Amino acid dipepetide frequency for Candidatus Atribacteria bacterium MT.SAG.1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.211AlaAla: 4.211 ± 0.124
0.669AlaCys: 0.669 ± 0.048
2.689AlaAsp: 2.689 ± 0.089
4.073AlaGlu: 4.073 ± 0.108
2.372AlaPhe: 2.372 ± 0.079
4.604AlaGly: 4.604 ± 0.147
0.924AlaHis: 0.924 ± 0.051
5.847AlaIle: 5.847 ± 0.146
4.987AlaLys: 4.987 ± 0.125
6.351AlaLeu: 6.351 ± 0.128
1.433AlaMet: 1.433 ± 0.063
2.239AlaAsn: 2.239 ± 0.08
1.581AlaPro: 1.581 ± 0.057
2.096AlaGln: 2.096 ± 0.077
2.827AlaArg: 2.827 ± 0.095
3.225AlaSer: 3.225 ± 0.089
2.594AlaThr: 2.594 ± 0.088
4.213AlaVal: 4.213 ± 0.119
0.442AlaTrp: 0.442 ± 0.035
1.923AlaTyr: 1.923 ± 0.067
0.0AlaXaa: 0.0 ± 0.0
Cys
0.592CysAla: 0.592 ± 0.034
0.143CysCys: 0.143 ± 0.026
0.478CysAsp: 0.478 ± 0.035
0.618CysGlu: 0.618 ± 0.04
0.498CysPhe: 0.498 ± 0.037
1.032CysGly: 1.032 ± 0.059
0.248CysHis: 0.248 ± 0.024
0.878CysIle: 0.878 ± 0.049
0.753CysLys: 0.753 ± 0.05
1.067CysLeu: 1.067 ± 0.044
0.204CysMet: 0.204 ± 0.024
0.506CysAsn: 0.506 ± 0.036
0.646CysPro: 0.646 ± 0.041
0.383CysGln: 0.383 ± 0.036
0.526CysArg: 0.526 ± 0.039
0.638CysSer: 0.638 ± 0.039
0.46CysThr: 0.46 ± 0.036
0.615CysVal: 0.615 ± 0.044
0.082CysTrp: 0.082 ± 0.013
0.429CysTyr: 0.429 ± 0.038
0.0CysXaa: 0.0 ± 0.0
Asp
2.38AspAla: 2.38 ± 0.094
0.465AspCys: 0.465 ± 0.034
2.01AspAsp: 2.01 ± 0.083
3.447AspGlu: 3.447 ± 0.106
2.607AspPhe: 2.607 ± 0.085
2.684AspGly: 2.684 ± 0.086
0.628AspHis: 0.628 ± 0.038
5.6AspIle: 5.6 ± 0.128
4.632AspLys: 4.632 ± 0.125
5.27AspLeu: 5.27 ± 0.136
1.098AspMet: 1.098 ± 0.053
2.168AspAsn: 2.168 ± 0.075
1.828AspPro: 1.828 ± 0.072
1.08AspGln: 1.08 ± 0.056
2.099AspArg: 2.099 ± 0.076
2.566AspSer: 2.566 ± 0.076
2.145AspThr: 2.145 ± 0.088
2.934AspVal: 2.934 ± 0.095
0.483AspTrp: 0.483 ± 0.036
2.158AspTyr: 2.158 ± 0.078
0.0AspXaa: 0.0 ± 0.0
Glu
4.474GluAla: 4.474 ± 0.107
0.595GluCys: 0.595 ± 0.04
3.82GluAsp: 3.82 ± 0.121
7.576GluGlu: 7.576 ± 0.194
2.755GluPhe: 2.755 ± 0.091
4.591GluGly: 4.591 ± 0.12
0.968GluHis: 0.968 ± 0.05
8.753GluIle: 8.753 ± 0.183
9.021GluLys: 9.021 ± 0.169
6.716GluLeu: 6.716 ± 0.143
1.818GluMet: 1.818 ± 0.073
3.989GluAsn: 3.989 ± 0.111
1.787GluPro: 1.787 ± 0.076
1.854GluGln: 1.854 ± 0.071
3.243GluArg: 3.243 ± 0.086
3.039GluSer: 3.039 ± 0.085
2.898GluThr: 2.898 ± 0.092
5.237GluVal: 5.237 ± 0.137
0.536GluTrp: 0.536 ± 0.037
2.474GluTyr: 2.474 ± 0.081
0.0GluXaa: 0.0 ± 0.0
Phe
2.467PheAla: 2.467 ± 0.082
0.575PheCys: 0.575 ± 0.038
2.216PheAsp: 2.216 ± 0.092
2.525PheGlu: 2.525 ± 0.08
2.099PhePhe: 2.099 ± 0.103
3.049PheGly: 3.049 ± 0.1
0.666PheHis: 0.666 ± 0.04
4.132PheIle: 4.132 ± 0.135
3.843PheLys: 3.843 ± 0.112
4.591PheLeu: 4.591 ± 0.166
0.917PheMet: 0.917 ± 0.047
2.403PheAsn: 2.403 ± 0.077
1.724PhePro: 1.724 ± 0.075
1.231PheGln: 1.231 ± 0.06
1.639PheArg: 1.639 ± 0.057
3.276PheSer: 3.276 ± 0.115
2.086PheThr: 2.086 ± 0.079
2.482PheVal: 2.482 ± 0.073
0.447PheTrp: 0.447 ± 0.036
1.65PheTyr: 1.65 ± 0.075
0.0PheXaa: 0.0 ± 0.0
Gly
4.267GlyAla: 4.267 ± 0.113
0.932GlyCys: 0.932 ± 0.061
2.903GlyAsp: 2.903 ± 0.097
4.951GlyGlu: 4.951 ± 0.124
3.105GlyPhe: 3.105 ± 0.105
4.852GlyGly: 4.852 ± 0.12
1.129GlyHis: 1.129 ± 0.06
7.477GlyIle: 7.477 ± 0.162
6.139GlyLys: 6.139 ± 0.134
6.363GlyLeu: 6.363 ± 0.146
1.861GlyMet: 1.861 ± 0.067
2.73GlyAsn: 2.73 ± 0.096
1.851GlyPro: 1.851 ± 0.072
1.678GlyGln: 1.678 ± 0.07
3.021GlyArg: 3.021 ± 0.094
3.45GlySer: 3.45 ± 0.087
3.35GlyThr: 3.35 ± 0.114
4.566GlyVal: 4.566 ± 0.113
0.636GlyTrp: 0.636 ± 0.037
2.635GlyTyr: 2.635 ± 0.074
0.0GlyXaa: 0.0 ± 0.0
His
0.827HisAla: 0.827 ± 0.049
0.245HisCys: 0.245 ± 0.027
0.564HisAsp: 0.564 ± 0.038
0.751HisGlu: 0.751 ± 0.039
0.715HisPhe: 0.715 ± 0.046
0.838HisGly: 0.838 ± 0.053
0.335HisHis: 0.335 ± 0.029
1.425HisIle: 1.425 ± 0.056
1.108HisLys: 1.108 ± 0.049
1.596HisLeu: 1.596 ± 0.066
0.286HisMet: 0.286 ± 0.029
0.815HisAsn: 0.815 ± 0.046
1.024HisPro: 1.024 ± 0.055
0.562HisGln: 0.562 ± 0.039
0.666HisArg: 0.666 ± 0.045
0.952HisSer: 0.952 ± 0.057
0.758HisThr: 0.758 ± 0.044
0.575HisVal: 0.575 ± 0.043
0.143HisTrp: 0.143 ± 0.019
0.603HisTyr: 0.603 ± 0.038
0.0HisXaa: 0.0 ± 0.0
Ile
6.465IleAla: 6.465 ± 0.132
1.19IleCys: 1.19 ± 0.056
5.268IleAsp: 5.268 ± 0.115
7.127IleGlu: 7.127 ± 0.166
4.755IlePhe: 4.755 ± 0.139
6.728IleGly: 6.728 ± 0.137
1.21IleHis: 1.21 ± 0.065
10.39IleIle: 10.39 ± 0.221
9.524IleLys: 9.524 ± 0.174
9.999IleLeu: 9.999 ± 0.181
1.938IleMet: 1.938 ± 0.076
5.199IleAsn: 5.199 ± 0.111
4.101IlePro: 4.101 ± 0.099
2.288IleGln: 2.288 ± 0.081
3.838IleArg: 3.838 ± 0.115
6.81IleSer: 6.81 ± 0.149
4.997IleThr: 4.997 ± 0.12
6.042IleVal: 6.042 ± 0.126
0.669IleTrp: 0.669 ± 0.049
3.279IleTyr: 3.279 ± 0.097
0.0IleXaa: 0.0 ± 0.0
Lys
4.757LysAla: 4.757 ± 0.138
0.776LysCys: 0.776 ± 0.05
5.26LysAsp: 5.26 ± 0.13
9.772LysGlu: 9.772 ± 0.178
2.911LysPhe: 2.911 ± 0.098
5.653LysGly: 5.653 ± 0.138
1.001LysHis: 1.001 ± 0.048
10.888LysIle: 10.888 ± 0.178
10.385LysLys: 10.385 ± 0.203
7.9LysLeu: 7.9 ± 0.166
2.464LysMet: 2.464 ± 0.072
5.311LysAsn: 5.311 ± 0.124
2.354LysPro: 2.354 ± 0.082
2.147LysGln: 2.147 ± 0.074
3.955LysArg: 3.955 ± 0.109
4.4LysSer: 4.4 ± 0.109
4.009LysThr: 4.009 ± 0.102
6.238LysVal: 6.238 ± 0.127
0.656LysTrp: 0.656 ± 0.044
3.708LysTyr: 3.708 ± 0.105
0.0LysXaa: 0.0 ± 0.0
Leu
6.391LeuAla: 6.391 ± 0.145
0.899LeuCys: 0.899 ± 0.052
4.767LeuAsp: 4.767 ± 0.11
7.323LeuGlu: 7.323 ± 0.146
4.211LeuPhe: 4.211 ± 0.134
7.137LeuGly: 7.137 ± 0.15
1.455LeuHis: 1.455 ± 0.07
9.101LeuIle: 9.101 ± 0.196
9.851LeuLys: 9.851 ± 0.189
8.746LeuLeu: 8.746 ± 0.21
1.956LeuMet: 1.956 ± 0.076
5.048LeuAsn: 5.048 ± 0.11
3.726LeuPro: 3.726 ± 0.097
2.365LeuGln: 2.365 ± 0.083
4.088LeuArg: 4.088 ± 0.102
6.894LeuSer: 6.894 ± 0.158
4.678LeuThr: 4.678 ± 0.119
5.676LeuVal: 5.676 ± 0.141
0.728LeuTrp: 0.728 ± 0.049
2.842LeuTyr: 2.842 ± 0.092
0.0LeuXaa: 0.0 ± 0.0
Met
1.652MetAla: 1.652 ± 0.076
0.174MetCys: 0.174 ± 0.018
1.088MetAsp: 1.088 ± 0.051
1.673MetGlu: 1.673 ± 0.067
0.843MetPhe: 0.843 ± 0.046
1.667MetGly: 1.667 ± 0.066
0.253MetHis: 0.253 ± 0.029
2.081MetIle: 2.081 ± 0.078
2.296MetLys: 2.296 ± 0.076
1.953MetLeu: 1.953 ± 0.078
0.559MetMet: 0.559 ± 0.043
1.039MetAsn: 1.039 ± 0.05
0.786MetPro: 0.786 ± 0.043
0.679MetGln: 0.679 ± 0.039
0.899MetArg: 0.899 ± 0.051
1.302MetSer: 1.302 ± 0.063
0.937MetThr: 0.937 ± 0.054
1.652MetVal: 1.652 ± 0.066
0.12MetTrp: 0.12 ± 0.02
0.462MetTyr: 0.462 ± 0.034
0.0MetXaa: 0.0 ± 0.0
Asn
2.163AsnAla: 2.163 ± 0.075
0.536AsnCys: 0.536 ± 0.034
1.918AsnAsp: 1.918 ± 0.069
2.607AsnGlu: 2.607 ± 0.089
2.582AsnPhe: 2.582 ± 0.082
2.255AsnGly: 2.255 ± 0.071
0.776AsnHis: 0.776 ± 0.038
5.916AsnIle: 5.916 ± 0.138
4.668AsnLys: 4.668 ± 0.133
5.681AsnLeu: 5.681 ± 0.15
1.072AsnMet: 1.072 ± 0.049
2.76AsnAsn: 2.76 ± 0.088
2.301AsnPro: 2.301 ± 0.078
1.598AsnGln: 1.598 ± 0.064
2.048AsnArg: 2.048 ± 0.073
2.74AsnSer: 2.74 ± 0.09
1.966AsnThr: 1.966 ± 0.082
2.441AsnVal: 2.441 ± 0.083
0.424AsnTrp: 0.424 ± 0.036
2.168AsnTyr: 2.168 ± 0.082
0.0AsnXaa: 0.0 ± 0.0
Pro
1.851ProAla: 1.851 ± 0.068
0.37ProCys: 0.37 ± 0.032
1.959ProAsp: 1.959 ± 0.09
3.228ProGlu: 3.228 ± 0.104
1.731ProPhe: 1.731 ± 0.07
2.584ProGly: 2.584 ± 0.094
0.687ProHis: 0.687 ± 0.043
2.87ProIle: 2.87 ± 0.085
2.589ProLys: 2.589 ± 0.076
3.651ProLeu: 3.651 ± 0.099
0.646ProMet: 0.646 ± 0.043
1.356ProAsn: 1.356 ± 0.073
1.221ProPro: 1.221 ± 0.061
1.09ProGln: 1.09 ± 0.047
1.315ProArg: 1.315 ± 0.053
2.176ProSer: 2.176 ± 0.067
1.754ProThr: 1.754 ± 0.068
2.4ProVal: 2.4 ± 0.081
0.289ProTrp: 0.289 ± 0.026
1.399ProTyr: 1.399 ± 0.056
0.0ProXaa: 0.0 ± 0.0
Gln
1.905GlnAla: 1.905 ± 0.07
0.258GlnCys: 0.258 ± 0.022
1.287GlnAsp: 1.287 ± 0.055
2.467GlnGlu: 2.467 ± 0.092
0.955GlnPhe: 0.955 ± 0.046
1.839GlnGly: 1.839 ± 0.073
0.393GlnHis: 0.393 ± 0.032
2.628GlnIle: 2.628 ± 0.087
2.862GlnLys: 2.862 ± 0.096
2.329GlnLeu: 2.329 ± 0.067
0.623GlnMet: 0.623 ± 0.038
1.392GlnAsn: 1.392 ± 0.057
0.718GlnPro: 0.718 ± 0.043
0.794GlnGln: 0.794 ± 0.052
1.392GlnArg: 1.392 ± 0.067
1.307GlnSer: 1.307 ± 0.064
1.21GlnThr: 1.21 ± 0.05
1.839GlnVal: 1.839 ± 0.069
0.194GlnTrp: 0.194 ± 0.022
0.825GlnTyr: 0.825 ± 0.049
0.0GlnXaa: 0.0 ± 0.0
Arg
2.49ArgAla: 2.49 ± 0.077
0.5ArgCys: 0.5 ± 0.041
1.994ArgAsp: 1.994 ± 0.073
3.935ArgGlu: 3.935 ± 0.109
1.762ArgPhe: 1.762 ± 0.063
2.865ArgGly: 2.865 ± 0.078
0.6ArgHis: 0.6 ± 0.041
4.17ArgIle: 4.17 ± 0.103
3.994ArgLys: 3.994 ± 0.12
3.835ArgLeu: 3.835 ± 0.093
1.083ArgMet: 1.083 ± 0.052
1.941ArgAsn: 1.941 ± 0.07
1.381ArgPro: 1.381 ± 0.062
1.264ArgGln: 1.264 ± 0.062
1.979ArgArg: 1.979 ± 0.076
2.002ArgSer: 2.002 ± 0.083
1.861ArgThr: 1.861 ± 0.074
2.75ArgVal: 2.75 ± 0.077
0.35ArgTrp: 0.35 ± 0.031
1.53ArgTyr: 1.53 ± 0.059
0.0ArgXaa: 0.0 ± 0.0
Ser
3.21SerAla: 3.21 ± 0.098
0.687SerCys: 0.687 ± 0.042
2.454SerAsp: 2.454 ± 0.093
3.649SerGlu: 3.649 ± 0.107
2.988SerPhe: 2.988 ± 0.082
4.446SerGly: 4.446 ± 0.117
0.998SerHis: 0.998 ± 0.056
5.329SerIle: 5.329 ± 0.136
4.933SerLys: 4.933 ± 0.115
6.629SerLeu: 6.629 ± 0.16
1.244SerMet: 1.244 ± 0.058
2.416SerAsn: 2.416 ± 0.089
2.084SerPro: 2.084 ± 0.068
1.798SerGln: 1.798 ± 0.071
2.551SerArg: 2.551 ± 0.081
3.736SerSer: 3.736 ± 0.104
2.676SerThr: 2.676 ± 0.084
3.381SerVal: 3.381 ± 0.099
0.526SerTrp: 0.526 ± 0.039
2.104SerTyr: 2.104 ± 0.07
0.0SerXaa: 0.0 ± 0.0
Thr
2.885ThrAla: 2.885 ± 0.091
0.534ThrCys: 0.534 ± 0.038
2.158ThrAsp: 2.158 ± 0.083
2.97ThrGlu: 2.97 ± 0.1
1.997ThrPhe: 1.997 ± 0.075
3.657ThrGly: 3.657 ± 0.108
0.763ThrHis: 0.763 ± 0.042
4.435ThrIle: 4.435 ± 0.11
3.608ThrLys: 3.608 ± 0.092
4.637ThrLeu: 4.637 ± 0.123
0.766ThrMet: 0.766 ± 0.037
1.982ThrAsn: 1.982 ± 0.076
2.091ThrPro: 2.091 ± 0.082
1.215ThrGln: 1.215 ± 0.05
1.844ThrArg: 1.844 ± 0.068
2.589ThrSer: 2.589 ± 0.078
2.439ThrThr: 2.439 ± 0.082
2.962ThrVal: 2.962 ± 0.092
0.375ThrTrp: 0.375 ± 0.036
1.504ThrTyr: 1.504 ± 0.057
0.0ThrXaa: 0.0 ± 0.0
Val
4.045ValAla: 4.045 ± 0.114
0.672ValCys: 0.672 ± 0.041
3.348ValAsp: 3.348 ± 0.099
4.691ValGlu: 4.691 ± 0.121
2.763ValPhe: 2.763 ± 0.083
4.372ValGly: 4.372 ± 0.118
0.896ValHis: 0.896 ± 0.047
6.136ValIle: 6.136 ± 0.14
5.679ValLys: 5.679 ± 0.129
5.809ValLeu: 5.809 ± 0.142
1.42ValMet: 1.42 ± 0.06
2.972ValAsn: 2.972 ± 0.092
2.201ValPro: 2.201 ± 0.077
1.381ValGln: 1.381 ± 0.055
2.472ValArg: 2.472 ± 0.076
4.052ValSer: 4.052 ± 0.11
2.801ValThr: 2.801 ± 0.087
4.441ValVal: 4.441 ± 0.125
0.48ValTrp: 0.48 ± 0.033
1.887ValTyr: 1.887 ± 0.069
0.0ValXaa: 0.0 ± 0.0
Trp
0.516TrpAla: 0.516 ± 0.037
0.074TrpCys: 0.074 ± 0.015
0.401TrpAsp: 0.401 ± 0.033
0.638TrpGlu: 0.638 ± 0.046
0.38TrpPhe: 0.38 ± 0.036
0.659TrpGly: 0.659 ± 0.052
0.14TrpHis: 0.14 ± 0.022
0.666TrpIle: 0.666 ± 0.04
0.677TrpLys: 0.677 ± 0.049
0.873TrpLeu: 0.873 ± 0.051
0.146TrpMet: 0.146 ± 0.02
0.368TrpAsn: 0.368 ± 0.031
0.245TrpPro: 0.245 ± 0.028
0.36TrpGln: 0.36 ± 0.028
0.347TrpArg: 0.347 ± 0.031
0.403TrpSer: 0.403 ± 0.031
0.317TrpThr: 0.317 ± 0.029
0.475TrpVal: 0.475 ± 0.035
0.097TrpTrp: 0.097 ± 0.017
0.253TrpTyr: 0.253 ± 0.03
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.752TyrAla: 1.752 ± 0.067
0.503TyrCys: 0.503 ± 0.035
1.701TyrAsp: 1.701 ± 0.069
2.124TyrGlu: 2.124 ± 0.076
1.989TyrPhe: 1.989 ± 0.074
2.385TyrGly: 2.385 ± 0.089
0.715TyrHis: 0.715 ± 0.04
3.095TyrIle: 3.095 ± 0.096
3.0TyrLys: 3.0 ± 0.094
3.884TyrLeu: 3.884 ± 0.113
0.58TyrMet: 0.58 ± 0.04
1.989TyrAsn: 1.989 ± 0.076
1.517TyrPro: 1.517 ± 0.067
1.351TyrGln: 1.351 ± 0.066
1.537TyrArg: 1.537 ± 0.064
2.278TyrSer: 2.278 ± 0.078
1.473TyrThr: 1.473 ± 0.063
1.598TyrVal: 1.598 ± 0.059
0.36TyrTrp: 0.36 ± 0.031
1.496TyrTyr: 1.496 ± 0.071
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1304 proteins (391623 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski