Amino acid dipepetide frequency for Thermoclostridium caenicola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.254AlaAla: 7.254 ± 0.126	1.202AlaCys: 1.202 ± 0.041	4.269AlaAsp: 4.269 ± 0.068	5.607AlaGlu: 5.607 ± 0.088	3.49AlaPhe: 3.49 ± 0.057	6.353AlaGly: 6.353 ± 0.1	1.238AlaHis: 1.238 ± 0.035	5.864AlaIle: 5.864 ± 0.078	3.886AlaLys: 3.886 ± 0.077	8.059AlaLeu: 8.059 ± 0.115	2.442AlaMet: 2.442 ± 0.055	2.571AlaAsn: 2.571 ± 0.05	2.196AlaPro: 2.196 ± 0.061	2.384AlaGln: 2.384 ± 0.058	4.492AlaArg: 4.492 ± 0.072	4.335AlaSer: 4.335 ± 0.081	3.207AlaThr: 3.207 ± 0.066	6.536AlaVal: 6.536 ± 0.097	0.772AlaTrp: 0.772 ± 0.036	2.86AlaTyr: 2.86 ± 0.068	0.0AlaXaa: 0.0 ± 0.0
Cys	0.893CysAla: 0.893 ± 0.037	0.234CysCys: 0.234 ± 0.017	0.68CysAsp: 0.68 ± 0.027	0.774CysGlu: 0.774 ± 0.032	0.496CysPhe: 0.496 ± 0.027	1.273CysGly: 1.273 ± 0.041	0.294CysHis: 0.294 ± 0.02	0.918CysIle: 0.918 ± 0.036	0.583CysLys: 0.583 ± 0.029	1.19CysLeu: 1.19 ± 0.043	0.358CysMet: 0.358 ± 0.021	0.411CysAsn: 0.411 ± 0.023	0.65CysPro: 0.65 ± 0.035	0.303CysGln: 0.303 ± 0.019	0.813CysArg: 0.813 ± 0.036	0.79CysSer: 0.79 ± 0.035	0.587CysThr: 0.587 ± 0.022	0.843CysVal: 0.843 ± 0.034	0.097CysTrp: 0.097 ± 0.012	0.399CysTyr: 0.399 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	4.404AspAla: 4.404 ± 0.075	0.658AspCys: 0.658 ± 0.031	2.74AspAsp: 2.74 ± 0.066	4.327AspGlu: 4.327 ± 0.066	2.522AspPhe: 2.522 ± 0.051	4.214AspGly: 4.214 ± 0.083	0.859AspHis: 0.859 ± 0.032	4.868AspIle: 4.868 ± 0.081	3.237AspLys: 3.237 ± 0.074	4.749AspLeu: 4.749 ± 0.075	1.808AspMet: 1.808 ± 0.048	2.094AspAsn: 2.094 ± 0.052	2.35AspPro: 2.35 ± 0.058	1.425AspGln: 1.425 ± 0.039	3.232AspArg: 3.232 ± 0.072	2.757AspSer: 2.757 ± 0.058	2.684AspThr: 2.684 ± 0.066	3.747AspVal: 3.747 ± 0.079	0.586AspTrp: 0.586 ± 0.026	2.438AspTyr: 2.438 ± 0.056	0.0AspXaa: 0.0 ± 0.0
Glu	5.953GluAla: 5.953 ± 0.109	0.641GluCys: 0.641 ± 0.029	3.789GluAsp: 3.789 ± 0.066	5.819GluGlu: 5.819 ± 0.098	2.328GluPhe: 2.328 ± 0.044	4.355GluGly: 4.355 ± 0.081	1.231GluHis: 1.231 ± 0.04	5.536GluIle: 5.536 ± 0.069	5.846GluLys: 5.846 ± 0.098	6.648GluLeu: 6.648 ± 0.092	2.225GluMet: 2.225 ± 0.052	3.479GluAsn: 3.479 ± 0.063	2.372GluPro: 2.372 ± 0.064	2.564GluGln: 2.564 ± 0.062	4.069GluArg: 4.069 ± 0.084	3.578GluSer: 3.578 ± 0.065	3.534GluThr: 3.534 ± 0.07	4.411GluVal: 4.411 ± 0.077	0.611GluTrp: 0.611 ± 0.025	2.583GluTyr: 2.583 ± 0.065	0.0GluXaa: 0.0 ± 0.0
Phe	2.913PheAla: 2.913 ± 0.072	0.597PheCys: 0.597 ± 0.029	2.427PheAsp: 2.427 ± 0.051	2.757PheGlu: 2.757 ± 0.06	1.874PhePhe: 1.874 ± 0.061	3.223PheGly: 3.223 ± 0.07	0.677PheHis: 0.677 ± 0.03	3.034PheIle: 3.034 ± 0.055	1.937PheLys: 1.937 ± 0.054	3.864PheLeu: 3.864 ± 0.085	1.184PheMet: 1.184 ± 0.037	1.677PheAsn: 1.677 ± 0.046	1.52PhePro: 1.52 ± 0.039	0.977PheGln: 0.977 ± 0.036	2.382PheArg: 2.382 ± 0.047	2.937PheSer: 2.937 ± 0.065	2.22PheThr: 2.22 ± 0.053	2.637PheVal: 2.637 ± 0.058	0.417PheTrp: 0.417 ± 0.023	1.452PheTyr: 1.452 ± 0.045	0.0PheXaa: 0.0 ± 0.0
Gly	4.933GlyAla: 4.933 ± 0.096	1.05GlyCys: 1.05 ± 0.041	3.721GlyAsp: 3.721 ± 0.076	4.644GlyGlu: 4.644 ± 0.073	3.444GlyPhe: 3.444 ± 0.07	4.908GlyGly: 4.908 ± 0.087	1.298GlyHis: 1.298 ± 0.03	6.418GlyIle: 6.418 ± 0.082	5.089GlyLys: 5.089 ± 0.09	6.917GlyLeu: 6.917 ± 0.099	2.531GlyMet: 2.531 ± 0.066	2.955GlyAsn: 2.955 ± 0.06	1.805GlyPro: 1.805 ± 0.053	2.033GlyGln: 2.033 ± 0.055	4.102GlyArg: 4.102 ± 0.065	4.323GlySer: 4.323 ± 0.083	4.093GlyThr: 4.093 ± 0.078	4.868GlyVal: 4.868 ± 0.084	0.72GlyTrp: 0.72 ± 0.032	3.157GlyTyr: 3.157 ± 0.061	0.0GlyXaa: 0.0 ± 0.0
His	1.317HisAla: 1.317 ± 0.043	0.252HisCys: 0.252 ± 0.021	0.966HisAsp: 0.966 ± 0.038	1.219HisGlu: 1.219 ± 0.042	0.75HisPhe: 0.75 ± 0.026	1.392HisGly: 1.392 ± 0.042	0.466HisHis: 0.466 ± 0.025	1.434HisIle: 1.434 ± 0.041	0.862HisLys: 0.862 ± 0.032	1.587HisLeu: 1.587 ± 0.044	0.484HisMet: 0.484 ± 0.024	0.676HisAsn: 0.676 ± 0.025	0.934HisPro: 0.934 ± 0.033	0.539HisGln: 0.539 ± 0.024	0.955HisArg: 0.955 ± 0.034	0.895HisSer: 0.895 ± 0.031	0.893HisThr: 0.893 ± 0.035	1.204HisVal: 1.204 ± 0.038	0.158HisTrp: 0.158 ± 0.012	0.694HisTyr: 0.694 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	6.247IleAla: 6.247 ± 0.091	1.018IleCys: 1.018 ± 0.036	4.064IleAsp: 4.064 ± 0.068	4.926IleGlu: 4.926 ± 0.085	2.676IlePhe: 2.676 ± 0.069	5.223IleGly: 5.223 ± 0.088	1.422IleHis: 1.422 ± 0.043	5.577IleIle: 5.577 ± 0.099	4.048IleLys: 4.048 ± 0.077	7.544IleLeu: 7.544 ± 0.104	2.057IleMet: 2.057 ± 0.047	3.099IleAsn: 3.099 ± 0.064	3.549IlePro: 3.549 ± 0.066	2.225IleGln: 2.225 ± 0.055	5.201IleArg: 5.201 ± 0.095	4.928IleSer: 4.928 ± 0.082	4.169IleThr: 4.169 ± 0.076	4.915IleVal: 4.915 ± 0.088	0.609IleTrp: 0.609 ± 0.026	2.441IleTyr: 2.441 ± 0.059	0.0IleXaa: 0.0 ± 0.0
Lys	5.507LysAla: 5.507 ± 0.092	0.619LysCys: 0.619 ± 0.031	3.485LysAsp: 3.485 ± 0.075	4.453LysGlu: 4.453 ± 0.085	1.587LysPhe: 1.587 ± 0.043	4.191LysGly: 4.191 ± 0.071	1.047LysHis: 1.047 ± 0.031	3.944LysIle: 3.944 ± 0.075	4.475LysLys: 4.475 ± 0.091	5.209LysLeu: 5.209 ± 0.082	1.599LysMet: 1.599 ± 0.044	2.815LysAsn: 2.815 ± 0.063	2.49LysPro: 2.49 ± 0.06	1.827LysGln: 1.827 ± 0.051	3.334LysArg: 3.334 ± 0.064	3.149LysSer: 3.149 ± 0.059	3.426LysThr: 3.426 ± 0.064	4.084LysVal: 4.084 ± 0.081	0.502LysTrp: 0.502 ± 0.022	2.308LysTyr: 2.308 ± 0.056	0.0LysXaa: 0.0 ± 0.0
Leu	7.857LeuAla: 7.857 ± 0.103	1.248LeuCys: 1.248 ± 0.041	5.502LeuAsp: 5.502 ± 0.097	6.894LeuGlu: 6.894 ± 0.1	4.133LeuPhe: 4.133 ± 0.095	6.513LeuGly: 6.513 ± 0.1	1.465LeuHis: 1.465 ± 0.048	6.634LeuIle: 6.634 ± 0.101	6.7LeuLys: 6.7 ± 0.096	9.314LeuLeu: 9.314 ± 0.142	2.709LeuMet: 2.709 ± 0.058	3.866LeuAsn: 3.866 ± 0.062	3.823LeuPro: 3.823 ± 0.064	2.456LeuGln: 2.456 ± 0.053	4.766LeuArg: 4.766 ± 0.086	6.465LeuSer: 6.465 ± 0.095	4.848LeuThr: 4.848 ± 0.077	6.629LeuVal: 6.629 ± 0.116	0.736LeuTrp: 0.736 ± 0.027	3.235LeuTyr: 3.235 ± 0.08	0.0LeuXaa: 0.0 ± 0.0
Met	2.611MetAla: 2.611 ± 0.059	0.259MetCys: 0.259 ± 0.019	1.852MetAsp: 1.852 ± 0.045	2.19MetGlu: 2.19 ± 0.052	0.882MetPhe: 0.882 ± 0.028	2.125MetGly: 2.125 ± 0.047	0.445MetHis: 0.445 ± 0.022	1.97MetIle: 1.97 ± 0.049	2.19MetLys: 2.19 ± 0.05	2.817MetLeu: 2.817 ± 0.06	0.807MetMet: 0.807 ± 0.034	1.31MetAsn: 1.31 ± 0.043	1.214MetPro: 1.214 ± 0.043	0.882MetGln: 0.882 ± 0.035	1.436MetArg: 1.436 ± 0.039	1.573MetSer: 1.573 ± 0.045	1.443MetThr: 1.443 ± 0.04	2.04MetVal: 2.04 ± 0.051	0.173MetTrp: 0.173 ± 0.012	0.634MetTyr: 0.634 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	3.159AsnAla: 3.159 ± 0.062	0.484AsnCys: 0.484 ± 0.027	1.98AsnAsp: 1.98 ± 0.049	2.439AsnGlu: 2.439 ± 0.059	1.379AsnPhe: 1.379 ± 0.045	3.283AsnGly: 3.283 ± 0.064	0.785AsnHis: 0.785 ± 0.031	3.231AsnIle: 3.231 ± 0.055	2.1AsnLys: 2.1 ± 0.058	3.87AsnLeu: 3.87 ± 0.075	1.148AsnMet: 1.148 ± 0.038	1.611AsnAsn: 1.611 ± 0.048	2.401AsnPro: 2.401 ± 0.05	1.345AsnGln: 1.345 ± 0.042	2.626AsnArg: 2.626 ± 0.057	1.992AsnSer: 1.992 ± 0.052	2.094AsnThr: 2.094 ± 0.051	2.515AsnVal: 2.515 ± 0.052	0.405AsnTrp: 0.405 ± 0.022	1.419AsnTyr: 1.419 ± 0.049	0.0AsnXaa: 0.0 ± 0.0
Pro	3.058ProAla: 3.058 ± 0.072	0.444ProCys: 0.444 ± 0.024	2.865ProAsp: 2.865 ± 0.056	3.961ProGlu: 3.961 ± 0.077	1.706ProPhe: 1.706 ± 0.052	3.231ProGly: 3.231 ± 0.074	0.686ProHis: 0.686 ± 0.027	2.288ProIle: 2.288 ± 0.051	1.712ProLys: 1.712 ± 0.05	3.141ProLeu: 3.141 ± 0.066	0.941ProMet: 0.941 ± 0.033	1.417ProAsn: 1.417 ± 0.045	1.237ProPro: 1.237 ± 0.047	1.158ProGln: 1.158 ± 0.036	1.639ProArg: 1.639 ± 0.05	2.136ProSer: 2.136 ± 0.051	1.63ProThr: 1.63 ± 0.047	3.601ProVal: 3.601 ± 0.068	0.412ProTrp: 0.412 ± 0.025	1.564ProTyr: 1.564 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	2.688GlnAla: 2.688 ± 0.056	0.319GlnCys: 0.319 ± 0.021	1.606GlnAsp: 1.606 ± 0.044	2.274GlnGlu: 2.274 ± 0.052	1.073GlnPhe: 1.073 ± 0.042	1.81GlnGly: 1.81 ± 0.049	0.501GlnHis: 0.501 ± 0.028	2.236GlnIle: 2.236 ± 0.057	2.172GlnLys: 2.172 ± 0.057	2.642GlnLeu: 2.642 ± 0.059	0.893GlnMet: 0.893 ± 0.033	1.353GlnAsn: 1.353 ± 0.043	1.021GlnPro: 1.021 ± 0.038	1.139GlnGln: 1.139 ± 0.045	1.407GlnArg: 1.407 ± 0.045	1.506GlnSer: 1.506 ± 0.046	1.397GlnThr: 1.397 ± 0.049	2.07GlnVal: 2.07 ± 0.048	0.308GlnTrp: 0.308 ± 0.02	1.224GlnTyr: 1.224 ± 0.042	0.0GlnXaa: 0.0 ± 0.0
Arg	3.531ArgAla: 3.531 ± 0.066	0.614ArgCys: 0.614 ± 0.034	2.999ArgAsp: 2.999 ± 0.066	4.818ArgGlu: 4.818 ± 0.092	2.533ArgPhe: 2.533 ± 0.059	3.06ArgGly: 3.06 ± 0.064	1.069ArgHis: 1.069 ± 0.037	5.169ArgIle: 5.169 ± 0.082	4.031ArgLys: 4.031 ± 0.072	5.807ArgLeu: 5.807 ± 0.094	1.852ArgMet: 1.852 ± 0.054	2.54ArgAsn: 2.54 ± 0.058	1.809ArgPro: 1.809 ± 0.048	1.996ArgGln: 1.996 ± 0.046	2.997ArgArg: 2.997 ± 0.074	2.812ArgSer: 2.812 ± 0.055	2.69ArgThr: 2.69 ± 0.059	3.597ArgVal: 3.597 ± 0.064	0.501ArgTrp: 0.501 ± 0.026	2.288ArgTyr: 2.288 ± 0.055	0.0ArgXaa: 0.0 ± 0.0
Ser	4.186SerAla: 4.186 ± 0.07	0.741SerCys: 0.741 ± 0.031	3.262SerAsp: 3.262 ± 0.064	3.758SerGlu: 3.758 ± 0.068	2.588SerPhe: 2.588 ± 0.059	5.247SerGly: 5.247 ± 0.099	1.073SerHis: 1.073 ± 0.034	4.221SerIle: 4.221 ± 0.07	2.824SerLys: 2.824 ± 0.061	5.648SerLeu: 5.648 ± 0.098	1.58SerMet: 1.58 ± 0.043	2.045SerAsn: 2.045 ± 0.059	2.327SerPro: 2.327 ± 0.054	1.677SerGln: 1.677 ± 0.047	3.758SerArg: 3.758 ± 0.063	3.253SerSer: 3.253 ± 0.071	2.503SerThr: 2.503 ± 0.055	4.232SerVal: 4.232 ± 0.078	0.521SerTrp: 0.521 ± 0.025	1.948SerTyr: 1.948 ± 0.053	0.0SerXaa: 0.0 ± 0.0
Thr	4.066ThrAla: 4.066 ± 0.074	0.525ThrCys: 0.525 ± 0.024	2.756ThrAsp: 2.756 ± 0.06	2.956ThrGlu: 2.956 ± 0.06	1.974ThrPhe: 1.974 ± 0.051	5.038ThrGly: 5.038 ± 0.085	0.935ThrHis: 0.935 ± 0.028	3.74ThrIle: 3.74 ± 0.072	1.991ThrLys: 1.991 ± 0.053	5.065ThrLeu: 5.065 ± 0.085	1.146ThrMet: 1.146 ± 0.04	1.598ThrAsn: 1.598 ± 0.052	2.427ThrPro: 2.427 ± 0.065	1.409ThrGln: 1.409 ± 0.045	2.766ThrArg: 2.766 ± 0.055	2.672ThrSer: 2.672 ± 0.055	2.393ThrThr: 2.393 ± 0.057	4.196ThrVal: 4.196 ± 0.082	0.451ThrTrp: 0.451 ± 0.025	1.767ThrTyr: 1.767 ± 0.047	0.0ThrXaa: 0.0 ± 0.0
Val	4.957ValAla: 4.957 ± 0.088	1.055ValCys: 1.055 ± 0.041	3.933ValAsp: 3.933 ± 0.068	4.654ValGlu: 4.654 ± 0.077	3.313ValPhe: 3.313 ± 0.065	4.245ValGly: 4.245 ± 0.083	1.147ValHis: 1.147 ± 0.041	5.481ValIle: 5.481 ± 0.084	3.956ValLys: 3.956 ± 0.074	7.244ValLeu: 7.244 ± 0.107	1.955ValMet: 1.955 ± 0.056	2.793ValAsn: 2.793 ± 0.068	2.9ValPro: 2.9 ± 0.058	1.777ValGln: 1.777 ± 0.052	3.932ValArg: 3.932 ± 0.073	4.7ValSer: 4.7 ± 0.081	3.689ValThr: 3.689 ± 0.077	5.191ValVal: 5.191 ± 0.091	0.681ValTrp: 0.681 ± 0.032	2.636ValTyr: 2.636 ± 0.061	0.0ValXaa: 0.0 ± 0.0
Trp	0.603TrpAla: 0.603 ± 0.028	0.125TrpCys: 0.125 ± 0.013	0.529TrpAsp: 0.529 ± 0.028	0.611TrpGlu: 0.611 ± 0.03	0.404TrpPhe: 0.404 ± 0.024	0.585TrpGly: 0.585 ± 0.028	0.228TrpHis: 0.228 ± 0.017	0.712TrpIle: 0.712 ± 0.029	0.526TrpLys: 0.526 ± 0.027	1.002TrpLeu: 1.002 ± 0.039	0.251TrpMet: 0.251 ± 0.016	0.427TrpAsn: 0.427 ± 0.022	0.297TrpPro: 0.297 ± 0.022	0.362TrpGln: 0.362 ± 0.023	0.448TrpArg: 0.448 ± 0.022	0.543TrpSer: 0.543 ± 0.025	0.414TrpThr: 0.414 ± 0.027	0.597TrpVal: 0.597 ± 0.028	0.104TrpTrp: 0.104 ± 0.011	0.37TrpTyr: 0.37 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.881TyrAla: 2.881 ± 0.061	0.503TyrCys: 0.503 ± 0.024	2.276TyrAsp: 2.276 ± 0.051	2.492TyrGlu: 2.492 ± 0.058	1.555TyrPhe: 1.555 ± 0.045	2.739TyrGly: 2.739 ± 0.058	0.813TyrHis: 0.813 ± 0.036	2.662TyrIle: 2.662 ± 0.057	1.883TyrLys: 1.883 ± 0.055	3.476TyrLeu: 3.476 ± 0.073	0.882TyrMet: 0.882 ± 0.031	1.531TyrAsn: 1.531 ± 0.049	1.503TyrPro: 1.503 ± 0.05	1.16TyrGln: 1.16 ± 0.036	2.36TyrArg: 2.36 ± 0.059	2.047TyrSer: 2.047 ± 0.048	1.958TyrThr: 1.958 ± 0.05	2.324TyrVal: 2.324 ± 0.046	0.372TyrTrp: 0.372 ± 0.022	1.593TyrTyr: 1.593 ± 0.054	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2603 proteins (834208 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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