Amino acid dipepetide frequency for Ruegeria marisrubri

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.136AlaAla: 15.136 ± 0.133	1.103AlaCys: 1.103 ± 0.033	6.543AlaAsp: 6.543 ± 0.083	8.831AlaGlu: 8.831 ± 0.093	4.171AlaPhe: 4.171 ± 0.065	9.892AlaGly: 9.892 ± 0.094	2.298AlaHis: 2.298 ± 0.048	5.771AlaIle: 5.771 ± 0.083	3.897AlaLys: 3.897 ± 0.072	12.764AlaLeu: 12.764 ± 0.133	3.735AlaMet: 3.735 ± 0.056	2.745AlaAsn: 2.745 ± 0.05	5.333AlaPro: 5.333 ± 0.07	4.213AlaGln: 4.213 ± 0.062	8.579AlaArg: 8.579 ± 0.098	5.353AlaSer: 5.353 ± 0.068	5.392AlaThr: 5.392 ± 0.073	8.076AlaVal: 8.076 ± 0.086	1.373AlaTrp: 1.373 ± 0.034	2.578AlaTyr: 2.578 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	1.136CysAla: 1.136 ± 0.034	0.117CysCys: 0.117 ± 0.01	0.641CysAsp: 0.641 ± 0.026	0.515CysGlu: 0.515 ± 0.02	0.331CysPhe: 0.331 ± 0.016	0.977CysGly: 0.977 ± 0.03	0.302CysHis: 0.302 ± 0.019	0.442CysIle: 0.442 ± 0.022	0.254CysLys: 0.254 ± 0.015	0.87CysLeu: 0.87 ± 0.027	0.208CysMet: 0.208 ± 0.013	0.248CysAsn: 0.248 ± 0.014	0.543CysPro: 0.543 ± 0.023	0.238CysGln: 0.238 ± 0.016	0.605CysArg: 0.605 ± 0.025	0.501CysSer: 0.501 ± 0.021	0.47CysThr: 0.47 ± 0.021	0.672CysVal: 0.672 ± 0.026	0.128CysTrp: 0.128 ± 0.011	0.263CysTyr: 0.263 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	6.567AspAla: 6.567 ± 0.075	0.55AspCys: 0.55 ± 0.022	3.168AspAsp: 3.168 ± 0.058	3.954AspGlu: 3.954 ± 0.058	2.28AspPhe: 2.28 ± 0.045	5.326AspGly: 5.326 ± 0.081	1.34AspHis: 1.34 ± 0.034	3.059AspIle: 3.059 ± 0.05	1.887AspLys: 1.887 ± 0.039	6.406AspLeu: 6.406 ± 0.076	1.679AspMet: 1.679 ± 0.034	1.276AspAsn: 1.276 ± 0.034	3.764AspPro: 3.764 ± 0.055	1.893AspGln: 1.893 ± 0.039	4.314AspArg: 4.314 ± 0.059	2.189AspSer: 2.189 ± 0.05	2.78AspThr: 2.78 ± 0.053	4.185AspVal: 4.185 ± 0.063	1.202AspTrp: 1.202 ± 0.035	1.556AspTyr: 1.556 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	8.539GluAla: 8.539 ± 0.101	0.419GluCys: 0.419 ± 0.02	3.482GluAsp: 3.482 ± 0.062	4.245GluGlu: 4.245 ± 0.083	2.125GluPhe: 2.125 ± 0.044	5.051GluGly: 5.051 ± 0.071	1.327GluHis: 1.327 ± 0.034	4.079GluIle: 4.079 ± 0.067	2.683GluLys: 2.683 ± 0.056	5.915GluLeu: 5.915 ± 0.079	2.004GluMet: 2.004 ± 0.04	2.058GluAsn: 2.058 ± 0.039	2.775GluPro: 2.775 ± 0.049	2.374GluGln: 2.374 ± 0.052	4.711GluArg: 4.711 ± 0.072	2.348GluSer: 2.348 ± 0.046	3.985GluThr: 3.985 ± 0.056	4.54GluVal: 4.54 ± 0.069	0.831GluTrp: 0.831 ± 0.026	1.298GluTyr: 1.298 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	4.31PheAla: 4.31 ± 0.066	0.465PheCys: 0.465 ± 0.022	2.901PheAsp: 2.901 ± 0.052	2.447PheGlu: 2.447 ± 0.044	1.432PhePhe: 1.432 ± 0.04	3.699PheGly: 3.699 ± 0.065	0.792PheHis: 0.792 ± 0.028	1.575PheIle: 1.575 ± 0.043	0.986PheLys: 0.986 ± 0.029	3.511PheLeu: 3.511 ± 0.062	0.884PheMet: 0.884 ± 0.029	1.076PheAsn: 1.076 ± 0.034	1.608PhePro: 1.608 ± 0.036	1.051PheGln: 1.051 ± 0.031	2.259PheArg: 2.259 ± 0.047	2.195PheSer: 2.195 ± 0.046	2.019PheThr: 2.019 ± 0.044	2.747PheVal: 2.747 ± 0.053	0.595PheTrp: 0.595 ± 0.026	0.941PheTyr: 0.941 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	9.111GlyAla: 9.111 ± 0.105	0.918GlyCys: 0.918 ± 0.033	4.738GlyAsp: 4.738 ± 0.07	5.064GlyGlu: 5.064 ± 0.071	3.71GlyPhe: 3.71 ± 0.056	7.329GlyGly: 7.329 ± 0.117	1.951GlyHis: 1.951 ± 0.043	4.437GlyIle: 4.437 ± 0.069	3.459GlyLys: 3.459 ± 0.061	8.896GlyLeu: 8.896 ± 0.103	2.601GlyMet: 2.601 ± 0.053	2.217GlyAsn: 2.217 ± 0.05	3.767GlyPro: 3.767 ± 0.06	3.205GlyGln: 3.205 ± 0.053	5.704GlyArg: 5.704 ± 0.075	4.091GlySer: 4.091 ± 0.064	4.456GlyThr: 4.456 ± 0.074	6.471GlyVal: 6.471 ± 0.074	1.482GlyTrp: 1.482 ± 0.043	2.393GlyTyr: 2.393 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	2.258HisAla: 2.258 ± 0.038	0.264HisCys: 0.264 ± 0.014	1.272HisAsp: 1.272 ± 0.031	1.209HisGlu: 1.209 ± 0.038	0.873HisPhe: 0.873 ± 0.028	1.977HisGly: 1.977 ± 0.042	0.553HisHis: 0.553 ± 0.026	0.983HisIle: 0.983 ± 0.031	0.578HisLys: 0.578 ± 0.023	2.157HisLeu: 2.157 ± 0.044	0.579HisMet: 0.579 ± 0.023	0.468HisAsn: 0.468 ± 0.019	1.438HisPro: 1.438 ± 0.04	0.57HisGln: 0.57 ± 0.026	1.414HisArg: 1.414 ± 0.035	0.979HisSer: 0.979 ± 0.031	0.853HisThr: 0.853 ± 0.026	1.704HisVal: 1.704 ± 0.042	0.388HisTrp: 0.388 ± 0.02	0.598HisTyr: 0.598 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	6.556IleAla: 6.556 ± 0.074	0.624IleCys: 0.624 ± 0.023	3.45IleAsp: 3.45 ± 0.057	3.756IleGlu: 3.756 ± 0.064	1.733IlePhe: 1.733 ± 0.044	4.704IleGly: 4.704 ± 0.071	0.98IleHis: 0.98 ± 0.031	2.132IleIle: 2.132 ± 0.048	1.519IleLys: 1.519 ± 0.035	4.804IleLeu: 4.804 ± 0.071	1.049IleMet: 1.049 ± 0.032	1.36IleAsn: 1.36 ± 0.036	2.441IlePro: 2.441 ± 0.051	1.244IleGln: 1.244 ± 0.035	3.425IleArg: 3.425 ± 0.058	2.952IleSer: 2.952 ± 0.053	2.724IleThr: 2.724 ± 0.051	3.775IleVal: 3.775 ± 0.056	0.756IleTrp: 0.756 ± 0.028	1.184IleTyr: 1.184 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	4.296LysAla: 4.296 ± 0.067	0.236LysCys: 0.236 ± 0.015	1.859LysAsp: 1.859 ± 0.049	1.922LysGlu: 1.922 ± 0.047	1.016LysPhe: 1.016 ± 0.03	2.95LysGly: 2.95 ± 0.054	0.657LysHis: 0.657 ± 0.021	1.8LysIle: 1.8 ± 0.04	1.415LysLys: 1.415 ± 0.043	3.261LysLeu: 3.261 ± 0.055	0.914LysMet: 0.914 ± 0.031	0.922LysAsn: 0.922 ± 0.029	2.081LysPro: 2.081 ± 0.05	1.022LysGln: 1.022 ± 0.034	2.412LysArg: 2.412 ± 0.048	1.838LysSer: 1.838 ± 0.04	2.028LysThr: 2.028 ± 0.046	2.583LysVal: 2.583 ± 0.051	0.454LysTrp: 0.454 ± 0.019	0.75LysTyr: 0.75 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	12.317LeuAla: 12.317 ± 0.143	0.952LeuCys: 0.952 ± 0.029	5.998LeuAsp: 5.998 ± 0.081	5.89LeuGlu: 5.89 ± 0.071	3.578LeuPhe: 3.578 ± 0.069	8.17LeuGly: 8.17 ± 0.087	1.909LeuHis: 1.909 ± 0.04	5.089LeuIle: 5.089 ± 0.086	3.594LeuLys: 3.594 ± 0.053	8.721LeuLeu: 8.721 ± 0.125	2.587LeuMet: 2.587 ± 0.05	2.832LeuAsn: 2.832 ± 0.051	5.466LeuPro: 5.466 ± 0.075	2.807LeuGln: 2.807 ± 0.057	6.956LeuArg: 6.956 ± 0.091	6.378LeuSer: 6.378 ± 0.086	5.671LeuThr: 5.671 ± 0.072	6.878LeuVal: 6.878 ± 0.085	1.27LeuTrp: 1.27 ± 0.038	1.979LeuTyr: 1.979 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	3.452MetAla: 3.452 ± 0.054	0.208MetCys: 0.208 ± 0.013	1.426MetAsp: 1.426 ± 0.034	1.487MetGlu: 1.487 ± 0.033	0.83MetPhe: 0.83 ± 0.026	2.257MetGly: 2.257 ± 0.045	0.506MetHis: 0.506 ± 0.02	1.467MetIle: 1.467 ± 0.038	1.166MetLys: 1.166 ± 0.032	2.571MetLeu: 2.571 ± 0.056	0.779MetMet: 0.779 ± 0.027	0.862MetAsn: 0.862 ± 0.027	1.476MetPro: 1.476 ± 0.04	0.986MetGln: 0.986 ± 0.03	1.925MetArg: 1.925 ± 0.038	1.775MetSer: 1.775 ± 0.04	1.986MetThr: 1.986 ± 0.046	1.943MetVal: 1.943 ± 0.039	0.254MetTrp: 0.254 ± 0.017	0.329MetTyr: 0.329 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.123AsnAla: 3.123 ± 0.053	0.297AsnCys: 0.297 ± 0.014	1.418AsnAsp: 1.418 ± 0.038	1.349AsnGlu: 1.349 ± 0.037	0.995AsnPhe: 0.995 ± 0.03	2.59AsnGly: 2.59 ± 0.052	0.564AsnHis: 0.564 ± 0.022	1.389AsnIle: 1.389 ± 0.039	0.735AsnLys: 0.735 ± 0.025	2.608AsnLeu: 2.608 ± 0.052	0.744AsnMet: 0.744 ± 0.029	0.663AsnAsn: 0.663 ± 0.025	1.955AsnPro: 1.955 ± 0.041	0.757AsnGln: 0.757 ± 0.027	1.92AsnArg: 1.92 ± 0.046	1.187AsnSer: 1.187 ± 0.032	1.34AsnThr: 1.34 ± 0.035	1.888AsnVal: 1.888 ± 0.04	0.475AsnTrp: 0.475 ± 0.02	0.725AsnTyr: 0.725 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	5.414ProAla: 5.414 ± 0.064	0.394ProCys: 0.394 ± 0.019	3.919ProAsp: 3.919 ± 0.058	4.624ProGlu: 4.624 ± 0.064	1.952ProPhe: 1.952 ± 0.042	4.614ProGly: 4.614 ± 0.061	1.098ProHis: 1.098 ± 0.033	2.259ProIle: 2.259 ± 0.047	1.754ProLys: 1.754 ± 0.046	4.555ProLeu: 4.555 ± 0.07	1.306ProMet: 1.306 ± 0.03	1.438ProAsn: 1.438 ± 0.038	2.276ProPro: 2.276 ± 0.05	1.654ProGln: 1.654 ± 0.036	2.777ProArg: 2.777 ± 0.056	2.454ProSer: 2.454 ± 0.047	2.347ProThr: 2.347 ± 0.043	4.386ProVal: 4.386 ± 0.066	0.703ProTrp: 0.703 ± 0.025	1.2ProTyr: 1.2 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	4.214GlnAla: 4.214 ± 0.064	0.224GlnCys: 0.224 ± 0.016	1.688GlnAsp: 1.688 ± 0.042	1.724GlnGlu: 1.724 ± 0.046	1.118GlnPhe: 1.118 ± 0.028	2.665GlnGly: 2.665 ± 0.055	0.582GlnHis: 0.582 ± 0.025	2.018GlnIle: 2.018 ± 0.046	1.208GlnLys: 1.208 ± 0.037	2.962GlnLeu: 2.962 ± 0.049	1.138GlnMet: 1.138 ± 0.032	0.887GlnAsn: 0.887 ± 0.031	1.665GlnPro: 1.665 ± 0.04	1.13GlnGln: 1.13 ± 0.034	2.198GlnArg: 2.198 ± 0.047	1.694GlnSer: 1.694 ± 0.039	1.65GlnThr: 1.65 ± 0.036	2.508GlnVal: 2.508 ± 0.042	0.393GlnTrp: 0.393 ± 0.016	0.614GlnTyr: 0.614 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	7.811ArgAla: 7.811 ± 0.09	0.541ArgCys: 0.541 ± 0.022	4.105ArgAsp: 4.105 ± 0.064	4.353ArgGlu: 4.353 ± 0.071	2.784ArgPhe: 2.784 ± 0.05	4.602ArgGly: 4.602 ± 0.063	1.619ArgHis: 1.619 ± 0.038	3.959ArgIle: 3.959 ± 0.058	2.604ArgLys: 2.604 ± 0.045	7.379ArgLeu: 7.379 ± 0.092	1.998ArgMet: 1.998 ± 0.043	1.897ArgAsn: 1.897 ± 0.04	3.372ArgPro: 3.372 ± 0.054	2.459ArgGln: 2.459 ± 0.054	5.039ArgArg: 5.039 ± 0.081	3.243ArgSer: 3.243 ± 0.057	3.032ArgThr: 3.032 ± 0.053	4.874ArgVal: 4.874 ± 0.059	0.975ArgTrp: 0.975 ± 0.03	1.609ArgTyr: 1.609 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	5.46SerAla: 5.46 ± 0.069	0.479SerCys: 0.479 ± 0.02	3.277SerAsp: 3.277 ± 0.059	3.11SerGlu: 3.11 ± 0.058	2.149SerPhe: 2.149 ± 0.047	5.245SerGly: 5.245 ± 0.076	1.104SerHis: 1.104 ± 0.034	2.309SerIle: 2.309 ± 0.052	1.677SerLys: 1.677 ± 0.04	4.834SerLeu: 4.834 ± 0.069	1.349SerMet: 1.349 ± 0.036	1.391SerAsn: 1.391 ± 0.038	2.56SerPro: 2.56 ± 0.054	1.599SerGln: 1.599 ± 0.04	3.32SerArg: 3.32 ± 0.071	2.424SerSer: 2.424 ± 0.048	2.418SerThr: 2.418 ± 0.042	3.833SerVal: 3.833 ± 0.057	0.702SerTrp: 0.702 ± 0.028	1.27SerTyr: 1.27 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	5.682ThrAla: 5.682 ± 0.081	0.536ThrCys: 0.536 ± 0.025	3.014ThrAsp: 3.014 ± 0.057	3.157ThrGlu: 3.157 ± 0.057	1.915ThrPhe: 1.915 ± 0.043	5.275ThrGly: 5.275 ± 0.066	1.168ThrHis: 1.168 ± 0.03	2.576ThrIle: 2.576 ± 0.051	1.487ThrLys: 1.487 ± 0.039	5.409ThrLeu: 5.409 ± 0.071	1.177ThrMet: 1.177 ± 0.031	1.248ThrAsn: 1.248 ± 0.032	3.171ThrPro: 3.171 ± 0.057	1.564ThrGln: 1.564 ± 0.035	3.451ThrArg: 3.451 ± 0.054	2.587ThrSer: 2.587 ± 0.04	2.582ThrThr: 2.582 ± 0.053	4.112ThrVal: 4.112 ± 0.06	0.644ThrTrp: 0.644 ± 0.026	1.281ThrTyr: 1.281 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	8.513ValAla: 8.513 ± 0.093	0.703ValCys: 0.703 ± 0.028	4.045ValAsp: 4.045 ± 0.067	4.988ValGlu: 4.988 ± 0.068	2.959ValPhe: 2.959 ± 0.056	5.493ValGly: 5.493 ± 0.072	1.431ValHis: 1.431 ± 0.039	4.218ValIle: 4.218 ± 0.059	2.322ValLys: 2.322 ± 0.047	7.477ValLeu: 7.477 ± 0.099	2.042ValMet: 2.042 ± 0.047	2.059ValAsn: 2.059 ± 0.048	3.62ValPro: 3.62 ± 0.058	2.219ValGln: 2.219 ± 0.042	4.447ValArg: 4.447 ± 0.066	4.305ValSer: 4.305 ± 0.068	4.439ValThr: 4.439 ± 0.059	5.753ValVal: 5.753 ± 0.088	1.014ValTrp: 1.014 ± 0.03	1.482ValTyr: 1.482 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.432TrpAla: 1.432 ± 0.038	0.153TrpCys: 0.153 ± 0.011	0.759TrpAsp: 0.759 ± 0.027	0.748TrpGlu: 0.748 ± 0.023	0.574TrpPhe: 0.574 ± 0.02	1.025TrpGly: 1.025 ± 0.033	0.359TrpHis: 0.359 ± 0.018	0.703TrpIle: 0.703 ± 0.022	0.523TrpLys: 0.523 ± 0.023	1.658TrpLeu: 1.658 ± 0.041	0.402TrpMet: 0.402 ± 0.022	0.474TrpAsn: 0.474 ± 0.024	0.682TrpPro: 0.682 ± 0.027	0.584TrpGln: 0.584 ± 0.027	1.134TrpArg: 1.134 ± 0.032	0.786TrpSer: 0.786 ± 0.029	0.777TrpThr: 0.777 ± 0.029	0.943TrpVal: 0.943 ± 0.032	0.221TrpTrp: 0.221 ± 0.014	0.299TrpTyr: 0.299 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.458TyrAla: 2.458 ± 0.042	0.278TyrCys: 0.278 ± 0.016	1.671TyrAsp: 1.671 ± 0.037	1.413TyrGlu: 1.413 ± 0.038	0.968TyrPhe: 0.968 ± 0.031	2.156TyrGly: 2.156 ± 0.041	0.575TyrHis: 0.575 ± 0.022	0.903TyrIle: 0.903 ± 0.029	0.67TyrLys: 0.67 ± 0.024	2.285TyrLeu: 2.285 ± 0.047	0.509TyrMet: 0.509 ± 0.021	0.603TyrAsn: 0.603 ± 0.025	1.13TyrPro: 1.13 ± 0.032	0.712TyrGln: 0.712 ± 0.021	1.668TyrArg: 1.668 ± 0.041	1.233TyrSer: 1.233 ± 0.037	1.085TyrThr: 1.085 ± 0.027	1.658TyrVal: 1.658 ± 0.037	0.374TyrTrp: 0.374 ± 0.018	0.639TyrTyr: 0.639 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3730 proteins (1179916 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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