Amino acid dipepetide frequency for Herpetosiphon aurantiacus (strain ATCC 23779 / DSM 785 / 114-95)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.214AlaAla: 12.214 ± 0.117	0.971AlaCys: 0.971 ± 0.02	5.337AlaAsp: 5.337 ± 0.061	6.44AlaGlu: 6.44 ± 0.077	3.273AlaPhe: 3.273 ± 0.043	7.719AlaGly: 7.719 ± 0.077	2.1AlaHis: 2.1 ± 0.038	6.728AlaIle: 6.728 ± 0.067	3.171AlaLys: 3.171 ± 0.045	12.207AlaLeu: 12.207 ± 0.133	2.612AlaMet: 2.612 ± 0.039	3.973AlaAsn: 3.973 ± 0.056	4.447AlaPro: 4.447 ± 0.069	5.919AlaGln: 5.919 ± 0.078	5.062AlaArg: 5.062 ± 0.062	5.92AlaSer: 5.92 ± 0.064	7.138AlaThr: 7.138 ± 0.093	6.72AlaVal: 6.72 ± 0.066	1.955AlaTrp: 1.955 ± 0.04	2.807AlaTyr: 2.807 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	0.744CysAla: 0.744 ± 0.024	0.133CysCys: 0.133 ± 0.01	0.454CysAsp: 0.454 ± 0.017	0.411CysGlu: 0.411 ± 0.015	0.33CysPhe: 0.33 ± 0.012	0.825CysGly: 0.825 ± 0.023	0.22CysHis: 0.22 ± 0.01	0.386CysIle: 0.386 ± 0.015	0.156CysLys: 0.156 ± 0.009	0.848CysLeu: 0.848 ± 0.021	0.144CysMet: 0.144 ± 0.008	0.26CysAsn: 0.26 ± 0.013	0.441CysPro: 0.441 ± 0.016	0.403CysGln: 0.403 ± 0.015	0.465CysArg: 0.465 ± 0.016	0.545CysSer: 0.545 ± 0.017	0.414CysThr: 0.414 ± 0.016	0.503CysVal: 0.503 ± 0.018	0.156CysTrp: 0.156 ± 0.01	0.311CysTyr: 0.311 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	4.815AspAla: 4.815 ± 0.064	0.4AspCys: 0.4 ± 0.015	2.867AspAsp: 2.867 ± 0.053	2.679AspGlu: 2.679 ± 0.051	1.827AspPhe: 1.827 ± 0.031	4.149AspGly: 4.149 ± 0.074	1.273AspHis: 1.273 ± 0.028	2.489AspIle: 2.489 ± 0.046	1.015AspLys: 1.015 ± 0.028	6.089AspLeu: 6.089 ± 0.065	0.868AspMet: 0.868 ± 0.021	1.446AspAsn: 1.446 ± 0.044	3.119AspPro: 3.119 ± 0.043	3.337AspGln: 3.337 ± 0.05	2.922AspArg: 2.922 ± 0.041	2.617AspSer: 2.617 ± 0.046	2.354AspThr: 2.354 ± 0.043	3.404AspVal: 3.404 ± 0.054	1.018AspTrp: 1.018 ± 0.022	1.669AspTyr: 1.669 ± 0.028	0.0AspXaa: 0.0 ± 0.0
Glu	5.758GluAla: 5.758 ± 0.07	0.352GluCys: 0.352 ± 0.015	1.8GluAsp: 1.8 ± 0.039	2.276GluGlu: 2.276 ± 0.045	1.653GluPhe: 1.653 ± 0.033	2.773GluGly: 2.773 ± 0.048	1.677GluHis: 1.677 ± 0.031	3.027GluIle: 3.027 ± 0.041	1.256GluLys: 1.256 ± 0.026	6.299GluLeu: 6.299 ± 0.068	1.107GluMet: 1.107 ± 0.027	1.372GluAsn: 1.372 ± 0.027	2.627GluPro: 2.627 ± 0.047	4.32GluGln: 4.32 ± 0.068	4.447GluArg: 4.447 ± 0.07	2.347GluSer: 2.347 ± 0.037	2.863GluThr: 2.863 ± 0.044	3.379GluVal: 3.379 ± 0.048	0.82GluTrp: 0.82 ± 0.023	1.52GluTyr: 1.52 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	3.571PheAla: 3.571 ± 0.043	0.365PheCys: 0.365 ± 0.015	2.408PheAsp: 2.408 ± 0.039	2.101PheGlu: 2.101 ± 0.037	1.387PhePhe: 1.387 ± 0.034	3.281PheGly: 3.281 ± 0.047	0.651PheHis: 0.651 ± 0.018	1.811PheIle: 1.811 ± 0.037	0.95PheLys: 0.95 ± 0.023	2.947PheLeu: 2.947 ± 0.049	0.709PheMet: 0.709 ± 0.021	1.489PheAsn: 1.489 ± 0.029	1.352PhePro: 1.352 ± 0.028	1.324PheGln: 1.324 ± 0.027	1.765PheArg: 1.765 ± 0.028	2.281PheSer: 2.281 ± 0.041	1.811PheThr: 1.811 ± 0.033	2.526PheVal: 2.526 ± 0.041	0.639PheTrp: 0.639 ± 0.02	1.067PheTyr: 1.067 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	6.069GlyAla: 6.069 ± 0.07	0.742GlyCys: 0.742 ± 0.022	3.64GlyAsp: 3.64 ± 0.06	3.504GlyGlu: 3.504 ± 0.042	2.922GlyPhe: 2.922 ± 0.048	5.253GlyGly: 5.253 ± 0.086	1.472GlyHis: 1.472 ± 0.026	4.487GlyIle: 4.487 ± 0.054	2.337GlyLys: 2.337 ± 0.041	8.225GlyLeu: 8.225 ± 0.08	1.873GlyMet: 1.873 ± 0.032	2.578GlyAsn: 2.578 ± 0.056	2.165GlyPro: 2.165 ± 0.039	3.641GlyGln: 3.641 ± 0.051	3.995GlyArg: 3.995 ± 0.053	4.642GlySer: 4.642 ± 0.059	4.269GlyThr: 4.269 ± 0.067	5.176GlyVal: 5.176 ± 0.066	1.528GlyTrp: 1.528 ± 0.036	2.549GlyTyr: 2.549 ± 0.036	0.0GlyXaa: 0.0 ± 0.0
His	2.177HisAla: 2.177 ± 0.039	0.266HisCys: 0.266 ± 0.012	1.347HisAsp: 1.347 ± 0.031	1.303HisGlu: 1.303 ± 0.03	0.841HisPhe: 0.841 ± 0.023	1.841HisGly: 1.841 ± 0.034	0.714HisHis: 0.714 ± 0.023	1.177HisIle: 1.177 ± 0.026	0.445HisLys: 0.445 ± 0.018	2.165HisLeu: 2.165 ± 0.04	0.432HisMet: 0.432 ± 0.017	0.808HisAsn: 0.808 ± 0.021	1.397HisPro: 1.397 ± 0.027	1.148HisGln: 1.148 ± 0.028	1.203HisArg: 1.203 ± 0.027	1.302HisSer: 1.302 ± 0.029	1.184HisThr: 1.184 ± 0.025	1.42HisVal: 1.42 ± 0.03	0.438HisTrp: 0.438 ± 0.017	0.861HisTyr: 0.861 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	6.795IleAla: 6.795 ± 0.074	0.533IleCys: 0.533 ± 0.017	3.809IleAsp: 3.809 ± 0.055	3.801IleGlu: 3.801 ± 0.042	1.905IlePhe: 1.905 ± 0.035	4.891IleGly: 4.891 ± 0.067	1.19IleHis: 1.19 ± 0.024	3.425IleIle: 3.425 ± 0.054	1.891IleLys: 1.891 ± 0.033	4.965IleLeu: 4.965 ± 0.062	1.019IleMet: 1.019 ± 0.027	2.737IleAsn: 2.737 ± 0.047	2.895IlePro: 2.895 ± 0.045	2.665IleGln: 2.665 ± 0.034	3.063IleArg: 3.063 ± 0.047	3.668IleSer: 3.668 ± 0.051	3.611IleThr: 3.611 ± 0.046	4.424IleVal: 4.424 ± 0.047	0.888IleTrp: 0.888 ± 0.022	1.757IleTyr: 1.757 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	2.908LysAla: 2.908 ± 0.05	0.129LysCys: 0.129 ± 0.008	1.036LysAsp: 1.036 ± 0.026	1.063LysGlu: 1.063 ± 0.026	0.761LysPhe: 0.761 ± 0.024	1.598LysGly: 1.598 ± 0.029	0.684LysHis: 0.684 ± 0.018	1.648LysIle: 1.648 ± 0.036	0.867LysLys: 0.867 ± 0.026	3.029LysLeu: 3.029 ± 0.045	0.612LysMet: 0.612 ± 0.018	0.857LysAsn: 0.857 ± 0.026	1.825LysPro: 1.825 ± 0.034	1.604LysGln: 1.604 ± 0.025	1.845LysArg: 1.845 ± 0.028	1.333LysSer: 1.333 ± 0.03	1.697LysThr: 1.697 ± 0.038	1.854LysVal: 1.854 ± 0.035	0.27LysTrp: 0.27 ± 0.011	0.667LysTyr: 0.667 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	13.676LeuAla: 13.676 ± 0.139	0.817LeuCys: 0.817 ± 0.021	5.879LeuAsp: 5.879 ± 0.065	5.765LeuGlu: 5.765 ± 0.075	3.502LeuPhe: 3.502 ± 0.049	8.285LeuGly: 8.285 ± 0.081	2.419LeuHis: 2.419 ± 0.04	6.723LeuIle: 6.723 ± 0.069	2.915LeuLys: 2.915 ± 0.048	12.123LeuLeu: 12.123 ± 0.123	2.09LeuMet: 2.09 ± 0.04	4.036LeuAsn: 4.036 ± 0.053	6.172LeuPro: 6.172 ± 0.068	5.119LeuGln: 5.119 ± 0.061	6.936LeuArg: 6.936 ± 0.077	6.618LeuSer: 6.618 ± 0.06	6.18LeuThr: 6.18 ± 0.059	7.642LeuVal: 7.642 ± 0.065	1.663LeuTrp: 1.663 ± 0.032	2.756LeuTyr: 2.756 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	2.219MetAla: 2.219 ± 0.037	0.122MetCys: 0.122 ± 0.008	0.772MetAsp: 0.772 ± 0.02	0.773MetGlu: 0.773 ± 0.023	0.662MetPhe: 0.662 ± 0.023	1.294MetGly: 1.294 ± 0.029	0.473MetHis: 0.473 ± 0.014	1.273MetIle: 1.273 ± 0.028	0.499MetLys: 0.499 ± 0.017	2.949MetLeu: 2.949 ± 0.045	0.45MetMet: 0.45 ± 0.015	0.718MetAsn: 0.718 ± 0.02	1.292MetPro: 1.292 ± 0.027	1.246MetGln: 1.246 ± 0.025	1.353MetArg: 1.353 ± 0.027	1.291MetSer: 1.291 ± 0.027	1.323MetThr: 1.323 ± 0.028	1.514MetVal: 1.514 ± 0.029	0.249MetTrp: 0.249 ± 0.012	0.465MetTyr: 0.465 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.53AsnAla: 3.53 ± 0.052	0.295AsnCys: 0.295 ± 0.014	2.213AsnAsp: 2.213 ± 0.055	1.752AsnGlu: 1.752 ± 0.034	1.197AsnPhe: 1.197 ± 0.034	2.965AsnGly: 2.965 ± 0.065	0.823AsnHis: 0.823 ± 0.02	1.904AsnIle: 1.904 ± 0.037	0.835AsnLys: 0.835 ± 0.024	3.815AsnLeu: 3.815 ± 0.051	0.585AsnMet: 0.585 ± 0.015	1.677AsnAsn: 1.677 ± 0.048	2.645AsnPro: 2.645 ± 0.044	2.459AsnGln: 2.459 ± 0.043	2.011AsnArg: 2.011 ± 0.034	2.07AsnSer: 2.07 ± 0.041	2.193AsnThr: 2.193 ± 0.058	2.293AsnVal: 2.293 ± 0.039	0.574AsnTrp: 0.574 ± 0.017	1.202AsnTyr: 1.202 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	5.615ProAla: 5.615 ± 0.076	0.301ProCys: 0.301 ± 0.015	2.886ProAsp: 2.886 ± 0.04	3.082ProGlu: 3.082 ± 0.049	1.783ProPhe: 1.783 ± 0.03	2.34ProGly: 2.34 ± 0.049	1.071ProHis: 1.071 ± 0.021	3.386ProIle: 3.386 ± 0.045	1.435ProLys: 1.435 ± 0.029	5.263ProLeu: 5.263 ± 0.059	1.078ProMet: 1.078 ± 0.023	2.391ProAsn: 2.391 ± 0.042	2.295ProPro: 2.295 ± 0.052	2.619ProGln: 2.619 ± 0.046	2.402ProArg: 2.402 ± 0.042	3.683ProSer: 3.683 ± 0.058	4.646ProThr: 4.646 ± 0.094	3.232ProVal: 3.232 ± 0.049	0.839ProTrp: 0.839 ± 0.023	1.306ProTyr: 1.306 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	7.548GlnAla: 7.548 ± 0.092	0.305GlnCys: 0.305 ± 0.013	1.326GlnAsp: 1.326 ± 0.027	1.792GlnGlu: 1.792 ± 0.031	1.705GlnPhe: 1.705 ± 0.033	3.021GlnGly: 3.021 ± 0.037	1.584GlnHis: 1.584 ± 0.035	3.32GlnIle: 3.32 ± 0.048	1.107GlnLys: 1.107 ± 0.024	6.723GlnLeu: 6.723 ± 0.087	1.005GlnMet: 1.005 ± 0.022	1.332GlnAsn: 1.332 ± 0.029	3.689GlnPro: 3.689 ± 0.056	4.402GlnGln: 4.402 ± 0.078	4.511GlnArg: 4.511 ± 0.053	2.848GlnSer: 2.848 ± 0.043	3.729GlnThr: 3.729 ± 0.049	3.28GlnVal: 3.28 ± 0.043	0.929GlnTrp: 0.929 ± 0.02	1.259GlnTyr: 1.259 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	4.957ArgAla: 4.957 ± 0.056	0.512ArgCys: 0.512 ± 0.016	3.054ArgAsp: 3.054 ± 0.04	3.657ArgGlu: 3.657 ± 0.058	2.366ArgPhe: 2.366 ± 0.037	3.635ArgGly: 3.635 ± 0.054	1.315ArgHis: 1.315 ± 0.027	3.328ArgIle: 3.328 ± 0.044	1.554ArgLys: 1.554 ± 0.034	6.787ArgLeu: 6.787 ± 0.074	1.436ArgMet: 1.436 ± 0.028	1.978ArgAsn: 1.978 ± 0.035	2.657ArgPro: 2.657 ± 0.041	3.416ArgGln: 3.416 ± 0.045	3.865ArgArg: 3.865 ± 0.053	3.623ArgSer: 3.623 ± 0.048	3.11ArgThr: 3.11 ± 0.045	3.685ArgVal: 3.685 ± 0.045	1.451ArgTrp: 1.451 ± 0.034	2.215ArgTyr: 2.215 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	5.598SerAla: 5.598 ± 0.073	0.414SerCys: 0.414 ± 0.015	3.086SerAsp: 3.086 ± 0.053	2.821SerGlu: 2.821 ± 0.039	2.382SerPhe: 2.382 ± 0.037	4.168SerGly: 4.168 ± 0.063	1.201SerHis: 1.201 ± 0.022	3.744SerIle: 3.744 ± 0.062	1.537SerLys: 1.537 ± 0.035	7.035SerLeu: 7.035 ± 0.072	1.321SerMet: 1.321 ± 0.027	2.563SerAsn: 2.563 ± 0.05	2.7SerPro: 2.7 ± 0.038	3.107SerGln: 3.107 ± 0.047	2.881SerArg: 2.881 ± 0.044	3.864SerSer: 3.864 ± 0.059	3.676SerThr: 3.676 ± 0.057	3.877SerVal: 3.877 ± 0.046	0.922SerTrp: 0.922 ± 0.024	1.939SerTyr: 1.939 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	6.347ThrAla: 6.347 ± 0.09	0.426ThrCys: 0.426 ± 0.016	2.597ThrAsp: 2.597 ± 0.05	2.591ThrGlu: 2.591 ± 0.041	2.011ThrPhe: 2.011 ± 0.036	4.324ThrGly: 4.324 ± 0.06	1.134ThrHis: 1.134 ± 0.027	4.745ThrIle: 4.745 ± 0.06	1.643ThrLys: 1.643 ± 0.038	6.498ThrLeu: 6.498 ± 0.053	1.344ThrMet: 1.344 ± 0.028	2.703ThrAsn: 2.703 ± 0.065	4.327ThrPro: 4.327 ± 0.082	2.433ThrGln: 2.433 ± 0.037	2.646ThrArg: 2.646 ± 0.038	3.715ThrSer: 3.715 ± 0.055	4.487ThrThr: 4.487 ± 0.097	4.283ThrVal: 4.283 ± 0.067	1.026ThrTrp: 1.026 ± 0.027	1.599ThrTyr: 1.599 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	7.795ValAla: 7.795 ± 0.081	0.603ValCys: 0.603 ± 0.02	3.514ValAsp: 3.514 ± 0.053	3.715ValGlu: 3.715 ± 0.048	2.193ValPhe: 2.193 ± 0.037	5.384ValGly: 5.384 ± 0.056	1.242ValHis: 1.242 ± 0.03	4.062ValIle: 4.062 ± 0.05	1.69ValLys: 1.69 ± 0.033	7.686ValLeu: 7.686 ± 0.074	1.429ValMet: 1.429 ± 0.032	2.31ValAsn: 2.31 ± 0.041	3.348ValPro: 3.348 ± 0.049	2.995ValGln: 2.995 ± 0.046	3.812ValArg: 3.812 ± 0.048	3.644ValSer: 3.644 ± 0.051	3.679ValThr: 3.679 ± 0.057	5.79ValVal: 5.79 ± 0.075	1.061ValTrp: 1.061 ± 0.024	1.795ValTyr: 1.795 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.38TrpAla: 1.38 ± 0.028	0.164TrpCys: 0.164 ± 0.009	0.677TrpAsp: 0.677 ± 0.021	0.721TrpGlu: 0.721 ± 0.021	0.701TrpPhe: 0.701 ± 0.021	1.045TrpGly: 1.045 ± 0.025	0.477TrpHis: 0.477 ± 0.017	0.864TrpIle: 0.864 ± 0.02	0.357TrpLys: 0.357 ± 0.013	2.58TrpLeu: 2.58 ± 0.045	0.406TrpMet: 0.406 ± 0.015	0.701TrpAsn: 0.701 ± 0.024	0.7TrpPro: 0.7 ± 0.022	1.525TrpGln: 1.525 ± 0.033	1.247TrpArg: 1.247 ± 0.027	1.075TrpSer: 1.075 ± 0.03	0.857TrpThr: 0.857 ± 0.024	0.991TrpVal: 0.991 ± 0.024	0.403TrpTrp: 0.403 ± 0.016	0.504TrpTyr: 0.504 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.998TyrAla: 2.998 ± 0.042	0.302TyrCys: 0.302 ± 0.013	1.655TyrAsp: 1.655 ± 0.045	1.426TyrGlu: 1.426 ± 0.031	1.034TyrPhe: 1.034 ± 0.026	2.277TyrGly: 2.277 ± 0.034	0.75TyrHis: 0.75 ± 0.02	1.403TyrIle: 1.403 ± 0.029	0.626TyrLys: 0.626 ± 0.02	3.084TyrLeu: 3.084 ± 0.043	0.415TyrMet: 0.415 ± 0.016	1.107TyrAsn: 1.107 ± 0.028	1.564TyrPro: 1.564 ± 0.031	1.734TyrGln: 1.734 ± 0.039	2.171TyrArg: 2.171 ± 0.033	1.748TyrSer: 1.748 ± 0.034	1.657TyrThr: 1.657 ± 0.038	1.753TyrVal: 1.753 ± 0.031	0.544TyrTrp: 0.544 ± 0.016	0.877TyrTyr: 0.877 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5254 proteins (1962024 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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