Amino acid dipepetide frequency for Sulcia muelleri (strain GWSS)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.664AlaAla: 1.664 ± 0.15
0.546AlaCys: 0.546 ± 0.101
1.385AlaAsp: 1.385 ± 0.148
1.664AlaGlu: 1.664 ± 0.145
1.638AlaPhe: 1.638 ± 0.157
2.13AlaGly: 2.13 ± 0.21
0.559AlaHis: 0.559 ± 0.084
4.726AlaIle: 4.726 ± 0.252
3.368AlaLys: 3.368 ± 0.234
3.501AlaLeu: 3.501 ± 0.238
0.972AlaMet: 0.972 ± 0.135
2.183AlaAsn: 2.183 ± 0.186
0.839AlaPro: 0.839 ± 0.119
1.012AlaGln: 1.012 ± 0.125
1.331AlaArg: 1.331 ± 0.132
2.263AlaSer: 2.263 ± 0.182
1.664AlaThr: 1.664 ± 0.167
1.677AlaVal: 1.677 ± 0.182
0.2AlaTrp: 0.2 ± 0.049
1.491AlaTyr: 1.491 ± 0.151
0.0AlaXaa: 0.0 ± 0.0
Cys
0.359CysAla: 0.359 ± 0.074
0.093CysCys: 0.093 ± 0.038
0.533CysAsp: 0.533 ± 0.086
0.493CysGlu: 0.493 ± 0.078
0.706CysPhe: 0.706 ± 0.105
0.639CysGly: 0.639 ± 0.1
0.24CysHis: 0.24 ± 0.089
1.531CysIle: 1.531 ± 0.148
1.212CysLys: 1.212 ± 0.132
1.012CysLeu: 1.012 ± 0.124
0.2CysMet: 0.2 ± 0.049
1.038CysAsn: 1.038 ± 0.114
0.479CysPro: 0.479 ± 0.088
0.266CysGln: 0.266 ± 0.052
0.186CysArg: 0.186 ± 0.053
0.852CysSer: 0.852 ± 0.115
0.652CysThr: 0.652 ± 0.108
0.519CysVal: 0.519 ± 0.08
0.08CysTrp: 0.08 ± 0.032
0.493CysTyr: 0.493 ± 0.081
0.0CysXaa: 0.0 ± 0.0
Asp
1.331AspAla: 1.331 ± 0.148
0.32AspCys: 0.32 ± 0.065
1.717AspAsp: 1.717 ± 0.217
1.877AspGlu: 1.877 ± 0.184
2.53AspPhe: 2.53 ± 0.195
1.984AspGly: 1.984 ± 0.153
0.493AspHis: 0.493 ± 0.082
6.058AspIle: 6.058 ± 0.303
4.367AspLys: 4.367 ± 0.322
3.914AspLeu: 3.914 ± 0.232
0.759AspMet: 0.759 ± 0.103
3.182AspAsn: 3.182 ± 0.203
1.331AspPro: 1.331 ± 0.13
0.626AspGln: 0.626 ± 0.086
1.065AspArg: 1.065 ± 0.127
2.516AspSer: 2.516 ± 0.232
1.611AspThr: 1.611 ± 0.135
1.957AspVal: 1.957 ± 0.157
0.333AspTrp: 0.333 ± 0.07
2.263AspTyr: 2.263 ± 0.3
0.0AspXaa: 0.0 ± 0.0
Glu
2.41GluAla: 2.41 ± 0.198
0.692GluCys: 0.692 ± 0.117
1.704GluAsp: 1.704 ± 0.15
3.422GluGlu: 3.422 ± 0.281
2.33GluPhe: 2.33 ± 0.194
2.663GluGly: 2.663 ± 0.232
0.652GluHis: 0.652 ± 0.103
7.602GluIle: 7.602 ± 0.438
7.189GluLys: 7.189 ± 0.324
4.646GluLeu: 4.646 ± 0.253
0.799GluMet: 0.799 ± 0.111
4.314GluAsn: 4.314 ± 0.282
0.972GluPro: 0.972 ± 0.125
1.092GluGln: 1.092 ± 0.115
1.864GluArg: 1.864 ± 0.175
3.062GluSer: 3.062 ± 0.263
2.09GluThr: 2.09 ± 0.161
2.317GluVal: 2.317 ± 0.204
0.28GluTrp: 0.28 ± 0.059
2.769GluTyr: 2.769 ± 0.219
0.0GluXaa: 0.0 ± 0.0
Phe
1.345PheAla: 1.345 ± 0.125
0.679PheCys: 0.679 ± 0.102
2.09PheAsp: 2.09 ± 0.191
2.716PheGlu: 2.716 ± 0.196
4.779PhePhe: 4.779 ± 0.369
2.649PheGly: 2.649 ± 0.183
0.479PheHis: 0.479 ± 0.09
6.763PheIle: 6.763 ± 0.372
5.778PheLys: 5.778 ± 0.327
6.271PheLeu: 6.271 ± 0.321
0.892PheMet: 0.892 ± 0.117
4.886PheAsn: 4.886 ± 0.285
1.425PhePro: 1.425 ± 0.139
0.825PheGln: 0.825 ± 0.094
1.345PheArg: 1.345 ± 0.141
3.914PheSer: 3.914 ± 0.227
1.97PheThr: 1.97 ± 0.159
1.624PheVal: 1.624 ± 0.186
0.426PheTrp: 0.426 ± 0.085
3.262PheTyr: 3.262 ± 0.231
0.0PheXaa: 0.0 ± 0.0
Gly
2.716GlyAla: 2.716 ± 0.225
0.746GlyCys: 0.746 ± 0.114
2.623GlyAsp: 2.623 ± 0.204
2.596GlyGlu: 2.596 ± 0.186
3.155GlyPhe: 3.155 ± 0.209
3.741GlyGly: 3.741 ± 0.302
1.012GlyHis: 1.012 ± 0.099
7.309GlyIle: 7.309 ± 0.328
5.139GlyLys: 5.139 ± 0.255
4.819GlyLeu: 4.819 ± 0.274
1.291GlyMet: 1.291 ± 0.156
3.102GlyAsn: 3.102 ± 0.24
1.305GlyPro: 1.305 ± 0.125
1.185GlyGln: 1.185 ± 0.123
2.223GlyArg: 2.223 ± 0.18
3.608GlySer: 3.608 ± 0.259
2.809GlyThr: 2.809 ± 0.214
3.275GlyVal: 3.275 ± 0.218
0.359GlyTrp: 0.359 ± 0.063
2.743GlyTyr: 2.743 ± 0.211
0.0GlyXaa: 0.0 ± 0.0
His
0.612HisAla: 0.612 ± 0.089
0.213HisCys: 0.213 ± 0.055
0.506HisAsp: 0.506 ± 0.07
0.679HisGlu: 0.679 ± 0.09
0.546HisPhe: 0.546 ± 0.079
0.932HisGly: 0.932 ± 0.122
0.226HisHis: 0.226 ± 0.053
1.944HisIle: 1.944 ± 0.155
1.385HisLys: 1.385 ± 0.135
1.065HisLeu: 1.065 ± 0.132
0.266HisMet: 0.266 ± 0.058
1.092HisAsn: 1.092 ± 0.121
0.732HisPro: 0.732 ± 0.096
0.213HisGln: 0.213 ± 0.057
0.493HisArg: 0.493 ± 0.08
1.038HisSer: 1.038 ± 0.141
0.612HisThr: 0.612 ± 0.08
0.533HisVal: 0.533 ± 0.075
0.2HisTrp: 0.2 ± 0.054
0.719HisTyr: 0.719 ± 0.106
0.0HisXaa: 0.0 ± 0.0
Ile
4.38IleAla: 4.38 ± 0.292
1.784IleCys: 1.784 ± 0.184
6.257IleAsp: 6.257 ± 0.47
7.495IleGlu: 7.495 ± 0.305
6.776IlePhe: 6.776 ± 0.368
7.269IleGly: 7.269 ± 0.349
2.09IleHis: 2.09 ± 0.181
17.866IleIle: 17.866 ± 0.631
16.682IleLys: 16.682 ± 0.569
12.022IleLeu: 12.022 ± 0.444
1.97IleMet: 1.97 ± 0.173
12.448IleAsn: 12.448 ± 0.436
4.433IlePro: 4.433 ± 0.244
2.263IleGln: 2.263 ± 0.198
3.887IleArg: 3.887 ± 0.225
10.637IleSer: 10.637 ± 0.365
5.352IleThr: 5.352 ± 0.27
4.633IleVal: 4.633 ± 0.24
0.812IleTrp: 0.812 ± 0.112
6.83IleTyr: 6.83 ± 0.38
0.0IleXaa: 0.0 ± 0.0
Lys
3.302LysAla: 3.302 ± 0.222
1.012LysCys: 1.012 ± 0.115
3.768LysAsp: 3.768 ± 0.255
7.775LysGlu: 7.775 ± 0.357
5.791LysPhe: 5.791 ± 0.291
5.112LysGly: 5.112 ± 0.33
1.265LysHis: 1.265 ± 0.127
18.745LysIle: 18.745 ± 0.581
23.831LysLys: 23.831 ± 0.817
9.905LysLeu: 9.905 ± 0.383
2.077LysMet: 2.077 ± 0.159
12.727LysAsn: 12.727 ± 0.515
1.93LysPro: 1.93 ± 0.165
2.25LysGln: 2.25 ± 0.171
3.741LysArg: 3.741 ± 0.235
6.39LysSer: 6.39 ± 0.464
4.779LysThr: 4.779 ± 0.266
4.3LysVal: 4.3 ± 0.222
0.692LysTrp: 0.692 ± 0.11
7.016LysTyr: 7.016 ± 0.372
0.0LysXaa: 0.0 ± 0.0
Leu
2.916LeuAla: 2.916 ± 0.216
1.038LeuCys: 1.038 ± 0.126
3.741LeuAsp: 3.741 ± 0.208
5.419LeuGlu: 5.419 ± 0.266
4.992LeuPhe: 4.992 ± 0.289
5.392LeuGly: 5.392 ± 0.285
1.212LeuHis: 1.212 ± 0.13
10.93LeuIle: 10.93 ± 0.409
12.128LeuLys: 12.128 ± 0.43
8.174LeuLeu: 8.174 ± 0.363
1.518LeuMet: 1.518 ± 0.143
7.562LeuAsn: 7.562 ± 0.363
2.516LeuPro: 2.516 ± 0.175
1.638LeuGln: 1.638 ± 0.143
2.569LeuArg: 2.569 ± 0.195
6.79LeuSer: 6.79 ± 0.339
3.075LeuThr: 3.075 ± 0.184
2.902LeuVal: 2.902 ± 0.197
0.439LeuTrp: 0.439 ± 0.094
4.433LeuTyr: 4.433 ± 0.225
0.0LeuXaa: 0.0 ± 0.0
Met
0.785MetAla: 0.785 ± 0.121
0.28MetCys: 0.28 ± 0.067
0.706MetAsp: 0.706 ± 0.101
0.719MetGlu: 0.719 ± 0.102
0.879MetPhe: 0.879 ± 0.119
1.318MetGly: 1.318 ± 0.155
0.266MetHis: 0.266 ± 0.057
2.143MetIle: 2.143 ± 0.172
2.01MetLys: 2.01 ± 0.165
1.531MetLeu: 1.531 ± 0.169
0.306MetMet: 0.306 ± 0.048
1.425MetAsn: 1.425 ± 0.146
0.799MetPro: 0.799 ± 0.094
0.306MetGln: 0.306 ± 0.068
0.559MetArg: 0.559 ± 0.094
1.145MetSer: 1.145 ± 0.134
0.706MetThr: 0.706 ± 0.094
0.785MetVal: 0.785 ± 0.09
0.12MetTrp: 0.12 ± 0.039
0.839MetTyr: 0.839 ± 0.118
0.0MetXaa: 0.0 ± 0.0
Asn
2.223AsnAla: 2.223 ± 0.202
1.038AsnCys: 1.038 ± 0.123
2.756AsnAsp: 2.756 ± 0.236
3.581AsnGlu: 3.581 ± 0.229
4.939AsnPhe: 4.939 ± 0.301
3.501AsnGly: 3.501 ± 0.217
1.198AsnHis: 1.198 ± 0.145
13.446AsnIle: 13.446 ± 0.531
11.503AsnLys: 11.503 ± 0.529
7.216AsnLeu: 7.216 ± 0.34
1.385AsnMet: 1.385 ± 0.15
9.146AsnAsn: 9.146 ± 0.543
2.53AsnPro: 2.53 ± 0.165
1.558AsnGln: 1.558 ± 0.157
2.064AsnArg: 2.064 ± 0.164
5.112AsnSer: 5.112 ± 0.229
2.849AsnThr: 2.849 ± 0.211
3.062AsnVal: 3.062 ± 0.179
0.559AsnTrp: 0.559 ± 0.09
4.673AsnTyr: 4.673 ± 0.238
0.0AsnXaa: 0.0 ± 0.0
Pro
0.919ProAla: 0.919 ± 0.121
0.28ProCys: 0.28 ± 0.064
1.225ProAsp: 1.225 ± 0.137
1.717ProGlu: 1.717 ± 0.129
1.504ProPhe: 1.504 ± 0.122
1.864ProGly: 1.864 ± 0.158
0.399ProHis: 0.399 ± 0.076
3.781ProIle: 3.781 ± 0.253
2.436ProLys: 2.436 ± 0.155
2.49ProLeu: 2.49 ± 0.159
0.413ProMet: 0.413 ± 0.074
2.064ProAsn: 2.064 ± 0.144
0.839ProPro: 0.839 ± 0.097
0.559ProGln: 0.559 ± 0.088
0.812ProArg: 0.812 ± 0.093
2.01ProSer: 2.01 ± 0.175
1.212ProThr: 1.212 ± 0.121
1.345ProVal: 1.345 ± 0.133
0.173ProTrp: 0.173 ± 0.043
1.571ProTyr: 1.571 ± 0.127
0.0ProXaa: 0.0 ± 0.0
Gln
0.932GlnAla: 0.932 ± 0.11
0.107GlnCys: 0.107 ± 0.033
0.626GlnAsp: 0.626 ± 0.094
1.038GlnGlu: 1.038 ± 0.126
0.945GlnPhe: 0.945 ± 0.124
1.251GlnGly: 1.251 ± 0.152
0.346GlnHis: 0.346 ± 0.068
2.822GlnIle: 2.822 ± 0.177
1.757GlnLys: 1.757 ± 0.146
1.584GlnLeu: 1.584 ± 0.168
0.639GlnMet: 0.639 ± 0.091
1.225GlnAsn: 1.225 ± 0.139
0.506GlnPro: 0.506 ± 0.087
0.359GlnGln: 0.359 ± 0.078
0.719GlnArg: 0.719 ± 0.107
1.251GlnSer: 1.251 ± 0.124
0.719GlnThr: 0.719 ± 0.08
0.879GlnVal: 0.879 ± 0.107
0.16GlnTrp: 0.16 ± 0.046
0.998GlnTyr: 0.998 ± 0.126
0.0GlnXaa: 0.0 ± 0.0
Arg
1.212ArgAla: 1.212 ± 0.135
0.306ArgCys: 0.306 ± 0.074
1.278ArgAsp: 1.278 ± 0.153
1.664ArgGlu: 1.664 ± 0.155
1.504ArgPhe: 1.504 ± 0.169
1.797ArgGly: 1.797 ± 0.145
0.413ArgHis: 0.413 ± 0.081
3.808ArgIle: 3.808 ± 0.225
3.741ArgLys: 3.741 ± 0.241
2.609ArgLeu: 2.609 ± 0.184
0.772ArgMet: 0.772 ± 0.105
2.13ArgAsn: 2.13 ± 0.174
0.839ArgPro: 0.839 ± 0.11
0.892ArgGln: 0.892 ± 0.115
1.052ArgArg: 1.052 ± 0.116
1.837ArgSer: 1.837 ± 0.177
1.251ArgThr: 1.251 ± 0.124
1.598ArgVal: 1.598 ± 0.151
0.107ArgTrp: 0.107 ± 0.039
1.518ArgTyr: 1.518 ± 0.129
0.0ArgXaa: 0.0 ± 0.0
Ser
2.436SerAla: 2.436 ± 0.21
0.639SerCys: 0.639 ± 0.101
2.849SerAsp: 2.849 ± 0.194
3.435SerGlu: 3.435 ± 0.261
3.728SerPhe: 3.728 ± 0.261
4.22SerGly: 4.22 ± 0.257
1.212SerHis: 1.212 ± 0.135
9.333SerIle: 9.333 ± 0.395
7.975SerLys: 7.975 ± 0.493
5.938SerLeu: 5.938 ± 0.258
1.038SerMet: 1.038 ± 0.124
4.287SerAsn: 4.287 ± 0.226
1.651SerPro: 1.651 ± 0.162
1.278SerGln: 1.278 ± 0.137
1.957SerArg: 1.957 ± 0.188
4.939SerSer: 4.939 ± 0.289
2.862SerThr: 2.862 ± 0.235
2.716SerVal: 2.716 ± 0.186
0.599SerTrp: 0.599 ± 0.124
3.941SerTyr: 3.941 ± 0.25
0.0SerXaa: 0.0 ± 0.0
Thr
1.797ThrAla: 1.797 ± 0.167
0.533ThrCys: 0.533 ± 0.079
1.638ThrAsp: 1.638 ± 0.148
1.771ThrGlu: 1.771 ± 0.185
2.09ThrPhe: 2.09 ± 0.151
3.382ThrGly: 3.382 ± 0.201
0.639ThrHis: 0.639 ± 0.089
4.779ThrIle: 4.779 ± 0.228
3.808ThrLys: 3.808 ± 0.231
3.555ThrLeu: 3.555 ± 0.204
0.586ThrMet: 0.586 ± 0.083
3.009ThrAsn: 3.009 ± 0.185
1.598ThrPro: 1.598 ± 0.179
0.852ThrGln: 0.852 ± 0.103
1.225ThrArg: 1.225 ± 0.129
2.822ThrSer: 2.822 ± 0.195
2.13ThrThr: 2.13 ± 0.195
2.09ThrVal: 2.09 ± 0.164
0.2ThrTrp: 0.2 ± 0.049
1.704ThrTyr: 1.704 ± 0.124
0.0ThrXaa: 0.0 ± 0.0
Val
1.757ValAla: 1.757 ± 0.235
0.479ValCys: 0.479 ± 0.089
1.771ValAsp: 1.771 ± 0.166
1.957ValGlu: 1.957 ± 0.182
2.263ValPhe: 2.263 ± 0.178
2.769ValGly: 2.769 ± 0.208
0.493ValHis: 0.493 ± 0.082
5.205ValIle: 5.205 ± 0.227
4.234ValLys: 4.234 ± 0.227
3.741ValLeu: 3.741 ± 0.238
0.759ValMet: 0.759 ± 0.109
2.942ValAsn: 2.942 ± 0.192
1.212ValPro: 1.212 ± 0.142
0.679ValGln: 0.679 ± 0.091
1.478ValArg: 1.478 ± 0.171
2.982ValSer: 2.982 ± 0.198
1.771ValThr: 1.771 ± 0.17
2.09ValVal: 2.09 ± 0.194
0.28ValTrp: 0.28 ± 0.063
1.624ValTyr: 1.624 ± 0.156
0.0ValXaa: 0.0 ± 0.0
Trp
0.306TrpAla: 0.306 ± 0.09
0.08TrpCys: 0.08 ± 0.033
0.24TrpAsp: 0.24 ± 0.057
0.359TrpGlu: 0.359 ± 0.07
0.24TrpPhe: 0.24 ± 0.063
0.399TrpGly: 0.399 ± 0.079
0.12TrpHis: 0.12 ± 0.039
0.879TrpIle: 0.879 ± 0.119
0.572TrpLys: 0.572 ± 0.081
0.639TrpLeu: 0.639 ± 0.095
0.146TrpMet: 0.146 ± 0.048
0.479TrpAsn: 0.479 ± 0.096
0.12TrpPro: 0.12 ± 0.041
0.173TrpGln: 0.173 ± 0.05
0.24TrpArg: 0.24 ± 0.058
0.306TrpSer: 0.306 ± 0.083
0.213TrpThr: 0.213 ± 0.049
0.333TrpVal: 0.333 ± 0.07
0.146TrpTrp: 0.146 ± 0.052
0.453TrpTyr: 0.453 ± 0.085
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.411TyrAla: 1.411 ± 0.15
0.719TyrCys: 0.719 ± 0.106
2.822TyrAsp: 2.822 ± 0.285
2.49TyrGlu: 2.49 ± 0.194
2.782TyrPhe: 2.782 ± 0.204
2.743TyrGly: 2.743 ± 0.218
0.692TyrHis: 0.692 ± 0.098
6.217TyrIle: 6.217 ± 0.37
7.296TyrLys: 7.296 ± 0.312
4.766TyrLeu: 4.766 ± 0.257
0.825TyrMet: 0.825 ± 0.097
5.099TyrAsn: 5.099 ± 0.281
1.558TyrPro: 1.558 ± 0.137
0.839TyrGln: 0.839 ± 0.113
1.518TyrArg: 1.518 ± 0.15
3.555TyrSer: 3.555 ± 0.234
1.877TyrThr: 1.877 ± 0.163
1.851TyrVal: 1.851 ± 0.15
0.28TyrTrp: 0.28 ± 0.071
2.663TyrTyr: 2.663 ± 0.198
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 227 proteins (75114 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski