Amino acid dipepetide frequency for Chlamydiales bacterium SCGC AB-751-O23

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.966AlaAla: 3.966 ± 0.149
0.877AlaCys: 0.877 ± 0.061
2.981AlaAsp: 2.981 ± 0.228
3.728AlaGlu: 3.728 ± 0.122
3.49AlaPhe: 3.49 ± 0.124
3.327AlaGly: 3.327 ± 0.146
1.132AlaHis: 1.132 ± 0.063
4.446AlaIle: 4.446 ± 0.131
4.762AlaLys: 4.762 ± 0.162
7.994AlaLeu: 7.994 ± 0.205
1.321AlaMet: 1.321 ± 0.07
2.779AlaAsn: 2.779 ± 0.125
2.061AlaPro: 2.061 ± 0.139
2.436AlaGln: 2.436 ± 0.112
2.084AlaArg: 2.084 ± 0.108
5.14AlaSer: 5.14 ± 0.16
3.118AlaThr: 3.118 ± 0.206
3.457AlaVal: 3.457 ± 0.126
0.44AlaTrp: 0.44 ± 0.039
2.11AlaTyr: 2.11 ± 0.098
0.0AlaXaa: 0.0 ± 0.0
Cys
0.6CysAla: 0.6 ± 0.044
0.15CysCys: 0.15 ± 0.024
0.401CysAsp: 0.401 ± 0.038
0.708CysGlu: 0.708 ± 0.055
0.835CysPhe: 0.835 ± 0.063
0.558CysGly: 0.558 ± 0.051
0.254CysHis: 0.254 ± 0.034
0.672CysIle: 0.672 ± 0.056
0.675CysLys: 0.675 ± 0.055
1.331CysLeu: 1.331 ± 0.077
0.215CysMet: 0.215 ± 0.024
0.427CysAsn: 0.427 ± 0.041
0.427CysPro: 0.427 ± 0.05
0.483CysGln: 0.483 ± 0.048
0.395CysArg: 0.395 ± 0.04
0.939CysSer: 0.939 ± 0.066
0.414CysThr: 0.414 ± 0.035
0.489CysVal: 0.489 ± 0.047
0.062CysTrp: 0.062 ± 0.014
0.437CysTyr: 0.437 ± 0.036
0.0CysXaa: 0.0 ± 0.0
Asp
2.922AspAla: 2.922 ± 0.165
0.532AspCys: 0.532 ± 0.047
2.639AspAsp: 2.639 ± 0.118
3.415AspGlu: 3.415 ± 0.135
3.62AspPhe: 3.62 ± 0.107
3.001AspGly: 3.001 ± 0.253
0.897AspHis: 0.897 ± 0.062
3.77AspIle: 3.77 ± 0.136
3.8AspLys: 3.8 ± 0.127
7.104AspLeu: 7.104 ± 0.165
0.89AspMet: 0.89 ± 0.063
2.224AspAsn: 2.224 ± 0.104
2.218AspPro: 2.218 ± 0.104
1.761AspGln: 1.761 ± 0.074
1.918AspArg: 1.918 ± 0.071
4.439AspSer: 4.439 ± 0.158
2.205AspThr: 2.205 ± 0.148
2.815AspVal: 2.815 ± 0.118
0.512AspTrp: 0.512 ± 0.046
1.748AspTyr: 1.748 ± 0.071
0.0AspXaa: 0.0 ± 0.0
Glu
5.16GluAla: 5.16 ± 0.16
0.444GluCys: 0.444 ± 0.043
4.501GluAsp: 4.501 ± 0.175
7.776GluGlu: 7.776 ± 0.268
2.841GluPhe: 2.841 ± 0.104
5.068GluGly: 5.068 ± 0.215
1.23GluHis: 1.23 ± 0.067
5.613GluIle: 5.613 ± 0.154
7.808GluLys: 7.808 ± 0.228
7.378GluLeu: 7.378 ± 0.211
1.696GluMet: 1.696 ± 0.093
4.38GluAsn: 4.38 ± 0.141
1.438GluPro: 1.438 ± 0.069
2.384GluGln: 2.384 ± 0.11
2.971GluArg: 2.971 ± 0.124
4.899GluSer: 4.899 ± 0.138
3.402GluThr: 3.402 ± 0.114
4.733GluVal: 4.733 ± 0.154
0.509GluTrp: 0.509 ± 0.045
1.742GluTyr: 1.742 ± 0.078
0.0GluXaa: 0.0 ± 0.0
Phe
2.779PheAla: 2.779 ± 0.106
0.721PheCys: 0.721 ± 0.052
2.674PheAsp: 2.674 ± 0.108
3.412PheGlu: 3.412 ± 0.098
3.829PhePhe: 3.829 ± 0.178
2.495PheGly: 2.495 ± 0.11
1.099PheHis: 1.099 ± 0.063
3.519PheIle: 3.519 ± 0.118
4.022PheLys: 4.022 ± 0.145
6.67PheLeu: 6.67 ± 0.233
0.858PheMet: 0.858 ± 0.052
2.736PheAsn: 2.736 ± 0.109
2.107PhePro: 2.107 ± 0.093
2.12PheGln: 2.12 ± 0.093
1.791PheArg: 1.791 ± 0.091
5.923PheSer: 5.923 ± 0.175
2.756PheThr: 2.756 ± 0.122
2.537PheVal: 2.537 ± 0.108
0.466PheTrp: 0.466 ± 0.05
2.019PheTyr: 2.019 ± 0.101
0.0PheXaa: 0.0 ± 0.0
Gly
4.09GlyAla: 4.09 ± 0.147
0.613GlyCys: 0.613 ± 0.055
3.555GlyAsp: 3.555 ± 0.264
4.168GlyGlu: 4.168 ± 0.166
3.056GlyPhe: 3.056 ± 0.111
3.754GlyGly: 3.754 ± 0.168
1.086GlyHis: 1.086 ± 0.065
4.234GlyIle: 4.234 ± 0.151
5.0GlyLys: 5.0 ± 0.181
5.89GlyLeu: 5.89 ± 0.171
1.406GlyMet: 1.406 ± 0.079
2.678GlyAsn: 2.678 ± 0.126
1.354GlyPro: 1.354 ± 0.06
1.758GlyGln: 1.758 ± 0.076
2.198GlyArg: 2.198 ± 0.091
4.824GlySer: 4.824 ± 0.236
3.082GlyThr: 3.082 ± 0.228
3.862GlyVal: 3.862 ± 0.149
0.535GlyTrp: 0.535 ± 0.05
1.804GlyTyr: 1.804 ± 0.078
0.0GlyXaa: 0.0 ± 0.0
His
0.9HisAla: 0.9 ± 0.049
0.222HisCys: 0.222 ± 0.028
0.714HisAsp: 0.714 ± 0.051
1.053HisGlu: 1.053 ± 0.061
1.249HisPhe: 1.249 ± 0.061
0.894HisGly: 0.894 ± 0.064
0.421HisHis: 0.421 ± 0.04
1.164HisIle: 1.164 ± 0.057
1.168HisLys: 1.168 ± 0.073
2.655HisLeu: 2.655 ± 0.108
0.346HisMet: 0.346 ± 0.036
0.838HisAsn: 0.838 ± 0.052
0.9HisPro: 0.9 ± 0.061
0.812HisGln: 0.812 ± 0.056
0.78HisArg: 0.78 ± 0.051
1.458HisSer: 1.458 ± 0.073
0.701HisThr: 0.701 ± 0.047
0.988HisVal: 0.988 ± 0.058
0.192HisTrp: 0.192 ± 0.028
0.789HisTyr: 0.789 ± 0.051
0.0HisXaa: 0.0 ± 0.0
Ile
4.654IleAla: 4.654 ± 0.136
0.832IleCys: 0.832 ± 0.072
3.823IleAsp: 3.823 ± 0.138
5.294IleGlu: 5.294 ± 0.141
3.493IlePhe: 3.493 ± 0.123
3.738IleGly: 3.738 ± 0.131
1.184IleHis: 1.184 ± 0.068
4.273IleIle: 4.273 ± 0.144
5.607IleLys: 5.607 ± 0.169
7.146IleLeu: 7.146 ± 0.158
1.011IleMet: 1.011 ± 0.071
3.389IleAsn: 3.389 ± 0.119
2.857IlePro: 2.857 ± 0.113
2.462IleGln: 2.462 ± 0.114
2.401IleArg: 2.401 ± 0.1
5.763IleSer: 5.763 ± 0.17
3.969IleThr: 3.969 ± 0.257
3.281IleVal: 3.281 ± 0.118
0.46IleTrp: 0.46 ± 0.04
1.993IleTyr: 1.993 ± 0.084
0.0IleXaa: 0.0 ± 0.0
Lys
5.636LysAla: 5.636 ± 0.181
0.564LysCys: 0.564 ± 0.047
4.726LysAsp: 4.726 ± 0.151
9.175LysGlu: 9.175 ± 0.298
2.717LysPhe: 2.717 ± 0.119
5.577LysGly: 5.577 ± 0.153
1.491LysHis: 1.491 ± 0.071
5.776LysIle: 5.776 ± 0.154
8.911LysLys: 8.911 ± 0.327
7.29LysLeu: 7.29 ± 0.199
1.559LysMet: 1.559 ± 0.08
4.491LysAsn: 4.491 ± 0.155
2.081LysPro: 2.081 ± 0.101
2.988LysGln: 2.988 ± 0.126
3.314LysArg: 3.314 ± 0.128
5.486LysSer: 5.486 ± 0.17
4.279LysThr: 4.279 ± 0.132
5.192LysVal: 5.192 ± 0.156
0.6LysTrp: 0.6 ± 0.048
2.055LysTyr: 2.055 ± 0.091
0.0LysXaa: 0.0 ± 0.0
Leu
7.022LeuAla: 7.022 ± 0.18
1.282LeuCys: 1.282 ± 0.079
6.415LeuAsp: 6.415 ± 0.159
9.175LeuGlu: 9.175 ± 0.236
6.066LeuPhe: 6.066 ± 0.197
6.657LeuGly: 6.657 ± 0.151
1.781LeuHis: 1.781 ± 0.074
6.898LeuIle: 6.898 ± 0.168
10.796LeuLys: 10.796 ± 0.326
11.716LeuLeu: 11.716 ± 0.29
2.123LeuMet: 2.123 ± 0.091
6.066LeuAsn: 6.066 ± 0.14
4.132LeuPro: 4.132 ± 0.127
3.787LeuGln: 3.787 ± 0.138
3.999LeuArg: 3.999 ± 0.148
10.525LeuSer: 10.525 ± 0.251
6.001LeuThr: 6.001 ± 0.254
5.613LeuVal: 5.613 ± 0.16
0.828LeuTrp: 0.828 ± 0.062
3.069LeuTyr: 3.069 ± 0.103
0.0LeuXaa: 0.0 ± 0.0
Met
1.236MetAla: 1.236 ± 0.067
0.209MetCys: 0.209 ± 0.036
0.848MetAsp: 0.848 ± 0.066
1.272MetGlu: 1.272 ± 0.073
0.799MetPhe: 0.799 ± 0.058
1.334MetGly: 1.334 ± 0.08
0.388MetHis: 0.388 ± 0.035
1.292MetIle: 1.292 ± 0.066
1.745MetLys: 1.745 ± 0.082
2.071MetLeu: 2.071 ± 0.074
0.479MetMet: 0.479 ± 0.057
0.809MetAsn: 0.809 ± 0.052
0.815MetPro: 0.815 ± 0.053
0.825MetGln: 0.825 ± 0.057
0.76MetArg: 0.76 ± 0.056
1.575MetSer: 1.575 ± 0.081
1.138MetThr: 1.138 ± 0.095
0.992MetVal: 0.992 ± 0.067
0.13MetTrp: 0.13 ± 0.024
0.339MetTyr: 0.339 ± 0.032
0.0MetXaa: 0.0 ± 0.0
Asn
2.759AsnAla: 2.759 ± 0.105
0.463AsnCys: 0.463 ± 0.038
2.29AsnAsp: 2.29 ± 0.151
3.043AsnGlu: 3.043 ± 0.123
2.952AsnPhe: 2.952 ± 0.122
2.355AsnGly: 2.355 ± 0.113
0.943AsnHis: 0.943 ± 0.052
3.558AsnIle: 3.558 ± 0.147
3.757AsnLys: 3.757 ± 0.138
6.65AsnLeu: 6.65 ± 0.152
0.825AsnMet: 0.825 ± 0.061
2.166AsnAsn: 2.166 ± 0.101
2.358AsnPro: 2.358 ± 0.09
1.931AsnGln: 1.931 ± 0.082
1.781AsnArg: 1.781 ± 0.084
3.982AsnSer: 3.982 ± 0.143
2.159AsnThr: 2.159 ± 0.102
2.208AsnVal: 2.208 ± 0.091
0.515AsnTrp: 0.515 ± 0.054
1.826AsnTyr: 1.826 ± 0.077
0.0AsnXaa: 0.0 ± 0.0
Pro
1.732ProAla: 1.732 ± 0.088
0.359ProCys: 0.359 ± 0.039
1.654ProAsp: 1.654 ± 0.088
3.007ProGlu: 3.007 ± 0.124
2.107ProPhe: 2.107 ± 0.087
1.931ProGly: 1.931 ± 0.09
0.747ProHis: 0.747 ± 0.05
2.293ProIle: 2.293 ± 0.089
2.671ProLys: 2.671 ± 0.129
4.09ProLeu: 4.09 ± 0.151
0.616ProMet: 0.616 ± 0.043
1.598ProAsn: 1.598 ± 0.08
1.383ProPro: 1.383 ± 0.085
1.321ProGln: 1.321 ± 0.057
1.047ProArg: 1.047 ± 0.057
3.209ProSer: 3.209 ± 0.129
1.654ProThr: 1.654 ± 0.1
1.95ProVal: 1.95 ± 0.117
0.316ProTrp: 0.316 ± 0.035
1.301ProTyr: 1.301 ± 0.068
0.0ProXaa: 0.0 ± 0.0
Gln
2.697GlnAla: 2.697 ± 0.113
0.241GlnCys: 0.241 ± 0.031
1.882GlnAsp: 1.882 ± 0.091
3.183GlnGlu: 3.183 ± 0.115
1.487GlnPhe: 1.487 ± 0.071
2.159GlnGly: 2.159 ± 0.089
0.682GlnHis: 0.682 ± 0.047
2.551GlnIle: 2.551 ± 0.133
3.597GlnLys: 3.597 ± 0.162
3.428GlnLeu: 3.428 ± 0.14
0.841GlnMet: 0.841 ± 0.05
2.006GlnAsn: 2.006 ± 0.085
0.698GlnPro: 0.698 ± 0.05
1.168GlnGln: 1.168 ± 0.075
1.566GlnArg: 1.566 ± 0.081
2.489GlnSer: 2.489 ± 0.098
1.735GlnThr: 1.735 ± 0.096
2.42GlnVal: 2.42 ± 0.092
0.274GlnTrp: 0.274 ± 0.034
0.887GlnTyr: 0.887 ± 0.059
0.0GlnXaa: 0.0 ± 0.0
Arg
2.41ArgAla: 2.41 ± 0.097
0.401ArgCys: 0.401 ± 0.04
1.996ArgAsp: 1.996 ± 0.086
3.112ArgGlu: 3.112 ± 0.135
2.162ArgPhe: 2.162 ± 0.087
2.175ArgGly: 2.175 ± 0.108
0.704ArgHis: 0.704 ± 0.046
2.518ArgIle: 2.518 ± 0.095
2.984ArgLys: 2.984 ± 0.147
4.051ArgLeu: 4.051 ± 0.178
0.737ArgMet: 0.737 ± 0.052
1.813ArgAsn: 1.813 ± 0.08
1.044ArgPro: 1.044 ± 0.068
1.197ArgGln: 1.197 ± 0.075
1.491ArgArg: 1.491 ± 0.081
2.495ArgSer: 2.495 ± 0.102
1.409ArgThr: 1.409 ± 0.074
2.697ArgVal: 2.697 ± 0.115
0.336ArgTrp: 0.336 ± 0.034
1.226ArgTyr: 1.226 ± 0.061
0.0ArgXaa: 0.0 ± 0.0
Ser
4.077SerAla: 4.077 ± 0.141
0.952SerCys: 0.952 ± 0.059
3.767SerAsp: 3.767 ± 0.171
4.915SerGlu: 4.915 ± 0.123
5.626SerPhe: 5.626 ± 0.165
4.791SerGly: 4.791 ± 0.249
1.491SerHis: 1.491 ± 0.073
5.734SerIle: 5.734 ± 0.157
6.171SerLys: 6.171 ± 0.161
10.962SerLeu: 10.962 ± 0.234
1.621SerMet: 1.621 ± 0.069
3.712SerAsn: 3.712 ± 0.147
3.284SerPro: 3.284 ± 0.13
3.118SerGln: 3.118 ± 0.114
3.121SerArg: 3.121 ± 0.116
8.063SerSer: 8.063 ± 0.271
3.986SerThr: 3.986 ± 0.18
3.956SerVal: 3.956 ± 0.135
0.74SerTrp: 0.74 ± 0.045
2.919SerTyr: 2.919 ± 0.112
0.0SerXaa: 0.0 ± 0.0
Thr
3.271ThrAla: 3.271 ± 0.171
0.535ThrCys: 0.535 ± 0.042
2.325ThrAsp: 2.325 ± 0.161
2.958ThrGlu: 2.958 ± 0.116
2.691ThrPhe: 2.691 ± 0.101
3.461ThrGly: 3.461 ± 0.242
0.913ThrHis: 0.913 ± 0.052
3.32ThrIle: 3.32 ± 0.195
3.193ThrLys: 3.193 ± 0.105
6.389ThrLeu: 6.389 ± 0.246
0.763ThrMet: 0.763 ± 0.05
2.042ThrAsn: 2.042 ± 0.119
2.394ThrPro: 2.394 ± 0.125
1.82ThrGln: 1.82 ± 0.114
1.631ThrArg: 1.631 ± 0.08
4.113ThrSer: 4.113 ± 0.204
2.847ThrThr: 2.847 ± 0.193
2.929ThrVal: 2.929 ± 0.162
0.378ThrTrp: 0.378 ± 0.036
1.575ThrTyr: 1.575 ± 0.094
0.0ThrXaa: 0.0 ± 0.0
Val
3.673ValAla: 3.673 ± 0.117
0.682ValCys: 0.682 ± 0.058
3.297ValAsp: 3.297 ± 0.136
4.035ValGlu: 4.035 ± 0.141
3.18ValPhe: 3.18 ± 0.103
3.356ValGly: 3.356 ± 0.122
0.903ValHis: 0.903 ± 0.054
3.545ValIle: 3.545 ± 0.121
4.338ValLys: 4.338 ± 0.131
6.298ValLeu: 6.298 ± 0.177
1.034ValMet: 1.034 ± 0.057
2.684ValAsn: 2.684 ± 0.093
1.928ValPro: 1.928 ± 0.098
1.856ValGln: 1.856 ± 0.083
1.967ValArg: 1.967 ± 0.095
4.543ValSer: 4.543 ± 0.138
2.763ValThr: 2.763 ± 0.135
3.252ValVal: 3.252 ± 0.124
0.375ValTrp: 0.375 ± 0.033
1.605ValTyr: 1.605 ± 0.077
0.0ValXaa: 0.0 ± 0.0
Trp
0.388TrpAla: 0.388 ± 0.036
0.052TrpCys: 0.052 ± 0.014
0.401TrpAsp: 0.401 ± 0.037
0.724TrpGlu: 0.724 ± 0.054
0.375TrpPhe: 0.375 ± 0.038
0.649TrpGly: 0.649 ± 0.048
0.163TrpHis: 0.163 ± 0.024
0.574TrpIle: 0.574 ± 0.046
0.708TrpLys: 0.708 ± 0.049
0.757TrpLeu: 0.757 ± 0.056
0.179TrpMet: 0.179 ± 0.026
0.378TrpAsn: 0.378 ± 0.034
0.235TrpPro: 0.235 ± 0.03
0.303TrpGln: 0.303 ± 0.031
0.329TrpArg: 0.329 ± 0.04
0.499TrpSer: 0.499 ± 0.045
0.398TrpThr: 0.398 ± 0.04
0.571TrpVal: 0.571 ± 0.047
0.088TrpTrp: 0.088 ± 0.016
0.274TrpTyr: 0.274 ± 0.032
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.676TyrAla: 1.676 ± 0.077
0.342TyrCys: 0.342 ± 0.036
1.539TyrAsp: 1.539 ± 0.112
1.82TyrGlu: 1.82 ± 0.088
1.957TyrPhe: 1.957 ± 0.085
1.667TyrGly: 1.667 ± 0.077
0.737TyrHis: 0.737 ± 0.051
1.879TyrIle: 1.879 ± 0.085
2.195TyrLys: 2.195 ± 0.094
4.083TyrLeu: 4.083 ± 0.131
0.532TyrMet: 0.532 ± 0.039
1.305TyrAsn: 1.305 ± 0.079
1.272TyrPro: 1.272 ± 0.07
1.461TyrGln: 1.461 ± 0.068
1.419TyrArg: 1.419 ± 0.076
2.645TyrSer: 2.645 ± 0.111
1.533TyrThr: 1.533 ± 0.108
1.37TyrVal: 1.37 ± 0.066
0.287TyrTrp: 0.287 ± 0.036
1.112TyrTyr: 1.112 ± 0.069
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 876 proteins (306603 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski