Amino acid dipepetide frequency for Prevotella bivia DSM 20514

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.455AlaAla: 5.455 ± 0.139
0.901AlaCys: 0.901 ± 0.038
3.96AlaAsp: 3.96 ± 0.071
4.623AlaGlu: 4.623 ± 0.095
3.306AlaPhe: 3.306 ± 0.069
4.411AlaGly: 4.411 ± 0.106
1.423AlaHis: 1.423 ± 0.048
5.301AlaIle: 5.301 ± 0.087
5.485AlaLys: 5.485 ± 0.114
6.667AlaLeu: 6.667 ± 0.099
2.173AlaMet: 2.173 ± 0.065
3.696AlaAsn: 3.696 ± 0.071
2.129AlaPro: 2.129 ± 0.049
3.061AlaGln: 3.061 ± 0.079
2.894AlaArg: 2.894 ± 0.068
4.291AlaSer: 4.291 ± 0.089
4.076AlaThr: 4.076 ± 0.09
4.33AlaVal: 4.33 ± 0.085
0.738AlaTrp: 0.738 ± 0.036
3.075AlaTyr: 3.075 ± 0.074
0.0AlaXaa: 0.0 ± 0.0
Cys
0.733CysAla: 0.733 ± 0.032
0.181CysCys: 0.181 ± 0.015
0.656CysAsp: 0.656 ± 0.028
0.678CysGlu: 0.678 ± 0.031
0.639CysPhe: 0.639 ± 0.038
1.064CysGly: 1.064 ± 0.048
0.315CysHis: 0.315 ± 0.02
0.852CysIle: 0.852 ± 0.037
0.822CysLys: 0.822 ± 0.037
1.068CysLeu: 1.068 ± 0.043
0.289CysMet: 0.289 ± 0.021
0.615CysAsn: 0.615 ± 0.031
0.516CysPro: 0.516 ± 0.029
0.315CysGln: 0.315 ± 0.023
0.536CysArg: 0.536 ± 0.026
0.733CysSer: 0.733 ± 0.033
0.618CysThr: 0.618 ± 0.03
0.736CysVal: 0.736 ± 0.028
0.14CysTrp: 0.14 ± 0.013
0.482CysTyr: 0.482 ± 0.026
0.0CysXaa: 0.0 ± 0.0
Asp
3.916AspAla: 3.916 ± 0.089
0.613AspCys: 0.613 ± 0.029
2.893AspAsp: 2.893 ± 0.077
3.793AspGlu: 3.793 ± 0.082
2.826AspPhe: 2.826 ± 0.069
3.527AspGly: 3.527 ± 0.077
1.051AspHis: 1.051 ± 0.039
4.448AspIle: 4.448 ± 0.08
4.36AspLys: 4.36 ± 0.083
4.523AspLeu: 4.523 ± 0.093
1.512AspMet: 1.512 ± 0.048
2.975AspAsn: 2.975 ± 0.071
1.859AspPro: 1.859 ± 0.053
1.415AspGln: 1.415 ± 0.047
2.304AspArg: 2.304 ± 0.062
2.773AspSer: 2.773 ± 0.07
3.017AspThr: 3.017 ± 0.073
3.556AspVal: 3.556 ± 0.072
0.717AspTrp: 0.717 ± 0.031
2.641AspTyr: 2.641 ± 0.067
0.0AspXaa: 0.0 ± 0.0
Glu
4.975GluAla: 4.975 ± 0.108
0.638GluCys: 0.638 ± 0.031
3.265GluAsp: 3.265 ± 0.066
4.967GluGlu: 4.967 ± 0.117
2.221GluPhe: 2.221 ± 0.059
4.077GluGly: 4.077 ± 0.069
1.364GluHis: 1.364 ± 0.046
4.484GluIle: 4.484 ± 0.092
5.178GluLys: 5.178 ± 0.109
5.756GluLeu: 5.756 ± 0.102
1.849GluMet: 1.849 ± 0.054
3.358GluAsn: 3.358 ± 0.076
1.601GluPro: 1.601 ± 0.048
2.892GluGln: 2.892 ± 0.079
3.232GluArg: 3.232 ± 0.076
2.636GluSer: 2.636 ± 0.068
3.235GluThr: 3.235 ± 0.064
4.265GluVal: 4.265 ± 0.089
0.695GluTrp: 0.695 ± 0.033
2.521GluTyr: 2.521 ± 0.057
0.0GluXaa: 0.0 ± 0.0
Phe
3.135PheAla: 3.135 ± 0.079
0.713PheCys: 0.713 ± 0.036
2.818PheAsp: 2.818 ± 0.068
2.411PheGlu: 2.411 ± 0.06
2.293PhePhe: 2.293 ± 0.079
3.323PheGly: 3.323 ± 0.078
1.03PheHis: 1.03 ± 0.036
3.312PheIle: 3.312 ± 0.089
2.752PheLys: 2.752 ± 0.056
3.92PheLeu: 3.92 ± 0.099
1.249PheMet: 1.249 ± 0.044
2.432PheAsn: 2.432 ± 0.066
1.59PhePro: 1.59 ± 0.048
1.268PheGln: 1.268 ± 0.048
1.908PheArg: 1.908 ± 0.052
3.373PheSer: 3.373 ± 0.072
2.75PheThr: 2.75 ± 0.065
3.071PheVal: 3.071 ± 0.079
0.467PheTrp: 0.467 ± 0.029
1.924PheTyr: 1.924 ± 0.057
0.0PheXaa: 0.0 ± 0.0
Gly
4.388GlyAla: 4.388 ± 0.096
0.853GlyCys: 0.853 ± 0.033
3.326GlyAsp: 3.326 ± 0.069
3.834GlyGlu: 3.834 ± 0.082
3.204GlyPhe: 3.204 ± 0.079
4.714GlyGly: 4.714 ± 0.095
1.333GlyHis: 1.333 ± 0.043
5.2GlyIle: 5.2 ± 0.104
5.683GlyLys: 5.683 ± 0.088
5.628GlyLeu: 5.628 ± 0.094
1.904GlyMet: 1.904 ± 0.057
3.428GlyAsn: 3.428 ± 0.087
1.064GlyPro: 1.064 ± 0.044
1.989GlyGln: 1.989 ± 0.06
2.658GlyArg: 2.658 ± 0.077
3.747GlySer: 3.747 ± 0.074
3.865GlyThr: 3.865 ± 0.079
4.721GlyVal: 4.721 ± 0.078
0.87GlyTrp: 0.87 ± 0.04
3.125GlyTyr: 3.125 ± 0.076
0.0GlyXaa: 0.0 ± 0.0
His
1.225HisAla: 1.225 ± 0.036
0.303HisCys: 0.303 ± 0.02
1.034HisAsp: 1.034 ± 0.043
1.068HisGlu: 1.068 ± 0.042
1.195HisPhe: 1.195 ± 0.043
1.239HisGly: 1.239 ± 0.046
0.615HisHis: 0.615 ± 0.033
1.686HisIle: 1.686 ± 0.055
1.326HisLys: 1.326 ± 0.047
1.989HisLeu: 1.989 ± 0.056
0.361HisMet: 0.361 ± 0.02
1.169HisAsn: 1.169 ± 0.039
1.021HisPro: 1.021 ± 0.041
0.77HisGln: 0.77 ± 0.035
0.989HisArg: 0.989 ± 0.032
1.249HisSer: 1.249 ± 0.047
1.228HisThr: 1.228 ± 0.042
1.103HisVal: 1.103 ± 0.041
0.266HisTrp: 0.266 ± 0.022
0.938HisTyr: 0.938 ± 0.039
0.0HisXaa: 0.0 ± 0.0
Ile
5.868IleAla: 5.868 ± 0.087
0.929IleCys: 0.929 ± 0.039
4.772IleAsp: 4.772 ± 0.08
4.647IleGlu: 4.647 ± 0.093
3.037IlePhe: 3.037 ± 0.083
4.782IleGly: 4.782 ± 0.084
1.436IleHis: 1.436 ± 0.048
5.296IleIle: 5.296 ± 0.107
5.005IleLys: 5.005 ± 0.072
6.182IleLeu: 6.182 ± 0.106
1.655IleMet: 1.655 ± 0.053
3.862IleAsn: 3.862 ± 0.087
3.049IlePro: 3.049 ± 0.059
2.28IleGln: 2.28 ± 0.058
3.029IleArg: 3.029 ± 0.062
4.608IleSer: 4.608 ± 0.094
4.465IleThr: 4.465 ± 0.078
4.649IleVal: 4.649 ± 0.105
0.588IleTrp: 0.588 ± 0.028
2.691IleTyr: 2.691 ± 0.055
0.0IleXaa: 0.0 ± 0.0
Lys
5.608LysAla: 5.608 ± 0.115
0.622LysCys: 0.622 ± 0.033
4.301LysAsp: 4.301 ± 0.078
5.861LysGlu: 5.861 ± 0.113
2.594LysPhe: 2.594 ± 0.06
4.769LysGly: 4.769 ± 0.074
1.459LysHis: 1.459 ± 0.045
4.634LysIle: 4.634 ± 0.083
5.632LysLys: 5.632 ± 0.116
6.155LysLeu: 6.155 ± 0.094
2.327LysMet: 2.327 ± 0.064
3.787LysAsn: 3.787 ± 0.071
2.375LysPro: 2.375 ± 0.056
3.235LysGln: 3.235 ± 0.067
3.522LysArg: 3.522 ± 0.074
3.745LysSer: 3.745 ± 0.081
3.996LysThr: 3.996 ± 0.09
4.841LysVal: 4.841 ± 0.079
0.854LysTrp: 0.854 ± 0.037
3.108LysTyr: 3.108 ± 0.077
0.0LysXaa: 0.0 ± 0.0
Leu
6.628LeuAla: 6.628 ± 0.107
1.29LeuCys: 1.29 ± 0.05
4.555LeuAsp: 4.555 ± 0.091
4.92LeuGlu: 4.92 ± 0.088
4.223LeuPhe: 4.223 ± 0.111
5.927LeuGly: 5.927 ± 0.104
1.925LeuHis: 1.925 ± 0.053
5.69LeuIle: 5.69 ± 0.108
6.343LeuLys: 6.343 ± 0.093
8.475LeuLeu: 8.475 ± 0.161
2.514LeuMet: 2.514 ± 0.057
4.565LeuAsn: 4.565 ± 0.079
3.813LeuPro: 3.813 ± 0.076
3.513LeuGln: 3.513 ± 0.088
4.299LeuArg: 4.299 ± 0.083
6.701LeuSer: 6.701 ± 0.105
5.199LeuThr: 5.199 ± 0.077
5.246LeuVal: 5.246 ± 0.098
0.924LeuTrp: 0.924 ± 0.04
3.489LeuTyr: 3.489 ± 0.074
0.0LeuXaa: 0.0 ± 0.0
Met
2.19MetAla: 2.19 ± 0.057
0.245MetCys: 0.245 ± 0.019
1.379MetAsp: 1.379 ± 0.049
1.743MetGlu: 1.743 ± 0.053
1.085MetPhe: 1.085 ± 0.04
1.893MetGly: 1.893 ± 0.056
0.516MetHis: 0.516 ± 0.026
1.722MetIle: 1.722 ± 0.047
2.474MetLys: 2.474 ± 0.058
2.664MetLeu: 2.664 ± 0.064
0.934MetMet: 0.934 ± 0.04
1.483MetAsn: 1.483 ± 0.045
1.181MetPro: 1.181 ± 0.042
1.248MetGln: 1.248 ± 0.037
1.34MetArg: 1.34 ± 0.048
1.524MetSer: 1.524 ± 0.054
1.374MetThr: 1.374 ± 0.04
1.657MetVal: 1.657 ± 0.048
0.187MetTrp: 0.187 ± 0.016
0.815MetTyr: 0.815 ± 0.036
0.0MetXaa: 0.0 ± 0.0
Asn
3.692AsnAla: 3.692 ± 0.081
0.522AsnCys: 0.522 ± 0.029
2.858AsnAsp: 2.858 ± 0.064
3.143AsnGlu: 3.143 ± 0.067
2.498AsnPhe: 2.498 ± 0.058
3.808AsnGly: 3.808 ± 0.086
1.045AsnHis: 1.045 ± 0.039
4.466AsnIle: 4.466 ± 0.086
3.788AsnLys: 3.788 ± 0.075
4.407AsnLeu: 4.407 ± 0.087
1.307AsnMet: 1.307 ± 0.042
3.133AsnAsn: 3.133 ± 0.076
2.282AsnPro: 2.282 ± 0.063
1.651AsnGln: 1.651 ± 0.053
2.18AsnArg: 2.18 ± 0.049
2.727AsnSer: 2.727 ± 0.059
3.107AsnThr: 3.107 ± 0.072
3.319AsnVal: 3.319 ± 0.074
0.615AsnTrp: 0.615 ± 0.032
2.314AsnTyr: 2.314 ± 0.057
0.0AsnXaa: 0.0 ± 0.0
Pro
2.239ProAla: 2.239 ± 0.063
0.368ProCys: 0.368 ± 0.024
1.901ProAsp: 1.901 ± 0.05
2.63ProGlu: 2.63 ± 0.059
1.76ProPhe: 1.76 ± 0.048
1.74ProGly: 1.74 ± 0.054
0.724ProHis: 0.724 ± 0.035
2.801ProIle: 2.801 ± 0.061
2.452ProLys: 2.452 ± 0.059
3.095ProLeu: 3.095 ± 0.069
0.978ProMet: 0.978 ± 0.036
1.993ProAsn: 1.993 ± 0.053
0.719ProPro: 0.719 ± 0.036
1.277ProGln: 1.277 ± 0.042
1.167ProArg: 1.167 ± 0.04
2.222ProSer: 2.222 ± 0.062
2.411ProThr: 2.411 ± 0.055
2.075ProVal: 2.075 ± 0.058
0.388ProTrp: 0.388 ± 0.029
1.613ProTyr: 1.613 ± 0.047
0.0ProXaa: 0.0 ± 0.0
Gln
2.64GlnAla: 2.64 ± 0.077
0.355GlnCys: 0.355 ± 0.024
1.599GlnAsp: 1.599 ± 0.051
2.344GlnGlu: 2.344 ± 0.068
1.422GlnPhe: 1.422 ± 0.04
2.17GlnGly: 2.17 ± 0.055
0.823GlnHis: 0.823 ± 0.037
2.541GlnIle: 2.541 ± 0.07
2.815GlnLys: 2.815 ± 0.081
3.684GlnLeu: 3.684 ± 0.081
1.096GlnMet: 1.096 ± 0.035
1.785GlnAsn: 1.785 ± 0.048
1.269GlnPro: 1.269 ± 0.046
1.961GlnGln: 1.961 ± 0.064
2.022GlnArg: 2.022 ± 0.063
1.964GlnSer: 1.964 ± 0.059
2.037GlnThr: 2.037 ± 0.061
2.085GlnVal: 2.085 ± 0.06
0.509GlnTrp: 0.509 ± 0.03
1.587GlnTyr: 1.587 ± 0.048
0.0GlnXaa: 0.0 ± 0.0
Arg
2.736ArgAla: 2.736 ± 0.075
0.482ArgCys: 0.482 ± 0.03
2.071ArgAsp: 2.071 ± 0.056
2.904ArgGlu: 2.904 ± 0.069
2.054ArgPhe: 2.054 ± 0.057
2.545ArgGly: 2.545 ± 0.059
1.003ArgHis: 1.003 ± 0.044
3.339ArgIle: 3.339 ± 0.06
3.46ArgLys: 3.46 ± 0.074
4.223ArgLeu: 4.223 ± 0.084
1.454ArgMet: 1.454 ± 0.044
2.354ArgAsn: 2.354 ± 0.062
1.451ArgPro: 1.451 ± 0.053
1.877ArgGln: 1.877 ± 0.062
2.177ArgArg: 2.177 ± 0.066
2.365ArgSer: 2.365 ± 0.059
2.341ArgThr: 2.341 ± 0.052
2.535ArgVal: 2.535 ± 0.059
0.576ArgTrp: 0.576 ± 0.027
2.132ArgTyr: 2.132 ± 0.06
0.0ArgXaa: 0.0 ± 0.0
Ser
4.03SerAla: 4.03 ± 0.071
0.796SerCys: 0.796 ± 0.036
3.094SerAsp: 3.094 ± 0.066
3.418SerGlu: 3.418 ± 0.077
3.344SerPhe: 3.344 ± 0.08
3.965SerGly: 3.965 ± 0.082
1.2SerHis: 1.2 ± 0.043
4.47SerIle: 4.47 ± 0.078
4.061SerLys: 4.061 ± 0.083
5.727SerLeu: 5.727 ± 0.107
1.57SerMet: 1.57 ± 0.05
2.907SerAsn: 2.907 ± 0.076
2.029SerPro: 2.029 ± 0.048
1.944SerGln: 1.944 ± 0.052
2.402SerArg: 2.402 ± 0.064
3.807SerSer: 3.807 ± 0.085
3.365SerThr: 3.365 ± 0.077
3.916SerVal: 3.916 ± 0.076
0.693SerTrp: 0.693 ± 0.036
2.621SerTyr: 2.621 ± 0.065
0.0SerXaa: 0.0 ± 0.0
Thr
4.094ThrAla: 4.094 ± 0.07
0.566ThrCys: 0.566 ± 0.029
3.392ThrAsp: 3.392 ± 0.067
3.347ThrGlu: 3.347 ± 0.08
2.73ThrPhe: 2.73 ± 0.071
3.698ThrGly: 3.698 ± 0.081
1.122ThrHis: 1.122 ± 0.04
4.443ThrIle: 4.443 ± 0.085
3.544ThrLys: 3.544 ± 0.07
5.669ThrLeu: 5.669 ± 0.099
1.381ThrMet: 1.381 ± 0.044
2.882ThrAsn: 2.882 ± 0.067
2.541ThrPro: 2.541 ± 0.062
1.84ThrGln: 1.84 ± 0.049
2.007ThrArg: 2.007 ± 0.055
3.595ThrSer: 3.595 ± 0.086
3.657ThrThr: 3.657 ± 0.086
3.688ThrVal: 3.688 ± 0.065
0.61ThrTrp: 0.61 ± 0.036
2.396ThrTyr: 2.396 ± 0.058
0.0ThrXaa: 0.0 ± 0.0
Val
4.797ValAla: 4.797 ± 0.087
0.948ValCys: 0.948 ± 0.033
3.674ValAsp: 3.674 ± 0.078
3.95ValGlu: 3.95 ± 0.076
2.764ValPhe: 2.764 ± 0.066
4.23ValGly: 4.23 ± 0.082
1.125ValHis: 1.125 ± 0.039
4.455ValIle: 4.455 ± 0.077
4.576ValLys: 4.576 ± 0.09
5.584ValLeu: 5.584 ± 0.085
1.749ValMet: 1.749 ± 0.054
3.136ValAsn: 3.136 ± 0.072
2.3ValPro: 2.3 ± 0.064
2.037ValGln: 2.037 ± 0.053
2.882ValArg: 2.882 ± 0.071
4.125ValSer: 4.125 ± 0.078
3.384ValThr: 3.384 ± 0.073
4.61ValVal: 4.61 ± 0.09
0.737ValTrp: 0.737 ± 0.033
2.418ValTyr: 2.418 ± 0.059
0.0ValXaa: 0.0 ± 0.0
Trp
0.754TrpAla: 0.754 ± 0.032
0.136TrpCys: 0.136 ± 0.014
0.648TrpAsp: 0.648 ± 0.029
0.593TrpGlu: 0.593 ± 0.03
0.506TrpPhe: 0.506 ± 0.03
0.788TrpGly: 0.788 ± 0.033
0.263TrpHis: 0.263 ± 0.021
0.758TrpIle: 0.758 ± 0.037
0.842TrpLys: 0.842 ± 0.038
1.164TrpLeu: 1.164 ± 0.045
0.356TrpMet: 0.356 ± 0.025
0.661TrpAsn: 0.661 ± 0.032
0.158TrpPro: 0.158 ± 0.017
0.581TrpGln: 0.581 ± 0.031
0.53TrpArg: 0.53 ± 0.029
0.624TrpSer: 0.624 ± 0.033
0.57TrpThr: 0.57 ± 0.033
0.7TrpVal: 0.7 ± 0.033
0.178TrpTrp: 0.178 ± 0.016
0.453TrpTyr: 0.453 ± 0.028
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.893TyrAla: 2.893 ± 0.058
0.528TyrCys: 0.528 ± 0.027
2.524TyrAsp: 2.524 ± 0.072
2.338TyrGlu: 2.338 ± 0.063
2.033TyrPhe: 2.033 ± 0.053
2.863TyrGly: 2.863 ± 0.075
1.002TyrHis: 1.002 ± 0.038
2.931TyrIle: 2.931 ± 0.08
2.829TyrLys: 2.829 ± 0.061
3.66TyrLeu: 3.66 ± 0.079
0.992TyrMet: 0.992 ± 0.038
2.643TyrAsn: 2.643 ± 0.067
1.606TyrPro: 1.606 ± 0.052
1.553TyrGln: 1.553 ± 0.041
2.0TyrArg: 2.0 ± 0.057
2.553TyrSer: 2.553 ± 0.072
2.507TyrThr: 2.507 ± 0.077
2.377TyrVal: 2.377 ± 0.061
0.512TyrTrp: 0.512 ± 0.028
2.041TyrTyr: 2.041 ± 0.065
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2064 proteins (706886 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski