Amino acid dipepetide frequency for Lactobacillus manihotivorans DSM 13343 = JCM 12514

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.664AlaAla: 9.664 ± 0.156
0.591AlaCys: 0.591 ± 0.028
6.259AlaAsp: 6.259 ± 0.105
5.008AlaGlu: 5.008 ± 0.08
3.745AlaPhe: 3.745 ± 0.071
7.485AlaGly: 7.485 ± 0.113
2.307AlaHis: 2.307 ± 0.054
6.498AlaIle: 6.498 ± 0.097
6.457AlaLys: 6.457 ± 0.111
10.305AlaLeu: 10.305 ± 0.128
3.167AlaMet: 3.167 ± 0.066
4.06AlaAsn: 4.06 ± 0.072
3.142AlaPro: 3.142 ± 0.067
5.375AlaGln: 5.375 ± 0.103
3.561AlaArg: 3.561 ± 0.061
5.301AlaSer: 5.301 ± 0.082
6.431AlaThr: 6.431 ± 0.102
7.201AlaVal: 7.201 ± 0.093
1.117AlaTrp: 1.117 ± 0.043
3.04AlaTyr: 3.04 ± 0.064
0.002AlaXaa: 0.002 ± 0.002
Cys
0.453CysAla: 0.453 ± 0.024
0.041CysCys: 0.041 ± 0.007
0.345CysAsp: 0.345 ± 0.021
0.244CysGlu: 0.244 ± 0.018
0.25CysPhe: 0.25 ± 0.018
0.59CysGly: 0.59 ± 0.026
0.174CysHis: 0.174 ± 0.013
0.246CysIle: 0.246 ± 0.017
0.162CysLys: 0.162 ± 0.013
0.546CysLeu: 0.546 ± 0.03
0.109CysMet: 0.109 ± 0.012
0.157CysAsn: 0.157 ± 0.014
0.224CysPro: 0.224 ± 0.02
0.191CysGln: 0.191 ± 0.015
0.191CysArg: 0.191 ± 0.014
0.234CysSer: 0.234 ± 0.017
0.252CysThr: 0.252 ± 0.015
0.319CysVal: 0.319 ± 0.019
0.099CysTrp: 0.099 ± 0.011
0.177CysTyr: 0.177 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
6.159AspAla: 6.159 ± 0.093
0.257AspCys: 0.257 ± 0.019
3.891AspAsp: 3.891 ± 0.081
3.348AspGlu: 3.348 ± 0.07
2.814AspPhe: 2.814 ± 0.06
4.035AspGly: 4.035 ± 0.078
1.758AspHis: 1.758 ± 0.047
3.138AspIle: 3.138 ± 0.066
2.767AspLys: 2.767 ± 0.064
6.008AspLeu: 6.008 ± 0.094
1.503AspMet: 1.503 ± 0.042
2.053AspAsn: 2.053 ± 0.046
2.878AspPro: 2.878 ± 0.068
3.216AspGln: 3.216 ± 0.064
2.545AspArg: 2.545 ± 0.069
2.769AspSer: 2.769 ± 0.067
3.416AspThr: 3.416 ± 0.072
4.113AspVal: 4.113 ± 0.076
0.911AspTrp: 0.911 ± 0.032
2.397AspTyr: 2.397 ± 0.057
0.0AspXaa: 0.0 ± 0.0
Glu
5.134GluAla: 5.134 ± 0.093
0.21GluCys: 0.21 ± 0.018
2.519GluAsp: 2.519 ± 0.064
2.148GluGlu: 2.148 ± 0.058
2.009GluPhe: 2.009 ± 0.055
2.248GluGly: 2.248 ± 0.052
1.261GluHis: 1.261 ± 0.042
2.917GluIle: 2.917 ± 0.058
2.823GluLys: 2.823 ± 0.07
5.107GluLeu: 5.107 ± 0.091
1.413GluMet: 1.413 ± 0.043
2.079GluAsn: 2.079 ± 0.048
1.766GluPro: 1.766 ± 0.045
2.349GluGln: 2.349 ± 0.058
2.157GluArg: 2.157 ± 0.061
2.498GluSer: 2.498 ± 0.056
2.903GluThr: 2.903 ± 0.059
3.215GluVal: 3.215 ± 0.063
0.455GluTrp: 0.455 ± 0.024
1.447GluTyr: 1.447 ± 0.043
0.0GluXaa: 0.0 ± 0.0
Phe
4.203PheAla: 4.203 ± 0.084
0.242PheCys: 0.242 ± 0.02
3.101PheAsp: 3.101 ± 0.06
2.079PheGlu: 2.079 ± 0.05
1.74PhePhe: 1.74 ± 0.05
3.593PheGly: 3.593 ± 0.068
0.85PheHis: 0.85 ± 0.036
2.439PheIle: 2.439 ± 0.059
2.099PheLys: 2.099 ± 0.055
3.359PheLeu: 3.359 ± 0.068
1.051PheMet: 1.051 ± 0.039
1.889PheAsn: 1.889 ± 0.044
1.408PhePro: 1.408 ± 0.036
1.4PheGln: 1.4 ± 0.038
1.268PheArg: 1.268 ± 0.04
2.544PheSer: 2.544 ± 0.063
2.723PheThr: 2.723 ± 0.063
3.132PheVal: 3.132 ± 0.068
0.588PheTrp: 0.588 ± 0.03
1.399PheTyr: 1.399 ± 0.047
0.0PheXaa: 0.0 ± 0.0
Gly
5.868GlyAla: 5.868 ± 0.101
0.433GlyCys: 0.433 ± 0.024
3.945GlyAsp: 3.945 ± 0.073
3.214GlyGlu: 3.214 ± 0.069
3.262GlyPhe: 3.262 ± 0.067
4.678GlyGly: 4.678 ± 0.092
1.708GlyHis: 1.708 ± 0.052
5.064GlyIle: 5.064 ± 0.095
4.008GlyLys: 4.008 ± 0.086
7.412GlyLeu: 7.412 ± 0.112
2.052GlyMet: 2.052 ± 0.049
2.564GlyAsn: 2.564 ± 0.06
1.74GlyPro: 1.74 ± 0.05
3.025GlyGln: 3.025 ± 0.073
2.729GlyArg: 2.729 ± 0.06
3.701GlySer: 3.701 ± 0.074
4.39GlyThr: 4.39 ± 0.08
5.76GlyVal: 5.76 ± 0.096
0.907GlyTrp: 0.907 ± 0.037
2.657GlyTyr: 2.657 ± 0.057
0.002GlyXaa: 0.002 ± 0.001
His
2.133HisAla: 2.133 ± 0.052
0.127HisCys: 0.127 ± 0.012
1.575HisAsp: 1.575 ± 0.039
1.217HisGlu: 1.217 ± 0.036
1.293HisPhe: 1.293 ± 0.038
1.717HisGly: 1.717 ± 0.048
0.868HisHis: 0.868 ± 0.036
1.326HisIle: 1.326 ± 0.039
0.969HisLys: 0.969 ± 0.029
2.581HisLeu: 2.581 ± 0.063
0.578HisMet: 0.578 ± 0.027
0.867HisAsn: 0.867 ± 0.03
1.236HisPro: 1.236 ± 0.04
1.353HisGln: 1.353 ± 0.045
1.081HisArg: 1.081 ± 0.039
1.075HisSer: 1.075 ± 0.04
1.338HisThr: 1.338 ± 0.039
1.698HisVal: 1.698 ± 0.051
0.37HisTrp: 0.37 ± 0.023
0.976HisTyr: 0.976 ± 0.035
0.0HisXaa: 0.0 ± 0.0
Ile
6.869IleAla: 6.869 ± 0.102
0.38IleCys: 0.38 ± 0.022
4.278IleAsp: 4.278 ± 0.058
2.884IleGlu: 2.884 ± 0.066
2.26IlePhe: 2.26 ± 0.065
5.026IleGly: 5.026 ± 0.096
1.379IleHis: 1.379 ± 0.04
3.566IleIle: 3.566 ± 0.08
3.111IleLys: 3.111 ± 0.065
5.252IleLeu: 5.252 ± 0.103
1.478IleMet: 1.478 ± 0.045
2.682IleAsn: 2.682 ± 0.052
2.559IlePro: 2.559 ± 0.054
2.672IleGln: 2.672 ± 0.061
2.283IleArg: 2.283 ± 0.05
3.45IleSer: 3.45 ± 0.067
4.081IleThr: 4.081 ± 0.068
4.633IleVal: 4.633 ± 0.074
0.588IleTrp: 0.588 ± 0.024
1.752IleTyr: 1.752 ± 0.048
0.001IleXaa: 0.001 ± 0.001
Lys
5.933LysAla: 5.933 ± 0.102
0.137LysCys: 0.137 ± 0.015
2.926LysAsp: 2.926 ± 0.064
2.234LysGlu: 2.234 ± 0.057
1.798LysPhe: 1.798 ± 0.048
2.797LysGly: 2.797 ± 0.07
1.412LysHis: 1.412 ± 0.042
3.02LysIle: 3.02 ± 0.06
3.342LysLys: 3.342 ± 0.09
5.251LysLeu: 5.251 ± 0.077
1.703LysMet: 1.703 ± 0.045
2.268LysAsn: 2.268 ± 0.049
2.417LysPro: 2.417 ± 0.065
3.255LysGln: 3.255 ± 0.07
2.773LysArg: 2.773 ± 0.058
3.013LysSer: 3.013 ± 0.067
3.772LysThr: 3.772 ± 0.075
3.68LysVal: 3.68 ± 0.065
0.53LysTrp: 0.53 ± 0.028
1.734LysTyr: 1.734 ± 0.054
0.0LysXaa: 0.0 ± 0.0
Leu
10.964LeuAla: 10.964 ± 0.146
0.591LeuCys: 0.591 ± 0.031
5.814LeuAsp: 5.814 ± 0.095
4.097LeuGlu: 4.097 ± 0.082
3.852LeuPhe: 3.852 ± 0.084
6.964LeuGly: 6.964 ± 0.101
2.263LeuHis: 2.263 ± 0.057
6.414LeuIle: 6.414 ± 0.113
5.718LeuLys: 5.718 ± 0.088
9.529LeuLeu: 9.529 ± 0.146
2.863LeuMet: 2.863 ± 0.069
4.423LeuAsn: 4.423 ± 0.081
4.664LeuPro: 4.664 ± 0.087
4.401LeuGln: 4.401 ± 0.085
4.067LeuArg: 4.067 ± 0.073
6.192LeuSer: 6.192 ± 0.09
7.16LeuThr: 7.16 ± 0.114
7.006LeuVal: 7.006 ± 0.103
1.116LeuTrp: 1.116 ± 0.041
2.685LeuTyr: 2.685 ± 0.069
0.0LeuXaa: 0.0 ± 0.0
Met
2.908MetAla: 2.908 ± 0.058
0.14MetCys: 0.14 ± 0.012
1.308MetAsp: 1.308 ± 0.042
0.885MetGlu: 0.885 ± 0.029
1.0MetPhe: 1.0 ± 0.037
1.734MetGly: 1.734 ± 0.043
0.614MetHis: 0.614 ± 0.031
1.866MetIle: 1.866 ± 0.049
1.59MetLys: 1.59 ± 0.043
2.738MetLeu: 2.738 ± 0.064
0.893MetMet: 0.893 ± 0.039
1.203MetAsn: 1.203 ± 0.045
1.277MetPro: 1.277 ± 0.044
1.53MetGln: 1.53 ± 0.039
1.193MetArg: 1.193 ± 0.036
1.712MetSer: 1.712 ± 0.051
2.039MetThr: 2.039 ± 0.046
1.862MetVal: 1.862 ± 0.05
0.226MetTrp: 0.226 ± 0.015
0.648MetTyr: 0.648 ± 0.027
0.0MetXaa: 0.0 ± 0.0
Asn
4.135AsnAla: 4.135 ± 0.073
0.218AsnCys: 0.218 ± 0.015
2.39AsnAsp: 2.39 ± 0.058
1.806AsnGlu: 1.806 ± 0.05
1.694AsnPhe: 1.694 ± 0.045
3.388AsnGly: 3.388 ± 0.072
1.087AsnHis: 1.087 ± 0.031
2.161AsnIle: 2.161 ± 0.053
1.794AsnLys: 1.794 ± 0.049
3.97AsnLeu: 3.97 ± 0.072
1.071AsnMet: 1.071 ± 0.04
1.666AsnAsn: 1.666 ± 0.056
1.846AsnPro: 1.846 ± 0.05
2.084AsnGln: 2.084 ± 0.058
1.791AsnArg: 1.791 ± 0.053
1.99AsnSer: 1.99 ± 0.055
2.532AsnThr: 2.532 ± 0.061
2.844AsnVal: 2.844 ± 0.059
0.594AsnTrp: 0.594 ± 0.028
1.433AsnTyr: 1.433 ± 0.044
0.0AsnXaa: 0.0 ± 0.0
Pro
3.878ProAla: 3.878 ± 0.076
0.126ProCys: 0.126 ± 0.013
2.895ProAsp: 2.895 ± 0.061
3.01ProGlu: 3.01 ± 0.061
1.608ProPhe: 1.608 ± 0.045
2.416ProGly: 2.416 ± 0.049
0.823ProHis: 0.823 ± 0.032
2.402ProIle: 2.402 ± 0.054
2.461ProLys: 2.461 ± 0.055
3.699ProLeu: 3.699 ± 0.071
0.972ProMet: 0.972 ± 0.037
1.705ProAsn: 1.705 ± 0.047
0.699ProPro: 0.699 ± 0.028
2.05ProGln: 2.05 ± 0.055
1.311ProArg: 1.311 ± 0.036
2.065ProSer: 2.065 ± 0.053
2.696ProThr: 2.696 ± 0.058
3.166ProVal: 3.166 ± 0.061
0.458ProTrp: 0.458 ± 0.022
1.332ProTyr: 1.332 ± 0.04
0.0ProXaa: 0.0 ± 0.0
Gln
6.072GlnAla: 6.072 ± 0.102
0.167GlnCys: 0.167 ± 0.012
2.195GlnAsp: 2.195 ± 0.055
1.896GlnGlu: 1.896 ± 0.055
1.904GlnPhe: 1.904 ± 0.045
2.481GlnGly: 2.481 ± 0.053
1.236GlnHis: 1.236 ± 0.039
2.922GlnIle: 2.922 ± 0.055
2.594GlnLys: 2.594 ± 0.051
5.748GlnLeu: 5.748 ± 0.108
1.317GlnMet: 1.317 ± 0.045
1.956GlnAsn: 1.956 ± 0.047
2.041GlnPro: 2.041 ± 0.057
3.039GlnGln: 3.039 ± 0.072
2.21GlnArg: 2.21 ± 0.054
2.667GlnSer: 2.667 ± 0.061
3.425GlnThr: 3.425 ± 0.077
3.731GlnVal: 3.731 ± 0.071
0.583GlnTrp: 0.583 ± 0.028
1.615GlnTyr: 1.615 ± 0.043
0.0GlnXaa: 0.0 ± 0.0
Arg
3.288ArgAla: 3.288 ± 0.053
0.175ArgCys: 0.175 ± 0.016
2.423ArgAsp: 2.423 ± 0.06
2.244ArgGlu: 2.244 ± 0.055
1.982ArgPhe: 1.982 ± 0.05
2.39ArgGly: 2.39 ± 0.051
1.142ArgHis: 1.142 ± 0.037
2.443ArgIle: 2.443 ± 0.058
2.333ArgLys: 2.333 ± 0.059
4.633ArgLeu: 4.633 ± 0.081
1.189ArgMet: 1.189 ± 0.036
1.578ArgAsn: 1.578 ± 0.048
1.544ArgPro: 1.544 ± 0.049
2.362ArgGln: 2.362 ± 0.054
2.306ArgArg: 2.306 ± 0.059
1.931ArgSer: 1.931 ± 0.045
2.119ArgThr: 2.119 ± 0.052
2.858ArgVal: 2.858 ± 0.065
0.49ArgTrp: 0.49 ± 0.028
1.647ArgTyr: 1.647 ± 0.048
0.0ArgXaa: 0.0 ± 0.0
Ser
5.298SerAla: 5.298 ± 0.087
0.202SerCys: 0.202 ± 0.015
3.413SerAsp: 3.413 ± 0.073
2.585SerGlu: 2.585 ± 0.059
2.458SerPhe: 2.458 ± 0.055
4.69SerGly: 4.69 ± 0.077
1.162SerHis: 1.162 ± 0.035
3.105SerIle: 3.105 ± 0.055
2.713SerLys: 2.713 ± 0.056
5.421SerLeu: 5.421 ± 0.077
1.41SerMet: 1.41 ± 0.041
2.123SerAsn: 2.123 ± 0.054
1.941SerPro: 1.941 ± 0.045
2.549SerGln: 2.549 ± 0.053
2.288SerArg: 2.288 ± 0.05
3.376SerSer: 3.376 ± 0.13
3.566SerThr: 3.566 ± 0.088
4.142SerVal: 4.142 ± 0.07
0.724SerTrp: 0.724 ± 0.028
1.674SerTyr: 1.674 ± 0.044
0.0SerXaa: 0.0 ± 0.0
Thr
6.113ThrAla: 6.113 ± 0.102
0.252ThrCys: 0.252 ± 0.019
3.585ThrAsp: 3.585 ± 0.077
2.679ThrGlu: 2.679 ± 0.054
2.477ThrPhe: 2.477 ± 0.051
4.651ThrGly: 4.651 ± 0.076
1.468ThrHis: 1.468 ± 0.039
4.316ThrIle: 4.316 ± 0.068
3.67ThrLys: 3.67 ± 0.079
6.62ThrLeu: 6.62 ± 0.097
1.508ThrMet: 1.508 ± 0.04
2.529ThrAsn: 2.529 ± 0.061
3.425ThrPro: 3.425 ± 0.078
3.011ThrGln: 3.011 ± 0.06
2.298ThrArg: 2.298 ± 0.054
3.647ThrSer: 3.647 ± 0.085
4.898ThrThr: 4.898 ± 0.134
5.127ThrVal: 5.127 ± 0.08
0.828ThrTrp: 0.828 ± 0.031
2.265ThrTyr: 2.265 ± 0.055
0.0ThrXaa: 0.0 ± 0.0
Val
7.754ValAla: 7.754 ± 0.109
0.433ValCys: 0.433 ± 0.024
4.596ValAsp: 4.596 ± 0.08
3.378ValGlu: 3.378 ± 0.069
2.829ValPhe: 2.829 ± 0.06
5.082ValGly: 5.082 ± 0.088
1.505ValHis: 1.505 ± 0.045
5.148ValIle: 5.148 ± 0.087
3.821ValLys: 3.821 ± 0.069
7.208ValLeu: 7.208 ± 0.112
2.053ValMet: 2.053 ± 0.052
2.958ValAsn: 2.958 ± 0.062
3.038ValPro: 3.038 ± 0.065
2.899ValGln: 2.899 ± 0.055
2.603ValArg: 2.603 ± 0.057
4.352ValSer: 4.352 ± 0.074
4.87ValThr: 4.87 ± 0.093
5.926ValVal: 5.926 ± 0.09
0.753ValTrp: 0.753 ± 0.033
2.192ValTyr: 2.192 ± 0.06
0.0ValXaa: 0.0 ± 0.0
Trp
0.927TrpAla: 0.927 ± 0.036
0.088TrpCys: 0.088 ± 0.011
0.525TrpAsp: 0.525 ± 0.027
0.399TrpGlu: 0.399 ± 0.022
0.583TrpPhe: 0.583 ± 0.029
0.771TrpGly: 0.771 ± 0.036
0.437TrpHis: 0.437 ± 0.025
0.625TrpIle: 0.625 ± 0.025
0.356TrpLys: 0.356 ± 0.023
1.764TrpLeu: 1.764 ± 0.057
0.295TrpMet: 0.295 ± 0.018
0.432TrpAsn: 0.432 ± 0.024
0.476TrpPro: 0.476 ± 0.023
0.957TrpGln: 0.957 ± 0.039
0.663TrpArg: 0.663 ± 0.029
0.627TrpSer: 0.627 ± 0.03
0.69TrpThr: 0.69 ± 0.029
0.792TrpVal: 0.792 ± 0.033
0.263TrpTrp: 0.263 ± 0.02
0.432TrpTyr: 0.432 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.965TyrAla: 2.965 ± 0.064
0.195TyrCys: 0.195 ± 0.015
1.99TyrAsp: 1.99 ± 0.046
1.304TyrGlu: 1.304 ± 0.04
1.55TyrPhe: 1.55 ± 0.043
2.386TyrGly: 2.386 ± 0.048
0.925TyrHis: 0.925 ± 0.034
1.566TyrIle: 1.566 ± 0.048
1.209TyrLys: 1.209 ± 0.04
3.635TyrLeu: 3.635 ± 0.064
0.738TyrMet: 0.738 ± 0.032
1.301TyrAsn: 1.301 ± 0.042
1.447TyrPro: 1.447 ± 0.04
2.079TyrGln: 2.079 ± 0.059
1.76TyrArg: 1.76 ± 0.044
1.694TyrSer: 1.694 ± 0.05
2.064TyrThr: 2.064 ± 0.058
2.193TyrVal: 2.193 ± 0.054
0.5TyrTrp: 0.5 ± 0.028
1.292TyrTyr: 1.292 ± 0.04
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.001XaaAla: 0.001 ± 0.001
0.0XaaCys: 0.0 ± 0.0
0.001XaaAsp: 0.001 ± 0.001
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.001XaaHis: 0.001 ± 0.001
0.001XaaIle: 0.001 ± 0.001
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.001XaaSer: 0.001 ± 0.001
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.062XaaXaa: 0.062 ± 0.033
Statistics based on 2921 proteins (852229 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski