Amino acid dipepetide frequency for Mycobacterium phage Fowlmouth

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.864AlaAla: 5.864 ± 1.367
0.546AlaCys: 0.546 ± 0.151
5.137AlaAsp: 5.137 ± 0.459
5.319AlaGlu: 5.319 ± 0.532
3.0AlaPhe: 3.0 ± 0.299
4.91AlaGly: 4.91 ± 0.623
1.637AlaHis: 1.637 ± 0.339
5.319AlaIle: 5.319 ± 0.514
5.864AlaLys: 5.864 ± 0.505
6.773AlaLeu: 6.773 ± 0.631
2.409AlaMet: 2.409 ± 0.379
3.955AlaAsn: 3.955 ± 0.582
2.455AlaPro: 2.455 ± 0.336
3.409AlaGln: 3.409 ± 0.648
4.5AlaArg: 4.5 ± 0.456
5.0AlaSer: 5.0 ± 0.533
4.728AlaThr: 4.728 ± 0.511
5.182AlaVal: 5.182 ± 0.463
1.5AlaTrp: 1.5 ± 0.242
1.727AlaTyr: 1.727 ± 0.236
0.0AlaXaa: 0.0 ± 0.0
Cys
0.727CysAla: 0.727 ± 0.187
0.227CysCys: 0.227 ± 0.107
0.909CysAsp: 0.909 ± 0.286
0.818CysGlu: 0.818 ± 0.228
0.409CysPhe: 0.409 ± 0.141
0.955CysGly: 0.955 ± 0.314
0.182CysHis: 0.182 ± 0.097
0.273CysIle: 0.273 ± 0.116
0.636CysLys: 0.636 ± 0.178
0.546CysLeu: 0.546 ± 0.169
0.273CysMet: 0.273 ± 0.132
0.182CysAsn: 0.182 ± 0.073
0.773CysPro: 0.773 ± 0.223
0.364CysGln: 0.364 ± 0.135
0.636CysArg: 0.636 ± 0.151
0.864CysSer: 0.864 ± 0.203
0.364CysThr: 0.364 ± 0.121
0.409CysVal: 0.409 ± 0.129
0.091CysTrp: 0.091 ± 0.067
0.364CysTyr: 0.364 ± 0.133
0.0CysXaa: 0.0 ± 0.0
Asp
4.319AspAla: 4.319 ± 0.456
0.909AspCys: 0.909 ± 0.275
5.0AspAsp: 5.0 ± 0.768
4.546AspGlu: 4.546 ± 0.503
3.5AspPhe: 3.5 ± 0.324
4.228AspGly: 4.228 ± 0.514
1.409AspHis: 1.409 ± 0.306
3.364AspIle: 3.364 ± 0.411
2.909AspLys: 2.909 ± 0.467
4.728AspLeu: 4.728 ± 0.406
1.5AspMet: 1.5 ± 0.229
2.046AspAsn: 2.046 ± 0.283
4.137AspPro: 4.137 ± 0.474
2.364AspGln: 2.364 ± 0.376
3.591AspArg: 3.591 ± 0.497
4.955AspSer: 4.955 ± 0.534
3.364AspThr: 3.364 ± 0.54
3.955AspVal: 3.955 ± 0.412
1.273AspTrp: 1.273 ± 0.241
2.318AspTyr: 2.318 ± 0.307
0.0AspXaa: 0.0 ± 0.0
Glu
5.682GluAla: 5.682 ± 0.534
0.636GluCys: 0.636 ± 0.163
4.182GluAsp: 4.182 ± 0.486
4.182GluGlu: 4.182 ± 0.535
2.728GluPhe: 2.728 ± 0.349
4.046GluGly: 4.046 ± 0.487
1.5GluHis: 1.5 ± 0.315
4.728GluIle: 4.728 ± 0.681
3.546GluLys: 3.546 ± 0.558
5.91GluLeu: 5.91 ± 0.543
1.909GluMet: 1.909 ± 0.323
2.455GluAsn: 2.455 ± 0.316
2.546GluPro: 2.546 ± 0.343
2.318GluGln: 2.318 ± 0.356
4.091GluArg: 4.091 ± 0.475
4.409GluSer: 4.409 ± 0.426
3.728GluThr: 3.728 ± 0.327
4.228GluVal: 4.228 ± 0.493
1.046GluTrp: 1.046 ± 0.241
2.137GluTyr: 2.137 ± 0.306
0.0GluXaa: 0.0 ± 0.0
Phe
2.637PheAla: 2.637 ± 0.377
0.318PheCys: 0.318 ± 0.145
2.409PheAsp: 2.409 ± 0.285
3.046PheGlu: 3.046 ± 0.361
1.182PhePhe: 1.182 ± 0.237
4.773PheGly: 4.773 ± 0.536
0.636PheHis: 0.636 ± 0.201
2.0PheIle: 2.0 ± 0.267
1.909PheLys: 1.909 ± 0.297
2.546PheLeu: 2.546 ± 0.391
0.727PheMet: 0.727 ± 0.175
1.955PheAsn: 1.955 ± 0.352
1.682PhePro: 1.682 ± 0.214
1.818PheGln: 1.818 ± 0.246
1.864PheArg: 1.864 ± 0.33
2.728PheSer: 2.728 ± 0.334
3.0PheThr: 3.0 ± 0.331
2.5PheVal: 2.5 ± 0.374
0.727PheTrp: 0.727 ± 0.175
1.182PheTyr: 1.182 ± 0.211
0.0PheXaa: 0.0 ± 0.0
Gly
5.046GlyAla: 5.046 ± 0.816
0.591GlyCys: 0.591 ± 0.167
4.591GlyAsp: 4.591 ± 0.67
3.955GlyGlu: 3.955 ± 0.356
3.318GlyPhe: 3.318 ± 0.354
6.546GlyGly: 6.546 ± 0.806
1.546GlyHis: 1.546 ± 0.275
4.819GlyIle: 4.819 ± 0.772
4.819GlyLys: 4.819 ± 0.53
5.273GlyLeu: 5.273 ± 0.489
2.0GlyMet: 2.0 ± 0.372
3.909GlyAsn: 3.909 ± 0.454
3.182GlyPro: 3.182 ± 0.354
3.773GlyGln: 3.773 ± 0.565
3.909GlyArg: 3.909 ± 0.379
4.819GlySer: 4.819 ± 0.772
5.137GlyThr: 5.137 ± 0.684
4.91GlyVal: 4.91 ± 0.44
1.773GlyTrp: 1.773 ± 0.227
3.318GlyTyr: 3.318 ± 0.414
0.0GlyXaa: 0.0 ± 0.0
His
1.227HisAla: 1.227 ± 0.273
0.273HisCys: 0.273 ± 0.11
0.955HisAsp: 0.955 ± 0.212
1.273HisGlu: 1.273 ± 0.209
1.0HisPhe: 1.0 ± 0.214
1.227HisGly: 1.227 ± 0.238
0.227HisHis: 0.227 ± 0.091
1.091HisIle: 1.091 ± 0.25
1.046HisLys: 1.046 ± 0.22
1.5HisLeu: 1.5 ± 0.267
0.5HisMet: 0.5 ± 0.138
0.5HisAsn: 0.5 ± 0.165
1.273HisPro: 1.273 ± 0.261
0.955HisGln: 0.955 ± 0.213
1.0HisArg: 1.0 ± 0.232
1.727HisSer: 1.727 ± 0.291
0.636HisThr: 0.636 ± 0.184
1.227HisVal: 1.227 ± 0.217
0.364HisTrp: 0.364 ± 0.129
1.0HisTyr: 1.0 ± 0.227
0.0HisXaa: 0.0 ± 0.0
Ile
5.273IleAla: 5.273 ± 0.496
0.546IleCys: 0.546 ± 0.185
4.228IleAsp: 4.228 ± 0.448
4.046IleGlu: 4.046 ± 0.557
2.273IlePhe: 2.273 ± 0.316
3.591IleGly: 3.591 ± 0.408
1.182IleHis: 1.182 ± 0.237
3.364IleIle: 3.364 ± 0.405
2.5IleLys: 2.5 ± 0.259
4.409IleLeu: 4.409 ± 0.359
1.046IleMet: 1.046 ± 0.238
2.5IleAsn: 2.5 ± 0.382
3.637IlePro: 3.637 ± 0.531
2.682IleGln: 2.682 ± 0.446
3.546IleArg: 3.546 ± 0.381
3.819IleSer: 3.819 ± 0.41
3.0IleThr: 3.0 ± 0.398
3.637IleVal: 3.637 ± 0.401
1.0IleTrp: 1.0 ± 0.22
1.318IleTyr: 1.318 ± 0.191
0.0IleXaa: 0.0 ± 0.0
Lys
6.046LysAla: 6.046 ± 0.52
0.955LysCys: 0.955 ± 0.261
3.182LysAsp: 3.182 ± 0.439
3.637LysGlu: 3.637 ± 0.463
1.409LysPhe: 1.409 ± 0.244
4.273LysGly: 4.273 ± 0.471
0.864LysHis: 0.864 ± 0.176
3.228LysIle: 3.228 ± 0.359
3.409LysLys: 3.409 ± 0.456
4.319LysLeu: 4.319 ± 0.497
1.682LysMet: 1.682 ± 0.36
2.455LysAsn: 2.455 ± 0.34
3.137LysPro: 3.137 ± 0.446
2.182LysGln: 2.182 ± 0.301
3.773LysArg: 3.773 ± 0.611
2.864LysSer: 2.864 ± 0.424
3.455LysThr: 3.455 ± 0.44
3.182LysVal: 3.182 ± 0.306
0.909LysTrp: 0.909 ± 0.194
1.773LysTyr: 1.773 ± 0.299
0.0LysXaa: 0.0 ± 0.0
Leu
7.046LeuAla: 7.046 ± 0.498
0.636LeuCys: 0.636 ± 0.189
4.409LeuAsp: 4.409 ± 0.421
5.501LeuGlu: 5.501 ± 0.505
2.909LeuPhe: 2.909 ± 0.434
6.546LeuGly: 6.546 ± 0.756
1.318LeuHis: 1.318 ± 0.22
3.591LeuIle: 3.591 ± 0.341
4.591LeuLys: 4.591 ± 0.441
5.501LeuLeu: 5.501 ± 0.596
1.818LeuMet: 1.818 ± 0.344
3.682LeuAsn: 3.682 ± 0.328
4.409LeuPro: 4.409 ± 0.418
3.228LeuGln: 3.228 ± 0.323
4.591LeuArg: 4.591 ± 0.401
5.546LeuSer: 5.546 ± 0.43
4.091LeuThr: 4.091 ± 0.342
4.864LeuVal: 4.864 ± 0.435
1.455LeuTrp: 1.455 ± 0.324
1.046LeuTyr: 1.046 ± 0.24
0.0LeuXaa: 0.0 ± 0.0
Met
2.682MetAla: 2.682 ± 0.353
0.318MetCys: 0.318 ± 0.13
1.637MetAsp: 1.637 ± 0.331
0.818MetGlu: 0.818 ± 0.185
0.682MetPhe: 0.682 ± 0.165
1.136MetGly: 1.136 ± 0.225
0.546MetHis: 0.546 ± 0.157
1.227MetIle: 1.227 ± 0.24
1.5MetLys: 1.5 ± 0.292
1.455MetLeu: 1.455 ± 0.219
0.546MetMet: 0.546 ± 0.135
1.773MetAsn: 1.773 ± 0.304
1.455MetPro: 1.455 ± 0.267
1.455MetGln: 1.455 ± 0.277
1.5MetArg: 1.5 ± 0.302
2.318MetSer: 2.318 ± 0.37
2.091MetThr: 2.091 ± 0.357
1.364MetVal: 1.364 ± 0.247
0.227MetTrp: 0.227 ± 0.095
0.364MetTyr: 0.364 ± 0.133
0.0MetXaa: 0.0 ± 0.0
Asn
3.728AsnAla: 3.728 ± 0.402
0.455AsnCys: 0.455 ± 0.139
2.773AsnAsp: 2.773 ± 0.372
3.546AsnGlu: 3.546 ± 0.501
1.364AsnPhe: 1.364 ± 0.285
3.773AsnGly: 3.773 ± 0.423
1.046AsnHis: 1.046 ± 0.272
1.909AsnIle: 1.909 ± 0.311
1.818AsnLys: 1.818 ± 0.256
3.728AsnLeu: 3.728 ± 0.397
0.909AsnMet: 0.909 ± 0.22
1.682AsnAsn: 1.682 ± 0.307
3.364AsnPro: 3.364 ± 0.402
2.046AsnGln: 2.046 ± 0.342
2.955AsnArg: 2.955 ± 0.362
2.591AsnSer: 2.591 ± 0.373
2.182AsnThr: 2.182 ± 0.328
2.637AsnVal: 2.637 ± 0.33
0.955AsnTrp: 0.955 ± 0.226
1.5AsnTyr: 1.5 ± 0.294
0.0AsnXaa: 0.0 ± 0.0
Pro
2.591ProAla: 2.591 ± 0.336
0.5ProCys: 0.5 ± 0.179
3.364ProAsp: 3.364 ± 0.375
4.091ProGlu: 4.091 ± 0.542
2.046ProPhe: 2.046 ± 0.298
4.228ProGly: 4.228 ± 0.444
1.046ProHis: 1.046 ± 0.207
2.909ProIle: 2.909 ± 0.408
3.5ProLys: 3.5 ± 0.427
3.864ProLeu: 3.864 ± 0.333
1.773ProMet: 1.773 ± 0.262
2.318ProAsn: 2.318 ± 0.331
2.0ProPro: 2.0 ± 0.28
1.5ProGln: 1.5 ± 0.281
2.318ProArg: 2.318 ± 0.336
3.046ProSer: 3.046 ± 0.36
2.318ProThr: 2.318 ± 0.37
3.273ProVal: 3.273 ± 0.422
1.227ProTrp: 1.227 ± 0.263
1.864ProTyr: 1.864 ± 0.302
0.0ProXaa: 0.0 ± 0.0
Gln
3.591GlnAla: 3.591 ± 0.684
0.227GlnCys: 0.227 ± 0.1
2.091GlnAsp: 2.091 ± 0.289
2.591GlnGlu: 2.591 ± 0.337
1.455GlnPhe: 1.455 ± 0.358
3.864GlnGly: 3.864 ± 0.628
0.636GlnHis: 0.636 ± 0.173
2.818GlnIle: 2.818 ± 0.324
1.955GlnLys: 1.955 ± 0.211
3.091GlnLeu: 3.091 ± 0.364
1.455GlnMet: 1.455 ± 0.255
2.137GlnAsn: 2.137 ± 0.428
1.318GlnPro: 1.318 ± 0.222
2.091GlnGln: 2.091 ± 0.536
2.318GlnArg: 2.318 ± 0.347
2.591GlnSer: 2.591 ± 0.353
1.727GlnThr: 1.727 ± 0.246
3.455GlnVal: 3.455 ± 0.373
0.682GlnTrp: 0.682 ± 0.188
0.909GlnTyr: 0.909 ± 0.214
0.0GlnXaa: 0.0 ± 0.0
Arg
4.182ArgAla: 4.182 ± 0.461
0.909ArgCys: 0.909 ± 0.217
3.864ArgAsp: 3.864 ± 0.534
4.0ArgGlu: 4.0 ± 0.496
2.591ArgPhe: 2.591 ± 0.391
3.0ArgGly: 3.0 ± 0.358
1.136ArgHis: 1.136 ± 0.228
3.5ArgIle: 3.5 ± 0.409
3.591ArgLys: 3.591 ± 0.422
4.955ArgLeu: 4.955 ± 0.515
1.318ArgMet: 1.318 ± 0.302
2.728ArgAsn: 2.728 ± 0.453
2.909ArgPro: 2.909 ± 0.346
2.455ArgGln: 2.455 ± 0.355
3.591ArgArg: 3.591 ± 0.552
2.773ArgSer: 2.773 ± 0.32
2.5ArgThr: 2.5 ± 0.338
4.637ArgVal: 4.637 ± 0.487
1.091ArgTrp: 1.091 ± 0.259
1.682ArgTyr: 1.682 ± 0.391
0.0ArgXaa: 0.0 ± 0.0
Ser
5.682SerAla: 5.682 ± 0.51
0.455SerCys: 0.455 ± 0.148
3.864SerAsp: 3.864 ± 0.44
3.909SerGlu: 3.909 ± 0.53
2.728SerPhe: 2.728 ± 0.332
7.319SerGly: 7.319 ± 0.96
1.091SerHis: 1.091 ± 0.251
3.728SerIle: 3.728 ± 0.428
3.909SerLys: 3.909 ± 0.364
5.091SerLeu: 5.091 ± 0.545
1.773SerMet: 1.773 ± 0.247
3.137SerAsn: 3.137 ± 0.392
2.591SerPro: 2.591 ± 0.37
2.682SerGln: 2.682 ± 0.317
2.682SerArg: 2.682 ± 0.411
4.955SerSer: 4.955 ± 0.601
3.819SerThr: 3.819 ± 0.396
3.909SerVal: 3.909 ± 0.478
1.637SerTrp: 1.637 ± 0.267
1.864SerTyr: 1.864 ± 0.32
0.0SerXaa: 0.0 ± 0.0
Thr
3.909ThrAla: 3.909 ± 0.525
0.5ThrCys: 0.5 ± 0.149
3.182ThrAsp: 3.182 ± 0.342
3.0ThrGlu: 3.0 ± 0.379
2.818ThrPhe: 2.818 ± 0.341
4.455ThrGly: 4.455 ± 0.54
0.955ThrHis: 0.955 ± 0.205
3.728ThrIle: 3.728 ± 0.482
3.728ThrLys: 3.728 ± 0.378
4.228ThrLeu: 4.228 ± 0.452
1.409ThrMet: 1.409 ± 0.279
2.182ThrAsn: 2.182 ± 0.342
3.455ThrPro: 3.455 ± 0.354
2.046ThrGln: 2.046 ± 0.356
2.818ThrArg: 2.818 ± 0.376
3.682ThrSer: 3.682 ± 0.474
2.909ThrThr: 2.909 ± 0.583
3.273ThrVal: 3.273 ± 0.455
1.273ThrTrp: 1.273 ± 0.222
1.773ThrTyr: 1.773 ± 0.248
0.0ThrXaa: 0.0 ± 0.0
Val
5.319ValAla: 5.319 ± 0.482
0.546ValCys: 0.546 ± 0.195
5.046ValAsp: 5.046 ± 0.483
5.137ValGlu: 5.137 ± 0.521
2.818ValPhe: 2.818 ± 0.36
4.228ValGly: 4.228 ± 0.459
0.864ValHis: 0.864 ± 0.17
3.591ValIle: 3.591 ± 0.385
2.818ValLys: 2.818 ± 0.328
4.364ValLeu: 4.364 ± 0.46
1.273ValMet: 1.273 ± 0.216
3.318ValAsn: 3.318 ± 0.434
2.864ValPro: 2.864 ± 0.348
1.727ValGln: 1.727 ± 0.286
3.773ValArg: 3.773 ± 0.493
5.41ValSer: 5.41 ± 0.559
4.273ValThr: 4.273 ± 0.444
4.546ValVal: 4.546 ± 0.464
0.773ValTrp: 0.773 ± 0.151
1.637ValTyr: 1.637 ± 0.266
0.0ValXaa: 0.0 ± 0.0
Trp
1.273TrpAla: 1.273 ± 0.241
0.091TrpCys: 0.091 ± 0.063
1.318TrpAsp: 1.318 ± 0.277
1.182TrpGlu: 1.182 ± 0.259
0.364TrpPhe: 0.364 ± 0.111
1.273TrpGly: 1.273 ± 0.25
0.636TrpHis: 0.636 ± 0.166
1.227TrpIle: 1.227 ± 0.301
1.273TrpLys: 1.273 ± 0.316
1.591TrpLeu: 1.591 ± 0.277
0.273TrpMet: 0.273 ± 0.151
1.091TrpAsn: 1.091 ± 0.186
0.727TrpPro: 0.727 ± 0.214
0.818TrpGln: 0.818 ± 0.205
1.227TrpArg: 1.227 ± 0.213
1.409TrpSer: 1.409 ± 0.21
0.909TrpThr: 0.909 ± 0.181
1.273TrpVal: 1.273 ± 0.229
0.682TrpTrp: 0.682 ± 0.219
0.682TrpTyr: 0.682 ± 0.172
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.409TyrAla: 2.409 ± 0.378
0.364TyrCys: 0.364 ± 0.144
2.273TyrAsp: 2.273 ± 0.319
1.409TyrGlu: 1.409 ± 0.246
1.046TyrPhe: 1.046 ± 0.217
2.864TyrGly: 2.864 ± 0.355
0.546TyrHis: 0.546 ± 0.149
1.227TyrIle: 1.227 ± 0.248
1.409TyrLys: 1.409 ± 0.258
2.909TyrLeu: 2.909 ± 0.337
0.455TyrMet: 0.455 ± 0.144
0.955TyrAsn: 0.955 ± 0.228
1.864TyrPro: 1.864 ± 0.343
1.091TyrGln: 1.091 ± 0.262
2.728TyrArg: 2.728 ± 0.362
1.318TyrSer: 1.318 ± 0.238
1.091TyrThr: 1.091 ± 0.235
1.864TyrVal: 1.864 ± 0.349
0.636TyrTrp: 0.636 ± 0.168
0.864TyrTyr: 0.864 ± 0.216
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 120 proteins (21999 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski