: 6.089 ± 0.185
7.156AlaLys: 7.156 ± 0.299
5.751AlaLeu: 5.751 ± 0.216
1.273AlaMet: 1.273 ± 0.095
4.615AlaAsn: 4.615 ± 0.218
1.243AlaPro: 1.243 ± 0.091
1.767AlaGln: 1.767 ± 0.099
2.158AlaArg: 2.158 ± 0.119
3.734AlaSer: 3.734 ± 0.142
3.123AlaThr: 3.123 ± 0.126
3.103AlaVal: 3.103 ± 0.125
0.533AlaTrp: 0.533 ± 0.067
2.623AlaTyr: 2.623 ± 0.109
0.0AlaXaa: 0.0 ± 0.0
Cys
0.303CysAla: 0.303 ± 0.042
0.069CysCys: 0.069 ± 0.019
0.357CysAsp: 0.357 ± 0.044
0.357CysGlu: 0.357 ± 0.05
0.303CysPhe: 0.303 ± 0.048
0.406CysGly: 0.406 ± 0.044
0.103CysHis: 0.103 ± 0.023
0.318CysIle: 0.318 ± 0.045
0.362CysLys: 0.362 ± 0.055
0.563CysLeu: 0.563 ± 0.058
0.064CysMet: 0.064 ± 0.019
0.313CysAsn: 0.313 ± 0.032
0.23CysPro: 0.23 ± 0.04
0.24CysGln: 0.24 ± 0.034
0.157CysArg: 0.157 ± 0.029
0.279CysSer: 0.279 ± 0.037
0.181CysThr: 0.181 ± 0.033
0.367CysVal: 0.367 ± 0.047
0.059CysTrp: 0.059 ± 0.016
0.142CysTyr: 0.142 ± 0.025
0.0CysXaa: 0.0 ± 0.0
Asp
3.005AspAla: 3.005 ± 0.179
0.21AspCys: 0.21 ± 0.03
2.501AspAsp: 2.501 ± 0.112
4.591AspGlu: 4.591 ± 0.203
3.681AspPhe: 3.681 ± 0.16
2.819AspGly: 2.819 ± 0.138
0.705AspHis: 0.705 ± 0.061
5.281AspIle: 5.281 ± 0.136
6.485AspLys: 6.485 ± 0.219
6.559AspLeu: 6.559 ± 0.222
0.852AspMet: 0.852 ± 0.073
4.013AspAsn: 4.013 ± 0.189
1.723AspPro: 1.723 ± 0.099
1.963AspGln: 1.963 ± 0.1
1.37AspArg: 1.37 ± 0.085
2.707AspSer: 2.707 ± 0.119
2.207AspThr: 2.207 ± 0.107
3.191AspVal: 3.191 ± 0.124
0.578AspTrp: 0.578 ± 0.05
2.961AspTyr: 2.961 ± 0.133
0.0AspXaa: 0.0 ± 0.0
Glu
4.655GluAla: 4.655 ± 0.21
0.24GluCys: 0.24 ± 0.042
4.121GluAsp: 4.121 ± 0.182
6.059GluGlu: 6.059 ± 0.25
3.318GluPhe: 3.318 ± 0.143
3.015GluGly: 3.015 ± 0.132
0.876GluHis: 0.876 ± 0.07
7.107GluIle: 7.107 ± 0.177
7.479GluLys: 7.479 ± 0.234
6.559GluLeu: 6.559 ± 0.196
1.532GluMet: 1.532 ± 0.1
5.824GluAsn: 5.824 ± 0.203
1.419GluPro: 1.419 ± 0.098
2.379GluGln: 2.379 ± 0.113
1.85GluArg: 1.85 ± 0.117
2.844GluSer: 2.844 ± 0.134
3.411GluThr: 3.411 ± 0.126
4.376GluVal: 4.376 ± 0.186
0.631GluTrp: 0.631 ± 0.052
2.971GluTyr: 2.971 ± 0.121
0.0GluXaa: 0.0 ± 0.0
Phe
3.093PheAla: 3.093 ± 0.135
0.303PheCys: 0.303 ± 0.041
3.397PheAsp: 3.397 ± 0.137
3.632PheGlu: 3.632 ± 0.142
2.002PhePhe: 2.002 ± 0.112
2.751PheGly: 2.751 ± 0.125
0.45PheHis: 0.45 ± 0.056
4.713PheIle: 4.713 ± 0.218
4.748PheLys: 4.748 ± 0.16
4.341PheLeu: 4.341 ± 0.18
0.886PheMet: 0.886 ± 0.067
3.999PheAsn: 3.999 ± 0.155
1.155PhePro: 1.155 ± 0.086
1.101PheGln: 1.101 ± 0.083
1.184PheArg: 1.184 ± 0.08
3.162PheSer: 3.162 ± 0.131
2.222PheThr: 2.222 ± 0.119
3.304PheVal: 3.304 ± 0.145
0.504PheTrp: 0.504 ± 0.049
2.1PheTyr: 2.1 ± 0.101
0.0PheXaa: 0.0 ± 0.0
Gly
2.902GlyAla: 2.902 ± 0.137
0.22GlyCys: 0.22 ± 0.04
2.457GlyAsp: 2.457 ± 0.118
2.858GlyGlu: 2.858 ± 0.126
2.711GlyPhe: 2.711 ± 0.124
2.927GlyGly: 2.927 ± 0.171
0.901GlyHis: 0.901 ± 0.073
4.42GlyIle: 4.42 ± 0.169
4.214GlyLys: 4.214 ± 0.151
4.689GlyLeu: 4.689 ± 0.163
0.974GlyMet: 0.974 ± 0.076
2.511GlyAsn: 2.511 ± 0.123
1.189GlyPro: 1.189 ± 0.093
1.703GlyGln: 1.703 ± 0.107
1.718GlyArg: 1.718 ± 0.108
2.966GlySer: 2.966 ± 0.12
2.32GlyThr: 2.32 ± 0.129
3.132GlyVal: 3.132 ± 0.149
0.602GlyTrp: 0.602 ± 0.054
2.261GlyTyr: 2.261 ± 0.113
0.0GlyXaa: 0.0 ± 0.0
His
0.803HisAla: 0.803 ± 0.06
0.073HisCys: 0.073 ± 0.019
0.671HisAsp: 0.671 ± 0.063
0.915HisGlu: 0.915 ± 0.065
0.812HisPhe: 0.812 ± 0.067
0.812HisGly: 0.812 ± 0.071
0.25HisHis: 0.25 ± 0.037
1.189HisIle: 1.189 ± 0.085
1.155HisLys: 1.155 ± 0.086
1.463HisLeu: 1.463 ± 0.093
0.245HisMet: 0.245 ± 0.036
0.925HisAsn: 0.925 ± 0.073
0.607HisPro: 0.607 ± 0.06
0.494HisGln: 0.494 ± 0.05
0.514HisArg: 0.514 ± 0.055
0.886HisSer: 0.886 ± 0.067
0.587HisThr: 0.587 ± 0.049
0.734HisVal: 0.734 ± 0.061
0.117HisTrp: 0.117 ± 0.021
0.553HisTyr: 0.553 ± 0.058
0.0HisXaa: 0.0 ± 0.0
Ile
5.516IleAla: 5.516 ± 0.196
0.719IleCys: 0.719 ± 0.079
5.976IleAsp: 5.976 ± 0.197
6.187IleGlu: 6.187 ± 0.164
4.287IlePhe: 4.287 ± 0.184
4.048IleGly: 4.048 ± 0.135
1.082IleHis: 1.082 ± 0.081
8.149IleIle: 8.149 ± 0.275
9.573IleLys: 9.573 ± 0.272
7.645IleLeu: 7.645 ± 0.246
1.556IleMet: 1.556 ± 0.091
8.149IleAsn: 8.149 ± 0.276
2.756IlePro: 2.756 ± 0.126
2.374IleGln: 2.374 ± 0.119
2.472IleArg: 2.472 ± 0.124
6.167IleSer: 6.167 ± 0.197
4.743IleThr: 4.743 ± 0.16
5.237IleVal: 5.237 ± 0.199
0.7IleTrp: 0.7 ± 0.063
4.053IleTyr: 4.053 ± 0.135
0.0IleXaa: 0.0 ± 0.0
Lys
6.328LysAla: 6.328 ± 0.266
0.382LysCys: 0.382 ± 0.046
6.309LysAsp: 6.309 ± 0.227
8.33LysGlu: 8.33 ± 0.259
3.774LysPhe: 3.774 ± 0.152
3.71LysGly: 3.71 ± 0.145
1.556LysHis: 1.556 ± 0.083
8.957LysIle: 8.957 ± 0.253
9.162LysLys: 9.162 ± 0.235
9.113LysLeu: 9.113 ± 0.242
2.638LysMet: 2.638 ± 0.12
8.962LysAsn: 8.962 ± 0.285
2.99LysPro: 2.99 ± 0.134
4.239LysGln: 4.239 ± 0.163
2.878LysArg: 2.878 ± 0.12
4.968LysSer: 4.968 ± 0.142
5.345LysThr: 5.345 ± 0.18
5.374LysVal: 5.374 ± 0.172
0.93LysTrp: 0.93 ± 0.079
4.968LysTyr: 4.968 ± 0.175
0.0LysXaa: 0.0 ± 0.0
Leu
6.324LeuAla: 6.324 ± 0.204
0.411LeuCys: 0.411 ± 0.046
5.819LeuAsp: 5.819 ± 0.227
6.749LeuGlu: 6.749 ± 0.229
4.483LeuPhe: 4.483 ± 0.197
4.694LeuGly: 4.694 ± 0.177
1.204LeuHis: 1.204 ± 0.082
8.986LeuIle: 8.986 ± 0.254
9.412LeuLys: 9.412 ± 0.242
8.193LeuLeu: 8.193 ± 0.272
1.689LeuMet: 1.689 ± 0.102
8.59LeuAsn: 8.59 ± 0.356
3.064LeuPro: 3.064 ± 0.121
2.741LeuGln: 2.741 ± 0.126
2.658LeuArg: 2.658 ± 0.124
6.358LeuSer: 6.358 ± 0.209
5.291LeuThr: 5.291 ± 0.17
5.281LeuVal: 5.281 ± 0.157
0.646LeuTrp: 0.646 ± 0.061
3.074LeuTyr: 3.074 ± 0.119
0.0LeuXaa: 0.0 ± 0.0
Met
1.405MetAla: 1.405 ± 0.082
0.093MetCys: 0.093 ± 0.022
0.852MetAsp: 0.852 ± 0.079
1.082MetGlu: 1.082 ± 0.09
1.126MetPhe: 1.126 ± 0.083
0.852MetGly: 0.852 ± 0.08
0.323MetHis: 0.323 ± 0.036
1.645MetIle: 1.645 ± 0.11
1.816MetLys: 1.816 ± 0.089
1.669MetLeu: 1.669 ± 0.087
0.524MetMet: 0.524 ± 0.057
1.219MetAsn: 1.219 ± 0.066
0.724MetPro: 0.724 ± 0.063
0.7MetGln: 0.7 ± 0.052
0.524MetArg: 0.524 ± 0.055
1.395MetSer: 1.395 ± 0.096
1.077MetThr: 1.077 ± 0.083
1.003MetVal: 1.003 ± 0.073
0.176MetTrp: 0.176 ± 0.028
0.602MetTyr: 0.602 ± 0.058
0.0MetXaa: 0.0 ± 0.0
Asn
3.842AsnAla: 3.842 ± 0.213
0.284AsnCys: 0.284 ± 0.037
4.395AsnAsp: 4.395 ± 0.205
5.247AsnGlu: 5.247 ± 0.188
3.778AsnPhe: 3.778 ± 0.165
3.504AsnGly: 3.504 ± 0.175
0.935AsnHis: 0.935 ± 0.074
7.112AsnIle: 7.112 ± 0.253
9.706AsnLys: 9.706 ± 0.297
8.311AsnLeu: 8.311 ± 0.318
1.224AsnMet: 1.224 ± 0.077
7.464AsnAsn: 7.464 ± 0.34
2.648AsnPro: 2.648 ± 0.131
3.372AsnGln: 3.372 ± 0.16
1.747AsnArg: 1.747 ± 0.093
4.405AsnSer: 4.405 ± 0.148
3.035AsnThr: 3.035 ± 0.16
3.945AsnVal: 3.945 ± 0.129
0.891AsnTrp: 0.891 ± 0.063
3.769AsnTyr: 3.769 ± 0.175
0.0AsnXaa: 0.0 ± 0.0
Pro
1.796ProAla: 1.796 ± 0.107
0.181ProCys: 0.181 ± 0.03
1.556ProAsp: 1.556 ± 0.092
2.413ProGlu: 2.413 ± 0.109
1.488ProPhe: 1.488 ± 0.092
1.258ProGly: 1.258 ± 0.083
0.548ProHis: 0.548 ± 0.052
2.53ProIle: 2.53 ± 0.127
2.574ProLys: 2.574 ± 0.117
2.526ProLeu: 2.526 ± 0.109
0.489ProMet: 0.489 ± 0.054
2.041ProAsn: 2.041 ± 0.098
0.533ProPro: 0.533 ± 0.07
1.091ProGln: 1.091 ± 0.078
0.666ProArg: 0.666 ± 0.059
1.801ProSer: 1.801 ± 0.095
1.63ProThr: 1.63 ± 0.102
1.821ProVal: 1.821 ± 0.106
0.313ProTrp: 0.313 ± 0.039
1.429ProTyr: 1.429 ± 0.095
0.0ProXaa: 0.0 ± 0.0
Gln
2.291GlnAla: 2.291 ± 0.123
0.117GlnCys: 0.117 ± 0.026
1.767GlnAsp: 1.767 ± 0.099
2.55GlnGlu: 2.55 ± 0.122
1.449GlnPhe: 1.449 ± 0.087
1.268GlnGly: 1.268 ± 0.069
0.475GlnHis: 0.475 ± 0.053
3.294GlnIle: 3.294 ± 0.136
3.73GlnLys: 3.73 ± 0.144
3.221GlnLeu: 3.221 ± 0.124
0.671GlnMet: 0.671 ± 0.064
2.77GlnAsn: 2.77 ± 0.134
0.984GlnPro: 0.984 ± 0.074
1.385GlnGln: 1.385 ± 0.095
1.062GlnArg: 1.062 ± 0.07
1.591GlnSer: 1.591 ± 0.098
1.86GlnThr: 1.86 ± 0.104
1.982GlnVal: 1.982 ± 0.093
0.279GlnTrp: 0.279 ± 0.039
1.449GlnTyr: 1.449 ± 0.075
0.0GlnXaa: 0.0 ± 0.0
Arg
1.61ArgAla: 1.61 ± 0.11
0.166ArgCys: 0.166 ± 0.034
1.478ArgAsp: 1.478 ± 0.092
2.002ArgGlu: 2.002 ± 0.119
1.37ArgPhe: 1.37 ± 0.08
1.488ArgGly: 1.488 ± 0.102
0.538ArgHis: 0.538 ± 0.053
2.457ArgIle: 2.457 ± 0.118
2.672ArgLys: 2.672 ± 0.134
2.804ArgLeu: 2.804 ± 0.128
0.592ArgMet: 0.592 ± 0.058
2.178ArgAsn: 2.178 ± 0.111
0.915ArgPro: 0.915 ± 0.069
1.214ArgGln: 1.214 ± 0.086
1.175ArgArg: 1.175 ± 0.079
1.459ArgSer: 1.459 ± 0.091
1.321ArgThr: 1.321 ± 0.083
1.762ArgVal: 1.762 ± 0.11
0.279ArgTrp: 0.279 ± 0.039
1.209ArgTyr: 1.209 ± 0.084
0.0ArgXaa: 0.0 ± 0.0
Ser
3.035SerAla: 3.035 ± 0.137
0.392SerCys: 0.392 ± 0.046
3.436SerAsp: 3.436 ± 0.15
4.15SerGlu: 4.15 ± 0.125
3.465SerPhe: 3.465 ± 0.14
3.088SerGly: 3.088 ± 0.126
0.803SerHis: 0.803 ± 0.063
5.257SerIle: 5.257 ± 0.165
5.589SerLys: 5.589 ± 0.172
6.25SerLeu: 6.25 ± 0.175
0.866SerMet: 0.866 ± 0.058
4.141SerAsn: 4.141 ± 0.165
1.463SerPro: 1.463 ± 0.085
2.168SerGln: 2.168 ± 0.112
1.723SerArg: 1.723 ± 0.106
3.979SerSer: 3.979 ± 0.157
2.726SerThr: 2.726 ± 0.104
3.074SerVal: 3.074 ± 0.119
0.563SerTrp: 0.563 ± 0.046
2.628SerTyr: 2.628 ± 0.121
0.0SerXaa: 0.0 ± 0.0
Thr
2.8ThrAla: 2.8 ± 0.13
0.264ThrCys: 0.264 ± 0.037
2.276ThrAsp: 2.276 ± 0.114
2.379ThrGlu: 2.379 ± 0.133
2.486ThrPhe: 2.486 ± 0.129
2.57ThrGly: 2.57 ± 0.13
0.739ThrHis: 0.739 ± 0.063
4.527ThrIle: 4.527 ± 0.137
4.606ThrLys: 4.606 ± 0.152
4.694ThrLeu: 4.694 ± 0.156
0.793ThrMet: 0.793 ± 0.07
3.891ThrAsn: 3.891 ± 0.164
1.948ThrPro: 1.948 ± 0.091
1.547ThrGln: 1.547 ± 0.098
1.463ThrArg: 1.463 ± 0.092
3.333ThrSer: 3.333 ± 0.111
2.883ThrThr: 2.883 ± 0.142
2.775ThrVal: 2.775 ± 0.119
0.489ThrTrp: 0.489 ± 0.049
2.237ThrTyr: 2.237 ± 0.113
0.0ThrXaa: 0.0 ± 0.0
Val
3.876ValAla: 3.876 ± 0.161
0.362ValCys: 0.362 ± 0.045
3.818ValAsp: 3.818 ± 0.132
4.067ValGlu: 4.067 ± 0.156
2.834ValPhe: 2.834 ± 0.111
2.912ValGly: 2.912 ± 0.135
0.685ValHis: 0.685 ± 0.061
4.978ValIle: 4.978 ± 0.177
5.408ValLys: 5.408 ± 0.21
5.57ValLeu: 5.57 ± 0.17
1.013ValMet: 1.013 ± 0.075
4.214ValAsn: 4.214 ± 0.142
1.625ValPro: 1.625 ± 0.105
1.356ValGln: 1.356 ± 0.095
1.669ValArg: 1.669 ± 0.098
3.651ValSer: 3.651 ± 0.13
2.325ValThr: 2.325 ± 0.111
3.73ValVal: 3.73 ± 0.164
0.558ValTrp: 0.558 ± 0.065
2.344ValTyr: 2.344 ± 0.099
0.0ValXaa: 0.0 ± 0.0
Trp
0.558TrpAla: 0.558 ± 0.049
0.049TrpCys: 0.049 ± 0.015
0.538TrpAsp: 0.538 ± 0.047
0.612TrpGlu: 0.612 ± 0.062
0.524TrpPhe: 0.524 ± 0.052
0.436TrpGly: 0.436 ± 0.049
0.152TrpHis: 0.152 ± 0.028
0.876TrpIle: 0.876 ± 0.068
0.852TrpLys: 0.852 ± 0.064
0.881TrpLeu: 0.881 ± 0.071
0.299TrpMet: 0.299 ± 0.035
0.788TrpAsn: 0.788 ± 0.075
0.274TrpPro: 0.274 ± 0.039
0.318TrpGln: 0.318 ± 0.043
0.377TrpArg: 0.377 ± 0.044
0.548TrpSer: 0.548 ± 0.051
0.436TrpThr: 0.436 ± 0.046
0.489TrpVal: 0.489 ± 0.052
0.108TrpTrp: 0.108 ± 0.022
0.367TrpTyr: 0.367 ± 0.047
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.276TyrAla: 2.276 ± 0.11
0.245TyrCys: 0.245 ± 0.035
2.716TyrAsp: 2.716 ± 0.123
2.868TyrGlu: 2.868 ± 0.122
2.413TyrPhe: 2.413 ± 0.127
2.31TyrGly: 2.31 ± 0.118
0.759TyrHis: 0.759 ± 0.064
3.504TyrIle: 3.504 ± 0.15
4.214TyrLys: 4.214 ± 0.149
4.865TyrLeu: 4.865 ± 0.162
0.626TyrMet: 0.626 ± 0.066
3.005TyrAsn: 3.005 ± 0.143
1.194TyrPro: 1.194 ± 0.089
2.041TyrGln: 2.041 ± 0.106
1.326TyrArg: 1.326 ± 0.087
2.565TyrSer: 2.565 ± 0.109
1.977TyrThr: 1.977 ± 0.1
2.315TyrVal: 2.315 ± 0.128
0.524TyrTrp: 0.524 ± 0.05
2.139TyrTyr: 2.139 ± 0.118
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 563 proteins (204316 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski