Amino acid dipepetide frequency for Candidatus Poribacteria bacterium

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.684AlaAla: 4.684 ± 0.089	0.66AlaCys: 0.66 ± 0.026	3.757AlaAsp: 3.757 ± 0.068	4.701AlaGlu: 4.701 ± 0.081	2.982AlaPhe: 2.982 ± 0.065	4.532AlaGly: 4.532 ± 0.079	1.348AlaHis: 1.348 ± 0.035	5.417AlaIle: 5.417 ± 0.072	3.402AlaLys: 3.402 ± 0.062	5.783AlaLeu: 5.783 ± 0.085	1.405AlaMet: 1.405 ± 0.035	2.642AlaAsn: 2.642 ± 0.043	2.085AlaPro: 2.085 ± 0.049	2.259AlaGln: 2.259 ± 0.051	2.647AlaArg: 2.647 ± 0.054	3.836AlaSer: 3.836 ± 0.065	3.679AlaThr: 3.679 ± 0.057	4.393AlaVal: 4.393 ± 0.068	0.785AlaTrp: 0.785 ± 0.025	2.3AlaTyr: 2.3 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.6CysAla: 0.6 ± 0.027	0.149CysCys: 0.149 ± 0.011	0.598CysAsp: 0.598 ± 0.022	0.583CysGlu: 0.583 ± 0.024	0.464CysPhe: 0.464 ± 0.023	0.868CysGly: 0.868 ± 0.03	0.318CysHis: 0.318 ± 0.019	0.836CysIle: 0.836 ± 0.027	0.441CysLys: 0.441 ± 0.02	1.017CysLeu: 1.017 ± 0.028	0.208CysMet: 0.208 ± 0.013	0.434CysAsn: 0.434 ± 0.023	0.467CysPro: 0.467 ± 0.023	0.337CysGln: 0.337 ± 0.017	0.398CysArg: 0.398 ± 0.02	0.563CysSer: 0.563 ± 0.02	0.532CysThr: 0.532 ± 0.025	0.72CysVal: 0.72 ± 0.028	0.158CysTrp: 0.158 ± 0.012	0.422CysTyr: 0.422 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	4.248AspAla: 4.248 ± 0.074	0.489AspCys: 0.489 ± 0.022	3.553AspAsp: 3.553 ± 0.064	4.437AspGlu: 4.437 ± 0.068	2.636AspPhe: 2.636 ± 0.061	5.453AspGly: 5.453 ± 0.108	1.048AspHis: 1.048 ± 0.028	5.209AspIle: 5.209 ± 0.073	3.156AspLys: 3.156 ± 0.048	5.154AspLeu: 5.154 ± 0.074	1.291AspMet: 1.291 ± 0.033	2.983AspAsn: 2.983 ± 0.051	2.601AspPro: 2.601 ± 0.051	1.575AspGln: 1.575 ± 0.036	2.737AspArg: 2.737 ± 0.05	3.667AspSer: 3.667 ± 0.056	3.948AspThr: 3.948 ± 0.057	4.375AspVal: 4.375 ± 0.068	0.91AspTrp: 0.91 ± 0.03	2.278AspTyr: 2.278 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	4.097GluAla: 4.097 ± 0.063	0.518GluCys: 0.518 ± 0.021	3.869GluAsp: 3.869 ± 0.066	4.855GluGlu: 4.855 ± 0.088	2.683GluPhe: 2.683 ± 0.058	3.966GluGly: 3.966 ± 0.061	1.52GluHis: 1.52 ± 0.039	5.802GluIle: 5.802 ± 0.088	4.453GluLys: 4.453 ± 0.074	6.548GluLeu: 6.548 ± 0.075	1.841GluMet: 1.841 ± 0.042	4.041GluAsn: 4.041 ± 0.061	2.388GluPro: 2.388 ± 0.054	2.614GluGln: 2.614 ± 0.056	3.323GluArg: 3.323 ± 0.056	4.131GluSer: 4.131 ± 0.083	4.121GluThr: 4.121 ± 0.068	4.053GluVal: 4.053 ± 0.059	0.982GluTrp: 0.982 ± 0.032	2.229GluTyr: 2.229 ± 0.046	0.0GluXaa: 0.0 ± 0.0
Phe	2.604PheAla: 2.604 ± 0.054	0.517PheCys: 0.517 ± 0.021	2.668PheAsp: 2.668 ± 0.05	2.512PheGlu: 2.512 ± 0.052	1.811PhePhe: 1.811 ± 0.045	3.179PheGly: 3.179 ± 0.061	0.953PheHis: 0.953 ± 0.042	2.99PheIle: 2.99 ± 0.062	1.841PheLys: 1.841 ± 0.044	3.904PheLeu: 3.904 ± 0.07	0.836PheMet: 0.836 ± 0.025	2.08PheAsn: 2.08 ± 0.045	1.768PhePro: 1.768 ± 0.038	1.489PheGln: 1.489 ± 0.037	1.92PheArg: 1.92 ± 0.039	3.48PheSer: 3.48 ± 0.077	2.711PheThr: 2.711 ± 0.049	2.546PheVal: 2.546 ± 0.051	0.636PheTrp: 0.636 ± 0.024	1.581PheTyr: 1.581 ± 0.042	0.0PheXaa: 0.0 ± 0.0
Gly	4.042GlyAla: 4.042 ± 0.076	0.935GlyCys: 0.935 ± 0.03	4.059GlyAsp: 4.059 ± 0.074	4.579GlyGlu: 4.579 ± 0.067	3.154GlyPhe: 3.154 ± 0.058	5.191GlyGly: 5.191 ± 0.084	1.776GlyHis: 1.776 ± 0.05	6.209GlyIle: 6.209 ± 0.081	4.588GlyLys: 4.588 ± 0.078	5.574GlyLeu: 5.574 ± 0.087	1.719GlyMet: 1.719 ± 0.041	3.499GlyAsn: 3.499 ± 0.071	1.895GlyPro: 1.895 ± 0.047	2.08GlyGln: 2.08 ± 0.041	3.153GlyArg: 3.153 ± 0.06	4.276GlySer: 4.276 ± 0.072	4.401GlyThr: 4.401 ± 0.065	4.681GlyVal: 4.681 ± 0.066	1.114GlyTrp: 1.114 ± 0.035	2.815GlyTyr: 2.815 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	1.478HisAla: 1.478 ± 0.036	0.227HisCys: 0.227 ± 0.012	1.117HisAsp: 1.117 ± 0.036	1.315HisGlu: 1.315 ± 0.036	1.086HisPhe: 1.086 ± 0.034	1.638HisGly: 1.638 ± 0.043	0.676HisHis: 0.676 ± 0.023	1.883HisIle: 1.883 ± 0.045	1.07HisLys: 1.07 ± 0.032	2.349HisLeu: 2.349 ± 0.046	0.333HisMet: 0.333 ± 0.019	1.034HisAsn: 1.034 ± 0.03	1.429HisPro: 1.429 ± 0.033	1.011HisGln: 1.011 ± 0.03	1.173HisArg: 1.173 ± 0.037	1.329HisSer: 1.329 ± 0.034	1.54HisThr: 1.54 ± 0.049	1.3HisVal: 1.3 ± 0.035	0.347HisTrp: 0.347 ± 0.018	0.88HisTyr: 0.88 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.808IleAla: 5.808 ± 0.074	0.883IleCys: 0.883 ± 0.026	5.293IleAsp: 5.293 ± 0.078	5.475IleGlu: 5.475 ± 0.079	2.911IlePhe: 2.911 ± 0.057	5.99IleGly: 5.99 ± 0.094	1.925IleHis: 1.925 ± 0.041	5.268IleIle: 5.268 ± 0.091	3.643IleLys: 3.643 ± 0.065	7.406IleLeu: 7.406 ± 0.084	1.246IleMet: 1.246 ± 0.032	3.48IleAsn: 3.48 ± 0.062	4.127IlePro: 4.127 ± 0.06	3.332IleGln: 3.332 ± 0.056	4.025IleArg: 4.025 ± 0.06	5.505IleSer: 5.505 ± 0.075	4.958IleThr: 4.958 ± 0.058	5.056IleVal: 5.056 ± 0.074	0.935IleTrp: 0.935 ± 0.033	2.672IleTyr: 2.672 ± 0.051	0.0IleXaa: 0.0 ± 0.0
Lys	3.303LysAla: 3.303 ± 0.064	0.429LysCys: 0.429 ± 0.018	3.061LysAsp: 3.061 ± 0.051	3.488LysGlu: 3.488 ± 0.056	1.671LysPhe: 1.671 ± 0.046	3.073LysGly: 3.073 ± 0.063	1.262LysHis: 1.262 ± 0.028	4.202LysIle: 4.202 ± 0.064	3.006LysLys: 3.006 ± 0.059	4.93LysLeu: 4.93 ± 0.075	1.265LysMet: 1.265 ± 0.032	2.824LysAsn: 2.824 ± 0.066	2.44LysPro: 2.44 ± 0.05	2.291LysGln: 2.291 ± 0.056	2.713LysArg: 2.713 ± 0.049	3.32LysSer: 3.32 ± 0.054	3.609LysThr: 3.609 ± 0.063	3.163LysVal: 3.163 ± 0.052	0.801LysTrp: 0.801 ± 0.024	1.934LysTyr: 1.934 ± 0.045	0.0LysXaa: 0.0 ± 0.0
Leu	6.227LeuAla: 6.227 ± 0.084	1.034LeuCys: 1.034 ± 0.03	5.333LeuAsp: 5.333 ± 0.078	5.824LeuGlu: 5.824 ± 0.08	3.913LeuPhe: 3.913 ± 0.072	5.874LeuGly: 5.874 ± 0.08	2.038LeuHis: 2.038 ± 0.047	7.138LeuIle: 7.138 ± 0.091	5.029LeuLys: 5.029 ± 0.079	8.509LeuLeu: 8.509 ± 0.116	2.04LeuMet: 2.04 ± 0.044	4.463LeuAsn: 4.463 ± 0.071	4.284LeuPro: 4.284 ± 0.068	3.422LeuGln: 3.422 ± 0.063	4.473LeuArg: 4.473 ± 0.067	6.606LeuSer: 6.606 ± 0.076	5.963LeuThr: 5.963 ± 0.071	5.213LeuVal: 5.213 ± 0.068	1.478LeuTrp: 1.478 ± 0.054	3.067LeuTyr: 3.067 ± 0.057	0.0LeuXaa: 0.0 ± 0.0
Met	1.479MetAla: 1.479 ± 0.04	0.223MetCys: 0.223 ± 0.013	1.237MetAsp: 1.237 ± 0.033	1.334MetGlu: 1.334 ± 0.032	0.763MetPhe: 0.763 ± 0.027	1.479MetGly: 1.479 ± 0.033	0.469MetHis: 0.469 ± 0.019	1.387MetIle: 1.387 ± 0.037	1.455MetLys: 1.455 ± 0.045	1.956MetLeu: 1.956 ± 0.043	0.557MetMet: 0.557 ± 0.023	1.155MetAsn: 1.155 ± 0.032	0.981MetPro: 0.981 ± 0.034	0.837MetGln: 0.837 ± 0.027	1.075MetArg: 1.075 ± 0.027	1.391MetSer: 1.391 ± 0.036	1.229MetThr: 1.229 ± 0.034	1.358MetVal: 1.358 ± 0.037	0.248MetTrp: 0.248 ± 0.014	0.595MetTyr: 0.595 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.22AsnAla: 3.22 ± 0.054	0.455AsnCys: 0.455 ± 0.02	2.594AsnAsp: 2.594 ± 0.052	2.936AsnGlu: 2.936 ± 0.062	1.811AsnPhe: 1.811 ± 0.042	3.606AsnGly: 3.606 ± 0.055	1.001AsnHis: 1.001 ± 0.028	4.017AsnIle: 4.017 ± 0.066	2.252AsnLys: 2.252 ± 0.046	4.595AsnLeu: 4.595 ± 0.068	0.911AsnMet: 0.911 ± 0.028	2.429AsnAsn: 2.429 ± 0.06	2.963AsnPro: 2.963 ± 0.055	1.976AsnGln: 1.976 ± 0.044	2.758AsnArg: 2.758 ± 0.065	3.05AsnSer: 3.05 ± 0.052	3.413AsnThr: 3.413 ± 0.062	2.961AsnVal: 2.961 ± 0.051	0.741AsnTrp: 0.741 ± 0.026	1.706AsnTyr: 1.706 ± 0.038	0.0AsnXaa: 0.0 ± 0.0
Pro	2.203ProAla: 2.203 ± 0.048	0.331ProCys: 0.331 ± 0.017	3.718ProAsp: 3.718 ± 0.071	3.704ProGlu: 3.704 ± 0.056	1.903ProPhe: 1.903 ± 0.044	2.599ProGly: 2.599 ± 0.049	1.115ProHis: 1.115 ± 0.028	3.646ProIle: 3.646 ± 0.061	2.171ProLys: 2.171 ± 0.043	3.542ProLeu: 3.542 ± 0.056	0.859ProMet: 0.859 ± 0.029	2.549ProAsn: 2.549 ± 0.049	1.908ProPro: 1.908 ± 0.044	1.41ProGln: 1.41 ± 0.035	1.73ProArg: 1.73 ± 0.04	2.49ProSer: 2.49 ± 0.049	2.763ProThr: 2.763 ± 0.055	2.822ProVal: 2.822 ± 0.05	0.543ProTrp: 0.543 ± 0.022	1.498ProTyr: 1.498 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	2.164GlnAla: 2.164 ± 0.057	0.286GlnCys: 0.286 ± 0.017	2.064GlnAsp: 2.064 ± 0.042	2.44GlnGlu: 2.44 ± 0.05	1.594GlnPhe: 1.594 ± 0.044	1.974GlnGly: 1.974 ± 0.037	0.957GlnHis: 0.957 ± 0.026	3.048GlnIle: 3.048 ± 0.049	2.184GlnLys: 2.184 ± 0.043	3.741GlnLeu: 3.741 ± 0.065	0.903GlnMet: 0.903 ± 0.025	1.958GlnAsn: 1.958 ± 0.047	1.49GlnPro: 1.49 ± 0.037	1.779GlnGln: 1.779 ± 0.057	1.908GlnArg: 1.908 ± 0.047	2.176GlnSer: 2.176 ± 0.042	2.294GlnThr: 2.294 ± 0.043	2.197GlnVal: 2.197 ± 0.041	0.548GlnTrp: 0.548 ± 0.02	1.217GlnTyr: 1.217 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	2.648ArgAla: 2.648 ± 0.05	0.482ArgCys: 0.482 ± 0.02	2.657ArgAsp: 2.657 ± 0.046	3.302ArgGlu: 3.302 ± 0.072	2.349ArgPhe: 2.349 ± 0.048	2.869ArgGly: 2.869 ± 0.048	1.149ArgHis: 1.149 ± 0.027	4.131ArgIle: 4.131 ± 0.077	2.695ArgLys: 2.695 ± 0.047	4.685ArgLeu: 4.685 ± 0.068	1.106ArgMet: 1.106 ± 0.033	2.43ArgAsn: 2.43 ± 0.042	1.62ArgPro: 1.62 ± 0.037	1.793ArgGln: 1.793 ± 0.041	2.693ArgArg: 2.693 ± 0.051	2.846ArgSer: 2.846 ± 0.047	2.659ArgThr: 2.659 ± 0.05	2.866ArgVal: 2.866 ± 0.049	0.752ArgTrp: 0.752 ± 0.027	1.935ArgTyr: 1.935 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	3.592SerAla: 3.592 ± 0.059	0.585SerCys: 0.585 ± 0.026	4.317SerAsp: 4.317 ± 0.062	4.598SerGlu: 4.598 ± 0.071	2.566SerPhe: 2.566 ± 0.052	4.934SerGly: 4.934 ± 0.088	1.492SerHis: 1.492 ± 0.034	5.251SerIle: 5.251 ± 0.071	3.053SerLys: 3.053 ± 0.061	5.895SerLeu: 5.895 ± 0.073	1.297SerMet: 1.297 ± 0.032	2.931SerAsn: 2.931 ± 0.053	3.148SerPro: 3.148 ± 0.077	2.341SerGln: 2.341 ± 0.043	2.789SerArg: 2.789 ± 0.055	3.894SerSer: 3.894 ± 0.072	3.592SerThr: 3.592 ± 0.054	4.296SerVal: 4.296 ± 0.067	0.823SerTrp: 0.823 ± 0.032	2.161SerTyr: 2.161 ± 0.047	0.0SerXaa: 0.0 ± 0.0
Thr	3.806ThrAla: 3.806 ± 0.067	0.545ThrCys: 0.545 ± 0.025	4.18ThrAsp: 4.18 ± 0.069	4.254ThrGlu: 4.254 ± 0.07	2.731ThrPhe: 2.731 ± 0.05	4.671ThrGly: 4.671 ± 0.078	1.531ThrHis: 1.531 ± 0.035	4.821ThrIle: 4.821 ± 0.069	2.614ThrLys: 2.614 ± 0.053	6.276ThrLeu: 6.276 ± 0.077	1.097ThrMet: 1.097 ± 0.048	2.575ThrAsn: 2.575 ± 0.053	3.337ThrPro: 3.337 ± 0.055	2.367ThrGln: 2.367 ± 0.052	2.457ThrArg: 2.457 ± 0.052	3.59ThrSer: 3.59 ± 0.069	3.834ThrThr: 3.834 ± 0.088	4.053ThrVal: 4.053 ± 0.074	0.864ThrTrp: 0.864 ± 0.029	2.136ThrTyr: 2.136 ± 0.047	0.0ThrXaa: 0.0 ± 0.0
Val	4.205ValAla: 4.205 ± 0.071	0.798ValCys: 0.798 ± 0.028	4.147ValAsp: 4.147 ± 0.07	4.647ValGlu: 4.647 ± 0.065	2.83ValPhe: 2.83 ± 0.055	4.409ValGly: 4.409 ± 0.073	1.242ValHis: 1.242 ± 0.035	4.927ValIle: 4.927 ± 0.071	3.206ValLys: 3.206 ± 0.054	5.501ValLeu: 5.501 ± 0.075	1.316ValMet: 1.316 ± 0.034	3.216ValAsn: 3.216 ± 0.056	2.607ValPro: 2.607 ± 0.047	1.872ValGln: 1.872 ± 0.046	2.914ValArg: 2.914 ± 0.045	4.36ValSer: 4.36 ± 0.061	3.613ValThr: 3.613 ± 0.069	4.426ValVal: 4.426 ± 0.077	0.91ValTrp: 0.91 ± 0.036	2.252ValTyr: 2.252 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	0.685TrpAla: 0.685 ± 0.026	0.163TrpCys: 0.163 ± 0.012	1.254TrpAsp: 1.254 ± 0.061	0.968TrpGlu: 0.968 ± 0.032	0.544TrpPhe: 0.544 ± 0.027	1.095TrpGly: 1.095 ± 0.035	0.489TrpHis: 0.489 ± 0.019	1.176TrpIle: 1.176 ± 0.032	0.818TrpLys: 0.818 ± 0.028	1.226TrpLeu: 1.226 ± 0.034	0.359TrpMet: 0.359 ± 0.019	0.877TrpAsn: 0.877 ± 0.03	0.272TrpPro: 0.272 ± 0.016	0.555TrpGln: 0.555 ± 0.022	0.725TrpArg: 0.725 ± 0.026	0.767TrpSer: 0.767 ± 0.03	0.739TrpThr: 0.739 ± 0.027	0.904TrpVal: 0.904 ± 0.031	0.215TrpTrp: 0.215 ± 0.016	0.464TrpTyr: 0.464 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.204TyrAla: 2.204 ± 0.044	0.404TyrCys: 0.404 ± 0.021	2.269TyrAsp: 2.269 ± 0.05	2.082TyrGlu: 2.082 ± 0.045	1.623TyrPhe: 1.623 ± 0.042	2.341TyrGly: 2.341 ± 0.044	0.909TyrHis: 0.909 ± 0.032	2.582TyrIle: 2.582 ± 0.05	1.71TyrLys: 1.71 ± 0.042	3.336TyrLeu: 3.336 ± 0.064	0.617TyrMet: 0.617 ± 0.024	1.796TyrAsn: 1.796 ± 0.046	1.695TyrPro: 1.695 ± 0.047	1.581TyrGln: 1.581 ± 0.039	2.058TyrArg: 2.058 ± 0.042	2.278TyrSer: 2.278 ± 0.044	2.139TyrThr: 2.139 ± 0.048	2.012TyrVal: 2.012 ± 0.045	0.506TyrTrp: 0.506 ± 0.021	1.346TyrTyr: 1.346 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3447 proteins (1197355 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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