Amino acid dipepetide frequency for Desulfobacter postgatei 2ac9

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.572AlaAla: 7.572 ± 0.121	1.236AlaCys: 1.236 ± 0.038	4.549AlaAsp: 4.549 ± 0.069	4.338AlaGlu: 4.338 ± 0.061	3.657AlaPhe: 3.657 ± 0.066	6.877AlaGly: 6.877 ± 0.091	1.619AlaHis: 1.619 ± 0.039	4.986AlaIle: 4.986 ± 0.068	4.519AlaLys: 4.519 ± 0.071	8.62AlaLeu: 8.62 ± 0.09	2.65AlaMet: 2.65 ± 0.053	2.508AlaAsn: 2.508 ± 0.053	2.778AlaPro: 2.778 ± 0.056	3.219AlaGln: 3.219 ± 0.063	4.304AlaArg: 4.304 ± 0.06	4.182AlaSer: 4.182 ± 0.072	3.516AlaThr: 3.516 ± 0.063	6.075AlaVal: 6.075 ± 0.093	0.973AlaTrp: 0.973 ± 0.03	2.336AlaTyr: 2.336 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	1.02CysAla: 1.02 ± 0.031	0.224CysCys: 0.224 ± 0.014	0.637CysAsp: 0.637 ± 0.026	0.619CysGlu: 0.619 ± 0.026	0.71CysPhe: 0.71 ± 0.026	1.198CysGly: 1.198 ± 0.041	0.413CysHis: 0.413 ± 0.024	0.839CysIle: 0.839 ± 0.029	0.593CysLys: 0.593 ± 0.026	1.256CysLeu: 1.256 ± 0.035	0.34CysMet: 0.34 ± 0.018	0.452CysAsn: 0.452 ± 0.019	0.762CysPro: 0.762 ± 0.031	0.382CysGln: 0.382 ± 0.018	0.887CysArg: 0.887 ± 0.03	0.768CysSer: 0.768 ± 0.024	0.7CysThr: 0.7 ± 0.026	0.813CysVal: 0.813 ± 0.026	0.125CysTrp: 0.125 ± 0.011	0.383CysTyr: 0.383 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	4.557AspAla: 4.557 ± 0.06	0.633AspCys: 0.633 ± 0.022	3.082AspAsp: 3.082 ± 0.068	3.582AspGlu: 3.582 ± 0.064	2.783AspPhe: 2.783 ± 0.053	3.441AspGly: 3.441 ± 0.067	1.311AspHis: 1.311 ± 0.034	4.907AspIle: 4.907 ± 0.072	3.403AspLys: 3.403 ± 0.055	6.24AspLeu: 6.24 ± 0.073	1.587AspMet: 1.587 ± 0.04	2.196AspAsn: 2.196 ± 0.046	2.92AspPro: 2.92 ± 0.055	2.269AspGln: 2.269 ± 0.049	3.155AspArg: 3.155 ± 0.057	2.829AspSer: 2.829 ± 0.053	3.097AspThr: 3.097 ± 0.06	3.381AspVal: 3.381 ± 0.062	0.621AspTrp: 0.621 ± 0.027	1.872AspTyr: 1.872 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	4.707GluAla: 4.707 ± 0.068	0.529GluCys: 0.529 ± 0.022	3.214GluAsp: 3.214 ± 0.065	3.833GluGlu: 3.833 ± 0.079	2.364GluPhe: 2.364 ± 0.053	3.238GluGly: 3.238 ± 0.057	1.196GluHis: 1.196 ± 0.032	5.023GluIle: 5.023 ± 0.077	5.833GluLys: 5.833 ± 0.094	5.663GluLeu: 5.663 ± 0.078	1.808GluMet: 1.808 ± 0.038	3.37GluAsn: 3.37 ± 0.046	2.069GluPro: 2.069 ± 0.047	2.8GluGln: 2.8 ± 0.058	3.073GluArg: 3.073 ± 0.048	3.409GluSer: 3.409 ± 0.066	3.736GluThr: 3.736 ± 0.059	3.374GluVal: 3.374 ± 0.062	0.585GluTrp: 0.585 ± 0.024	1.857GluTyr: 1.857 ± 0.045	0.0GluXaa: 0.0 ± 0.0
Phe	3.033PheAla: 3.033 ± 0.051	0.718PheCys: 0.718 ± 0.024	2.97PheAsp: 2.97 ± 0.051	2.742PheGlu: 2.742 ± 0.054	2.548PhePhe: 2.548 ± 0.06	3.143PheGly: 3.143 ± 0.051	0.98PheHis: 0.98 ± 0.033	3.216PheIle: 3.216 ± 0.061	2.9PheLys: 2.9 ± 0.054	4.392PheLeu: 4.392 ± 0.078	1.176PheMet: 1.176 ± 0.036	1.978PheAsn: 1.978 ± 0.04	1.781PhePro: 1.781 ± 0.04	1.386PheGln: 1.386 ± 0.039	1.953PheArg: 1.953 ± 0.043	3.603PheSer: 3.603 ± 0.06	2.384PheThr: 2.384 ± 0.052	2.67PheVal: 2.67 ± 0.051	0.504PheTrp: 0.504 ± 0.024	1.501PheTyr: 1.501 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	5.173GlyAla: 5.173 ± 0.086	1.088GlyCys: 1.088 ± 0.037	3.472GlyAsp: 3.472 ± 0.059	3.838GlyGlu: 3.838 ± 0.057	3.644GlyPhe: 3.644 ± 0.055	4.738GlyGly: 4.738 ± 0.087	1.578GlyHis: 1.578 ± 0.038	5.765GlyIle: 5.765 ± 0.075	4.943GlyLys: 4.943 ± 0.07	6.922GlyLeu: 6.922 ± 0.082	2.272GlyMet: 2.272 ± 0.054	2.635GlyAsn: 2.635 ± 0.054	2.214GlyPro: 2.214 ± 0.049	2.492GlyGln: 2.492 ± 0.049	3.776GlyArg: 3.776 ± 0.061	3.923GlySer: 3.923 ± 0.067	4.098GlyThr: 4.098 ± 0.06	4.798GlyVal: 4.798 ± 0.076	0.829GlyTrp: 0.829 ± 0.029	2.462GlyTyr: 2.462 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	1.597HisAla: 1.597 ± 0.039	0.342HisCys: 0.342 ± 0.019	1.138HisAsp: 1.138 ± 0.036	1.15HisGlu: 1.15 ± 0.03	1.023HisPhe: 1.023 ± 0.029	1.451HisGly: 1.451 ± 0.041	0.577HisHis: 0.577 ± 0.023	1.563HisIle: 1.563 ± 0.039	1.141HisLys: 1.141 ± 0.027	2.168HisLeu: 2.168 ± 0.047	0.525HisMet: 0.525 ± 0.022	0.807HisAsn: 0.807 ± 0.027	1.244HisPro: 1.244 ± 0.03	0.744HisGln: 0.744 ± 0.027	1.079HisArg: 1.079 ± 0.034	1.119HisSer: 1.119 ± 0.03	1.102HisThr: 1.102 ± 0.032	1.221HisVal: 1.221 ± 0.032	0.216HisTrp: 0.216 ± 0.014	0.721HisTyr: 0.721 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.457IleAla: 5.457 ± 0.067	1.104IleCys: 1.104 ± 0.035	4.301IleAsp: 4.301 ± 0.066	4.901IleGlu: 4.901 ± 0.071	3.129IlePhe: 3.129 ± 0.055	4.675IleGly: 4.675 ± 0.075	1.732IleHis: 1.732 ± 0.044	5.038IleIle: 5.038 ± 0.089	4.656IleLys: 4.656 ± 0.075	6.971IleLeu: 6.971 ± 0.086	1.703IleMet: 1.703 ± 0.036	3.233IleAsn: 3.233 ± 0.056	3.465IlePro: 3.465 ± 0.053	2.567IleGln: 2.567 ± 0.048	4.051IleArg: 4.051 ± 0.071	5.093IleSer: 5.093 ± 0.07	4.026IleThr: 4.026 ± 0.065	4.392IleVal: 4.392 ± 0.073	0.636IleTrp: 0.636 ± 0.023	1.904IleTyr: 1.904 ± 0.047	0.0IleXaa: 0.0 ± 0.0
Lys	5.522LysAla: 5.522 ± 0.075	0.547LysCys: 0.547 ± 0.026	3.576LysAsp: 3.576 ± 0.05	4.669LysGlu: 4.669 ± 0.08	2.018LysPhe: 2.018 ± 0.043	4.473LysGly: 4.473 ± 0.07	1.11LysHis: 1.11 ± 0.033	5.103LysIle: 5.103 ± 0.07	5.804LysLys: 5.804 ± 0.09	4.822LysLeu: 4.822 ± 0.081	1.768LysMet: 1.768 ± 0.042	3.408LysAsn: 3.408 ± 0.063	2.503LysPro: 2.503 ± 0.05	2.605LysGln: 2.605 ± 0.053	3.137LysArg: 3.137 ± 0.054	3.689LysSer: 3.689 ± 0.057	4.107LysThr: 4.107 ± 0.07	3.457LysVal: 3.457 ± 0.068	0.541LysTrp: 0.541 ± 0.024	1.815LysTyr: 1.815 ± 0.049	0.0LysXaa: 0.0 ± 0.0
Leu	8.133LeuAla: 8.133 ± 0.097	1.301LeuCys: 1.301 ± 0.031	5.943LeuAsp: 5.943 ± 0.078	6.383LeuGlu: 6.383 ± 0.08	4.591LeuPhe: 4.591 ± 0.08	6.498LeuGly: 6.498 ± 0.083	1.718LeuHis: 1.718 ± 0.038	6.463LeuIle: 6.463 ± 0.097	6.786LeuLys: 6.786 ± 0.09	8.538LeuLeu: 8.538 ± 0.102	2.438LeuMet: 2.438 ± 0.042	4.231LeuAsn: 4.231 ± 0.062	4.553LeuPro: 4.553 ± 0.061	2.625LeuGln: 2.625 ± 0.054	3.979LeuArg: 3.979 ± 0.064	7.211LeuSer: 7.211 ± 0.086	5.423LeuThr: 5.423 ± 0.076	6.06LeuVal: 6.06 ± 0.073	0.874LeuTrp: 0.874 ± 0.031	2.598LeuTyr: 2.598 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	2.887MetAla: 2.887 ± 0.055	0.212MetCys: 0.212 ± 0.014	1.868MetAsp: 1.868 ± 0.045	1.821MetGlu: 1.821 ± 0.044	0.921MetPhe: 0.921 ± 0.03	2.165MetGly: 2.165 ± 0.048	0.436MetHis: 0.436 ± 0.019	1.925MetIle: 1.925 ± 0.046	1.894MetLys: 1.894 ± 0.038	2.376MetLeu: 2.376 ± 0.045	0.749MetMet: 0.749 ± 0.03	1.306MetAsn: 1.306 ± 0.032	1.339MetPro: 1.339 ± 0.038	0.816MetGln: 0.816 ± 0.029	1.097MetArg: 1.097 ± 0.033	1.489MetSer: 1.489 ± 0.035	1.78MetThr: 1.78 ± 0.039	1.962MetVal: 1.962 ± 0.042	0.161MetTrp: 0.161 ± 0.013	0.511MetTyr: 0.511 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.217AsnAla: 3.217 ± 0.056	0.553AsnCys: 0.553 ± 0.02	2.098AsnAsp: 2.098 ± 0.054	2.144AsnGlu: 2.144 ± 0.052	1.735AsnPhe: 1.735 ± 0.041	2.603AsnGly: 2.603 ± 0.051	0.928AsnHis: 0.928 ± 0.031	3.388AsnIle: 3.388 ± 0.058	2.352AsnLys: 2.352 ± 0.053	4.243AsnLeu: 4.243 ± 0.059	1.106AsnMet: 1.106 ± 0.033	1.642AsnAsn: 1.642 ± 0.043	2.41AsnPro: 2.41 ± 0.05	1.567AsnGln: 1.567 ± 0.039	2.434AsnArg: 2.434 ± 0.047	2.095AsnSer: 2.095 ± 0.042	2.238AsnThr: 2.238 ± 0.047	2.177AsnVal: 2.177 ± 0.049	0.455AsnTrp: 0.455 ± 0.02	1.234AsnTyr: 1.234 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	3.399ProAla: 3.399 ± 0.07	0.559ProCys: 0.559 ± 0.024	3.587ProAsp: 3.587 ± 0.058	3.733ProGlu: 3.733 ± 0.052	2.015ProPhe: 2.015 ± 0.044	3.789ProGly: 3.789 ± 0.074	0.852ProHis: 0.852 ± 0.028	2.268ProIle: 2.268 ± 0.056	2.231ProLys: 2.231 ± 0.048	3.838ProLeu: 3.838 ± 0.069	1.091ProMet: 1.091 ± 0.034	1.293ProAsn: 1.293 ± 0.033	1.65ProPro: 1.65 ± 0.045	1.403ProGln: 1.403 ± 0.035	1.657ProArg: 1.657 ± 0.042	2.251ProSer: 2.251 ± 0.049	1.755ProThr: 1.755 ± 0.04	3.766ProVal: 3.766 ± 0.056	0.512ProTrp: 0.512 ± 0.022	1.272ProTyr: 1.272 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	3.572GlnAla: 3.572 ± 0.056	0.386GlnCys: 0.386 ± 0.021	1.918GlnAsp: 1.918 ± 0.04	2.342GlnGlu: 2.342 ± 0.047	1.381GlnPhe: 1.381 ± 0.035	2.638GlnGly: 2.638 ± 0.057	0.597GlnHis: 0.597 ± 0.024	2.966GlnIle: 2.966 ± 0.056	2.547GlnLys: 2.547 ± 0.057	3.014GlnLeu: 3.014 ± 0.054	1.142GlnMet: 1.142 ± 0.034	1.527GlnAsn: 1.527 ± 0.038	1.216GlnPro: 1.216 ± 0.036	1.3GlnGln: 1.3 ± 0.049	1.688GlnArg: 1.688 ± 0.04	2.036GlnSer: 2.036 ± 0.043	2.201GlnThr: 2.201 ± 0.05	2.541GlnVal: 2.541 ± 0.051	0.404GlnTrp: 0.404 ± 0.018	0.955GlnTyr: 0.955 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	3.55ArgAla: 3.55 ± 0.054	0.601ArgCys: 0.601 ± 0.024	2.635ArgAsp: 2.635 ± 0.054	3.248ArgGlu: 3.248 ± 0.059	2.611ArgPhe: 2.611 ± 0.054	2.704ArgGly: 2.704 ± 0.054	1.24ArgHis: 1.24 ± 0.032	4.258ArgIle: 4.258 ± 0.065	3.239ArgLys: 3.239 ± 0.061	5.378ArgLeu: 5.378 ± 0.07	1.45ArgMet: 1.45 ± 0.032	1.992ArgAsn: 1.992 ± 0.05	2.0ArgPro: 2.0 ± 0.044	2.247ArgGln: 2.247 ± 0.051	2.711ArgArg: 2.711 ± 0.059	2.665ArgSer: 2.665 ± 0.051	2.409ArgThr: 2.409 ± 0.045	3.308ArgVal: 3.308 ± 0.061	0.523ArgTrp: 0.523 ± 0.024	1.764ArgTyr: 1.764 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	4.572SerAla: 4.572 ± 0.067	0.795SerCys: 0.795 ± 0.023	3.462SerAsp: 3.462 ± 0.056	3.281SerGlu: 3.281 ± 0.055	2.917SerPhe: 2.917 ± 0.054	5.165SerGly: 5.165 ± 0.079	1.262SerHis: 1.262 ± 0.028	4.021SerIle: 4.021 ± 0.062	3.289SerLys: 3.289 ± 0.067	5.834SerLeu: 5.834 ± 0.071	1.777SerMet: 1.777 ± 0.038	2.026SerAsn: 2.026 ± 0.044	2.602SerPro: 2.602 ± 0.044	2.213SerGln: 2.213 ± 0.047	3.323SerArg: 3.323 ± 0.057	3.621SerSer: 3.621 ± 0.065	2.884SerThr: 2.884 ± 0.054	3.894SerVal: 3.894 ± 0.053	0.667SerTrp: 0.667 ± 0.028	1.658SerTyr: 1.658 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	4.681ThrAla: 4.681 ± 0.07	0.747ThrCys: 0.747 ± 0.03	3.134ThrAsp: 3.134 ± 0.061	2.717ThrGlu: 2.717 ± 0.057	2.214ThrPhe: 2.214 ± 0.044	5.069ThrGly: 5.069 ± 0.069	1.161ThrHis: 1.161 ± 0.034	3.982ThrIle: 3.982 ± 0.074	2.408ThrLys: 2.408 ± 0.05	5.686ThrLeu: 5.686 ± 0.085	1.319ThrMet: 1.319 ± 0.036	1.821ThrAsn: 1.821 ± 0.039	2.941ThrPro: 2.941 ± 0.057	1.941ThrGln: 1.941 ± 0.039	2.983ThrArg: 2.983 ± 0.056	2.775ThrSer: 2.775 ± 0.051	2.713ThrThr: 2.713 ± 0.065	3.707ThrVal: 3.707 ± 0.058	0.546ThrTrp: 0.546 ± 0.023	1.44ThrTyr: 1.44 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	4.909ValAla: 4.909 ± 0.077	0.994ValCys: 0.994 ± 0.029	3.898ValAsp: 3.898 ± 0.057	3.968ValGlu: 3.968 ± 0.069	3.266ValPhe: 3.266 ± 0.054	4.015ValGly: 4.015 ± 0.068	1.306ValHis: 1.306 ± 0.036	4.682ValIle: 4.682 ± 0.071	3.872ValLys: 3.872 ± 0.056	6.3ValLeu: 6.3 ± 0.073	1.809ValMet: 1.809 ± 0.048	2.609ValAsn: 2.609 ± 0.049	2.701ValPro: 2.701 ± 0.039	2.078ValGln: 2.078 ± 0.047	3.058ValArg: 3.058 ± 0.055	4.337ValSer: 4.337 ± 0.065	3.669ValThr: 3.669 ± 0.064	4.633ValVal: 4.633 ± 0.081	0.58ValTrp: 0.58 ± 0.022	1.813ValTyr: 1.813 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	0.75TrpAla: 0.75 ± 0.027	0.14TrpCys: 0.14 ± 0.01	0.617TrpAsp: 0.617 ± 0.023	0.662TrpGlu: 0.662 ± 0.025	0.497TrpPhe: 0.497 ± 0.022	0.666TrpGly: 0.666 ± 0.026	0.224TrpHis: 0.224 ± 0.016	0.736TrpIle: 0.736 ± 0.027	0.609TrpLys: 0.609 ± 0.021	1.048TrpLeu: 1.048 ± 0.032	0.289TrpMet: 0.289 ± 0.017	0.403TrpAsn: 0.403 ± 0.021	0.389TrpPro: 0.389 ± 0.019	0.526TrpGln: 0.526 ± 0.023	0.516TrpArg: 0.516 ± 0.025	0.487TrpSer: 0.487 ± 0.02	0.495TrpThr: 0.495 ± 0.021	0.701TrpVal: 0.701 ± 0.027	0.121TrpTrp: 0.121 ± 0.011	0.335TrpTyr: 0.335 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.207TyrAla: 2.207 ± 0.049	0.41TyrCys: 0.41 ± 0.017	1.767TyrAsp: 1.767 ± 0.035	1.713TyrGlu: 1.713 ± 0.045	1.552TyrPhe: 1.552 ± 0.035	2.117TyrGly: 2.117 ± 0.043	0.687TyrHis: 0.687 ± 0.026	1.903TyrIle: 1.903 ± 0.044	1.658TyrLys: 1.658 ± 0.046	3.036TyrLeu: 3.036 ± 0.054	0.717TyrMet: 0.717 ± 0.028	1.185TyrAsn: 1.185 ± 0.035	1.383TyrPro: 1.383 ± 0.033	1.19TyrGln: 1.19 ± 0.029	1.673TyrArg: 1.673 ± 0.042	1.679TyrSer: 1.679 ± 0.037	1.65TyrThr: 1.65 ± 0.04	1.568TyrVal: 1.568 ± 0.037	0.337TyrTrp: 0.337 ± 0.018	1.053TyrTyr: 1.053 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3396 proteins (1120179 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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