Amino acid dipepetide frequency for Enterococcus phoeniculicola ATCC BAA-412

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.137AlaAla: 5.137 ± 0.095	0.513AlaCys: 0.513 ± 0.025	3.458AlaAsp: 3.458 ± 0.158	4.307AlaGlu: 4.307 ± 0.073	3.141AlaPhe: 3.141 ± 0.058	4.757AlaGly: 4.757 ± 0.08	1.168AlaHis: 1.168 ± 0.035	5.631AlaIle: 5.631 ± 0.077	4.678AlaLys: 4.678 ± 0.074	6.655AlaLeu: 6.655 ± 0.1	1.884AlaMet: 1.884 ± 0.044	2.861AlaAsn: 2.861 ± 0.049	1.992AlaPro: 1.992 ± 0.054	2.485AlaGln: 2.485 ± 0.052	2.154AlaArg: 2.154 ± 0.04	4.01AlaSer: 4.01 ± 0.07	3.876AlaThr: 3.876 ± 0.062	4.807AlaVal: 4.807 ± 0.082	0.606AlaTrp: 0.606 ± 0.028	2.445AlaTyr: 2.445 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.38CysAla: 0.38 ± 0.02	0.079CysCys: 0.079 ± 0.008	0.281CysAsp: 0.281 ± 0.016	0.408CysGlu: 0.408 ± 0.019	0.34CysPhe: 0.34 ± 0.018	0.602CysGly: 0.602 ± 0.021	0.156CysHis: 0.156 ± 0.014	0.472CysIle: 0.472 ± 0.023	0.289CysLys: 0.289 ± 0.017	0.694CysLeu: 0.694 ± 0.027	0.172CysMet: 0.172 ± 0.013	0.229CysAsn: 0.229 ± 0.015	0.254CysPro: 0.254 ± 0.016	0.297CysGln: 0.297 ± 0.016	0.243CysArg: 0.243 ± 0.014	0.447CysSer: 0.447 ± 0.023	0.337CysThr: 0.337 ± 0.017	0.378CysVal: 0.378 ± 0.022	0.077CysTrp: 0.077 ± 0.008	0.285CysTyr: 0.285 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.417AspAla: 3.417 ± 0.166	0.355AspCys: 0.355 ± 0.019	2.24AspAsp: 2.24 ± 0.05	4.418AspGlu: 4.418 ± 0.068	2.645AspPhe: 2.645 ± 0.045	3.462AspGly: 3.462 ± 0.06	0.816AspHis: 0.816 ± 0.027	3.675AspIle: 3.675 ± 0.063	3.264AspLys: 3.264 ± 0.054	4.664AspLeu: 4.664 ± 0.076	1.242AspMet: 1.242 ± 0.036	1.965AspAsn: 1.965 ± 0.046	1.698AspPro: 1.698 ± 0.05	1.747AspGln: 1.747 ± 0.041	1.67AspArg: 1.67 ± 0.04	3.24AspSer: 3.24 ± 0.049	2.893AspThr: 2.893 ± 0.058	3.542AspVal: 3.542 ± 0.054	0.639AspTrp: 0.639 ± 0.024	2.581AspTyr: 2.581 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	5.275GluAla: 5.275 ± 0.091	0.347GluCys: 0.347 ± 0.019	3.467GluAsp: 3.467 ± 0.058	7.281GluGlu: 7.281 ± 0.097	2.785GluPhe: 2.785 ± 0.056	4.035GluGly: 4.035 ± 0.067	1.115GluHis: 1.115 ± 0.034	5.773GluIle: 5.773 ± 0.081	7.265GluLys: 7.265 ± 0.092	7.473GluLeu: 7.473 ± 0.108	2.249GluMet: 2.249 ± 0.05	4.25GluAsn: 4.25 ± 0.066	1.852GluPro: 1.852 ± 0.047	3.293GluGln: 3.293 ± 0.064	2.802GluArg: 2.802 ± 0.058	3.827GluSer: 3.827 ± 0.06	4.487GluThr: 4.487 ± 0.069	4.914GluVal: 4.914 ± 0.08	0.735GluTrp: 0.735 ± 0.029	2.305GluTyr: 2.305 ± 0.052	0.0GluXaa: 0.0 ± 0.0
Phe	2.803PheAla: 2.803 ± 0.058	0.385PheCys: 0.385 ± 0.019	2.767PheAsp: 2.767 ± 0.055	2.937PheGlu: 2.937 ± 0.052	2.803PhePhe: 2.803 ± 0.071	3.322PheGly: 3.322 ± 0.057	0.876PheHis: 0.876 ± 0.029	3.801PheIle: 3.801 ± 0.071	2.435PheLys: 2.435 ± 0.048	5.174PheLeu: 5.174 ± 0.095	1.184PheMet: 1.184 ± 0.029	1.915PheAsn: 1.915 ± 0.045	1.712PhePro: 1.712 ± 0.042	1.77PheGln: 1.77 ± 0.046	1.475PheArg: 1.475 ± 0.035	4.082PheSer: 4.082 ± 0.072	2.773PheThr: 2.773 ± 0.048	3.324PheVal: 3.324 ± 0.059	0.545PheTrp: 0.545 ± 0.024	2.015PheTyr: 2.015 ± 0.046	0.0PheXaa: 0.0 ± 0.0
Gly	4.441GlyAla: 4.441 ± 0.08	0.504GlyCys: 0.504 ± 0.023	2.88GlyAsp: 2.88 ± 0.059	4.35GlyGlu: 4.35 ± 0.071	3.349GlyPhe: 3.349 ± 0.067	4.508GlyGly: 4.508 ± 0.076	1.122GlyHis: 1.122 ± 0.038	5.951GlyIle: 5.951 ± 0.087	4.744GlyLys: 4.744 ± 0.071	6.33GlyLeu: 6.33 ± 0.095	2.006GlyMet: 2.006 ± 0.049	3.0GlyAsn: 3.0 ± 0.072	1.502GlyPro: 1.502 ± 0.043	2.205GlyGln: 2.205 ± 0.048	2.165GlyArg: 2.165 ± 0.052	3.825GlySer: 3.825 ± 0.065	4.129GlyThr: 4.129 ± 0.075	4.656GlyVal: 4.656 ± 0.072	0.741GlyTrp: 0.741 ± 0.025	2.806GlyTyr: 2.806 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	1.105HisAla: 1.105 ± 0.034	0.154HisCys: 0.154 ± 0.011	0.825HisAsp: 0.825 ± 0.027	1.163HisGlu: 1.163 ± 0.034	1.064HisPhe: 1.064 ± 0.032	1.201HisGly: 1.201 ± 0.039	0.45HisHis: 0.45 ± 0.024	1.143HisIle: 1.143 ± 0.029	0.794HisLys: 0.794 ± 0.026	1.933HisLeu: 1.933 ± 0.043	0.41HisMet: 0.41 ± 0.019	0.579HisAsn: 0.579 ± 0.02	0.884HisPro: 0.884 ± 0.026	0.881HisGln: 0.881 ± 0.033	0.697HisArg: 0.697 ± 0.028	1.112HisSer: 1.112 ± 0.032	0.991HisThr: 0.991 ± 0.029	1.156HisVal: 1.156 ± 0.035	0.229HisTrp: 0.229 ± 0.017	0.878HisTyr: 0.878 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.425IleAla: 5.425 ± 0.083	0.678IleCys: 0.678 ± 0.028	4.466IleAsp: 4.466 ± 0.065	5.505IleGlu: 5.505 ± 0.084	3.561IlePhe: 3.561 ± 0.069	5.45IleGly: 5.45 ± 0.083	1.7IleHis: 1.7 ± 0.039	5.562IleIle: 5.562 ± 0.088	4.412IleLys: 4.412 ± 0.069	7.554IleLeu: 7.554 ± 0.091	1.602IleMet: 1.602 ± 0.034	3.23IleAsn: 3.23 ± 0.057	3.243IlePro: 3.243 ± 0.058	3.551IleGln: 3.551 ± 0.069	2.992IleArg: 2.992 ± 0.06	5.41IleSer: 5.41 ± 0.08	4.329IleThr: 4.329 ± 0.08	5.165IleVal: 5.165 ± 0.076	0.622IleTrp: 0.622 ± 0.023	2.891IleTyr: 2.891 ± 0.05	0.0IleXaa: 0.0 ± 0.0
Lys	4.101LysAla: 4.101 ± 0.069	0.225LysCys: 0.225 ± 0.014	3.621LysAsp: 3.621 ± 0.062	7.942LysGlu: 7.942 ± 0.103	2.049LysPhe: 2.049 ± 0.04	3.973LysGly: 3.973 ± 0.056	1.046LysHis: 1.046 ± 0.031	5.33LysIle: 5.33 ± 0.081	7.401LysLys: 7.401 ± 0.115	5.65LysLeu: 5.65 ± 0.068	2.317LysMet: 2.317 ± 0.045	4.265LysAsn: 4.265 ± 0.072	1.819LysPro: 1.819 ± 0.04	3.365LysGln: 3.365 ± 0.06	3.001LysArg: 3.001 ± 0.056	3.447LysSer: 3.447 ± 0.056	4.115LysThr: 4.115 ± 0.076	4.27LysVal: 4.27 ± 0.07	0.636LysTrp: 0.636 ± 0.026	2.159LysTyr: 2.159 ± 0.051	0.0LysXaa: 0.0 ± 0.0
Leu	7.367LeuAla: 7.367 ± 0.095	0.657LeuCys: 0.657 ± 0.027	4.974LeuAsp: 4.974 ± 0.074	6.23LeuGlu: 6.23 ± 0.091	5.476LeuPhe: 5.476 ± 0.099	6.331LeuGly: 6.331 ± 0.099	1.55LeuHis: 1.55 ± 0.042	7.384LeuIle: 7.384 ± 0.105	6.459LeuLys: 6.459 ± 0.084	10.786LeuLeu: 10.786 ± 0.143	2.531LeuMet: 2.531 ± 0.049	4.414LeuAsn: 4.414 ± 0.062	4.062LeuPro: 4.062 ± 0.061	3.332LeuGln: 3.332 ± 0.056	3.151LeuArg: 3.151 ± 0.051	7.742LeuSer: 7.742 ± 0.094	6.375LeuThr: 6.375 ± 0.094	6.673LeuVal: 6.673 ± 0.076	0.82LeuTrp: 0.82 ± 0.032	3.263LeuTyr: 3.263 ± 0.062	0.0LeuXaa: 0.0 ± 0.0
Met	1.899MetAla: 1.899 ± 0.039	0.125MetCys: 0.125 ± 0.012	1.417MetAsp: 1.417 ± 0.036	1.758MetGlu: 1.758 ± 0.042	1.011MetPhe: 1.011 ± 0.034	1.754MetGly: 1.754 ± 0.044	0.381MetHis: 0.381 ± 0.017	2.348MetIle: 2.348 ± 0.045	2.47MetLys: 2.47 ± 0.039	2.233MetLeu: 2.233 ± 0.048	0.827MetMet: 0.827 ± 0.031	1.727MetAsn: 1.727 ± 0.047	0.87MetPro: 0.87 ± 0.029	0.882MetGln: 0.882 ± 0.029	0.916MetArg: 0.916 ± 0.029	1.711MetSer: 1.711 ± 0.043	1.769MetThr: 1.769 ± 0.034	1.697MetVal: 1.697 ± 0.042	0.173MetTrp: 0.173 ± 0.014	0.757MetTyr: 0.757 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	2.583AsnAla: 2.583 ± 0.049	0.279AsnCys: 0.279 ± 0.014	2.211AsnAsp: 2.211 ± 0.05	3.75AsnGlu: 3.75 ± 0.063	2.018AsnPhe: 2.018 ± 0.041	3.269AsnGly: 3.269 ± 0.057	1.102AsnHis: 1.102 ± 0.032	3.146AsnIle: 3.146 ± 0.061	3.072AsnLys: 3.072 ± 0.063	4.202AsnLeu: 4.202 ± 0.067	1.169AsnMet: 1.169 ± 0.032	1.974AsnAsn: 1.974 ± 0.045	2.009AsnPro: 2.009 ± 0.046	2.795AsnGln: 2.795 ± 0.052	1.904AsnArg: 1.904 ± 0.046	2.556AsnSer: 2.556 ± 0.051	2.562AsnThr: 2.562 ± 0.057	2.885AsnVal: 2.885 ± 0.058	0.593AsnTrp: 0.593 ± 0.024	2.231AsnTyr: 2.231 ± 0.049	0.0AsnXaa: 0.0 ± 0.0
Pro	2.161ProAla: 2.161 ± 0.043	0.167ProCys: 0.167 ± 0.013	1.841ProAsp: 1.841 ± 0.041	3.072ProGlu: 3.072 ± 0.058	1.812ProPhe: 1.812 ± 0.04	1.799ProGly: 1.799 ± 0.046	0.617ProHis: 0.617 ± 0.025	2.688ProIle: 2.688 ± 0.045	2.322ProLys: 2.322 ± 0.046	3.225ProLeu: 3.225 ± 0.05	0.903ProMet: 0.903 ± 0.023	1.71ProAsn: 1.71 ± 0.036	0.607ProPro: 0.607 ± 0.024	1.12ProGln: 1.12 ± 0.031	0.908ProArg: 0.908 ± 0.03	2.059ProSer: 2.059 ± 0.051	2.244ProThr: 2.244 ± 0.044	2.698ProVal: 2.698 ± 0.053	0.345ProTrp: 0.345 ± 0.018	1.365ProTyr: 1.365 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	3.022GlnAla: 3.022 ± 0.057	0.154GlnCys: 0.154 ± 0.012	1.475GlnAsp: 1.475 ± 0.038	3.304GlnGlu: 3.304 ± 0.062	1.829GlnPhe: 1.829 ± 0.044	2.126GlnGly: 2.126 ± 0.047	0.609GlnHis: 0.609 ± 0.026	2.894GlnIle: 2.894 ± 0.057	3.209GlnLys: 3.209 ± 0.061	4.848GlnLeu: 4.848 ± 0.081	1.144GlnMet: 1.144 ± 0.031	1.682GlnAsn: 1.682 ± 0.047	1.314GlnPro: 1.314 ± 0.034	2.129GlnGln: 2.129 ± 0.054	1.551GlnArg: 1.551 ± 0.043	2.377GlnSer: 2.377 ± 0.047	2.771GlnThr: 2.771 ± 0.055	2.64GlnVal: 2.64 ± 0.049	0.488GlnTrp: 0.488 ± 0.022	1.294GlnTyr: 1.294 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	1.994ArgAla: 1.994 ± 0.047	0.192ArgCys: 0.192 ± 0.013	1.498ArgAsp: 1.498 ± 0.037	2.73ArgGlu: 2.73 ± 0.062	1.811ArgPhe: 1.811 ± 0.045	1.949ArgGly: 1.949 ± 0.049	0.642ArgHis: 0.642 ± 0.024	2.787ArgIle: 2.787 ± 0.051	2.93ArgLys: 2.93 ± 0.05	3.662ArgLeu: 3.662 ± 0.07	1.126ArgMet: 1.126 ± 0.031	1.702ArgAsn: 1.702 ± 0.04	1.084ArgPro: 1.084 ± 0.033	1.541ArgGln: 1.541 ± 0.043	1.531ArgArg: 1.531 ± 0.043	1.85ArgSer: 1.85 ± 0.043	1.897ArgThr: 1.897 ± 0.049	2.413ArgVal: 2.413 ± 0.051	0.375ArgTrp: 0.375 ± 0.02	1.611ArgTyr: 1.611 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	3.817SerAla: 3.817 ± 0.068	0.416SerCys: 0.416 ± 0.02	3.211SerAsp: 3.211 ± 0.052	4.527SerGlu: 4.527 ± 0.071	3.499SerPhe: 3.499 ± 0.054	4.621SerGly: 4.621 ± 0.076	1.098SerHis: 1.098 ± 0.03	5.182SerIle: 5.182 ± 0.071	4.082SerLys: 4.082 ± 0.064	6.687SerLeu: 6.687 ± 0.092	1.611SerMet: 1.611 ± 0.042	2.774SerAsn: 2.774 ± 0.065	1.947SerPro: 1.947 ± 0.04	2.435SerGln: 2.435 ± 0.05	2.055SerArg: 2.055 ± 0.044	4.263SerSer: 4.263 ± 0.101	3.617SerThr: 3.617 ± 0.067	4.396SerVal: 4.396 ± 0.058	0.743SerTrp: 0.743 ± 0.027	2.664SerTyr: 2.664 ± 0.051	0.0SerXaa: 0.0 ± 0.0
Thr	3.962ThrAla: 3.962 ± 0.066	0.339ThrCys: 0.339 ± 0.02	3.219ThrAsp: 3.219 ± 0.062	3.943ThrGlu: 3.943 ± 0.062	2.913ThrPhe: 2.913 ± 0.053	4.156ThrGly: 4.156 ± 0.065	1.13ThrHis: 1.13 ± 0.029	5.211ThrIle: 5.211 ± 0.071	3.803ThrLys: 3.803 ± 0.064	5.883ThrLeu: 5.883 ± 0.076	1.454ThrMet: 1.454 ± 0.036	2.879ThrAsn: 2.879 ± 0.059	2.432ThrPro: 2.432 ± 0.055	2.136ThrGln: 2.136 ± 0.042	1.854ThrArg: 1.854 ± 0.046	3.75ThrSer: 3.75 ± 0.067	3.739ThrThr: 3.739 ± 0.093	4.32ThrVal: 4.32 ± 0.075	0.57ThrTrp: 0.57 ± 0.025	2.371ThrTyr: 2.371 ± 0.062	0.0ThrXaa: 0.0 ± 0.0
Val	4.877ValAla: 4.877 ± 0.083	0.478ValCys: 0.478 ± 0.023	3.697ValAsp: 3.697 ± 0.063	4.652ValGlu: 4.652 ± 0.074	3.279ValPhe: 3.279 ± 0.055	4.585ValGly: 4.585 ± 0.067	1.071ValHis: 1.071 ± 0.035	5.286ValIle: 5.286 ± 0.083	4.319ValLys: 4.319 ± 0.062	6.537ValLeu: 6.537 ± 0.079	1.749ValMet: 1.749 ± 0.036	3.046ValAsn: 3.046 ± 0.056	2.579ValPro: 2.579 ± 0.048	2.214ValGln: 2.214 ± 0.047	2.25ValArg: 2.25 ± 0.053	4.851ValSer: 4.851 ± 0.059	4.403ValThr: 4.403 ± 0.061	4.832ValVal: 4.832 ± 0.077	0.593ValTrp: 0.593 ± 0.023	2.348ValTyr: 2.348 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	0.558TrpAla: 0.558 ± 0.023	0.072TrpCys: 0.072 ± 0.008	0.506TrpAsp: 0.506 ± 0.027	0.664TrpGlu: 0.664 ± 0.027	0.504TrpPhe: 0.504 ± 0.023	0.723TrpGly: 0.723 ± 0.028	0.199TrpHis: 0.199 ± 0.013	0.687TrpIle: 0.687 ± 0.026	0.658TrpLys: 0.658 ± 0.027	1.152TrpLeu: 1.152 ± 0.035	0.314TrpMet: 0.314 ± 0.017	0.564TrpAsn: 0.564 ± 0.028	0.242TrpPro: 0.242 ± 0.015	0.554TrpGln: 0.554 ± 0.024	0.417TrpArg: 0.417 ± 0.02	0.609TrpSer: 0.609 ± 0.027	0.585TrpThr: 0.585 ± 0.026	0.574TrpVal: 0.574 ± 0.023	0.144TrpTrp: 0.144 ± 0.011	0.39TrpTyr: 0.39 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.243TyrAla: 2.243 ± 0.044	0.3TyrCys: 0.3 ± 0.017	2.117TyrAsp: 2.117 ± 0.067	2.591TyrGlu: 2.591 ± 0.054	2.211TyrPhe: 2.211 ± 0.047	2.587TyrGly: 2.587 ± 0.051	0.803TyrHis: 0.803 ± 0.029	2.395TyrIle: 2.395 ± 0.043	2.128TyrLys: 2.128 ± 0.044	4.234TyrLeu: 4.234 ± 0.065	0.832TyrMet: 0.832 ± 0.024	1.541TyrAsn: 1.541 ± 0.037	1.562TyrPro: 1.562 ± 0.039	2.13TyrGln: 2.13 ± 0.047	1.589TyrArg: 1.589 ± 0.038	2.479TyrSer: 2.479 ± 0.05	2.172TyrThr: 2.172 ± 0.051	2.304TyrVal: 2.304 ± 0.042	0.442TyrTrp: 0.442 ± 0.019	1.686TyrTyr: 1.686 ± 0.049	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3510 proteins (1105453 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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