Amino acid dipepetide frequency for Scardovia inopinata F0304

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.17AlaAla: 10.17 ± 0.223
0.908AlaCys: 0.908 ± 0.043
5.95AlaAsp: 5.95 ± 0.109
4.495AlaGlu: 4.495 ± 0.11
3.165AlaPhe: 3.165 ± 0.086
7.199AlaGly: 7.199 ± 0.135
2.113AlaHis: 2.113 ± 0.068
5.007AlaIle: 5.007 ± 0.107
3.845AlaLys: 3.845 ± 0.103
9.396AlaLeu: 9.396 ± 0.174
2.246AlaMet: 2.246 ± 0.063
2.84AlaAsn: 2.84 ± 0.074
3.107AlaPro: 3.107 ± 0.085
4.869AlaGln: 4.869 ± 0.112
5.158AlaArg: 5.158 ± 0.111
6.555AlaSer: 6.555 ± 0.129
4.431AlaThr: 4.431 ± 0.101
6.884AlaVal: 6.884 ± 0.131
1.166AlaTrp: 1.166 ± 0.043
2.808AlaTyr: 2.808 ± 0.083
0.0AlaXaa: 0.0 ± 0.0
Cys
0.74CysAla: 0.74 ± 0.04
0.104CysCys: 0.104 ± 0.014
0.488CysAsp: 0.488 ± 0.029
0.382CysGlu: 0.382 ± 0.031
0.345CysPhe: 0.345 ± 0.024
0.906CysGly: 0.906 ± 0.044
0.209CysHis: 0.209 ± 0.022
0.497CysIle: 0.497 ± 0.029
0.254CysLys: 0.254 ± 0.022
1.017CysLeu: 1.017 ± 0.048
0.183CysMet: 0.183 ± 0.018
0.217CysAsn: 0.217 ± 0.021
0.471CysPro: 0.471 ± 0.039
0.409CysGln: 0.409 ± 0.031
0.529CysArg: 0.529 ± 0.031
0.668CysSer: 0.668 ± 0.033
0.505CysThr: 0.505 ± 0.035
0.503CysVal: 0.503 ± 0.032
0.107CysTrp: 0.107 ± 0.016
0.232CysTyr: 0.232 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
4.7AspAla: 4.7 ± 0.106
0.565AspCys: 0.565 ± 0.034
3.87AspAsp: 3.87 ± 0.114
3.316AspGlu: 3.316 ± 0.095
2.472AspPhe: 2.472 ± 0.079
4.235AspGly: 4.235 ± 0.111
1.269AspHis: 1.269 ± 0.053
3.531AspIle: 3.531 ± 0.083
3.007AspLys: 3.007 ± 0.096
5.698AspLeu: 5.698 ± 0.118
1.537AspMet: 1.537 ± 0.055
2.122AspAsn: 2.122 ± 0.076
3.263AspPro: 3.263 ± 0.087
3.067AspGln: 3.067 ± 0.091
3.437AspArg: 3.437 ± 0.121
4.981AspSer: 4.981 ± 0.125
3.066AspThr: 3.066 ± 0.09
3.438AspVal: 3.438 ± 0.101
0.87AspTrp: 0.87 ± 0.043
2.096AspTyr: 2.096 ± 0.067
0.0AspXaa: 0.0 ± 0.0
Glu
4.832GluAla: 4.832 ± 0.108
0.395GluCys: 0.395 ± 0.031
3.269GluAsp: 3.269 ± 0.086
3.8GluGlu: 3.8 ± 0.11
1.685GluPhe: 1.685 ± 0.057
3.608GluGly: 3.608 ± 0.089
1.068GluHis: 1.068 ± 0.047
3.086GluIle: 3.086 ± 0.078
3.163GluLys: 3.163 ± 0.097
4.246GluLeu: 4.246 ± 0.099
1.126GluMet: 1.126 ± 0.052
2.342GluAsn: 2.342 ± 0.079
1.94GluPro: 1.94 ± 0.081
2.429GluGln: 2.429 ± 0.079
2.776GluArg: 2.776 ± 0.089
3.301GluSer: 3.301 ± 0.078
2.898GluThr: 2.898 ± 0.071
3.054GluVal: 3.054 ± 0.089
0.631GluTrp: 0.631 ± 0.034
1.578GluTyr: 1.578 ± 0.06
0.0GluXaa: 0.0 ± 0.0
Phe
3.412PheAla: 3.412 ± 0.085
0.414PheCys: 0.414 ± 0.03
2.305PheAsp: 2.305 ± 0.073
1.552PheGlu: 1.552 ± 0.067
1.587PhePhe: 1.587 ± 0.067
2.74PheGly: 2.74 ± 0.08
0.893PheHis: 0.893 ± 0.038
2.482PheIle: 2.482 ± 0.084
1.235PheLys: 1.235 ± 0.048
3.538PheLeu: 3.538 ± 0.109
0.797PheMet: 0.797 ± 0.039
1.48PheAsn: 1.48 ± 0.061
1.54PhePro: 1.54 ± 0.058
1.139PheGln: 1.139 ± 0.049
1.629PheArg: 1.629 ± 0.052
2.988PheSer: 2.988 ± 0.077
2.461PheThr: 2.461 ± 0.087
2.358PheVal: 2.358 ± 0.064
0.488PheTrp: 0.488 ± 0.033
1.151PheTyr: 1.151 ± 0.053
0.0PheXaa: 0.0 ± 0.0
Gly
5.632GlyAla: 5.632 ± 0.131
0.576GlyCys: 0.576 ± 0.039
3.581GlyAsp: 3.581 ± 0.094
3.342GlyGlu: 3.342 ± 0.092
2.998GlyPhe: 2.998 ± 0.082
4.879GlyGly: 4.879 ± 0.109
1.68GlyHis: 1.68 ± 0.068
4.966GlyIle: 4.966 ± 0.114
4.67GlyLys: 4.67 ± 0.096
6.973GlyLeu: 6.973 ± 0.127
1.889GlyMet: 1.889 ± 0.08
2.696GlyAsn: 2.696 ± 0.088
2.374GlyPro: 2.374 ± 0.071
3.661GlyGln: 3.661 ± 0.089
4.224GlyArg: 4.224 ± 0.104
5.658GlySer: 5.658 ± 0.113
4.444GlyThr: 4.444 ± 0.105
4.651GlyVal: 4.651 ± 0.101
1.066GlyTrp: 1.066 ± 0.049
2.661GlyTyr: 2.661 ± 0.074
0.0GlyXaa: 0.0 ± 0.0
His
1.559HisAla: 1.559 ± 0.049
0.215HisCys: 0.215 ± 0.019
1.469HisAsp: 1.469 ± 0.058
1.087HisGlu: 1.087 ± 0.041
0.774HisPhe: 0.774 ± 0.037
1.708HisGly: 1.708 ± 0.059
0.648HisHis: 0.648 ± 0.034
1.343HisIle: 1.343 ± 0.043
1.002HisLys: 1.002 ± 0.043
1.906HisLeu: 1.906 ± 0.07
0.574HisMet: 0.574 ± 0.039
0.821HisAsn: 0.821 ± 0.042
1.425HisPro: 1.425 ± 0.054
1.049HisGln: 1.049 ± 0.042
1.431HisArg: 1.431 ± 0.053
1.424HisSer: 1.424 ± 0.047
1.282HisThr: 1.282 ± 0.048
1.497HisVal: 1.497 ± 0.058
0.309HisTrp: 0.309 ± 0.026
0.697HisTyr: 0.697 ± 0.037
0.0HisXaa: 0.0 ± 0.0
Ile
5.756IleAla: 5.756 ± 0.111
0.684IleCys: 0.684 ± 0.044
3.917IleAsp: 3.917 ± 0.091
2.806IleGlu: 2.806 ± 0.075
2.482IlePhe: 2.482 ± 0.086
4.114IleGly: 4.114 ± 0.1
1.284IleHis: 1.284 ± 0.049
4.173IleIle: 4.173 ± 0.121
2.495IleLys: 2.495 ± 0.067
5.63IleLeu: 5.63 ± 0.13
1.444IleMet: 1.444 ± 0.057
2.518IleAsn: 2.518 ± 0.079
3.186IlePro: 3.186 ± 0.075
1.891IleGln: 1.891 ± 0.064
3.197IleArg: 3.197 ± 0.077
4.868IleSer: 4.868 ± 0.093
3.868IleThr: 3.868 ± 0.09
4.502IleVal: 4.502 ± 0.105
0.623IleTrp: 0.623 ± 0.036
1.627IleTyr: 1.627 ± 0.06
0.0IleXaa: 0.0 ± 0.0
Lys
4.903LysAla: 4.903 ± 0.118
0.179LysCys: 0.179 ± 0.019
3.069LysAsp: 3.069 ± 0.088
3.018LysGlu: 3.018 ± 0.088
1.194LysPhe: 1.194 ± 0.051
3.186LysGly: 3.186 ± 0.087
0.889LysHis: 0.889 ± 0.038
2.954LysIle: 2.954 ± 0.07
3.657LysLys: 3.657 ± 0.1
3.597LysLeu: 3.597 ± 0.096
1.113LysMet: 1.113 ± 0.053
2.687LysAsn: 2.687 ± 0.096
2.156LysPro: 2.156 ± 0.064
1.966LysGln: 1.966 ± 0.068
2.519LysArg: 2.519 ± 0.09
3.075LysSer: 3.075 ± 0.083
3.307LysThr: 3.307 ± 0.101
2.951LysVal: 2.951 ± 0.081
0.503LysTrp: 0.503 ± 0.033
1.407LysTyr: 1.407 ± 0.064
0.0LysXaa: 0.0 ± 0.0
Leu
9.308LeuAla: 9.308 ± 0.149
0.911LeuCys: 0.911 ± 0.048
5.606LeuAsp: 5.606 ± 0.136
4.369LeuGlu: 4.369 ± 0.091
3.297LeuPhe: 3.297 ± 0.094
6.687LeuGly: 6.687 ± 0.121
1.907LeuHis: 1.907 ± 0.063
6.075LeuIle: 6.075 ± 0.155
4.047LeuLys: 4.047 ± 0.088
8.468LeuLeu: 8.468 ± 0.182
2.158LeuMet: 2.158 ± 0.066
3.314LeuAsn: 3.314 ± 0.076
4.753LeuPro: 4.753 ± 0.103
2.947LeuGln: 2.947 ± 0.077
4.57LeuArg: 4.57 ± 0.112
7.649LeuSer: 7.649 ± 0.143
6.214LeuThr: 6.214 ± 0.118
6.775LeuVal: 6.775 ± 0.124
1.12LeuTrp: 1.12 ± 0.052
2.446LeuTyr: 2.446 ± 0.07
0.0LeuXaa: 0.0 ± 0.0
Met
2.273MetAla: 2.273 ± 0.076
0.196MetCys: 0.196 ± 0.02
1.375MetAsp: 1.375 ± 0.053
1.13MetGlu: 1.13 ± 0.047
0.618MetPhe: 0.618 ± 0.036
1.789MetGly: 1.789 ± 0.055
0.471MetHis: 0.471 ± 0.032
1.531MetIle: 1.531 ± 0.053
1.318MetLys: 1.318 ± 0.044
1.804MetLeu: 1.804 ± 0.056
0.591MetMet: 0.591 ± 0.035
1.021MetAsn: 1.021 ± 0.04
1.154MetPro: 1.154 ± 0.048
0.766MetGln: 0.766 ± 0.037
1.393MetArg: 1.393 ± 0.048
1.787MetSer: 1.787 ± 0.069
2.036MetThr: 2.036 ± 0.07
1.659MetVal: 1.659 ± 0.062
0.29MetTrp: 0.29 ± 0.024
0.54MetTyr: 0.54 ± 0.031
0.0MetXaa: 0.0 ± 0.0
Asn
2.994AsnAla: 2.994 ± 0.094
0.281AsnCys: 0.281 ± 0.025
2.0AsnAsp: 2.0 ± 0.07
1.619AsnGlu: 1.619 ± 0.059
1.356AsnPhe: 1.356 ± 0.051
2.708AsnGly: 2.708 ± 0.098
0.926AsnHis: 0.926 ± 0.039
1.964AsnIle: 1.964 ± 0.064
2.068AsnLys: 2.068 ± 0.08
3.482AsnLeu: 3.482 ± 0.088
0.926AsnMet: 0.926 ± 0.043
1.719AsnAsn: 1.719 ± 0.084
2.657AsnPro: 2.657 ± 0.079
1.956AsnGln: 1.956 ± 0.076
2.145AsnArg: 2.145 ± 0.065
2.875AsnSer: 2.875 ± 0.09
2.158AsnThr: 2.158 ± 0.068
2.002AsnVal: 2.002 ± 0.068
0.497AsnTrp: 0.497 ± 0.031
1.284AsnTyr: 1.284 ± 0.055
0.0AsnXaa: 0.0 ± 0.0
Pro
4.273ProAla: 4.273 ± 0.099
0.311ProCys: 0.311 ± 0.028
3.154ProAsp: 3.154 ± 0.076
2.67ProGlu: 2.67 ± 0.08
1.601ProPhe: 1.601 ± 0.062
3.288ProGly: 3.288 ± 0.083
1.175ProHis: 1.175 ± 0.05
2.207ProIle: 2.207 ± 0.063
1.476ProLys: 1.476 ± 0.061
4.128ProLeu: 4.128 ± 0.097
0.877ProMet: 0.877 ± 0.041
1.397ProAsn: 1.397 ± 0.052
1.235ProPro: 1.235 ± 0.055
2.631ProGln: 2.631 ± 0.081
2.192ProArg: 2.192 ± 0.075
3.356ProSer: 3.356 ± 0.083
2.568ProThr: 2.568 ± 0.063
3.521ProVal: 3.521 ± 0.083
0.638ProTrp: 0.638 ± 0.041
1.442ProTyr: 1.442 ± 0.064
0.0ProXaa: 0.0 ± 0.0
Gln
5.37GlnAla: 5.37 ± 0.123
0.243GlnCys: 0.243 ± 0.023
2.324GlnAsp: 2.324 ± 0.071
3.263GlnGlu: 3.263 ± 0.094
1.213GlnPhe: 1.213 ± 0.05
3.442GlnGly: 3.442 ± 0.089
0.721GlnHis: 0.721 ± 0.035
2.698GlnIle: 2.698 ± 0.075
2.484GlnLys: 2.484 ± 0.074
3.766GlnLeu: 3.766 ± 0.083
1.053GlnMet: 1.053 ± 0.044
1.546GlnAsn: 1.546 ± 0.055
1.892GlnPro: 1.892 ± 0.071
2.041GlnGln: 2.041 ± 0.075
2.271GlnArg: 2.271 ± 0.066
2.875GlnSer: 2.875 ± 0.089
2.964GlnThr: 2.964 ± 0.077
3.017GlnVal: 3.017 ± 0.075
0.644GlnTrp: 0.644 ± 0.038
1.245GlnTyr: 1.245 ± 0.054
0.0GlnXaa: 0.0 ± 0.0
Arg
4.05ArgAla: 4.05 ± 0.099
0.41ArgCys: 0.41 ± 0.03
2.738ArgAsp: 2.738 ± 0.079
2.936ArgGlu: 2.936 ± 0.087
2.0ArgPhe: 2.0 ± 0.06
3.489ArgGly: 3.489 ± 0.094
1.312ArgHis: 1.312 ± 0.056
3.67ArgIle: 3.67 ± 0.086
3.064ArgLys: 3.064 ± 0.08
5.297ArgLeu: 5.297 ± 0.126
1.484ArgMet: 1.484 ± 0.049
2.094ArgAsn: 2.094 ± 0.065
2.154ArgPro: 2.154 ± 0.072
3.254ArgGln: 3.254 ± 0.092
3.983ArgArg: 3.983 ± 0.106
3.924ArgSer: 3.924 ± 0.098
3.02ArgThr: 3.02 ± 0.074
3.523ArgVal: 3.523 ± 0.072
0.847ArgTrp: 0.847 ± 0.039
1.872ArgTyr: 1.872 ± 0.062
0.0ArgXaa: 0.0 ± 0.0
Ser
6.877SerAla: 6.877 ± 0.148
0.657SerCys: 0.657 ± 0.039
4.691SerAsp: 4.691 ± 0.118
3.107SerGlu: 3.107 ± 0.085
2.819SerPhe: 2.819 ± 0.07
5.95SerGly: 5.95 ± 0.137
1.964SerHis: 1.964 ± 0.058
3.922SerIle: 3.922 ± 0.101
2.945SerLys: 2.945 ± 0.071
7.873SerLeu: 7.873 ± 0.16
1.698SerMet: 1.698 ± 0.065
2.367SerAsn: 2.367 ± 0.073
3.18SerPro: 3.18 ± 0.093
4.128SerGln: 4.128 ± 0.111
4.578SerArg: 4.578 ± 0.102
7.174SerSer: 7.174 ± 0.219
4.158SerThr: 4.158 ± 0.11
4.792SerVal: 4.792 ± 0.091
1.111SerTrp: 1.111 ± 0.051
2.305SerTyr: 2.305 ± 0.071
0.0SerXaa: 0.0 ± 0.0
Thr
5.824ThrAla: 5.824 ± 0.128
0.482ThrCys: 0.482 ± 0.032
3.845ThrAsp: 3.845 ± 0.097
2.606ThrGlu: 2.606 ± 0.084
2.265ThrPhe: 2.265 ± 0.064
4.762ThrGly: 4.762 ± 0.111
1.307ThrHis: 1.307 ± 0.056
4.099ThrIle: 4.099 ± 0.092
2.344ThrLys: 2.344 ± 0.079
5.446ThrLeu: 5.446 ± 0.11
1.444ThrMet: 1.444 ± 0.059
2.096ThrAsn: 2.096 ± 0.074
2.627ThrPro: 2.627 ± 0.075
2.184ThrGln: 2.184 ± 0.06
2.877ThrArg: 2.877 ± 0.073
4.305ThrSer: 4.305 ± 0.092
3.455ThrThr: 3.455 ± 0.103
5.395ThrVal: 5.395 ± 0.119
0.765ThrTrp: 0.765 ± 0.039
1.938ThrTyr: 1.938 ± 0.071
0.0ThrXaa: 0.0 ± 0.0
Val
5.905ValAla: 5.905 ± 0.121
0.757ValCys: 0.757 ± 0.04
4.361ValAsp: 4.361 ± 0.109
3.606ValGlu: 3.606 ± 0.09
2.602ValPhe: 2.602 ± 0.076
4.589ValGly: 4.589 ± 0.11
1.452ValHis: 1.452 ± 0.051
4.495ValIle: 4.495 ± 0.1
3.167ValLys: 3.167 ± 0.082
6.218ValLeu: 6.218 ± 0.126
1.604ValMet: 1.604 ± 0.059
2.519ValAsn: 2.519 ± 0.083
3.092ValPro: 3.092 ± 0.087
2.416ValGln: 2.416 ± 0.074
3.666ValArg: 3.666 ± 0.08
5.626ValSer: 5.626 ± 0.113
4.504ValThr: 4.504 ± 0.122
4.837ValVal: 4.837 ± 0.118
0.772ValTrp: 0.772 ± 0.039
1.915ValTyr: 1.915 ± 0.061
0.0ValXaa: 0.0 ± 0.0
Trp
1.03TrpAla: 1.03 ± 0.046
0.137TrpCys: 0.137 ± 0.017
0.774TrpAsp: 0.774 ± 0.039
0.638TrpGlu: 0.638 ± 0.035
0.512TrpPhe: 0.512 ± 0.029
0.908TrpGly: 0.908 ± 0.044
0.286TrpHis: 0.286 ± 0.026
0.836TrpIle: 0.836 ± 0.045
0.736TrpLys: 0.736 ± 0.038
1.333TrpLeu: 1.333 ± 0.057
0.384TrpMet: 0.384 ± 0.028
0.65TrpAsn: 0.65 ± 0.035
0.441TrpPro: 0.441 ± 0.033
0.652TrpGln: 0.652 ± 0.034
0.668TrpArg: 0.668 ± 0.034
0.896TrpSer: 0.896 ± 0.043
0.83TrpThr: 0.83 ± 0.039
0.81TrpVal: 0.81 ± 0.039
0.354TrpTrp: 0.354 ± 0.03
0.386TrpTyr: 0.386 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.702TyrAla: 2.702 ± 0.065
0.339TyrCys: 0.339 ± 0.026
1.755TyrAsp: 1.755 ± 0.064
1.486TyrGlu: 1.486 ± 0.055
1.203TyrPhe: 1.203 ± 0.047
2.435TyrGly: 2.435 ± 0.074
0.644TyrHis: 0.644 ± 0.036
1.529TyrIle: 1.529 ± 0.05
1.352TyrLys: 1.352 ± 0.055
2.806TyrLeu: 2.806 ± 0.067
0.61TyrMet: 0.61 ± 0.036
1.171TyrAsn: 1.171 ± 0.053
1.491TyrPro: 1.491 ± 0.063
1.618TyrGln: 1.618 ± 0.07
1.881TyrArg: 1.881 ± 0.058
2.31TyrSer: 2.31 ± 0.081
1.898TyrThr: 1.898 ± 0.08
1.936TyrVal: 1.936 ± 0.061
0.461TyrTrp: 0.461 ± 0.031
1.071TyrTyr: 1.071 ± 0.053
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1482 proteins (531064 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski