Amino acid dipepetide frequency for Papillibacter cinnamivorans DSM 12816

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.681AlaAla: 11.681 ± 0.165	1.289AlaCys: 1.289 ± 0.045	4.942AlaAsp: 4.942 ± 0.082	6.68AlaGlu: 6.68 ± 0.106	3.529AlaPhe: 3.529 ± 0.068	8.506AlaGly: 8.506 ± 0.108	1.257AlaHis: 1.257 ± 0.037	4.758AlaIle: 4.758 ± 0.088	4.28AlaLys: 4.28 ± 0.085	9.558AlaLeu: 9.558 ± 0.124	2.641AlaMet: 2.641 ± 0.064	2.277AlaAsn: 2.277 ± 0.056	3.0AlaPro: 3.0 ± 0.061	2.527AlaGln: 2.527 ± 0.054	4.524AlaArg: 4.524 ± 0.092	5.324AlaSer: 5.324 ± 0.098	3.523AlaThr: 3.523 ± 0.088	8.495AlaVal: 8.495 ± 0.113	0.772AlaTrp: 0.772 ± 0.034	2.878AlaTyr: 2.878 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	1.325CysAla: 1.325 ± 0.041	0.313CysCys: 0.313 ± 0.027	0.774CysAsp: 0.774 ± 0.032	0.706CysGlu: 0.706 ± 0.035	0.562CysPhe: 0.562 ± 0.029	1.647CysGly: 1.647 ± 0.051	0.253CysHis: 0.253 ± 0.015	0.826CysIle: 0.826 ± 0.035	0.467CysLys: 0.467 ± 0.027	1.257CysLeu: 1.257 ± 0.042	0.307CysMet: 0.307 ± 0.019	0.387CysAsn: 0.387 ± 0.025	0.77CysPro: 0.77 ± 0.036	0.303CysGln: 0.303 ± 0.017	1.104CysArg: 1.104 ± 0.04	0.933CysSer: 0.933 ± 0.037	0.688CysThr: 0.688 ± 0.029	1.027CysVal: 1.027 ± 0.043	0.134CysTrp: 0.134 ± 0.015	0.425CysTyr: 0.425 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	4.714AspAla: 4.714 ± 0.074	0.742AspCys: 0.742 ± 0.035	2.358AspAsp: 2.358 ± 0.06	3.641AspGlu: 3.641 ± 0.077	2.32AspPhe: 2.32 ± 0.047	4.786AspGly: 4.786 ± 0.091	0.681AspHis: 0.681 ± 0.028	3.701AspIle: 3.701 ± 0.063	2.693AspLys: 2.693 ± 0.055	4.928AspLeu: 4.928 ± 0.077	1.53AspMet: 1.53 ± 0.041	1.595AspAsn: 1.595 ± 0.051	2.397AspPro: 2.397 ± 0.061	1.111AspGln: 1.111 ± 0.038	2.959AspArg: 2.959 ± 0.069	3.065AspSer: 3.065 ± 0.077	3.104AspThr: 3.104 ± 0.073	3.522AspVal: 3.522 ± 0.07	0.522AspTrp: 0.522 ± 0.024	2.032AspTyr: 2.032 ± 0.057	0.0AspXaa: 0.0 ± 0.0
Glu	6.428GluAla: 6.428 ± 0.11	0.686GluCys: 0.686 ± 0.03	3.588GluAsp: 3.588 ± 0.078	5.883GluGlu: 5.883 ± 0.127	2.209GluPhe: 2.209 ± 0.063	4.643GluGly: 4.643 ± 0.094	1.098GluHis: 1.098 ± 0.04	4.906GluIle: 4.906 ± 0.097	4.675GluLys: 4.675 ± 0.109	6.816GluLeu: 6.816 ± 0.128	1.943GluMet: 1.943 ± 0.053	3.143GluAsn: 3.143 ± 0.061	2.165GluPro: 2.165 ± 0.055	2.087GluGln: 2.087 ± 0.059	3.877GluArg: 3.877 ± 0.101	3.398GluSer: 3.398 ± 0.063	4.073GluThr: 4.073 ± 0.082	3.755GluVal: 3.755 ± 0.083	0.521GluTrp: 0.521 ± 0.03	2.654GluTyr: 2.654 ± 0.066	0.0GluXaa: 0.0 ± 0.0
Phe	3.448PheAla: 3.448 ± 0.07	0.712PheCys: 0.712 ± 0.033	2.252PheAsp: 2.252 ± 0.052	2.283PheGlu: 2.283 ± 0.055	1.936PhePhe: 1.936 ± 0.056	3.34PheGly: 3.34 ± 0.065	0.653PheHis: 0.653 ± 0.03	2.45PheIle: 2.45 ± 0.066	1.439PheLys: 1.439 ± 0.04	4.177PheLeu: 4.177 ± 0.093	0.928PheMet: 0.928 ± 0.034	1.25PheAsn: 1.25 ± 0.04	1.637PhePro: 1.637 ± 0.05	1.083PheGln: 1.083 ± 0.04	2.31PheArg: 2.31 ± 0.051	3.389PheSer: 3.389 ± 0.067	2.365PheThr: 2.365 ± 0.059	2.584PheVal: 2.584 ± 0.065	0.379PheTrp: 0.379 ± 0.027	1.431PheTyr: 1.431 ± 0.044	0.0PheXaa: 0.0 ± 0.0
Gly	7.063GlyAla: 7.063 ± 0.101	1.335GlyCys: 1.335 ± 0.05	4.101GlyAsp: 4.101 ± 0.083	5.488GlyGlu: 5.488 ± 0.085	3.436GlyPhe: 3.436 ± 0.065	6.982GlyGly: 6.982 ± 0.127	1.293GlyHis: 1.293 ± 0.041	6.176GlyIle: 6.176 ± 0.101	4.987GlyLys: 4.987 ± 0.079	7.291GlyLeu: 7.291 ± 0.109	2.435GlyMet: 2.435 ± 0.058	2.913GlyAsn: 2.913 ± 0.068	2.013GlyPro: 2.013 ± 0.049	2.001GlyGln: 2.001 ± 0.05	4.502GlyArg: 4.502 ± 0.094	5.281GlySer: 5.281 ± 0.129	5.235GlyThr: 5.235 ± 0.135	5.702GlyVal: 5.702 ± 0.09	0.778GlyTrp: 0.778 ± 0.032	3.233GlyTyr: 3.233 ± 0.07	0.0GlyXaa: 0.0 ± 0.0
His	1.127HisAla: 1.127 ± 0.044	0.291HisCys: 0.291 ± 0.019	0.701HisAsp: 0.701 ± 0.029	0.894HisGlu: 0.894 ± 0.035	0.71HisPhe: 0.71 ± 0.031	1.246HisGly: 1.246 ± 0.04	0.313HisHis: 0.313 ± 0.019	1.065HisIle: 1.065 ± 0.042	0.681HisLys: 0.681 ± 0.029	1.553HisLeu: 1.553 ± 0.044	0.457HisMet: 0.457 ± 0.023	0.551HisAsn: 0.551 ± 0.026	0.949HisPro: 0.949 ± 0.031	0.375HisGln: 0.375 ± 0.025	0.976HisArg: 0.976 ± 0.04	0.953HisSer: 0.953 ± 0.032	0.882HisThr: 0.882 ± 0.037	1.046HisVal: 1.046 ± 0.036	0.195HisTrp: 0.195 ± 0.015	0.556HisTyr: 0.556 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.758IleAla: 5.758 ± 0.086	0.971IleCys: 0.971 ± 0.039	3.281IleAsp: 3.281 ± 0.07	3.403IleGlu: 3.403 ± 0.078	2.412IlePhe: 2.412 ± 0.064	4.741IleGly: 4.741 ± 0.081	1.092IleHis: 1.092 ± 0.041	3.631IleIle: 3.631 ± 0.082	2.571IleLys: 2.571 ± 0.064	7.134IleLeu: 7.134 ± 0.124	1.34IleMet: 1.34 ± 0.041	2.166IleAsn: 2.166 ± 0.051	3.212IlePro: 3.212 ± 0.061	1.736IleGln: 1.736 ± 0.048	4.044IleArg: 4.044 ± 0.082	4.639IleSer: 4.639 ± 0.078	3.853IleThr: 3.853 ± 0.089	4.403IleVal: 4.403 ± 0.091	0.481IleTrp: 0.481 ± 0.029	1.995IleTyr: 1.995 ± 0.054	0.0IleXaa: 0.0 ± 0.0
Lys	4.529LysAla: 4.529 ± 0.084	0.518LysCys: 0.518 ± 0.028	2.708LysAsp: 2.708 ± 0.063	3.986LysGlu: 3.986 ± 0.088	1.315LysPhe: 1.315 ± 0.046	3.258LysGly: 3.258 ± 0.069	0.781LysHis: 0.781 ± 0.037	3.349LysIle: 3.349 ± 0.074	3.61LysLys: 3.61 ± 0.077	4.508LysLeu: 4.508 ± 0.095	1.535LysMet: 1.535 ± 0.046	2.482LysAsn: 2.482 ± 0.057	1.977LysPro: 1.977 ± 0.049	1.487LysGln: 1.487 ± 0.05	2.903LysArg: 2.903 ± 0.058	2.915LysSer: 2.915 ± 0.069	3.517LysThr: 3.517 ± 0.067	3.022LysVal: 3.022 ± 0.076	0.426LysTrp: 0.426 ± 0.024	1.85LysTyr: 1.85 ± 0.05	0.001LysXaa: 0.001 ± 0.001
Leu	8.861LeuAla: 8.861 ± 0.127	1.59LeuCys: 1.59 ± 0.054	5.059LeuAsp: 5.059 ± 0.095	6.389LeuGlu: 6.389 ± 0.117	4.366LeuPhe: 4.366 ± 0.096	7.424LeuGly: 7.424 ± 0.112	1.524LeuHis: 1.524 ± 0.043	5.725LeuIle: 5.725 ± 0.098	5.088LeuLys: 5.088 ± 0.088	10.174LeuLeu: 10.174 ± 0.162	2.496LeuMet: 2.496 ± 0.06	3.277LeuAsn: 3.277 ± 0.061	4.617LeuPro: 4.617 ± 0.078	2.662LeuGln: 2.662 ± 0.057	5.949LeuArg: 5.949 ± 0.111	7.689LeuSer: 7.689 ± 0.114	5.678LeuThr: 5.678 ± 0.111	6.303LeuVal: 6.303 ± 0.099	0.829LeuTrp: 0.829 ± 0.04	3.232LeuTyr: 3.232 ± 0.067	0.0LeuXaa: 0.0 ± 0.0
Met	2.488MetAla: 2.488 ± 0.061	0.262MetCys: 0.262 ± 0.019	1.631MetAsp: 1.631 ± 0.044	2.108MetGlu: 2.108 ± 0.06	0.726MetPhe: 0.726 ± 0.028	2.18MetGly: 2.18 ± 0.055	0.42MetHis: 0.42 ± 0.023	1.595MetIle: 1.595 ± 0.052	1.928MetLys: 1.928 ± 0.049	2.608MetLeu: 2.608 ± 0.06	0.648MetMet: 0.648 ± 0.034	1.121MetAsn: 1.121 ± 0.036	1.14MetPro: 1.14 ± 0.035	0.75MetGln: 0.75 ± 0.028	1.345MetArg: 1.345 ± 0.036	1.707MetSer: 1.707 ± 0.049	1.653MetThr: 1.653 ± 0.041	1.682MetVal: 1.682 ± 0.048	0.151MetTrp: 0.151 ± 0.014	0.658MetTyr: 0.658 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	3.027AsnAla: 3.027 ± 0.072	0.474AsnCys: 0.474 ± 0.024	1.566AsnAsp: 1.566 ± 0.056	1.769AsnGlu: 1.769 ± 0.052	1.186AsnPhe: 1.186 ± 0.043	3.042AsnGly: 3.042 ± 0.071	0.572AsnHis: 0.572 ± 0.03	2.41AsnIle: 2.41 ± 0.058	1.551AsnLys: 1.551 ± 0.051	3.432AsnLeu: 3.432 ± 0.067	0.899AsnMet: 0.899 ± 0.034	1.149AsnAsn: 1.149 ± 0.048	2.154AsnPro: 2.154 ± 0.053	0.955AsnGln: 0.955 ± 0.034	2.234AsnArg: 2.234 ± 0.058	2.016AsnSer: 2.016 ± 0.064	2.006AsnThr: 2.006 ± 0.054	2.246AsnVal: 2.246 ± 0.052	0.357AsnTrp: 0.357 ± 0.023	1.257AsnTyr: 1.257 ± 0.04	0.0AsnXaa: 0.0 ± 0.0
Pro	3.954ProAla: 3.954 ± 0.077	0.516ProCys: 0.516 ± 0.025	2.828ProAsp: 2.828 ± 0.051	4.19ProGlu: 4.19 ± 0.086	1.698ProPhe: 1.698 ± 0.054	3.717ProGly: 3.717 ± 0.072	0.658ProHis: 0.658 ± 0.027	2.004ProIle: 2.004 ± 0.05	1.706ProLys: 1.706 ± 0.044	3.396ProLeu: 3.396 ± 0.069	1.004ProMet: 1.004 ± 0.036	1.171ProAsn: 1.171 ± 0.047	1.537ProPro: 1.537 ± 0.058	1.135ProGln: 1.135 ± 0.038	1.887ProArg: 1.887 ± 0.043	2.46ProSer: 2.46 ± 0.058	1.893ProThr: 1.893 ± 0.068	3.605ProVal: 3.605 ± 0.068	0.389ProTrp: 0.389 ± 0.025	1.442ProTyr: 1.442 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	2.488GlnAla: 2.488 ± 0.056	0.301GlnCys: 0.301 ± 0.017	1.275GlnAsp: 1.275 ± 0.039	1.984GlnGlu: 1.984 ± 0.056	0.95GlnPhe: 0.95 ± 0.036	1.826GlnGly: 1.826 ± 0.049	0.365GlnHis: 0.365 ± 0.02	1.907GlnIle: 1.907 ± 0.05	1.767GlnLys: 1.767 ± 0.048	2.408GlnLeu: 2.408 ± 0.058	0.905GlnMet: 0.905 ± 0.037	1.195GlnAsn: 1.195 ± 0.037	0.937GlnPro: 0.937 ± 0.034	0.891GlnGln: 0.891 ± 0.039	1.473GlnArg: 1.473 ± 0.044	1.687GlnSer: 1.687 ± 0.051	1.545GlnThr: 1.545 ± 0.05	1.885GlnVal: 1.885 ± 0.051	0.285GlnTrp: 0.285 ± 0.018	1.126GlnTyr: 1.126 ± 0.041	0.0GlnXaa: 0.0 ± 0.0
Arg	4.633ArgAla: 4.633 ± 0.091	0.793ArgCys: 0.793 ± 0.036	2.787ArgAsp: 2.787 ± 0.062	5.107ArgGlu: 5.107 ± 0.102	2.484ArgPhe: 2.484 ± 0.065	3.966ArgGly: 3.966 ± 0.083	0.911ArgHis: 0.911 ± 0.043	3.923ArgIle: 3.923 ± 0.077	3.042ArgLys: 3.042 ± 0.069	5.942ArgLeu: 5.942 ± 0.114	1.744ArgMet: 1.744 ± 0.048	1.879ArgAsn: 1.879 ± 0.054	2.209ArgPro: 2.209 ± 0.055	1.864ArgGln: 1.864 ± 0.054	4.137ArgArg: 4.137 ± 0.105	3.087ArgSer: 3.087 ± 0.067	2.596ArgThr: 2.596 ± 0.056	3.621ArgVal: 3.621 ± 0.076	0.526ArgTrp: 0.526 ± 0.032	2.098ArgTyr: 2.098 ± 0.06	0.0ArgXaa: 0.0 ± 0.0
Ser	6.167SerAla: 6.167 ± 0.102	0.867SerCys: 0.867 ± 0.037	3.442SerAsp: 3.442 ± 0.074	3.897SerGlu: 3.897 ± 0.077	2.862SerPhe: 2.862 ± 0.066	6.793SerGly: 6.793 ± 0.141	1.0SerHis: 1.0 ± 0.04	3.778SerIle: 3.778 ± 0.074	2.511SerLys: 2.511 ± 0.065	6.298SerLeu: 6.298 ± 0.1	1.73SerMet: 1.73 ± 0.043	1.763SerAsn: 1.763 ± 0.054	2.857SerPro: 2.857 ± 0.069	1.793SerGln: 1.793 ± 0.052	3.8SerArg: 3.8 ± 0.076	4.26SerSer: 4.26 ± 0.11	2.85SerThr: 2.85 ± 0.085	5.058SerVal: 5.058 ± 0.103	0.599SerTrp: 0.599 ± 0.028	2.176SerTyr: 2.176 ± 0.068	0.0SerXaa: 0.0 ± 0.0
Thr	5.894ThrAla: 5.894 ± 0.119	0.614ThrCys: 0.614 ± 0.027	3.086ThrAsp: 3.086 ± 0.083	3.54ThrGlu: 3.54 ± 0.07	2.085ThrPhe: 2.085 ± 0.056	5.74ThrGly: 5.74 ± 0.12	0.846ThrHis: 0.846 ± 0.035	3.143ThrIle: 3.143 ± 0.074	2.149ThrLys: 2.149 ± 0.061	5.469ThrLeu: 5.469 ± 0.103	1.288ThrMet: 1.288 ± 0.037	1.649ThrAsn: 1.649 ± 0.061	2.753ThrPro: 2.753 ± 0.063	1.428ThrGln: 1.428 ± 0.045	2.543ThrArg: 2.543 ± 0.058	2.873ThrSer: 2.873 ± 0.088	2.636ThrThr: 2.636 ± 0.089	5.432ThrVal: 5.432 ± 0.132	0.435ThrTrp: 0.435 ± 0.023	1.874ThrTyr: 1.874 ± 0.071	0.0ThrXaa: 0.0 ± 0.0
Val	5.403ValAla: 5.403 ± 0.096	1.249ValCys: 1.249 ± 0.044	3.503ValAsp: 3.503 ± 0.062	3.989ValGlu: 3.989 ± 0.08	3.266ValPhe: 3.266 ± 0.07	4.763ValGly: 4.763 ± 0.092	1.041ValHis: 1.041 ± 0.038	4.711ValIle: 4.711 ± 0.078	3.527ValLys: 3.527 ± 0.073	7.645ValLeu: 7.645 ± 0.107	1.941ValMet: 1.941 ± 0.055	2.661ValAsn: 2.661 ± 0.064	3.127ValPro: 3.127 ± 0.059	1.714ValGln: 1.714 ± 0.048	4.088ValArg: 4.088 ± 0.076	5.833ValSer: 5.833 ± 0.093	4.725ValThr: 4.725 ± 0.129	5.026ValVal: 5.026 ± 0.106	0.678ValTrp: 0.678 ± 0.032	2.369ValTyr: 2.369 ± 0.067	0.0ValXaa: 0.0 ± 0.0
Trp	0.721TrpAla: 0.721 ± 0.033	0.129TrpCys: 0.129 ± 0.013	0.5TrpAsp: 0.5 ± 0.025	0.569TrpGlu: 0.569 ± 0.028	0.411TrpPhe: 0.411 ± 0.027	0.731TrpGly: 0.731 ± 0.032	0.166TrpHis: 0.166 ± 0.014	0.583TrpIle: 0.583 ± 0.03	0.472TrpLys: 0.472 ± 0.025	0.915TrpLeu: 0.915 ± 0.041	0.246TrpMet: 0.246 ± 0.016	0.368TrpAsn: 0.368 ± 0.023	0.286TrpPro: 0.286 ± 0.02	0.298TrpGln: 0.298 ± 0.02	0.464TrpArg: 0.464 ± 0.027	0.551TrpSer: 0.551 ± 0.027	0.464TrpThr: 0.464 ± 0.028	0.57TrpVal: 0.57 ± 0.03	0.113TrpTrp: 0.113 ± 0.011	0.345TrpTyr: 0.345 ± 0.026	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.736TyrAla: 2.736 ± 0.063	0.555TyrCys: 0.555 ± 0.026	2.02TyrAsp: 2.02 ± 0.056	2.041TyrGlu: 2.041 ± 0.056	1.582TyrPhe: 1.582 ± 0.051	2.915TyrGly: 2.915 ± 0.064	0.598TyrHis: 0.598 ± 0.028	2.221TyrIle: 2.221 ± 0.056	1.532TyrLys: 1.532 ± 0.047	3.422TyrLeu: 3.422 ± 0.067	0.781TyrMet: 0.781 ± 0.029	1.305TyrAsn: 1.305 ± 0.049	1.453TyrPro: 1.453 ± 0.045	0.997TyrGln: 0.997 ± 0.033	2.231TyrArg: 2.231 ± 0.056	2.441TyrSer: 2.441 ± 0.064	2.193TyrThr: 2.193 ± 0.091	2.278TyrVal: 2.278 ± 0.061	0.33TyrTrp: 0.33 ± 0.021	1.508TyrTyr: 1.508 ± 0.06	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.004XaaXaa: 0.004 ± 0.004

Statistics based on 2640 proteins (814393 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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