Amino acid dipepetide frequency for Candidatus Rhodoluna planktonica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.532AlaAla: 15.532 ± 0.28
0.478AlaCys: 0.478 ± 0.035
6.161AlaAsp: 6.161 ± 0.136
7.786AlaGlu: 7.786 ± 0.215
3.768AlaPhe: 3.768 ± 0.108
9.439AlaGly: 9.439 ± 0.258
1.818AlaHis: 1.818 ± 0.073
7.306AlaIle: 7.306 ± 0.139
6.399AlaLys: 6.399 ± 0.163
11.346AlaLeu: 11.346 ± 0.222
2.354AlaMet: 2.354 ± 0.085
4.143AlaAsn: 4.143 ± 0.14
4.122AlaPro: 4.122 ± 0.12
4.14AlaGln: 4.14 ± 0.092
5.401AlaArg: 5.401 ± 0.145
6.811AlaSer: 6.811 ± 0.207
6.78AlaThr: 6.78 ± 0.308
8.666AlaVal: 8.666 ± 0.162
1.261AlaTrp: 1.261 ± 0.055
2.247AlaTyr: 2.247 ± 0.069
0.0AlaXaa: 0.0 ± 0.0
Cys
0.531CysAla: 0.531 ± 0.036
0.023CysCys: 0.023 ± 0.007
0.315CysAsp: 0.315 ± 0.024
0.322CysGlu: 0.322 ± 0.031
0.166CysPhe: 0.166 ± 0.02
0.515CysGly: 0.515 ± 0.032
0.088CysHis: 0.088 ± 0.017
0.227CysIle: 0.227 ± 0.022
0.134CysLys: 0.134 ± 0.02
0.44CysLeu: 0.44 ± 0.035
0.061CysMet: 0.061 ± 0.012
0.152CysAsn: 0.152 ± 0.018
0.302CysPro: 0.302 ± 0.027
0.163CysGln: 0.163 ± 0.019
0.24CysArg: 0.24 ± 0.022
0.417CysSer: 0.417 ± 0.034
0.288CysThr: 0.288 ± 0.027
0.381CysVal: 0.381 ± 0.028
0.041CysTrp: 0.041 ± 0.009
0.125CysTyr: 0.125 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
5.902AspAla: 5.902 ± 0.121
0.283AspCys: 0.283 ± 0.029
2.587AspAsp: 2.587 ± 0.093
3.898AspGlu: 3.898 ± 0.124
2.426AspPhe: 2.426 ± 0.078
4.401AspGly: 4.401 ± 0.122
0.891AspHis: 0.891 ± 0.042
2.703AspIle: 2.703 ± 0.099
1.825AspLys: 1.825 ± 0.073
5.963AspLeu: 5.963 ± 0.124
0.866AspMet: 0.866 ± 0.046
1.399AspAsn: 1.399 ± 0.082
2.889AspPro: 2.889 ± 0.087
1.968AspGln: 1.968 ± 0.055
3.07AspArg: 3.07 ± 0.107
3.417AspSer: 3.417 ± 0.102
2.138AspThr: 2.138 ± 0.07
4.065AspVal: 4.065 ± 0.105
0.771AspTrp: 0.771 ± 0.046
1.472AspTyr: 1.472 ± 0.06
0.0AspXaa: 0.0 ± 0.0
Glu
6.358GluAla: 6.358 ± 0.186
0.243GluCys: 0.243 ± 0.022
2.725GluAsp: 2.725 ± 0.091
3.172GluGlu: 3.172 ± 0.11
2.601GluPhe: 2.601 ± 0.096
3.553GluGly: 3.553 ± 0.096
1.218GluHis: 1.218 ± 0.066
4.696GluIle: 4.696 ± 0.109
2.959GluLys: 2.959 ± 0.122
7.668GluLeu: 7.668 ± 0.204
1.161GluMet: 1.161 ± 0.059
2.419GluAsn: 2.419 ± 0.077
2.392GluPro: 2.392 ± 0.085
2.594GluGln: 2.594 ± 0.091
3.635GluArg: 3.635 ± 0.145
3.505GluSer: 3.505 ± 0.1
3.426GluThr: 3.426 ± 0.102
5.054GluVal: 5.054 ± 0.138
0.726GluTrp: 0.726 ± 0.041
1.247GluTyr: 1.247 ± 0.058
0.0GluXaa: 0.0 ± 0.0
Phe
4.603PheAla: 4.603 ± 0.121
0.24PheCys: 0.24 ± 0.03
2.827PheAsp: 2.827 ± 0.086
2.737PheGlu: 2.737 ± 0.086
1.587PhePhe: 1.587 ± 0.083
4.063PheGly: 4.063 ± 0.111
0.522PheHis: 0.522 ± 0.043
1.991PheIle: 1.991 ± 0.079
1.413PheLys: 1.413 ± 0.063
3.204PheLeu: 3.204 ± 0.119
0.626PheMet: 0.626 ± 0.043
1.367PheAsn: 1.367 ± 0.066
1.263PhePro: 1.263 ± 0.056
1.038PheGln: 1.038 ± 0.048
1.705PheArg: 1.705 ± 0.064
2.725PheSer: 2.725 ± 0.104
2.283PheThr: 2.283 ± 0.12
3.056PheVal: 3.056 ± 0.093
0.526PheTrp: 0.526 ± 0.041
0.968PheTyr: 0.968 ± 0.056
0.0PheXaa: 0.0 ± 0.0
Gly
8.015GlyAla: 8.015 ± 0.206
0.531GlyCys: 0.531 ± 0.035
3.83GlyAsp: 3.83 ± 0.14
4.728GlyGlu: 4.728 ± 0.108
3.573GlyPhe: 3.573 ± 0.119
6.045GlyGly: 6.045 ± 0.196
1.528GlyHis: 1.528 ± 0.065
5.102GlyIle: 5.102 ± 0.12
4.045GlyLys: 4.045 ± 0.095
8.342GlyLeu: 8.342 ± 0.15
1.682GlyMet: 1.682 ± 0.067
2.741GlyAsn: 2.741 ± 0.208
2.821GlyPro: 2.821 ± 0.106
2.895GlyGln: 2.895 ± 0.09
4.02GlyArg: 4.02 ± 0.104
5.508GlySer: 5.508 ± 0.156
4.34GlyThr: 4.34 ± 0.194
6.272GlyVal: 6.272 ± 0.175
1.195GlyTrp: 1.195 ± 0.056
2.27GlyTyr: 2.27 ± 0.079
0.0GlyXaa: 0.0 ± 0.0
His
1.571HisAla: 1.571 ± 0.073
0.091HisCys: 0.091 ± 0.013
0.95HisAsp: 0.95 ± 0.056
1.077HisGlu: 1.077 ± 0.045
0.678HisPhe: 0.678 ± 0.039
1.553HisGly: 1.553 ± 0.076
0.453HisHis: 0.453 ± 0.04
0.966HisIle: 0.966 ± 0.052
0.556HisLys: 0.556 ± 0.038
1.732HisLeu: 1.732 ± 0.077
0.302HisMet: 0.302 ± 0.027
0.537HisAsn: 0.537 ± 0.038
1.136HisPro: 1.136 ± 0.063
0.63HisGln: 0.63 ± 0.039
1.059HisArg: 1.059 ± 0.054
1.113HisSer: 1.113 ± 0.051
0.805HisThr: 0.805 ± 0.049
1.188HisVal: 1.188 ± 0.055
0.186HisTrp: 0.186 ± 0.023
0.415HisTyr: 0.415 ± 0.033
0.0HisXaa: 0.0 ± 0.0
Ile
7.63IleAla: 7.63 ± 0.135
0.336IleCys: 0.336 ± 0.027
3.88IleAsp: 3.88 ± 0.091
4.381IleGlu: 4.381 ± 0.114
2.333IlePhe: 2.333 ± 0.081
5.186IleGly: 5.186 ± 0.126
0.821IleHis: 0.821 ± 0.051
3.025IleIle: 3.025 ± 0.087
2.272IleLys: 2.272 ± 0.07
4.916IleLeu: 4.916 ± 0.121
0.889IleMet: 0.889 ± 0.045
2.002IleAsn: 2.002 ± 0.08
2.689IlePro: 2.689 ± 0.091
1.68IleGln: 1.68 ± 0.067
3.188IleArg: 3.188 ± 0.098
4.548IleSer: 4.548 ± 0.115
3.549IleThr: 3.549 ± 0.185
4.358IleVal: 4.358 ± 0.09
0.789IleTrp: 0.789 ± 0.042
1.313IleTyr: 1.313 ± 0.056
0.0IleXaa: 0.0 ± 0.0
Lys
4.673LysAla: 4.673 ± 0.127
0.175LysCys: 0.175 ± 0.02
1.916LysAsp: 1.916 ± 0.071
1.966LysGlu: 1.966 ± 0.079
1.769LysPhe: 1.769 ± 0.068
2.664LysGly: 2.664 ± 0.093
0.794LysHis: 0.794 ± 0.047
2.864LysIle: 2.864 ± 0.083
2.456LysLys: 2.456 ± 0.106
4.703LysLeu: 4.703 ± 0.113
1.043LysMet: 1.043 ± 0.051
1.739LysAsn: 1.739 ± 0.071
2.349LysPro: 2.349 ± 0.08
1.428LysGln: 1.428 ± 0.067
2.44LysArg: 2.44 ± 0.089
2.982LysSer: 2.982 ± 0.078
2.866LysThr: 2.866 ± 0.084
3.576LysVal: 3.576 ± 0.102
0.467LysTrp: 0.467 ± 0.035
1.063LysTyr: 1.063 ± 0.059
0.0LysXaa: 0.0 ± 0.0
Leu
13.253LeuAla: 13.253 ± 0.263
0.469LeuCys: 0.469 ± 0.037
5.693LeuAsp: 5.693 ± 0.158
6.186LeuGlu: 6.186 ± 0.172
3.313LeuPhe: 3.313 ± 0.118
8.519LeuGly: 8.519 ± 0.154
1.519LeuHis: 1.519 ± 0.062
5.945LeuIle: 5.945 ± 0.16
3.977LeuLys: 3.977 ± 0.094
9.557LeuLeu: 9.557 ± 0.275
1.873LeuMet: 1.873 ± 0.079
3.406LeuAsn: 3.406 ± 0.1
4.909LeuPro: 4.909 ± 0.125
3.063LeuGln: 3.063 ± 0.085
5.573LeuArg: 5.573 ± 0.134
6.365LeuSer: 6.365 ± 0.123
6.036LeuThr: 6.036 ± 0.173
8.823LeuVal: 8.823 ± 0.163
1.102LeuTrp: 1.102 ± 0.059
1.73LeuTyr: 1.73 ± 0.074
0.0LeuXaa: 0.0 ± 0.0
Met
2.299MetAla: 2.299 ± 0.079
0.104MetCys: 0.104 ± 0.015
0.789MetAsp: 0.789 ± 0.043
0.549MetGlu: 0.549 ± 0.035
0.592MetPhe: 0.592 ± 0.039
1.465MetGly: 1.465 ± 0.063
0.356MetHis: 0.356 ± 0.031
1.05MetIle: 1.05 ± 0.059
0.855MetLys: 0.855 ± 0.047
1.859MetLeu: 1.859 ± 0.071
0.338MetMet: 0.338 ± 0.026
0.773MetAsn: 0.773 ± 0.043
1.107MetPro: 1.107 ± 0.056
0.732MetGln: 0.732 ± 0.04
1.127MetArg: 1.127 ± 0.052
1.608MetSer: 1.608 ± 0.068
1.304MetThr: 1.304 ± 0.052
1.528MetVal: 1.528 ± 0.064
0.168MetTrp: 0.168 ± 0.018
0.302MetTyr: 0.302 ± 0.028
0.0MetXaa: 0.0 ± 0.0
Asn
3.476AsnAla: 3.476 ± 0.124
0.211AsnCys: 0.211 ± 0.021
1.68AsnAsp: 1.68 ± 0.079
1.852AsnGlu: 1.852 ± 0.073
1.551AsnPhe: 1.551 ± 0.068
2.857AsnGly: 2.857 ± 0.18
0.594AsnHis: 0.594 ± 0.036
1.76AsnIle: 1.76 ± 0.075
1.209AsnLys: 1.209 ± 0.055
3.918AsnLeu: 3.918 ± 0.108
0.782AsnMet: 0.782 ± 0.048
1.256AsnAsn: 1.256 ± 0.113
2.313AsnPro: 2.313 ± 0.085
1.694AsnGln: 1.694 ± 0.07
2.057AsnArg: 2.057 ± 0.076
2.469AsnSer: 2.469 ± 0.123
1.744AsnThr: 1.744 ± 0.16
2.288AsnVal: 2.288 ± 0.089
0.617AsnTrp: 0.617 ± 0.038
0.966AsnTyr: 0.966 ± 0.061
0.0AsnXaa: 0.0 ± 0.0
Pro
5.009ProAla: 5.009 ± 0.123
0.186ProCys: 0.186 ± 0.023
2.476ProAsp: 2.476 ± 0.078
3.388ProGlu: 3.388 ± 0.109
1.512ProPhe: 1.512 ± 0.058
3.546ProGly: 3.546 ± 0.086
0.764ProHis: 0.764 ± 0.042
2.68ProIle: 2.68 ± 0.069
2.261ProLys: 2.261 ± 0.088
3.814ProLeu: 3.814 ± 0.094
0.809ProMet: 0.809 ± 0.042
1.979ProAsn: 1.979 ± 0.067
1.091ProPro: 1.091 ± 0.051
1.519ProGln: 1.519 ± 0.058
1.848ProArg: 1.848 ± 0.09
2.712ProSer: 2.712 ± 0.082
2.911ProThr: 2.911 ± 0.109
3.963ProVal: 3.963 ± 0.104
0.54ProTrp: 0.54 ± 0.034
0.975ProTyr: 0.975 ± 0.046
0.0ProXaa: 0.0 ± 0.0
Gln
3.784GlnAla: 3.784 ± 0.094
0.111GlnCys: 0.111 ± 0.017
1.562GlnAsp: 1.562 ± 0.063
1.628GlnGlu: 1.628 ± 0.076
1.317GlnPhe: 1.317 ± 0.055
2.14GlnGly: 2.14 ± 0.071
0.642GlnHis: 0.642 ± 0.043
2.576GlnIle: 2.576 ± 0.091
1.583GlnLys: 1.583 ± 0.068
4.177GlnLeu: 4.177 ± 0.129
0.687GlnMet: 0.687 ± 0.044
1.326GlnAsn: 1.326 ± 0.059
1.617GlnPro: 1.617 ± 0.097
1.578GlnGln: 1.578 ± 0.068
1.921GlnArg: 1.921 ± 0.085
2.12GlnSer: 2.12 ± 0.074
2.013GlnThr: 2.013 ± 0.071
3.004GlnVal: 3.004 ± 0.086
0.39GlnTrp: 0.39 ± 0.033
0.726GlnTyr: 0.726 ± 0.042
0.0GlnXaa: 0.0 ± 0.0
Arg
5.464ArgAla: 5.464 ± 0.128
0.234ArgCys: 0.234 ± 0.022
2.998ArgAsp: 2.998 ± 0.107
3.716ArgGlu: 3.716 ± 0.137
2.186ArgPhe: 2.186 ± 0.069
3.666ArgGly: 3.666 ± 0.118
0.977ArgHis: 0.977 ± 0.057
3.372ArgIle: 3.372 ± 0.091
2.324ArgLys: 2.324 ± 0.1
5.297ArgLeu: 5.297 ± 0.138
1.211ArgMet: 1.211 ± 0.053
1.921ArgAsn: 1.921 ± 0.078
2.265ArgPro: 2.265 ± 0.097
1.862ArgGln: 1.862 ± 0.082
3.263ArgArg: 3.263 ± 0.127
3.261ArgSer: 3.261 ± 0.103
2.589ArgThr: 2.589 ± 0.077
4.367ArgVal: 4.367 ± 0.114
0.746ArgTrp: 0.746 ± 0.046
1.256ArgTyr: 1.256 ± 0.053
0.0ArgXaa: 0.0 ± 0.0
Ser
7.829SerAla: 7.829 ± 0.231
0.34SerCys: 0.34 ± 0.032
3.163SerAsp: 3.163 ± 0.087
3.716SerGlu: 3.716 ± 0.11
2.451SerPhe: 2.451 ± 0.07
5.854SerGly: 5.854 ± 0.181
1.07SerHis: 1.07 ± 0.057
3.827SerIle: 3.827 ± 0.116
2.993SerLys: 2.993 ± 0.099
6.487SerLeu: 6.487 ± 0.154
1.299SerMet: 1.299 ± 0.06
2.413SerAsn: 2.413 ± 0.118
2.843SerPro: 2.843 ± 0.088
2.326SerGln: 2.326 ± 0.079
3.356SerArg: 3.356 ± 0.1
4.335SerSer: 4.335 ± 0.141
3.721SerThr: 3.721 ± 0.185
5.378SerVal: 5.378 ± 0.155
0.848SerTrp: 0.848 ± 0.039
1.483SerTyr: 1.483 ± 0.06
0.0SerXaa: 0.0 ± 0.0
Thr
6.625ThrAla: 6.625 ± 0.328
0.222ThrCys: 0.222 ± 0.022
2.916ThrAsp: 2.916 ± 0.103
3.478ThrGlu: 3.478 ± 0.105
2.163ThrPhe: 2.163 ± 0.124
5.251ThrGly: 5.251 ± 0.232
0.995ThrHis: 0.995 ± 0.05
3.143ThrIle: 3.143 ± 0.11
2.481ThrLys: 2.481 ± 0.076
5.403ThrLeu: 5.403 ± 0.139
0.98ThrMet: 0.98 ± 0.046
2.063ThrAsn: 2.063 ± 0.11
2.952ThrPro: 2.952 ± 0.115
1.651ThrGln: 1.651 ± 0.098
2.682ThrArg: 2.682 ± 0.082
3.573ThrSer: 3.573 ± 0.235
3.304ThrThr: 3.304 ± 0.232
4.995ThrVal: 4.995 ± 0.205
0.746ThrTrp: 0.746 ± 0.039
1.345ThrTyr: 1.345 ± 0.087
0.0ThrXaa: 0.0 ± 0.0
Val
9.924ValAla: 9.924 ± 0.175
0.44ValCys: 0.44 ± 0.032
4.705ValAsp: 4.705 ± 0.099
4.982ValGlu: 4.982 ± 0.135
3.066ValPhe: 3.066 ± 0.084
6.102ValGly: 6.102 ± 0.13
1.354ValHis: 1.354 ± 0.061
4.991ValIle: 4.991 ± 0.119
2.975ValLys: 2.975 ± 0.093
7.972ValLeu: 7.972 ± 0.18
1.345ValMet: 1.345 ± 0.064
2.512ValAsn: 2.512 ± 0.112
3.333ValPro: 3.333 ± 0.082
2.252ValGln: 2.252 ± 0.073
4.131ValArg: 4.131 ± 0.099
5.777ValSer: 5.777 ± 0.144
5.217ValThr: 5.217 ± 0.268
7.263ValVal: 7.263 ± 0.151
0.941ValTrp: 0.941 ± 0.05
1.596ValTyr: 1.596 ± 0.064
0.0ValXaa: 0.0 ± 0.0
Trp
1.29TrpAla: 1.29 ± 0.058
0.063TrpCys: 0.063 ± 0.012
0.574TrpAsp: 0.574 ± 0.038
0.422TrpGlu: 0.422 ± 0.034
0.648TrpPhe: 0.648 ± 0.044
0.848TrpGly: 0.848 ± 0.04
0.292TrpHis: 0.292 ± 0.024
0.635TrpIle: 0.635 ± 0.039
0.458TrpLys: 0.458 ± 0.036
1.825TrpLeu: 1.825 ± 0.073
0.279TrpMet: 0.279 ± 0.03
0.449TrpAsn: 0.449 ± 0.028
0.551TrpPro: 0.551 ± 0.042
0.726TrpGln: 0.726 ± 0.047
0.73TrpArg: 0.73 ± 0.041
0.828TrpSer: 0.828 ± 0.049
0.512TrpThr: 0.512 ± 0.036
0.993TrpVal: 0.993 ± 0.051
0.254TrpTrp: 0.254 ± 0.021
0.272TrpTyr: 0.272 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.188TyrAla: 2.188 ± 0.071
0.15TyrCys: 0.15 ± 0.016
1.188TyrAsp: 1.188 ± 0.049
1.37TyrGlu: 1.37 ± 0.05
1.045TyrPhe: 1.045 ± 0.051
1.814TyrGly: 1.814 ± 0.057
0.302TyrHis: 0.302 ± 0.028
0.927TyrIle: 0.927 ± 0.047
0.76TyrLys: 0.76 ± 0.056
2.687TyrLeu: 2.687 ± 0.085
0.315TyrMet: 0.315 ± 0.026
0.694TyrAsn: 0.694 ± 0.043
1.041TyrPro: 1.041 ± 0.052
0.961TyrGln: 0.961 ± 0.049
1.528TyrArg: 1.528 ± 0.063
1.66TyrSer: 1.66 ± 0.076
1.145TyrThr: 1.145 ± 0.07
1.657TyrVal: 1.657 ± 0.073
0.338TyrTrp: 0.338 ± 0.024
0.519TyrTyr: 0.519 ± 0.04
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1327 proteins (441031 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski