Amino acid dipepetide frequency for Vibrio phage KVP40 (isolate Vibrio parahaemolyticus/Japan/Matsuzaki/1991) (KVP40) (Bacteriophage KVP40)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.478AlaAla: 5.478 ± 0.347
0.816AlaCys: 0.816 ± 0.118
4.228AlaAsp: 4.228 ± 0.253
5.737AlaGlu: 5.737 ± 0.339
2.855AlaPhe: 2.855 ± 0.231
4.133AlaGly: 4.133 ± 0.318
1.359AlaHis: 1.359 ± 0.129
5.098AlaIle: 5.098 ± 0.241
4.595AlaLys: 4.595 ± 0.289
5.56AlaLeu: 5.56 ± 0.263
2.093AlaMet: 2.093 ± 0.171
3.222AlaAsn: 3.222 ± 0.212
2.121AlaPro: 2.121 ± 0.186
2.705AlaGln: 2.705 ± 0.228
3.684AlaArg: 3.684 ± 0.246
4.051AlaSer: 4.051 ± 0.289
4.418AlaThr: 4.418 ± 0.284
4.568AlaVal: 4.568 ± 0.225
0.911AlaTrp: 0.911 ± 0.101
2.664AlaTyr: 2.664 ± 0.197
0.0AlaXaa: 0.0 ± 0.0
Cys
0.775CysAla: 0.775 ± 0.099
0.218CysCys: 0.218 ± 0.057
1.02CysAsp: 1.02 ± 0.12
0.965CysGlu: 0.965 ± 0.118
0.367CysPhe: 0.367 ± 0.065
0.924CysGly: 0.924 ± 0.133
0.408CysHis: 0.408 ± 0.079
0.748CysIle: 0.748 ± 0.108
1.115CysLys: 1.115 ± 0.125
0.829CysLeu: 0.829 ± 0.111
0.285CysMet: 0.285 ± 0.073
0.598CysAsn: 0.598 ± 0.078
0.408CysPro: 0.408 ± 0.08
0.435CysGln: 0.435 ± 0.08
0.653CysArg: 0.653 ± 0.099
0.693CysSer: 0.693 ± 0.097
0.625CysThr: 0.625 ± 0.076
0.884CysVal: 0.884 ± 0.109
0.163CysTrp: 0.163 ± 0.048
0.476CysTyr: 0.476 ± 0.077
0.0CysXaa: 0.0 ± 0.0
Asp
4.581AspAla: 4.581 ± 0.267
0.911AspCys: 0.911 ± 0.113
4.88AspAsp: 4.88 ± 0.264
5.397AspGlu: 5.397 ± 0.333
3.29AspPhe: 3.29 ± 0.213
4.744AspGly: 4.744 ± 0.248
1.196AspHis: 1.196 ± 0.115
4.826AspIle: 4.826 ± 0.282
4.16AspLys: 4.16 ± 0.209
4.717AspLeu: 4.717 ± 0.228
1.93AspMet: 1.93 ± 0.162
3.154AspAsn: 3.154 ± 0.231
2.433AspPro: 2.433 ± 0.196
1.604AspGln: 1.604 ± 0.14
2.651AspArg: 2.651 ± 0.175
3.657AspSer: 3.657 ± 0.209
3.439AspThr: 3.439 ± 0.171
5.03AspVal: 5.03 ± 0.284
1.332AspTrp: 1.332 ± 0.178
3.358AspTyr: 3.358 ± 0.232
0.0AspXaa: 0.0 ± 0.0
Glu
5.777GluAla: 5.777 ± 0.299
0.87GluCys: 0.87 ± 0.113
3.82GluAsp: 3.82 ± 0.214
5.791GluGlu: 5.791 ± 0.367
3.725GluPhe: 3.725 ± 0.257
3.059GluGly: 3.059 ± 0.178
2.161GluHis: 2.161 ± 0.184
5.873GluIle: 5.873 ± 0.3
5.057GluLys: 5.057 ± 0.294
7.3GluLeu: 7.3 ± 0.339
2.393GluMet: 2.393 ± 0.196
3.684GluAsn: 3.684 ± 0.231
1.482GluPro: 1.482 ± 0.142
3.018GluGln: 3.018 ± 0.229
4.404GluArg: 4.404 ± 0.255
3.969GluSer: 3.969 ± 0.233
4.54GluThr: 4.54 ± 0.261
4.636GluVal: 4.636 ± 0.259
0.979GluTrp: 0.979 ± 0.108
3.548GluTyr: 3.548 ± 0.209
0.0GluXaa: 0.0 ± 0.0
Phe
3.018PheAla: 3.018 ± 0.205
0.503PheCys: 0.503 ± 0.092
3.983PheAsp: 3.983 ± 0.232
3.385PheGlu: 3.385 ± 0.199
1.536PhePhe: 1.536 ± 0.152
2.841PheGly: 2.841 ± 0.199
0.911PheHis: 0.911 ± 0.121
2.923PheIle: 2.923 ± 0.226
3.018PheLys: 3.018 ± 0.241
2.433PheLeu: 2.433 ± 0.189
1.427PheMet: 1.427 ± 0.132
2.433PheAsn: 2.433 ± 0.174
1.115PhePro: 1.115 ± 0.127
1.291PheGln: 1.291 ± 0.139
1.631PheArg: 1.631 ± 0.145
2.61PheSer: 2.61 ± 0.197
2.583PheThr: 2.583 ± 0.173
2.936PheVal: 2.936 ± 0.188
0.612PheTrp: 0.612 ± 0.098
1.699PheTyr: 1.699 ± 0.138
0.0PheXaa: 0.0 ± 0.0
Gly
3.67GlyAla: 3.67 ± 0.241
1.033GlyCys: 1.033 ± 0.11
4.377GlyAsp: 4.377 ± 0.33
4.037GlyGlu: 4.037 ± 0.224
2.651GlyPhe: 2.651 ± 0.237
3.834GlyGly: 3.834 ± 0.292
1.183GlyHis: 1.183 ± 0.121
3.956GlyIle: 3.956 ± 0.244
4.037GlyLys: 4.037 ± 0.23
3.969GlyLeu: 3.969 ± 0.201
1.767GlyMet: 1.767 ± 0.166
2.977GlyAsn: 2.977 ± 0.217
0.748GlyPro: 0.748 ± 0.105
1.998GlyGln: 1.998 ± 0.153
2.596GlyArg: 2.596 ± 0.168
4.01GlySer: 4.01 ± 0.319
3.997GlyThr: 3.997 ± 0.261
4.35GlyVal: 4.35 ± 0.27
1.088GlyTrp: 1.088 ± 0.122
2.664GlyTyr: 2.664 ± 0.186
0.0GlyXaa: 0.0 ± 0.0
His
1.726HisAla: 1.726 ± 0.151
0.285HisCys: 0.285 ± 0.065
1.726HisAsp: 1.726 ± 0.179
1.699HisGlu: 1.699 ± 0.162
1.115HisPhe: 1.115 ± 0.125
1.441HisGly: 1.441 ± 0.139
0.489HisHis: 0.489 ± 0.081
1.4HisIle: 1.4 ± 0.154
1.346HisLys: 1.346 ± 0.121
1.699HisLeu: 1.699 ± 0.163
0.517HisMet: 0.517 ± 0.076
0.992HisAsn: 0.992 ± 0.107
1.06HisPro: 1.06 ± 0.145
0.598HisGln: 0.598 ± 0.084
0.992HisArg: 0.992 ± 0.117
1.319HisSer: 1.319 ± 0.126
1.373HisThr: 1.373 ± 0.14
1.917HisVal: 1.917 ± 0.157
0.299HisTrp: 0.299 ± 0.058
1.088HisTyr: 1.088 ± 0.109
0.0HisXaa: 0.0 ± 0.0
Ile
5.234IleAla: 5.234 ± 0.302
0.653IleCys: 0.653 ± 0.092
5.383IleAsp: 5.383 ± 0.283
6.389IleGlu: 6.389 ± 0.264
2.433IlePhe: 2.433 ± 0.176
3.834IleGly: 3.834 ± 0.242
1.427IleHis: 1.427 ± 0.14
4.214IleIle: 4.214 ± 0.313
4.486IleLys: 4.486 ± 0.276
3.956IleLeu: 3.956 ± 0.229
2.107IleMet: 2.107 ± 0.174
3.82IleAsn: 3.82 ± 0.261
2.325IlePro: 2.325 ± 0.167
2.148IleGln: 2.148 ± 0.159
3.195IleArg: 3.195 ± 0.216
3.847IleSer: 3.847 ± 0.208
3.942IleThr: 3.942 ± 0.207
4.704IleVal: 4.704 ± 0.23
0.585IleTrp: 0.585 ± 0.096
1.971IleTyr: 1.971 ± 0.159
0.0IleXaa: 0.0 ± 0.0
Lys
5.03LysAla: 5.03 ± 0.33
0.625LysCys: 0.625 ± 0.106
3.793LysAsp: 3.793 ± 0.222
4.69LysGlu: 4.69 ± 0.244
2.637LysPhe: 2.637 ± 0.189
3.303LysGly: 3.303 ± 0.224
1.903LysHis: 1.903 ± 0.174
4.309LysIle: 4.309 ± 0.264
4.826LysLys: 4.826 ± 0.351
5.37LysLeu: 5.37 ± 0.304
2.42LysMet: 2.42 ± 0.182
2.882LysAsn: 2.882 ± 0.219
2.393LysPro: 2.393 ± 0.2
2.732LysGln: 2.732 ± 0.189
3.997LysArg: 3.997 ± 0.265
3.793LysSer: 3.793 ± 0.208
3.684LysThr: 3.684 ± 0.223
4.228LysVal: 4.228 ± 0.247
0.952LysTrp: 0.952 ± 0.122
2.95LysTyr: 2.95 ± 0.213
0.0LysXaa: 0.0 ± 0.0
Leu
5.614LeuAla: 5.614 ± 0.273
0.992LeuCys: 0.992 ± 0.118
5.465LeuAsp: 5.465 ± 0.278
5.655LeuGlu: 5.655 ± 0.296
2.76LeuPhe: 2.76 ± 0.204
4.133LeuGly: 4.133 ± 0.229
1.713LeuHis: 1.713 ± 0.14
4.282LeuIle: 4.282 ± 0.257
4.799LeuLys: 4.799 ± 0.262
5.723LeuLeu: 5.723 ± 0.304
2.175LeuMet: 2.175 ± 0.202
4.133LeuAsn: 4.133 ± 0.283
3.113LeuPro: 3.113 ± 0.211
2.379LeuGln: 2.379 ± 0.175
4.336LeuArg: 4.336 ± 0.214
4.839LeuSer: 4.839 ± 0.305
4.595LeuThr: 4.595 ± 0.235
4.663LeuVal: 4.663 ± 0.221
0.911LeuTrp: 0.911 ± 0.1
3.127LeuTyr: 3.127 ± 0.22
0.0LeuXaa: 0.0 ± 0.0
Met
1.536MetAla: 1.536 ± 0.149
0.421MetCys: 0.421 ± 0.079
1.02MetAsp: 1.02 ± 0.143
1.128MetGlu: 1.128 ± 0.116
1.251MetPhe: 1.251 ± 0.121
1.387MetGly: 1.387 ± 0.145
0.625MetHis: 0.625 ± 0.093
2.189MetIle: 2.189 ± 0.18
2.474MetLys: 2.474 ± 0.219
2.134MetLeu: 2.134 ± 0.192
0.952MetMet: 0.952 ± 0.133
1.985MetAsn: 1.985 ± 0.18
1.074MetPro: 1.074 ± 0.115
1.359MetGln: 1.359 ± 0.129
1.55MetArg: 1.55 ± 0.162
2.692MetSer: 2.692 ± 0.204
2.121MetThr: 2.121 ± 0.16
1.21MetVal: 1.21 ± 0.137
0.285MetTrp: 0.285 ± 0.062
1.169MetTyr: 1.169 ± 0.137
0.0MetXaa: 0.0 ± 0.0
Asn
3.616AsnAla: 3.616 ± 0.23
0.557AsnCys: 0.557 ± 0.094
3.195AsnAsp: 3.195 ± 0.209
3.847AsnGlu: 3.847 ± 0.237
2.216AsnPhe: 2.216 ± 0.153
4.024AsnGly: 4.024 ± 0.24
1.088AsnHis: 1.088 ± 0.119
3.575AsnIle: 3.575 ± 0.208
3.385AsnLys: 3.385 ± 0.241
3.534AsnLeu: 3.534 ± 0.217
1.251AsnMet: 1.251 ± 0.102
2.692AsnAsn: 2.692 ± 0.188
2.161AsnPro: 2.161 ± 0.191
1.536AsnGln: 1.536 ± 0.149
2.406AsnArg: 2.406 ± 0.154
2.868AsnSer: 2.868 ± 0.205
2.732AsnThr: 2.732 ± 0.198
3.575AsnVal: 3.575 ± 0.309
0.612AsnTrp: 0.612 ± 0.079
2.134AsnTyr: 2.134 ± 0.184
0.0AsnXaa: 0.0 ± 0.0
Pro
1.971ProAla: 1.971 ± 0.166
0.435ProCys: 0.435 ± 0.078
2.352ProAsp: 2.352 ± 0.177
3.072ProGlu: 3.072 ± 0.192
1.523ProPhe: 1.523 ± 0.159
1.482ProGly: 1.482 ± 0.143
0.829ProHis: 0.829 ± 0.114
1.631ProIle: 1.631 ± 0.147
1.781ProLys: 1.781 ± 0.176
2.325ProLeu: 2.325 ± 0.175
0.843ProMet: 0.843 ± 0.095
1.794ProAsn: 1.794 ± 0.135
0.693ProPro: 0.693 ± 0.112
1.088ProGln: 1.088 ± 0.106
1.237ProArg: 1.237 ± 0.135
2.121ProSer: 2.121 ± 0.22
1.93ProThr: 1.93 ± 0.186
2.488ProVal: 2.488 ± 0.179
0.367ProTrp: 0.367 ± 0.068
1.482ProTyr: 1.482 ± 0.135
0.0ProXaa: 0.0 ± 0.0
Gln
2.624GlnAla: 2.624 ± 0.212
0.381GlnCys: 0.381 ± 0.075
1.794GlnAsp: 1.794 ± 0.182
2.8GlnGlu: 2.8 ± 0.188
1.441GlnPhe: 1.441 ± 0.137
1.876GlnGly: 1.876 ± 0.164
0.639GlnHis: 0.639 ± 0.112
2.501GlnIle: 2.501 ± 0.184
2.501GlnLys: 2.501 ± 0.172
2.855GlnLeu: 2.855 ± 0.209
1.128GlnMet: 1.128 ± 0.115
1.523GlnAsn: 1.523 ± 0.137
1.06GlnPro: 1.06 ± 0.116
1.06GlnGln: 1.06 ± 0.134
1.794GlnArg: 1.794 ± 0.166
2.026GlnSer: 2.026 ± 0.193
1.917GlnThr: 1.917 ± 0.193
2.093GlnVal: 2.093 ± 0.181
0.612GlnTrp: 0.612 ± 0.087
1.509GlnTyr: 1.509 ± 0.147
0.0GlnXaa: 0.0 ± 0.0
Arg
3.344ArgAla: 3.344 ± 0.242
0.666ArgCys: 0.666 ± 0.099
3.154ArgAsp: 3.154 ± 0.221
3.997ArgGlu: 3.997 ± 0.272
2.229ArgPhe: 2.229 ± 0.148
3.018ArgGly: 3.018 ± 0.209
1.251ArgHis: 1.251 ± 0.14
3.494ArgIle: 3.494 ± 0.229
3.575ArgLys: 3.575 ± 0.263
4.01ArgLeu: 4.01 ± 0.23
1.223ArgMet: 1.223 ± 0.147
2.352ArgAsn: 2.352 ± 0.166
1.468ArgPro: 1.468 ± 0.147
1.4ArgGln: 1.4 ± 0.128
2.583ArgArg: 2.583 ± 0.192
2.896ArgSer: 2.896 ± 0.199
2.732ArgThr: 2.732 ± 0.246
3.466ArgVal: 3.466 ± 0.226
0.856ArgTrp: 0.856 ± 0.12
2.189ArgTyr: 2.189 ± 0.173
0.0ArgXaa: 0.0 ± 0.0
Ser
3.983SerAla: 3.983 ± 0.236
0.748SerCys: 0.748 ± 0.109
4.255SerAsp: 4.255 ± 0.259
4.065SerGlu: 4.065 ± 0.241
2.76SerPhe: 2.76 ± 0.163
4.01SerGly: 4.01 ± 0.317
1.482SerHis: 1.482 ± 0.127
3.82SerIle: 3.82 ± 0.224
4.133SerLys: 4.133 ± 0.277
4.731SerLeu: 4.731 ± 0.238
1.577SerMet: 1.577 ± 0.164
3.099SerAsn: 3.099 ± 0.221
1.822SerPro: 1.822 ± 0.159
2.026SerGln: 2.026 ± 0.179
2.909SerArg: 2.909 ± 0.245
3.956SerSer: 3.956 ± 0.316
4.051SerThr: 4.051 ± 0.279
4.037SerVal: 4.037 ± 0.209
0.693SerTrp: 0.693 ± 0.1
2.474SerTyr: 2.474 ± 0.209
0.0SerXaa: 0.0 ± 0.0
Thr
4.105ThrAla: 4.105 ± 0.317
0.707ThrCys: 0.707 ± 0.106
3.643ThrAsp: 3.643 ± 0.254
4.269ThrGlu: 4.269 ± 0.254
2.664ThrPhe: 2.664 ± 0.193
3.915ThrGly: 3.915 ± 0.273
1.251ThrHis: 1.251 ± 0.113
4.799ThrIle: 4.799 ± 0.274
3.113ThrLys: 3.113 ± 0.23
4.88ThrLeu: 4.88 ± 0.298
1.305ThrMet: 1.305 ± 0.145
2.923ThrAsn: 2.923 ± 0.192
2.528ThrPro: 2.528 ± 0.19
2.311ThrGln: 2.311 ± 0.212
2.841ThrArg: 2.841 ± 0.182
3.63ThrSer: 3.63 ± 0.298
3.602ThrThr: 3.602 ± 0.4
4.799ThrVal: 4.799 ± 0.272
0.775ThrTrp: 0.775 ± 0.11
2.27ThrTyr: 2.27 ± 0.228
0.0ThrXaa: 0.0 ± 0.0
Val
4.391ValAla: 4.391 ± 0.26
0.924ValCys: 0.924 ± 0.116
4.867ValAsp: 4.867 ± 0.26
5.288ValGlu: 5.288 ± 0.247
3.167ValPhe: 3.167 ± 0.226
3.711ValGly: 3.711 ± 0.24
1.563ValHis: 1.563 ± 0.158
4.201ValIle: 4.201 ± 0.253
4.513ValLys: 4.513 ± 0.259
5.084ValLeu: 5.084 ± 0.257
1.604ValMet: 1.604 ± 0.16
3.426ValAsn: 3.426 ± 0.219
2.134ValPro: 2.134 ± 0.195
2.42ValGln: 2.42 ± 0.174
3.602ValArg: 3.602 ± 0.243
4.404ValSer: 4.404 ± 0.247
4.54ValThr: 4.54 ± 0.281
5.016ValVal: 5.016 ± 0.259
0.829ValTrp: 0.829 ± 0.105
2.936ValTyr: 2.936 ± 0.186
0.0ValXaa: 0.0 ± 0.0
Trp
0.829TrpAla: 0.829 ± 0.096
0.177TrpCys: 0.177 ± 0.047
0.992TrpAsp: 0.992 ± 0.103
0.965TrpGlu: 0.965 ± 0.097
0.666TrpPhe: 0.666 ± 0.09
0.72TrpGly: 0.72 ± 0.102
0.435TrpHis: 0.435 ± 0.08
0.517TrpIle: 0.517 ± 0.087
0.87TrpLys: 0.87 ± 0.119
1.155TrpLeu: 1.155 ± 0.121
0.489TrpMet: 0.489 ± 0.068
0.802TrpAsn: 0.802 ± 0.114
0.122TrpPro: 0.122 ± 0.043
0.503TrpGln: 0.503 ± 0.08
0.775TrpArg: 0.775 ± 0.096
0.884TrpSer: 0.884 ± 0.113
0.761TrpThr: 0.761 ± 0.121
0.979TrpVal: 0.979 ± 0.11
0.19TrpTrp: 0.19 ± 0.051
0.761TrpTyr: 0.761 ± 0.105
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.991TyrAla: 2.991 ± 0.216
0.666TyrCys: 0.666 ± 0.1
3.344TyrAsp: 3.344 ± 0.205
2.909TyrGlu: 2.909 ± 0.234
1.604TyrPhe: 1.604 ± 0.148
2.556TyrGly: 2.556 ± 0.207
1.169TyrHis: 1.169 ± 0.13
2.311TyrIle: 2.311 ± 0.166
2.732TyrLys: 2.732 ± 0.188
3.14TyrLeu: 3.14 ± 0.183
1.06TyrMet: 1.06 ± 0.13
2.515TyrAsn: 2.515 ± 0.223
1.183TyrPro: 1.183 ± 0.122
1.523TyrGln: 1.523 ± 0.155
2.066TyrArg: 2.066 ± 0.164
2.365TyrSer: 2.365 ± 0.195
2.746TyrThr: 2.746 ± 0.154
3.045TyrVal: 3.045 ± 0.202
0.544TyrTrp: 0.544 ± 0.089
1.563TyrTyr: 1.563 ± 0.175
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 380 proteins (73563 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski