Amino acid dipepetide frequency for Streptomyces sp. Tue6028

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.843AlaAla: 20.843 ± 0.157
1.083AlaCys: 1.083 ± 0.021
8.33AlaAsp: 8.33 ± 0.07
8.548AlaGlu: 8.548 ± 0.099
3.561AlaPhe: 3.561 ± 0.041
12.941AlaGly: 12.941 ± 0.097
2.919AlaHis: 2.919 ± 0.044
3.342AlaIle: 3.342 ± 0.053
2.994AlaLys: 2.994 ± 0.043
14.521AlaLeu: 14.521 ± 0.125
2.41AlaMet: 2.41 ± 0.031
1.863AlaAsn: 1.863 ± 0.034
7.13AlaPro: 7.13 ± 0.098
3.755AlaGln: 3.755 ± 0.053
10.149AlaArg: 10.149 ± 0.081
6.074AlaSer: 6.074 ± 0.056
6.931AlaThr: 6.931 ± 0.06
12.463AlaVal: 12.463 ± 0.101
1.902AlaTrp: 1.902 ± 0.029
2.884AlaTyr: 2.884 ± 0.04
0.0AlaXaa: 0.0 ± 0.0
Cys
1.074CysAla: 1.074 ± 0.024
0.086CysCys: 0.086 ± 0.007
0.447CysAsp: 0.447 ± 0.015
0.388CysGlu: 0.388 ± 0.015
0.217CysPhe: 0.217 ± 0.01
0.952CysGly: 0.952 ± 0.02
0.186CysHis: 0.186 ± 0.011
0.163CysIle: 0.163 ± 0.009
0.108CysLys: 0.108 ± 0.007
0.72CysLeu: 0.72 ± 0.019
0.116CysMet: 0.116 ± 0.008
0.133CysAsn: 0.133 ± 0.008
0.447CysPro: 0.447 ± 0.014
0.15CysGln: 0.15 ± 0.009
0.549CysArg: 0.549 ± 0.015
0.434CysSer: 0.434 ± 0.016
0.535CysThr: 0.535 ± 0.018
0.672CysVal: 0.672 ± 0.017
0.124CysTrp: 0.124 ± 0.008
0.155CysTyr: 0.155 ± 0.009
0.0CysXaa: 0.0 ± 0.0
Asp
7.819AspAla: 7.819 ± 0.062
0.431AspCys: 0.431 ± 0.015
3.655AspAsp: 3.655 ± 0.043
3.949AspGlu: 3.949 ± 0.049
1.709AspPhe: 1.709 ± 0.031
6.687AspGly: 6.687 ± 0.068
1.4AspHis: 1.4 ± 0.023
1.897AspIle: 1.897 ± 0.031
1.35AspLys: 1.35 ± 0.031
6.101AspLeu: 6.101 ± 0.049
0.866AspMet: 0.866 ± 0.019
1.003AspAsn: 1.003 ± 0.024
4.464AspPro: 4.464 ± 0.057
1.485AspGln: 1.485 ± 0.031
4.823AspArg: 4.823 ± 0.051
2.669AspSer: 2.669 ± 0.039
3.281AspThr: 3.281 ± 0.042
4.864AspVal: 4.864 ± 0.05
1.044AspTrp: 1.044 ± 0.025
1.14AspTyr: 1.14 ± 0.028
0.0AspXaa: 0.0 ± 0.0
Glu
7.189GluAla: 7.189 ± 0.082
0.355GluCys: 0.355 ± 0.014
2.881GluAsp: 2.881 ± 0.039
3.52GluGlu: 3.52 ± 0.054
1.444GluPhe: 1.444 ± 0.027
4.375GluGly: 4.375 ± 0.055
1.516GluHis: 1.516 ± 0.03
2.197GluIle: 2.197 ± 0.036
1.512GluLys: 1.512 ± 0.033
6.761GluLeu: 6.761 ± 0.084
0.87GluMet: 0.87 ± 0.02
1.003GluAsn: 1.003 ± 0.024
3.394GluPro: 3.394 ± 0.052
2.131GluGln: 2.131 ± 0.035
5.367GluArg: 5.367 ± 0.059
2.621GluSer: 2.621 ± 0.035
2.856GluThr: 2.856 ± 0.042
4.392GluVal: 4.392 ± 0.055
0.736GluTrp: 0.736 ± 0.018
1.136GluTyr: 1.136 ± 0.021
0.0GluXaa: 0.0 ± 0.0
Phe
3.749PheAla: 3.749 ± 0.045
0.264PheCys: 0.264 ± 0.011
1.941PheAsp: 1.941 ± 0.035
1.409PheGlu: 1.409 ± 0.026
0.909PhePhe: 0.909 ± 0.028
3.12PheGly: 3.12 ± 0.047
0.614PheHis: 0.614 ± 0.017
0.716PheIle: 0.716 ± 0.02
0.57PheLys: 0.57 ± 0.015
2.647PheLeu: 2.647 ± 0.041
0.431PheMet: 0.431 ± 0.014
0.574PheAsn: 0.574 ± 0.015
1.4PhePro: 1.4 ± 0.025
0.692PheGln: 0.692 ± 0.019
1.812PheArg: 1.812 ± 0.032
1.525PheSer: 1.525 ± 0.029
2.054PheThr: 2.054 ± 0.033
2.382PheVal: 2.382 ± 0.034
0.434PheTrp: 0.434 ± 0.015
0.589PheTyr: 0.589 ± 0.017
0.0PheXaa: 0.0 ± 0.0
Gly
11.362GlyAla: 11.362 ± 0.082
0.81GlyCys: 0.81 ± 0.02
5.393GlyAsp: 5.393 ± 0.055
5.017GlyGlu: 5.017 ± 0.046
2.997GlyPhe: 2.997 ± 0.041
9.003GlyGly: 9.003 ± 0.091
2.342GlyHis: 2.342 ± 0.04
3.501GlyIle: 3.501 ± 0.044
2.598GlyLys: 2.598 ± 0.05
9.696GlyLeu: 9.696 ± 0.092
2.007GlyMet: 2.007 ± 0.032
1.757GlyAsn: 1.757 ± 0.034
5.226GlyPro: 5.226 ± 0.057
2.643GlyGln: 2.643 ± 0.037
7.726GlyArg: 7.726 ± 0.064
5.613GlySer: 5.613 ± 0.053
6.594GlyThr: 6.594 ± 0.071
7.63GlyVal: 7.63 ± 0.062
1.747GlyTrp: 1.747 ± 0.033
2.289GlyTyr: 2.289 ± 0.032
0.0GlyXaa: 0.0 ± 0.0
His
2.673HisAla: 2.673 ± 0.037
0.204HisCys: 0.204 ± 0.012
1.358HisAsp: 1.358 ± 0.028
1.258HisGlu: 1.258 ± 0.024
0.687HisPhe: 0.687 ± 0.018
2.52HisGly: 2.52 ± 0.037
0.663HisHis: 0.663 ± 0.018
0.683HisIle: 0.683 ± 0.017
0.385HisLys: 0.385 ± 0.014
2.333HisLeu: 2.333 ± 0.039
0.349HisMet: 0.349 ± 0.013
0.382HisAsn: 0.382 ± 0.013
1.78HisPro: 1.78 ± 0.032
0.613HisGln: 0.613 ± 0.017
2.04HisArg: 2.04 ± 0.034
0.996HisSer: 0.996 ± 0.021
1.325HisThr: 1.325 ± 0.027
1.714HisVal: 1.714 ± 0.03
0.385HisTrp: 0.385 ± 0.014
0.473HisTyr: 0.473 ± 0.015
0.0HisXaa: 0.0 ± 0.0
Ile
4.697IleAla: 4.697 ± 0.054
0.286IleCys: 0.286 ± 0.011
2.186IleAsp: 2.186 ± 0.036
1.904IleGlu: 1.904 ± 0.029
0.709IlePhe: 0.709 ± 0.02
3.628IleGly: 3.628 ± 0.045
0.594IleHis: 0.594 ± 0.017
0.862IleIle: 0.862 ± 0.023
0.765IleLys: 0.765 ± 0.021
2.352IleLeu: 2.352 ± 0.04
0.461IleMet: 0.461 ± 0.017
0.688IleAsn: 0.688 ± 0.02
1.727IlePro: 1.727 ± 0.028
0.709IleGln: 0.709 ± 0.019
2.088IleArg: 2.088 ± 0.03
1.651IleSer: 1.651 ± 0.03
2.158IleThr: 2.158 ± 0.03
2.745IleVal: 2.745 ± 0.039
0.384IleTrp: 0.384 ± 0.013
0.521IleTyr: 0.521 ± 0.016
0.0IleXaa: 0.0 ± 0.0
Lys
3.147LysAla: 3.147 ± 0.049
0.125LysCys: 0.125 ± 0.008
1.485LysAsp: 1.485 ± 0.035
1.249LysGlu: 1.249 ± 0.03
0.493LysPhe: 0.493 ± 0.016
2.02LysGly: 2.02 ± 0.04
0.437LysHis: 0.437 ± 0.016
0.918LysIle: 0.918 ± 0.027
1.003LysLys: 1.003 ± 0.031
2.127LysLeu: 2.127 ± 0.039
0.403LysMet: 0.403 ± 0.015
0.589LysAsn: 0.589 ± 0.019
1.373LysPro: 1.373 ± 0.03
0.75LysGln: 0.75 ± 0.019
1.444LysArg: 1.444 ± 0.027
1.292LysSer: 1.292 ± 0.029
1.351LysThr: 1.351 ± 0.031
2.047LysVal: 2.047 ± 0.034
0.299LysTrp: 0.299 ± 0.014
0.532LysTyr: 0.532 ± 0.019
0.0LysXaa: 0.0 ± 0.0
Leu
14.754LeuAla: 14.754 ± 0.12
0.843LeuCys: 0.843 ± 0.017
6.819LeuAsp: 6.819 ± 0.06
4.556LeuGlu: 4.556 ± 0.049
2.689LeuPhe: 2.689 ± 0.039
9.466LeuGly: 9.466 ± 0.076
2.297LeuHis: 2.297 ± 0.037
3.191LeuIle: 3.191 ± 0.045
2.224LeuLys: 2.224 ± 0.038
11.297LeuLeu: 11.297 ± 0.123
1.655LeuMet: 1.655 ± 0.028
1.657LeuAsn: 1.657 ± 0.03
6.399LeuPro: 6.399 ± 0.062
2.183LeuGln: 2.183 ± 0.037
8.418LeuArg: 8.418 ± 0.081
5.32LeuSer: 5.32 ± 0.053
6.69LeuThr: 6.69 ± 0.065
9.167LeuVal: 9.167 ± 0.081
1.342LeuTrp: 1.342 ± 0.027
1.91LeuTyr: 1.91 ± 0.033
0.0LeuXaa: 0.0 ± 0.0
Met
2.248MetAla: 2.248 ± 0.034
0.129MetCys: 0.129 ± 0.008
0.893MetAsp: 0.893 ± 0.022
0.756MetGlu: 0.756 ± 0.019
0.469MetPhe: 0.469 ± 0.014
1.332MetGly: 1.332 ± 0.026
0.383MetHis: 0.383 ± 0.013
0.646MetIle: 0.646 ± 0.017
0.451MetLys: 0.451 ± 0.016
1.673MetLeu: 1.673 ± 0.025
0.302MetMet: 0.302 ± 0.012
0.426MetAsn: 0.426 ± 0.015
1.108MetPro: 1.108 ± 0.024
0.446MetGln: 0.446 ± 0.016
1.4MetArg: 1.4 ± 0.028
1.328MetSer: 1.328 ± 0.025
1.518MetThr: 1.518 ± 0.025
1.295MetVal: 1.295 ± 0.025
0.213MetTrp: 0.213 ± 0.01
0.341MetTyr: 0.341 ± 0.012
0.0MetXaa: 0.0 ± 0.0
Asn
2.18AsnAla: 2.18 ± 0.037
0.167AsnCys: 0.167 ± 0.009
0.97AsnAsp: 0.97 ± 0.022
0.788AsnGlu: 0.788 ± 0.021
0.494AsnPhe: 0.494 ± 0.014
1.862AsnGly: 1.862 ± 0.035
0.391AsnHis: 0.391 ± 0.012
0.646AsnIle: 0.646 ± 0.018
0.468AsnLys: 0.468 ± 0.017
1.626AsnLeu: 1.626 ± 0.03
0.296AsnMet: 0.296 ± 0.012
0.453AsnAsn: 0.453 ± 0.02
1.301AsnPro: 1.301 ± 0.026
0.511AsnGln: 0.511 ± 0.017
1.204AsnArg: 1.204 ± 0.021
0.995AsnSer: 0.995 ± 0.024
1.151AsnThr: 1.151 ± 0.026
1.383AsnVal: 1.383 ± 0.031
0.304AsnTrp: 0.304 ± 0.012
0.43AsnTyr: 0.43 ± 0.016
0.0AsnXaa: 0.0 ± 0.0
Pro
8.393ProAla: 8.393 ± 0.089
0.297ProCys: 0.297 ± 0.011
4.395ProAsp: 4.395 ± 0.047
4.306ProGlu: 4.306 ± 0.053
1.527ProPhe: 1.527 ± 0.031
6.634ProGly: 6.634 ± 0.073
1.412ProHis: 1.412 ± 0.03
1.195ProIle: 1.195 ± 0.026
1.259ProLys: 1.259 ± 0.029
5.374ProLeu: 5.374 ± 0.052
0.972ProMet: 0.972 ± 0.021
0.879ProAsn: 0.879 ± 0.019
3.322ProPro: 3.322 ± 0.061
1.737ProGln: 1.737 ± 0.039
3.885ProArg: 3.885 ± 0.048
3.274ProSer: 3.274 ± 0.049
3.113ProThr: 3.113 ± 0.047
5.56ProVal: 5.56 ± 0.065
0.894ProTrp: 0.894 ± 0.022
1.511ProTyr: 1.511 ± 0.026
0.0ProXaa: 0.0 ± 0.0
Gln
3.502GlnAla: 3.502 ± 0.049
0.168GlnCys: 0.168 ± 0.007
1.452GlnAsp: 1.452 ± 0.026
1.438GlnGlu: 1.438 ± 0.028
0.696GlnPhe: 0.696 ± 0.019
2.362GlnGly: 2.362 ± 0.038
0.618GlnHis: 0.618 ± 0.018
1.088GlnIle: 1.088 ± 0.021
0.651GlnLys: 0.651 ± 0.017
2.977GlnLeu: 2.977 ± 0.044
0.498GlnMet: 0.498 ± 0.016
0.497GlnAsn: 0.497 ± 0.016
1.647GlnPro: 1.647 ± 0.042
1.25GlnGln: 1.25 ± 0.035
2.241GlnArg: 2.241 ± 0.033
1.324GlnSer: 1.324 ± 0.028
1.356GlnThr: 1.356 ± 0.029
2.374GlnVal: 2.374 ± 0.039
0.453GlnTrp: 0.453 ± 0.015
0.63GlnTyr: 0.63 ± 0.017
0.0GlnXaa: 0.0 ± 0.0
Arg
9.718ArgAla: 9.718 ± 0.098
0.534ArgCys: 0.534 ± 0.016
4.273ArgAsp: 4.273 ± 0.046
4.62ArgGlu: 4.62 ± 0.057
2.324ArgPhe: 2.324 ± 0.033
5.833ArgGly: 5.833 ± 0.059
2.074ArgHis: 2.074 ± 0.031
3.167ArgIle: 3.167 ± 0.041
1.666ArgLys: 1.666 ± 0.03
8.63ArgLeu: 8.63 ± 0.086
1.661ArgMet: 1.661 ± 0.028
1.291ArgAsn: 1.291 ± 0.027
4.749ArgPro: 4.749 ± 0.051
2.159ArgGln: 2.159 ± 0.034
7.538ArgArg: 7.538 ± 0.079
3.984ArgSer: 3.984 ± 0.045
5.5ArgThr: 5.5 ± 0.051
5.805ArgVal: 5.805 ± 0.063
1.324ArgTrp: 1.324 ± 0.026
1.768ArgTyr: 1.768 ± 0.031
0.0ArgXaa: 0.0 ± 0.0
Ser
6.943SerAla: 6.943 ± 0.058
0.386SerCys: 0.386 ± 0.014
2.829SerAsp: 2.829 ± 0.037
2.477SerGlu: 2.477 ± 0.037
1.556SerPhe: 1.556 ± 0.025
6.153SerGly: 6.153 ± 0.061
1.008SerHis: 1.008 ± 0.021
1.403SerIle: 1.403 ± 0.026
1.139SerLys: 1.139 ± 0.032
4.839SerLeu: 4.839 ± 0.051
1.121SerMet: 1.121 ± 0.023
0.892SerAsn: 0.892 ± 0.019
3.123SerPro: 3.123 ± 0.046
1.241SerGln: 1.241 ± 0.025
3.646SerArg: 3.646 ± 0.045
2.992SerSer: 2.992 ± 0.053
3.159SerThr: 3.159 ± 0.048
4.45SerVal: 4.45 ± 0.051
0.933SerTrp: 0.933 ± 0.021
1.307SerTyr: 1.307 ± 0.027
0.0SerXaa: 0.0 ± 0.0
Thr
8.886ThrAla: 8.886 ± 0.075
0.411ThrCys: 0.411 ± 0.013
3.73ThrAsp: 3.73 ± 0.048
3.194ThrGlu: 3.194 ± 0.043
1.674ThrPhe: 1.674 ± 0.032
6.774ThrGly: 6.774 ± 0.064
1.201ThrHis: 1.201 ± 0.025
1.63ThrIle: 1.63 ± 0.03
1.271ThrLys: 1.271 ± 0.029
5.745ThrLeu: 5.745 ± 0.057
0.925ThrMet: 0.925 ± 0.022
0.975ThrAsn: 0.975 ± 0.025
4.121ThrPro: 4.121 ± 0.054
1.362ThrGln: 1.362 ± 0.026
3.866ThrArg: 3.866 ± 0.041
3.192ThrSer: 3.192 ± 0.046
3.893ThrThr: 3.893 ± 0.056
6.345ThrVal: 6.345 ± 0.064
0.897ThrTrp: 0.897 ± 0.024
1.423ThrTyr: 1.423 ± 0.027
0.0ThrXaa: 0.0 ± 0.0
Val
10.877ValAla: 10.877 ± 0.082
0.75ValCys: 0.75 ± 0.021
5.105ValAsp: 5.105 ± 0.048
4.785ValGlu: 4.785 ± 0.048
2.486ValPhe: 2.486 ± 0.034
6.747ValGly: 6.747 ± 0.068
2.02ValHis: 2.02 ± 0.031
2.78ValIle: 2.78 ± 0.038
1.831ValLys: 1.831 ± 0.037
9.611ValLeu: 9.611 ± 0.097
1.447ValMet: 1.447 ± 0.026
1.675ValAsn: 1.675 ± 0.032
5.382ValPro: 5.382 ± 0.053
2.188ValGln: 2.188 ± 0.03
7.284ValArg: 7.284 ± 0.07
4.415ValSer: 4.415 ± 0.051
5.791ValThr: 5.791 ± 0.058
8.427ValVal: 8.427 ± 0.083
1.155ValTrp: 1.155 ± 0.025
1.652ValTyr: 1.652 ± 0.03
0.0ValXaa: 0.0 ± 0.0
Trp
1.652TrpAla: 1.652 ± 0.03
0.146TrpCys: 0.146 ± 0.008
0.856TrpAsp: 0.856 ± 0.021
0.72TrpGlu: 0.72 ± 0.018
0.516TrpPhe: 0.516 ± 0.015
1.113TrpGly: 1.113 ± 0.027
0.37TrpHis: 0.37 ± 0.013
0.576TrpIle: 0.576 ± 0.015
0.394TrpLys: 0.394 ± 0.014
1.788TrpLeu: 1.788 ± 0.03
0.305TrpMet: 0.305 ± 0.013
0.447TrpAsn: 0.447 ± 0.014
0.77TrpPro: 0.77 ± 0.022
0.617TrpGln: 0.617 ± 0.018
1.315TrpArg: 1.315 ± 0.026
0.919TrpSer: 0.919 ± 0.021
1.055TrpThr: 1.055 ± 0.025
0.978TrpVal: 0.978 ± 0.024
0.355TrpTrp: 0.355 ± 0.015
0.393TrpTyr: 0.393 ± 0.013
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.938TyrAla: 2.938 ± 0.04
0.18TyrCys: 0.18 ± 0.009
1.639TyrAsp: 1.639 ± 0.035
1.376TyrGlu: 1.376 ± 0.031
0.676TyrPhe: 0.676 ± 0.018
2.428TyrGly: 2.428 ± 0.038
0.375TyrHis: 0.375 ± 0.014
0.512TyrIle: 0.512 ± 0.014
0.445TyrLys: 0.445 ± 0.016
2.059TyrLeu: 2.059 ± 0.031
0.26TyrMet: 0.26 ± 0.011
0.437TyrAsn: 0.437 ± 0.017
1.074TyrPro: 1.074 ± 0.024
0.6TyrGln: 0.6 ± 0.018
1.823TyrArg: 1.823 ± 0.032
0.979TyrSer: 0.979 ± 0.023
1.205TyrThr: 1.205 ± 0.027
1.715TyrVal: 1.715 ± 0.028
0.36TyrTrp: 0.36 ± 0.013
0.481TyrTyr: 0.481 ± 0.016
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6527 proteins (2208326 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski