Amino acid dipepetide frequency for Aspergillus avenaceus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.808AlaAla: 7.808 ± 0.049	1.133AlaCys: 1.133 ± 0.014	4.048AlaAsp: 4.048 ± 0.031	4.738AlaGlu: 4.738 ± 0.035	3.182AlaPhe: 3.182 ± 0.025	5.407AlaGly: 5.407 ± 0.038	1.748AlaHis: 1.748 ± 0.019	4.273AlaIle: 4.273 ± 0.034	3.642AlaLys: 3.642 ± 0.027	7.695AlaLeu: 7.695 ± 0.043	1.968AlaMet: 1.968 ± 0.019	2.841AlaAsn: 2.841 ± 0.022	4.39AlaPro: 4.39 ± 0.037	3.274AlaGln: 3.274 ± 0.032	4.678AlaArg: 4.678 ± 0.03	6.85AlaSer: 6.85 ± 0.046	5.072AlaThr: 5.072 ± 0.032	5.396AlaVal: 5.396 ± 0.035	1.156AlaTrp: 1.156 ± 0.015	2.228AlaTyr: 2.228 ± 0.022	0.0AlaXaa: 0.0 ± 0.0
Cys	1.001CysAla: 1.001 ± 0.015	0.269CysCys: 0.269 ± 0.008	0.729CysAsp: 0.729 ± 0.011	0.651CysGlu: 0.651 ± 0.011	0.601CysPhe: 0.601 ± 0.012	0.97CysGly: 0.97 ± 0.016	0.382CysHis: 0.382 ± 0.008	0.78CysIle: 0.78 ± 0.012	0.512CysLys: 0.512 ± 0.011	1.43CysLeu: 1.43 ± 0.019	0.313CysMet: 0.313 ± 0.008	0.463CysAsn: 0.463 ± 0.01	0.695CysPro: 0.695 ± 0.012	0.506CysGln: 0.506 ± 0.01	0.849CysArg: 0.849 ± 0.013	1.02CysSer: 1.02 ± 0.015	0.76CysThr: 0.76 ± 0.013	0.87CysVal: 0.87 ± 0.013	0.215CysTrp: 0.215 ± 0.007	0.4CysTyr: 0.4 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.486AspAla: 4.486 ± 0.031	0.663AspCys: 0.663 ± 0.012	3.944AspAsp: 3.944 ± 0.041	4.158AspGlu: 4.158 ± 0.037	2.162AspPhe: 2.162 ± 0.021	3.947AspGly: 3.947 ± 0.029	1.297AspHis: 1.297 ± 0.015	3.189AspIle: 3.189 ± 0.026	2.295AspLys: 2.295 ± 0.027	5.204AspLeu: 5.204 ± 0.038	1.304AspMet: 1.304 ± 0.017	1.948AspAsn: 1.948 ± 0.019	3.386AspPro: 3.386 ± 0.026	1.967AspGln: 1.967 ± 0.02	3.173AspArg: 3.173 ± 0.027	4.191AspSer: 4.191 ± 0.039	3.072AspThr: 3.072 ± 0.023	3.687AspVal: 3.687 ± 0.028	0.883AspTrp: 0.883 ± 0.013	1.677AspTyr: 1.677 ± 0.017	0.0AspXaa: 0.0 ± 0.0
Glu	4.956GluAla: 4.956 ± 0.034	0.667GluCys: 0.667 ± 0.01	4.002GluAsp: 4.002 ± 0.037	5.07GluGlu: 5.07 ± 0.055	1.97GluPhe: 1.97 ± 0.019	3.646GluGly: 3.646 ± 0.027	1.421GluHis: 1.421 ± 0.016	3.079GluIle: 3.079 ± 0.025	3.498GluLys: 3.498 ± 0.033	5.08GluLeu: 5.08 ± 0.037	1.415GluMet: 1.415 ± 0.016	2.337GluAsn: 2.337 ± 0.023	2.763GluPro: 2.763 ± 0.035	2.49GluGln: 2.49 ± 0.025	3.853GluArg: 3.853 ± 0.03	4.439GluSer: 4.439 ± 0.036	3.508GluThr: 3.508 ± 0.028	3.493GluVal: 3.493 ± 0.028	0.903GluTrp: 0.903 ± 0.014	1.766GluTyr: 1.766 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	3.032PheAla: 3.032 ± 0.03	0.618PheCys: 0.618 ± 0.011	2.28PheAsp: 2.28 ± 0.021	2.117PheGlu: 2.117 ± 0.022	1.741PhePhe: 1.741 ± 0.02	2.888PheGly: 2.888 ± 0.028	1.009PheHis: 1.009 ± 0.014	1.938PheIle: 1.938 ± 0.02	1.468PheLys: 1.468 ± 0.016	3.747PheLeu: 3.747 ± 0.028	0.839PheMet: 0.839 ± 0.012	1.468PheAsn: 1.468 ± 0.018	2.043PhePro: 2.043 ± 0.019	1.463PheGln: 1.463 ± 0.015	2.067PheArg: 2.067 ± 0.021	3.088PheSer: 3.088 ± 0.026	2.261PheThr: 2.261 ± 0.02	2.418PheVal: 2.418 ± 0.025	0.67PheTrp: 0.67 ± 0.013	1.223PheTyr: 1.223 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	5.052GlyAla: 5.052 ± 0.039	0.947GlyCys: 0.947 ± 0.015	3.626GlyAsp: 3.626 ± 0.026	3.525GlyGlu: 3.525 ± 0.026	2.855GlyPhe: 2.855 ± 0.027	5.221GlyGly: 5.221 ± 0.052	1.711GlyHis: 1.711 ± 0.02	3.659GlyIle: 3.659 ± 0.027	3.256GlyLys: 3.256 ± 0.028	6.242GlyLeu: 6.242 ± 0.036	1.532GlyMet: 1.532 ± 0.018	2.524GlyAsn: 2.524 ± 0.026	3.293GlyPro: 3.293 ± 0.028	2.531GlyGln: 2.531 ± 0.021	4.032GlyArg: 4.032 ± 0.034	5.707GlySer: 5.707 ± 0.039	3.936GlyThr: 3.936 ± 0.03	4.568GlyVal: 4.568 ± 0.035	1.174GlyTrp: 1.174 ± 0.016	2.274GlyTyr: 2.274 ± 0.024	0.0GlyXaa: 0.0 ± 0.0
His	1.851HisAla: 1.851 ± 0.021	0.371HisCys: 0.371 ± 0.009	1.359HisAsp: 1.359 ± 0.016	1.346HisGlu: 1.346 ± 0.018	0.972HisPhe: 0.972 ± 0.014	1.745HisGly: 1.745 ± 0.021	0.859HisHis: 0.859 ± 0.016	1.302HisIle: 1.302 ± 0.015	0.892HisLys: 0.892 ± 0.013	2.353HisLeu: 2.353 ± 0.02	0.532HisMet: 0.532 ± 0.011	0.91HisAsn: 0.91 ± 0.014	1.75HisPro: 1.75 ± 0.019	0.998HisGln: 0.998 ± 0.014	1.609HisArg: 1.609 ± 0.018	1.947HisSer: 1.947 ± 0.021	1.36HisThr: 1.36 ± 0.015	1.473HisVal: 1.473 ± 0.019	0.368HisTrp: 0.368 ± 0.008	0.748HisTyr: 0.748 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	4.244IleAla: 4.244 ± 0.031	0.85IleCys: 0.85 ± 0.013	2.889IleAsp: 2.889 ± 0.025	2.823IleGlu: 2.823 ± 0.023	2.101IlePhe: 2.101 ± 0.024	3.316IleGly: 3.316 ± 0.03	1.319IleHis: 1.319 ± 0.016	2.647IleIle: 2.647 ± 0.026	2.06IleLys: 2.06 ± 0.022	4.87IleLeu: 4.87 ± 0.037	1.063IleMet: 1.063 ± 0.014	1.836IleAsn: 1.836 ± 0.018	3.253IlePro: 3.253 ± 0.024	2.009IleGln: 2.009 ± 0.02	2.851IleArg: 2.851 ± 0.025	3.995IleSer: 3.995 ± 0.03	2.91IleThr: 2.91 ± 0.024	3.264IleVal: 3.264 ± 0.026	0.742IleTrp: 0.742 ± 0.013	1.53IleTyr: 1.53 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	3.839LysAla: 3.839 ± 0.032	0.542LysCys: 0.542 ± 0.01	2.69LysAsp: 2.69 ± 0.024	3.204LysGlu: 3.204 ± 0.031	1.395LysPhe: 1.395 ± 0.015	2.91LysGly: 2.91 ± 0.026	1.11LysHis: 1.11 ± 0.014	2.136LysIle: 2.136 ± 0.021	2.913LysLys: 2.913 ± 0.039	3.886LysLeu: 3.886 ± 0.034	0.942LysMet: 0.942 ± 0.015	1.68LysAsn: 1.68 ± 0.018	2.634LysPro: 2.634 ± 0.03	1.839LysGln: 1.839 ± 0.022	3.253LysArg: 3.253 ± 0.028	3.373LysSer: 3.373 ± 0.028	2.648LysThr: 2.648 ± 0.024	2.762LysVal: 2.762 ± 0.024	0.658LysTrp: 0.658 ± 0.011	1.354LysTyr: 1.354 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	7.655LeuAla: 7.655 ± 0.045	1.349LeuCys: 1.349 ± 0.016	5.259LeuAsp: 5.259 ± 0.033	5.531LeuGlu: 5.531 ± 0.042	3.568LeuPhe: 3.568 ± 0.029	6.087LeuGly: 6.087 ± 0.038	2.353LeuHis: 2.353 ± 0.025	4.122LeuIle: 4.122 ± 0.035	4.059LeuLys: 4.059 ± 0.034	8.652LeuLeu: 8.652 ± 0.055	1.879LeuMet: 1.879 ± 0.019	3.336LeuAsn: 3.336 ± 0.025	5.514LeuPro: 5.514 ± 0.038	3.926LeuGln: 3.926 ± 0.029	5.869LeuArg: 5.869 ± 0.042	7.732LeuSer: 7.732 ± 0.045	4.972LeuThr: 4.972 ± 0.032	5.653LeuVal: 5.653 ± 0.042	1.27LeuTrp: 1.27 ± 0.015	2.596LeuTyr: 2.596 ± 0.024	0.0LeuXaa: 0.0 ± 0.0
Met	2.123MetAla: 2.123 ± 0.018	0.267MetCys: 0.267 ± 0.007	1.257MetAsp: 1.257 ± 0.019	1.297MetGlu: 1.297 ± 0.015	0.798MetPhe: 0.798 ± 0.012	1.508MetGly: 1.508 ± 0.019	0.503MetHis: 0.503 ± 0.011	1.058MetIle: 1.058 ± 0.014	1.027MetLys: 1.027 ± 0.014	1.92MetLeu: 1.92 ± 0.02	0.569MetMet: 0.569 ± 0.011	0.836MetAsn: 0.836 ± 0.013	1.233MetPro: 1.233 ± 0.015	0.862MetGln: 0.862 ± 0.013	1.266MetArg: 1.266 ± 0.017	1.916MetSer: 1.916 ± 0.016	1.341MetThr: 1.341 ± 0.015	1.381MetVal: 1.381 ± 0.015	0.273MetTrp: 0.273 ± 0.007	0.555MetTyr: 0.555 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	3.004AsnAla: 3.004 ± 0.023	0.509AsnCys: 0.509 ± 0.011	2.009AsnAsp: 2.009 ± 0.02	2.051AsnGlu: 2.051 ± 0.02	1.358AsnPhe: 1.358 ± 0.016	2.919AsnGly: 2.919 ± 0.027	0.897AsnHis: 0.897 ± 0.013	2.13AsnIle: 2.13 ± 0.019	1.527AsnLys: 1.527 ± 0.019	3.306AsnLeu: 3.306 ± 0.029	0.891AsnMet: 0.891 ± 0.012	1.489AsnAsn: 1.489 ± 0.021	2.514AsnPro: 2.514 ± 0.024	1.398AsnGln: 1.398 ± 0.017	2.025AsnArg: 2.025 ± 0.018	2.752AsnSer: 2.752 ± 0.03	2.257AsnThr: 2.257 ± 0.024	2.421AsnVal: 2.421 ± 0.02	0.591AsnTrp: 0.591 ± 0.012	1.11AsnTyr: 1.11 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	4.693ProAla: 4.693 ± 0.041	0.584ProCys: 0.584 ± 0.01	3.247ProAsp: 3.247 ± 0.025	3.917ProGlu: 3.917 ± 0.035	2.166ProPhe: 2.166 ± 0.02	3.933ProGly: 3.933 ± 0.039	1.341ProHis: 1.341 ± 0.019	2.588ProIle: 2.588 ± 0.024	2.545ProLys: 2.545 ± 0.026	4.745ProLeu: 4.745 ± 0.034	1.104ProMet: 1.104 ± 0.015	2.238ProAsn: 2.238 ± 0.024	4.629ProPro: 4.629 ± 0.065	2.398ProGln: 2.398 ± 0.032	3.396ProArg: 3.396 ± 0.032	5.939ProSer: 5.939 ± 0.047	3.944ProThr: 3.944 ± 0.033	3.744ProVal: 3.744 ± 0.029	0.791ProTrp: 0.791 ± 0.013	1.579ProTyr: 1.579 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	3.269GlnAla: 3.269 ± 0.028	0.508GlnCys: 0.508 ± 0.011	2.096GlnAsp: 2.096 ± 0.023	2.434GlnGlu: 2.434 ± 0.025	1.337GlnPhe: 1.337 ± 0.015	2.458GlnGly: 2.458 ± 0.022	1.065GlnHis: 1.065 ± 0.016	1.945GlnIle: 1.945 ± 0.019	1.991GlnLys: 1.991 ± 0.022	3.547GlnLeu: 3.547 ± 0.029	0.91GlnMet: 0.91 ± 0.014	1.596GlnAsn: 1.596 ± 0.02	2.49GlnPro: 2.49 ± 0.031	2.187GlnGln: 2.187 ± 0.036	2.654GlnArg: 2.654 ± 0.025	3.26GlnSer: 3.26 ± 0.028	2.354GlnThr: 2.354 ± 0.023	2.245GlnVal: 2.245 ± 0.019	0.608GlnTrp: 0.608 ± 0.012	1.229GlnTyr: 1.229 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	4.514ArgAla: 4.514 ± 0.03	0.798ArgCys: 0.798 ± 0.013	3.325ArgAsp: 3.325 ± 0.031	3.76ArgGlu: 3.76 ± 0.029	2.277ArgPhe: 2.277 ± 0.022	3.647ArgGly: 3.647 ± 0.03	1.596ArgHis: 1.596 ± 0.019	2.941ArgIle: 2.941 ± 0.022	3.317ArgLys: 3.317 ± 0.031	5.654ArgLeu: 5.654 ± 0.047	1.328ArgMet: 1.328 ± 0.016	2.299ArgAsn: 2.299 ± 0.021	3.456ArgPro: 3.456 ± 0.033	2.605ArgGln: 2.605 ± 0.022	4.934ArgArg: 4.934 ± 0.043	4.868ArgSer: 4.868 ± 0.04	3.308ArgThr: 3.308 ± 0.025	3.539ArgVal: 3.539 ± 0.027	0.958ArgTrp: 0.958 ± 0.014	1.808ArgTyr: 1.808 ± 0.02	0.0ArgXaa: 0.0 ± 0.0
Ser	6.432SerAla: 6.432 ± 0.041	0.97SerCys: 0.97 ± 0.014	4.414SerAsp: 4.414 ± 0.036	4.27SerGlu: 4.27 ± 0.032	3.174SerPhe: 3.174 ± 0.029	5.511SerGly: 5.511 ± 0.039	2.06SerHis: 2.06 ± 0.021	4.139SerIle: 4.139 ± 0.033	3.588SerLys: 3.588 ± 0.028	7.565SerLeu: 7.565 ± 0.038	1.729SerMet: 1.729 ± 0.02	3.037SerAsn: 3.037 ± 0.025	5.364SerPro: 5.364 ± 0.049	3.378SerGln: 3.378 ± 0.032	5.03SerArg: 5.03 ± 0.04	8.484SerSer: 8.484 ± 0.074	5.541SerThr: 5.541 ± 0.038	4.832SerVal: 4.832 ± 0.037	1.18SerTrp: 1.18 ± 0.015	2.206SerTyr: 2.206 ± 0.019	0.0SerXaa: 0.0 ± 0.0
Thr	5.067ThrAla: 5.067 ± 0.031	0.81ThrCys: 0.81 ± 0.013	2.989ThrAsp: 2.989 ± 0.025	3.191ThrGlu: 3.191 ± 0.024	2.285ThrPhe: 2.285 ± 0.023	4.308ThrGly: 4.308 ± 0.033	1.37ThrHis: 1.37 ± 0.016	3.101ThrIle: 3.101 ± 0.026	2.488ThrLys: 2.488 ± 0.022	5.383ThrLeu: 5.383 ± 0.033	1.227ThrMet: 1.227 ± 0.014	2.119ThrAsn: 2.119 ± 0.021	4.212ThrPro: 4.212 ± 0.037	2.117ThrGln: 2.117 ± 0.02	3.131ThrArg: 3.131 ± 0.028	5.161ThrSer: 5.161 ± 0.035	4.059ThrThr: 4.059 ± 0.038	4.014ThrVal: 4.014 ± 0.033	0.911ThrTrp: 0.911 ± 0.015	1.715ThrTyr: 1.715 ± 0.018	0.0ThrXaa: 0.0 ± 0.0
Val	5.129ValAla: 5.129 ± 0.038	0.896ValCys: 0.896 ± 0.013	3.855ValAsp: 3.855 ± 0.027	3.808ValGlu: 3.808 ± 0.03	2.597ValPhe: 2.597 ± 0.023	4.095ValGly: 4.095 ± 0.037	1.51ValHis: 1.51 ± 0.017	3.152ValIle: 3.152 ± 0.027	2.766ValLys: 2.766 ± 0.024	5.819ValLeu: 5.819 ± 0.039	1.391ValMet: 1.391 ± 0.017	2.355ValAsn: 2.355 ± 0.023	3.676ValPro: 3.676 ± 0.028	2.486ValGln: 2.486 ± 0.022	3.536ValArg: 3.536 ± 0.028	4.913ValSer: 4.913 ± 0.034	3.654ValThr: 3.654 ± 0.033	4.36ValVal: 4.36 ± 0.037	0.918ValTrp: 0.918 ± 0.014	1.896ValTyr: 1.896 ± 0.019	0.0ValXaa: 0.0 ± 0.0
Trp	1.121TrpAla: 1.121 ± 0.015	0.21TrpCys: 0.21 ± 0.006	0.914TrpAsp: 0.914 ± 0.013	0.864TrpGlu: 0.864 ± 0.013	0.566TrpPhe: 0.566 ± 0.009	0.96TrpGly: 0.96 ± 0.014	0.374TrpHis: 0.374 ± 0.008	0.804TrpIle: 0.804 ± 0.014	0.814TrpLys: 0.814 ± 0.012	1.433TrpLeu: 1.433 ± 0.019	0.391TrpMet: 0.391 ± 0.008	0.659TrpAsn: 0.659 ± 0.013	0.613TrpPro: 0.613 ± 0.011	0.576TrpGln: 0.576 ± 0.011	0.981TrpArg: 0.981 ± 0.013	1.116TrpSer: 1.116 ± 0.016	0.936TrpThr: 0.936 ± 0.015	0.935TrpVal: 0.935 ± 0.014	0.286TrpTrp: 0.286 ± 0.008	0.467TrpTyr: 0.467 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.251TyrAla: 2.251 ± 0.023	0.455TyrCys: 0.455 ± 0.01	1.699TyrAsp: 1.699 ± 0.017	1.599TyrGlu: 1.599 ± 0.019	1.274TyrPhe: 1.274 ± 0.015	2.19TyrGly: 2.19 ± 0.023	0.821TyrHis: 0.821 ± 0.013	1.586TyrIle: 1.586 ± 0.019	1.111TyrLys: 1.111 ± 0.017	2.852TyrLeu: 2.852 ± 0.021	0.666TyrMet: 0.666 ± 0.012	1.189TyrAsn: 1.189 ± 0.016	1.613TyrPro: 1.613 ± 0.017	1.17TyrGln: 1.17 ± 0.015	1.742TyrArg: 1.742 ± 0.017	2.152TyrSer: 2.152 ± 0.023	1.768TyrThr: 1.768 ± 0.017	1.756TyrVal: 1.756 ± 0.02	0.465TyrTrp: 0.465 ± 0.009	1.019TyrTyr: 1.019 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 11290 proteins (5386922 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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