Amino acid dipepetide frequency for Alteromonas phage ZP6

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.795AlaAla: 10.795 ± 1.821
0.837AlaCys: 0.837 ± 0.272
5.523AlaAsp: 5.523 ± 0.686
7.029AlaGlu: 7.029 ± 0.885
3.264AlaPhe: 3.264 ± 0.56
6.862AlaGly: 6.862 ± 0.755
1.255AlaHis: 1.255 ± 0.323
5.021AlaIle: 5.021 ± 0.666
4.937AlaLys: 4.937 ± 0.816
5.858AlaLeu: 5.858 ± 0.638
3.515AlaMet: 3.515 ± 0.632
4.017AlaAsn: 4.017 ± 0.777
3.013AlaPro: 3.013 ± 0.781
4.603AlaGln: 4.603 ± 0.814
4.77AlaArg: 4.77 ± 0.633
5.439AlaSer: 5.439 ± 0.782
4.351AlaThr: 4.351 ± 0.595
6.109AlaVal: 6.109 ± 0.571
1.088AlaTrp: 1.088 ± 0.308
2.176AlaTyr: 2.176 ± 0.347
0.0AlaXaa: 0.0 ± 0.0
Cys
0.502CysAla: 0.502 ± 0.208
0.084CysCys: 0.084 ± 0.094
0.921CysAsp: 0.921 ± 0.298
0.586CysGlu: 0.586 ± 0.237
0.669CysPhe: 0.669 ± 0.251
0.753CysGly: 0.753 ± 0.255
0.084CysHis: 0.084 ± 0.11
0.502CysIle: 0.502 ± 0.231
0.167CysLys: 0.167 ± 0.166
0.837CysLeu: 0.837 ± 0.305
0.084CysMet: 0.084 ± 0.13
0.586CysAsn: 0.586 ± 0.198
0.167CysPro: 0.167 ± 0.117
0.251CysGln: 0.251 ± 0.147
0.251CysArg: 0.251 ± 0.153
0.753CysSer: 0.753 ± 0.339
0.837CysThr: 0.837 ± 0.322
0.753CysVal: 0.753 ± 0.29
0.084CysTrp: 0.084 ± 0.088
0.502CysTyr: 0.502 ± 0.213
0.0CysXaa: 0.0 ± 0.0
Asp
4.351AspAla: 4.351 ± 0.763
1.088AspCys: 1.088 ± 0.321
4.1AspAsp: 4.1 ± 0.633
4.854AspGlu: 4.854 ± 0.616
2.176AspPhe: 2.176 ± 0.459
5.439AspGly: 5.439 ± 0.774
0.837AspHis: 0.837 ± 0.285
4.268AspIle: 4.268 ± 0.6
3.598AspLys: 3.598 ± 0.908
5.356AspLeu: 5.356 ± 0.584
1.841AspMet: 1.841 ± 0.339
2.259AspAsn: 2.259 ± 0.482
2.51AspPro: 2.51 ± 0.563
2.51AspGln: 2.51 ± 0.52
3.096AspArg: 3.096 ± 0.527
4.77AspSer: 4.77 ± 0.7
3.431AspThr: 3.431 ± 0.8
3.515AspVal: 3.515 ± 0.45
1.339AspTrp: 1.339 ± 0.471
2.259AspTyr: 2.259 ± 0.435
0.0AspXaa: 0.0 ± 0.0
Glu
7.615GluAla: 7.615 ± 1.244
0.418GluCys: 0.418 ± 0.225
4.017GluAsp: 4.017 ± 0.603
5.607GluGlu: 5.607 ± 0.978
2.678GluPhe: 2.678 ± 0.534
5.858GluGly: 5.858 ± 0.74
1.088GluHis: 1.088 ± 0.361
4.603GluIle: 4.603 ± 0.499
3.682GluLys: 3.682 ± 0.68
6.276GluLeu: 6.276 ± 0.966
2.092GluMet: 2.092 ± 0.406
3.18GluAsn: 3.18 ± 0.448
2.259GluPro: 2.259 ± 0.453
3.264GluGln: 3.264 ± 0.712
3.849GluArg: 3.849 ± 0.534
4.351GluSer: 4.351 ± 0.525
5.439GluThr: 5.439 ± 0.621
4.603GluVal: 4.603 ± 0.61
1.674GluTrp: 1.674 ± 0.373
1.674GluTyr: 1.674 ± 0.37
0.0GluXaa: 0.0 ± 0.0
Phe
2.343PheAla: 2.343 ± 0.555
0.586PheCys: 0.586 ± 0.244
3.515PheAsp: 3.515 ± 0.515
2.762PheGlu: 2.762 ± 0.418
1.004PhePhe: 1.004 ± 0.277
2.845PheGly: 2.845 ± 0.576
0.502PheHis: 0.502 ± 0.182
1.088PheIle: 1.088 ± 0.33
1.841PheLys: 1.841 ± 0.445
1.841PheLeu: 1.841 ± 0.411
0.837PheMet: 0.837 ± 0.257
2.51PheAsn: 2.51 ± 0.474
1.255PhePro: 1.255 ± 0.431
0.669PheGln: 0.669 ± 0.197
1.506PheArg: 1.506 ± 0.376
1.925PheSer: 1.925 ± 0.412
2.092PheThr: 2.092 ± 0.802
1.841PheVal: 1.841 ± 0.401
0.669PheTrp: 0.669 ± 0.242
1.423PheTyr: 1.423 ± 0.362
0.0PheXaa: 0.0 ± 0.0
Gly
6.36GlyAla: 6.36 ± 0.943
0.837GlyCys: 0.837 ± 0.303
5.356GlyAsp: 5.356 ± 0.836
4.603GlyGlu: 4.603 ± 0.602
3.264GlyPhe: 3.264 ± 0.516
7.197GlyGly: 7.197 ± 1.168
1.925GlyHis: 1.925 ± 0.393
3.682GlyIle: 3.682 ± 0.516
4.184GlyLys: 4.184 ± 0.6
5.105GlyLeu: 5.105 ± 0.62
1.841GlyMet: 1.841 ± 0.38
4.268GlyAsn: 4.268 ± 1.018
1.757GlyPro: 1.757 ± 0.354
3.515GlyGln: 3.515 ± 0.516
4.017GlyArg: 4.017 ± 0.608
4.351GlySer: 4.351 ± 0.823
5.523GlyThr: 5.523 ± 0.938
3.515GlyVal: 3.515 ± 0.63
1.423GlyTrp: 1.423 ± 0.437
3.682GlyTyr: 3.682 ± 0.606
0.0GlyXaa: 0.0 ± 0.0
His
1.088HisAla: 1.088 ± 0.384
0.418HisCys: 0.418 ± 0.217
1.004HisAsp: 1.004 ± 0.334
1.004HisGlu: 1.004 ± 0.305
0.502HisPhe: 0.502 ± 0.184
1.506HisGly: 1.506 ± 0.243
0.084HisHis: 0.084 ± 0.084
1.088HisIle: 1.088 ± 0.3
1.004HisLys: 1.004 ± 0.337
1.59HisLeu: 1.59 ± 0.375
0.167HisMet: 0.167 ± 0.128
1.088HisAsn: 1.088 ± 0.253
0.418HisPro: 0.418 ± 0.213
0.418HisGln: 0.418 ± 0.186
1.255HisArg: 1.255 ± 0.382
0.837HisSer: 0.837 ± 0.265
0.669HisThr: 0.669 ± 0.252
1.423HisVal: 1.423 ± 0.322
0.251HisTrp: 0.251 ± 0.128
0.586HisTyr: 0.586 ± 0.199
0.0HisXaa: 0.0 ± 0.0
Ile
4.77IleAla: 4.77 ± 0.866
0.586IleCys: 0.586 ± 0.242
4.351IleAsp: 4.351 ± 0.66
4.268IleGlu: 4.268 ± 0.604
1.59IlePhe: 1.59 ± 0.327
4.603IleGly: 4.603 ± 0.719
0.837IleHis: 0.837 ± 0.357
1.841IleIle: 1.841 ± 0.393
3.682IleLys: 3.682 ± 0.669
4.1IleLeu: 4.1 ± 0.608
1.339IleMet: 1.339 ± 0.347
2.594IleAsn: 2.594 ± 0.449
1.925IlePro: 1.925 ± 0.395
2.259IleGln: 2.259 ± 0.311
3.347IleArg: 3.347 ± 0.506
2.929IleSer: 2.929 ± 0.442
3.096IleThr: 3.096 ± 0.556
3.347IleVal: 3.347 ± 0.609
0.837IleTrp: 0.837 ± 0.258
1.841IleTyr: 1.841 ± 0.41
0.0IleXaa: 0.0 ± 0.0
Lys
5.941LysAla: 5.941 ± 0.983
0.586LysCys: 0.586 ± 0.204
3.347LysAsp: 3.347 ± 0.54
3.766LysGlu: 3.766 ± 0.526
1.423LysPhe: 1.423 ± 0.344
3.515LysGly: 3.515 ± 0.749
1.172LysHis: 1.172 ± 0.381
3.347LysIle: 3.347 ± 0.629
3.682LysLys: 3.682 ± 0.689
4.017LysLeu: 4.017 ± 0.511
2.427LysMet: 2.427 ± 0.68
2.762LysAsn: 2.762 ± 0.446
2.008LysPro: 2.008 ± 0.48
2.092LysGln: 2.092 ± 0.366
3.096LysArg: 3.096 ± 0.558
3.096LysSer: 3.096 ± 0.604
3.598LysThr: 3.598 ± 0.602
3.264LysVal: 3.264 ± 0.555
0.837LysTrp: 0.837 ± 0.277
2.092LysTyr: 2.092 ± 0.475
0.0LysXaa: 0.0 ± 0.0
Leu
6.611LeuAla: 6.611 ± 0.987
0.586LeuCys: 0.586 ± 0.246
4.435LeuAsp: 4.435 ± 0.548
4.603LeuGlu: 4.603 ± 0.593
2.176LeuPhe: 2.176 ± 0.525
5.439LeuGly: 5.439 ± 0.705
1.004LeuHis: 1.004 ± 0.267
3.431LeuIle: 3.431 ± 0.478
4.603LeuLys: 4.603 ± 0.592
4.017LeuLeu: 4.017 ± 0.58
2.594LeuMet: 2.594 ± 0.625
5.607LeuAsn: 5.607 ± 0.647
3.18LeuPro: 3.18 ± 0.641
3.096LeuGln: 3.096 ± 0.562
4.017LeuArg: 4.017 ± 0.731
4.603LeuSer: 4.603 ± 0.659
4.435LeuThr: 4.435 ± 0.649
4.435LeuVal: 4.435 ± 0.583
0.586LeuTrp: 0.586 ± 0.234
2.176LeuTyr: 2.176 ± 0.402
0.0LeuXaa: 0.0 ± 0.0
Met
3.264MetAla: 3.264 ± 0.615
0.251MetCys: 0.251 ± 0.124
1.506MetAsp: 1.506 ± 0.334
1.925MetGlu: 1.925 ± 0.374
1.088MetPhe: 1.088 ± 0.266
2.008MetGly: 2.008 ± 0.348
0.502MetHis: 0.502 ± 0.226
1.674MetIle: 1.674 ± 0.278
1.925MetLys: 1.925 ± 0.51
2.092MetLeu: 2.092 ± 0.522
0.586MetMet: 0.586 ± 0.217
1.841MetAsn: 1.841 ± 0.401
1.255MetPro: 1.255 ± 0.412
1.59MetGln: 1.59 ± 0.37
1.506MetArg: 1.506 ± 0.386
2.427MetSer: 2.427 ± 0.606
1.674MetThr: 1.674 ± 0.347
1.59MetVal: 1.59 ± 0.3
0.335MetTrp: 0.335 ± 0.168
0.921MetTyr: 0.921 ± 0.263
0.0MetXaa: 0.0 ± 0.0
Asn
4.1AsnAla: 4.1 ± 0.689
0.335AsnCys: 0.335 ± 0.203
2.343AsnAsp: 2.343 ± 0.495
3.682AsnGlu: 3.682 ± 0.687
1.255AsnPhe: 1.255 ± 0.314
4.519AsnGly: 4.519 ± 1.136
1.004AsnHis: 1.004 ± 0.234
3.013AsnIle: 3.013 ± 0.497
3.347AsnLys: 3.347 ± 0.442
3.096AsnLeu: 3.096 ± 0.382
1.506AsnMet: 1.506 ± 0.428
2.929AsnAsn: 2.929 ± 0.699
2.343AsnPro: 2.343 ± 0.424
1.925AsnGln: 1.925 ± 0.334
2.929AsnArg: 2.929 ± 0.465
4.017AsnSer: 4.017 ± 0.531
2.427AsnThr: 2.427 ± 0.316
4.268AsnVal: 4.268 ± 0.654
0.753AsnTrp: 0.753 ± 0.305
1.925AsnTyr: 1.925 ± 0.311
0.0AsnXaa: 0.0 ± 0.0
Pro
2.929ProAla: 2.929 ± 0.337
0.251ProCys: 0.251 ± 0.144
2.929ProAsp: 2.929 ± 0.665
4.184ProGlu: 4.184 ± 0.613
0.921ProPhe: 0.921 ± 0.327
0.084ProGly: 0.084 ± 0.127
0.753ProHis: 0.753 ± 0.337
2.092ProIle: 2.092 ± 0.41
2.51ProLys: 2.51 ± 0.409
2.092ProLeu: 2.092 ± 0.435
0.837ProMet: 0.837 ± 0.307
1.925ProAsn: 1.925 ± 0.38
0.837ProPro: 0.837 ± 0.203
1.423ProGln: 1.423 ± 0.447
1.59ProArg: 1.59 ± 0.441
3.096ProSer: 3.096 ± 0.503
2.008ProThr: 2.008 ± 0.439
2.008ProVal: 2.008 ± 0.367
0.753ProTrp: 0.753 ± 0.248
1.088ProTyr: 1.088 ± 0.339
0.0ProXaa: 0.0 ± 0.0
Gln
3.849GlnAla: 3.849 ± 0.562
0.251GlnCys: 0.251 ± 0.145
2.259GlnAsp: 2.259 ± 0.41
3.598GlnGlu: 3.598 ± 0.62
1.172GlnPhe: 1.172 ± 0.33
3.096GlnGly: 3.096 ± 0.478
0.669GlnHis: 0.669 ± 0.171
2.929GlnIle: 2.929 ± 0.443
2.259GlnLys: 2.259 ± 0.296
3.096GlnLeu: 3.096 ± 0.69
1.59GlnMet: 1.59 ± 0.395
1.423GlnAsn: 1.423 ± 0.257
1.423GlnPro: 1.423 ± 0.297
3.264GlnGln: 3.264 ± 0.49
2.343GlnArg: 2.343 ± 0.552
2.51GlnSer: 2.51 ± 0.467
2.51GlnThr: 2.51 ± 0.437
2.092GlnVal: 2.092 ± 0.44
0.586GlnTrp: 0.586 ± 0.228
1.255GlnTyr: 1.255 ± 0.354
0.0GlnXaa: 0.0 ± 0.0
Arg
5.858ArgAla: 5.858 ± 0.908
0.335ArgCys: 0.335 ± 0.16
3.18ArgAsp: 3.18 ± 0.513
4.686ArgGlu: 4.686 ± 0.699
1.841ArgPhe: 1.841 ± 0.302
3.264ArgGly: 3.264 ± 0.529
0.837ArgHis: 0.837 ± 0.288
2.259ArgIle: 2.259 ± 0.462
3.933ArgLys: 3.933 ± 0.6
4.603ArgLeu: 4.603 ± 0.766
1.757ArgMet: 1.757 ± 0.405
2.845ArgAsn: 2.845 ± 0.481
1.506ArgPro: 1.506 ± 0.328
1.925ArgGln: 1.925 ± 0.549
3.598ArgArg: 3.598 ± 0.673
2.762ArgSer: 2.762 ± 0.472
3.096ArgThr: 3.096 ± 0.61
4.519ArgVal: 4.519 ± 0.731
1.59ArgTrp: 1.59 ± 0.437
1.925ArgTyr: 1.925 ± 0.41
0.0ArgXaa: 0.0 ± 0.0
Ser
5.523SerAla: 5.523 ± 0.883
0.586SerCys: 0.586 ± 0.245
3.682SerAsp: 3.682 ± 0.542
3.849SerGlu: 3.849 ± 0.627
2.427SerPhe: 2.427 ± 0.4
5.523SerGly: 5.523 ± 1.208
0.921SerHis: 0.921 ± 0.289
3.431SerIle: 3.431 ± 0.534
2.929SerLys: 2.929 ± 0.574
4.519SerLeu: 4.519 ± 0.7
2.008SerMet: 2.008 ± 0.415
4.519SerAsn: 4.519 ± 1.103
2.176SerPro: 2.176 ± 0.483
2.51SerGln: 2.51 ± 0.396
4.603SerArg: 4.603 ± 0.661
4.1SerSer: 4.1 ± 0.713
3.515SerThr: 3.515 ± 0.68
4.937SerVal: 4.937 ± 0.658
1.172SerTrp: 1.172 ± 0.235
1.757SerTyr: 1.757 ± 0.394
0.0SerXaa: 0.0 ± 0.0
Thr
5.021ThrAla: 5.021 ± 0.567
0.0ThrCys: 0.0 ± 0.0
3.598ThrAsp: 3.598 ± 0.512
3.682ThrGlu: 3.682 ± 0.605
1.757ThrPhe: 1.757 ± 0.33
5.105ThrGly: 5.105 ± 1.04
0.921ThrHis: 0.921 ± 0.285
3.933ThrIle: 3.933 ± 0.751
2.51ThrLys: 2.51 ± 0.477
4.435ThrLeu: 4.435 ± 0.842
2.008ThrMet: 2.008 ± 0.398
2.427ThrAsn: 2.427 ± 0.444
3.431ThrPro: 3.431 ± 0.442
1.841ThrGln: 1.841 ± 0.412
3.933ThrArg: 3.933 ± 0.519
4.435ThrSer: 4.435 ± 0.673
3.264ThrThr: 3.264 ± 0.79
3.933ThrVal: 3.933 ± 0.568
0.921ThrTrp: 0.921 ± 0.324
2.594ThrTyr: 2.594 ± 0.538
0.0ThrXaa: 0.0 ± 0.0
Val
6.276ValAla: 6.276 ± 0.817
0.753ValCys: 0.753 ± 0.265
3.933ValAsp: 3.933 ± 0.503
5.272ValGlu: 5.272 ± 0.66
1.841ValPhe: 1.841 ± 0.557
5.356ValGly: 5.356 ± 0.936
0.753ValHis: 0.753 ± 0.287
3.515ValIle: 3.515 ± 0.622
2.845ValLys: 2.845 ± 0.532
4.1ValLeu: 4.1 ± 0.674
1.255ValMet: 1.255 ± 0.299
2.762ValAsn: 2.762 ± 0.482
1.506ValPro: 1.506 ± 0.347
2.929ValGln: 2.929 ± 0.467
4.268ValArg: 4.268 ± 0.643
4.351ValSer: 4.351 ± 0.635
4.77ValThr: 4.77 ± 0.815
5.188ValVal: 5.188 ± 0.527
1.506ValTrp: 1.506 ± 0.42
1.674ValTyr: 1.674 ± 0.294
0.0ValXaa: 0.0 ± 0.0
Trp
0.921TrpAla: 0.921 ± 0.255
0.167TrpCys: 0.167 ± 0.113
1.674TrpAsp: 1.674 ± 0.536
1.088TrpGlu: 1.088 ± 0.306
1.004TrpPhe: 1.004 ± 0.335
0.753TrpGly: 0.753 ± 0.2
0.586TrpHis: 0.586 ± 0.314
0.418TrpIle: 0.418 ± 0.192
0.669TrpLys: 0.669 ± 0.247
2.092TrpLeu: 2.092 ± 0.416
0.669TrpMet: 0.669 ± 0.237
0.921TrpAsn: 0.921 ± 0.297
0.669TrpPro: 0.669 ± 0.243
0.586TrpGln: 0.586 ± 0.166
0.753TrpArg: 0.753 ± 0.247
1.339TrpSer: 1.339 ± 0.348
0.837TrpThr: 0.837 ± 0.38
1.172TrpVal: 1.172 ± 0.352
0.418TrpTrp: 0.418 ± 0.171
0.837TrpTyr: 0.837 ± 0.274
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.343TyrAla: 2.343 ± 0.429
0.502TyrCys: 0.502 ± 0.224
1.925TyrAsp: 1.925 ± 0.368
3.18TyrGlu: 3.18 ± 0.556
1.004TyrPhe: 1.004 ± 0.283
2.678TyrGly: 2.678 ± 0.57
0.669TyrHis: 0.669 ± 0.205
2.008TyrIle: 2.008 ± 0.359
1.757TyrLys: 1.757 ± 0.541
2.51TyrLeu: 2.51 ± 0.429
0.921TyrMet: 0.921 ± 0.255
1.255TyrAsn: 1.255 ± 0.293
0.669TyrPro: 0.669 ± 0.216
1.506TyrGln: 1.506 ± 0.263
1.59TyrArg: 1.59 ± 0.328
2.594TyrSer: 2.594 ± 0.371
2.176TyrThr: 2.176 ± 0.362
2.343TyrVal: 2.343 ± 0.407
0.753TyrTrp: 0.753 ± 0.293
0.921TyrTyr: 0.921 ± 0.295
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 48 proteins (11951 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski