Amino acid dipepetide frequency for Streptomyces lavendulae subsp. lavendulae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	24.283AlaAla: 24.283 ± 0.177	1.135AlaCys: 1.135 ± 0.023	8.603AlaAsp: 8.603 ± 0.08	9.043AlaGlu: 9.043 ± 0.095	3.709AlaPhe: 3.709 ± 0.052	14.78AlaGly: 14.78 ± 0.126	3.103AlaHis: 3.103 ± 0.041	3.113AlaIle: 3.113 ± 0.041	2.723AlaLys: 2.723 ± 0.044	15.658AlaLeu: 15.658 ± 0.125	2.486AlaMet: 2.486 ± 0.033	1.838AlaAsn: 1.838 ± 0.03	8.475AlaPro: 8.475 ± 0.091	3.692AlaGln: 3.692 ± 0.044	10.936AlaArg: 10.936 ± 0.093	5.912AlaSer: 5.912 ± 0.054	7.024AlaThr: 7.024 ± 0.058	12.965AlaVal: 12.965 ± 0.09	1.972AlaTrp: 1.972 ± 0.032	2.77AlaTyr: 2.77 ± 0.034	0.0AlaXaa: 0.0 ± 0.0
Cys	1.203CysAla: 1.203 ± 0.024	0.098CysCys: 0.098 ± 0.007	0.483CysAsp: 0.483 ± 0.016	0.4CysGlu: 0.4 ± 0.013	0.23CysPhe: 0.23 ± 0.01	0.986CysGly: 0.986 ± 0.025	0.186CysHis: 0.186 ± 0.01	0.147CysIle: 0.147 ± 0.007	0.117CysLys: 0.117 ± 0.008	0.762CysLeu: 0.762 ± 0.02	0.125CysMet: 0.125 ± 0.007	0.12CysAsn: 0.12 ± 0.008	0.493CysPro: 0.493 ± 0.016	0.156CysGln: 0.156 ± 0.008	0.615CysArg: 0.615 ± 0.016	0.431CysSer: 0.431 ± 0.016	0.509CysThr: 0.509 ± 0.015	0.682CysVal: 0.682 ± 0.017	0.134CysTrp: 0.134 ± 0.007	0.139CysTyr: 0.139 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.699AspAla: 7.699 ± 0.086	0.451AspCys: 0.451 ± 0.015	2.922AspAsp: 2.922 ± 0.035	3.532AspGlu: 3.532 ± 0.044	1.518AspPhe: 1.518 ± 0.023	6.474AspGly: 6.474 ± 0.069	1.401AspHis: 1.401 ± 0.027	1.6AspIle: 1.6 ± 0.034	1.063AspLys: 1.063 ± 0.029	6.04AspLeu: 6.04 ± 0.059	0.732AspMet: 0.732 ± 0.019	0.851AspAsn: 0.851 ± 0.021	4.771AspPro: 4.771 ± 0.045	1.368AspGln: 1.368 ± 0.024	5.042AspArg: 5.042 ± 0.051	2.357AspSer: 2.357 ± 0.034	3.062AspThr: 3.062 ± 0.033	4.323AspVal: 4.323 ± 0.047	1.037AspTrp: 1.037 ± 0.022	1.02AspTyr: 1.02 ± 0.022	0.0AspXaa: 0.0 ± 0.0
Glu	7.825GluAla: 7.825 ± 0.088	0.364GluCys: 0.364 ± 0.012	2.843GluAsp: 2.843 ± 0.04	3.597GluGlu: 3.597 ± 0.057	1.442GluPhe: 1.442 ± 0.024	4.556GluGly: 4.556 ± 0.053	1.502GluHis: 1.502 ± 0.024	2.066GluIle: 2.066 ± 0.032	1.246GluLys: 1.246 ± 0.027	6.806GluLeu: 6.806 ± 0.071	0.828GluMet: 0.828 ± 0.021	0.942GluAsn: 0.942 ± 0.019	3.355GluPro: 3.355 ± 0.045	2.06GluGln: 2.06 ± 0.031	5.511GluArg: 5.511 ± 0.056	2.396GluSer: 2.396 ± 0.035	2.724GluThr: 2.724 ± 0.036	4.48GluVal: 4.48 ± 0.047	0.736GluTrp: 0.736 ± 0.018	1.095GluTyr: 1.095 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	3.752PheAla: 3.752 ± 0.04	0.257PheCys: 0.257 ± 0.01	1.903PheAsp: 1.903 ± 0.035	1.423PheGlu: 1.423 ± 0.024	0.848PhePhe: 0.848 ± 0.02	3.002PheGly: 3.002 ± 0.036	0.625PheHis: 0.625 ± 0.017	0.66PheIle: 0.66 ± 0.017	0.483PheLys: 0.483 ± 0.015	2.566PheLeu: 2.566 ± 0.035	0.388PheMet: 0.388 ± 0.012	0.535PheAsn: 0.535 ± 0.015	1.457PhePro: 1.457 ± 0.022	0.633PheGln: 0.633 ± 0.012	1.866PheArg: 1.866 ± 0.027	1.414PheSer: 1.414 ± 0.023	1.954PheThr: 1.954 ± 0.03	2.142PheVal: 2.142 ± 0.028	0.403PheTrp: 0.403 ± 0.012	0.546PheTyr: 0.546 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	12.494GlyAla: 12.494 ± 0.109	0.889GlyCys: 0.889 ± 0.022	4.971GlyAsp: 4.971 ± 0.052	5.199GlyGlu: 5.199 ± 0.057	2.922GlyPhe: 2.922 ± 0.038	9.412GlyGly: 9.412 ± 0.099	2.418GlyHis: 2.418 ± 0.033	3.47GlyIle: 3.47 ± 0.04	2.278GlyLys: 2.278 ± 0.043	9.851GlyLeu: 9.851 ± 0.067	1.982GlyMet: 1.982 ± 0.03	1.708GlyAsn: 1.708 ± 0.031	6.188GlyPro: 6.188 ± 0.062	2.605GlyGln: 2.605 ± 0.042	8.345GlyArg: 8.345 ± 0.079	5.507GlySer: 5.507 ± 0.063	6.445GlyThr: 6.445 ± 0.066	7.441GlyVal: 7.441 ± 0.083	1.742GlyTrp: 1.742 ± 0.028	2.242GlyTyr: 2.242 ± 0.033	0.0GlyXaa: 0.0 ± 0.0
His	2.727HisAla: 2.727 ± 0.033	0.207HisCys: 0.207 ± 0.009	1.262HisAsp: 1.262 ± 0.026	1.19HisGlu: 1.19 ± 0.022	0.612HisPhe: 0.612 ± 0.017	2.444HisGly: 2.444 ± 0.034	0.709HisHis: 0.709 ± 0.02	0.596HisIle: 0.596 ± 0.016	0.334HisLys: 0.334 ± 0.013	2.431HisLeu: 2.431 ± 0.032	0.347HisMet: 0.347 ± 0.01	0.335HisAsn: 0.335 ± 0.014	1.987HisPro: 1.987 ± 0.032	0.576HisGln: 0.576 ± 0.016	2.123HisArg: 2.123 ± 0.032	0.995HisSer: 0.995 ± 0.021	1.372HisThr: 1.372 ± 0.026	1.7HisVal: 1.7 ± 0.026	0.392HisTrp: 0.392 ± 0.012	0.455HisTyr: 0.455 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.589IleAla: 4.589 ± 0.044	0.266IleCys: 0.266 ± 0.01	1.962IleAsp: 1.962 ± 0.027	1.852IleGlu: 1.852 ± 0.029	0.599IlePhe: 0.599 ± 0.017	3.436IleGly: 3.436 ± 0.048	0.567IleHis: 0.567 ± 0.014	0.735IleIle: 0.735 ± 0.02	0.677IleLys: 0.677 ± 0.017	2.212IleLeu: 2.212 ± 0.039	0.406IleMet: 0.406 ± 0.012	0.63IleAsn: 0.63 ± 0.018	1.649IlePro: 1.649 ± 0.032	0.667IleGln: 0.667 ± 0.016	2.168IleArg: 2.168 ± 0.035	1.543IleSer: 1.543 ± 0.025	2.067IleThr: 2.067 ± 0.028	2.445IleVal: 2.445 ± 0.039	0.338IleTrp: 0.338 ± 0.011	0.467IleTyr: 0.467 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	2.818LysAla: 2.818 ± 0.044	0.102LysCys: 0.102 ± 0.007	1.24LysAsp: 1.24 ± 0.026	1.112LysGlu: 1.112 ± 0.027	0.428LysPhe: 0.428 ± 0.014	1.728LysGly: 1.728 ± 0.033	0.394LysHis: 0.394 ± 0.013	0.806LysIle: 0.806 ± 0.02	0.749LysLys: 0.749 ± 0.026	1.806LysLeu: 1.806 ± 0.034	0.375LysMet: 0.375 ± 0.011	0.483LysAsn: 0.483 ± 0.016	1.315LysPro: 1.315 ± 0.028	0.65LysGln: 0.65 ± 0.018	1.295LysArg: 1.295 ± 0.024	0.995LysSer: 0.995 ± 0.021	1.216LysThr: 1.216 ± 0.027	1.762LysVal: 1.762 ± 0.032	0.243LysTrp: 0.243 ± 0.011	0.405LysTyr: 0.405 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	16.05LeuAla: 16.05 ± 0.112	0.895LeuCys: 0.895 ± 0.019	6.67LeuAsp: 6.67 ± 0.061	4.78LeuGlu: 4.78 ± 0.054	2.646LeuPhe: 2.646 ± 0.04	9.579LeuGly: 9.579 ± 0.066	2.339LeuHis: 2.339 ± 0.033	3.042LeuIle: 3.042 ± 0.045	1.856LeuLys: 1.856 ± 0.03	11.909LeuLeu: 11.909 ± 0.114	1.584LeuMet: 1.584 ± 0.024	1.55LeuAsn: 1.55 ± 0.03	6.88LeuPro: 6.88 ± 0.054	2.089LeuGln: 2.089 ± 0.033	8.853LeuArg: 8.853 ± 0.079	5.112LeuSer: 5.112 ± 0.045	6.888LeuThr: 6.888 ± 0.057	8.809LeuVal: 8.809 ± 0.073	1.353LeuTrp: 1.353 ± 0.026	1.835LeuTyr: 1.835 ± 0.03	0.0LeuXaa: 0.0 ± 0.0
Met	2.227MetAla: 2.227 ± 0.029	0.135MetCys: 0.135 ± 0.008	0.919MetAsp: 0.919 ± 0.022	0.756MetGlu: 0.756 ± 0.017	0.409MetPhe: 0.409 ± 0.014	1.306MetGly: 1.306 ± 0.026	0.315MetHis: 0.315 ± 0.01	0.637MetIle: 0.637 ± 0.018	0.401MetLys: 0.401 ± 0.013	1.642MetLeu: 1.642 ± 0.024	0.284MetMet: 0.284 ± 0.011	0.431MetAsn: 0.431 ± 0.013	1.06MetPro: 1.06 ± 0.018	0.397MetGln: 0.397 ± 0.013	1.372MetArg: 1.372 ± 0.024	1.283MetSer: 1.283 ± 0.025	1.473MetThr: 1.473 ± 0.029	1.205MetVal: 1.205 ± 0.024	0.216MetTrp: 0.216 ± 0.01	0.306MetTyr: 0.306 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.106AsnAla: 2.106 ± 0.033	0.157AsnCys: 0.157 ± 0.008	0.826AsnAsp: 0.826 ± 0.019	0.793AsnGlu: 0.793 ± 0.02	0.458AsnPhe: 0.458 ± 0.016	1.792AsnGly: 1.792 ± 0.034	0.368AsnHis: 0.368 ± 0.013	0.588AsnIle: 0.588 ± 0.018	0.37AsnLys: 0.37 ± 0.012	1.569AsnLeu: 1.569 ± 0.027	0.277AsnMet: 0.277 ± 0.011	0.383AsnAsn: 0.383 ± 0.016	1.313AsnPro: 1.313 ± 0.026	0.477AsnGln: 0.477 ± 0.014	1.22AsnArg: 1.22 ± 0.022	0.835AsnSer: 0.835 ± 0.02	1.057AsnThr: 1.057 ± 0.026	1.254AsnVal: 1.254 ± 0.027	0.262AsnTrp: 0.262 ± 0.011	0.333AsnTyr: 0.333 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	10.614ProAla: 10.614 ± 0.108	0.354ProCys: 0.354 ± 0.014	4.564ProAsp: 4.564 ± 0.053	4.427ProGlu: 4.427 ± 0.052	1.564ProPhe: 1.564 ± 0.031	7.617ProGly: 7.617 ± 0.078	1.396ProHis: 1.396 ± 0.023	1.132ProIle: 1.132 ± 0.021	1.13ProLys: 1.13 ± 0.026	5.663ProLeu: 5.663 ± 0.057	1.043ProMet: 1.043 ± 0.022	0.83ProAsn: 0.83 ± 0.018	3.935ProPro: 3.935 ± 0.067	1.869ProGln: 1.869 ± 0.034	4.251ProArg: 4.251 ± 0.049	3.167ProSer: 3.167 ± 0.043	3.142ProThr: 3.142 ± 0.039	5.819ProVal: 5.819 ± 0.054	0.968ProTrp: 0.968 ± 0.021	1.435ProTyr: 1.435 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	3.7GlnAla: 3.7 ± 0.053	0.166GlnCys: 0.166 ± 0.008	1.396GlnAsp: 1.396 ± 0.023	1.385GlnGlu: 1.385 ± 0.026	0.624GlnPhe: 0.624 ± 0.016	2.269GlnGly: 2.269 ± 0.037	0.569GlnHis: 0.569 ± 0.016	0.97GlnIle: 0.97 ± 0.02	0.565GlnLys: 0.565 ± 0.017	2.741GlnLeu: 2.741 ± 0.037	0.448GlnMet: 0.448 ± 0.015	0.491GlnAsn: 0.491 ± 0.015	1.621GlnPro: 1.621 ± 0.033	1.118GlnGln: 1.118 ± 0.036	2.212GlnArg: 2.212 ± 0.035	1.163GlnSer: 1.163 ± 0.024	1.234GlnThr: 1.234 ± 0.022	2.184GlnVal: 2.184 ± 0.028	0.465GlnTrp: 0.465 ± 0.014	0.554GlnTyr: 0.554 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	10.649ArgAla: 10.649 ± 0.09	0.589ArgCys: 0.589 ± 0.017	4.099ArgAsp: 4.099 ± 0.045	4.922ArgGlu: 4.922 ± 0.047	2.357ArgPhe: 2.357 ± 0.031	6.148ArgGly: 6.148 ± 0.063	2.109ArgHis: 2.109 ± 0.03	3.333ArgIle: 3.333 ± 0.046	1.49ArgLys: 1.49 ± 0.026	9.055ArgLeu: 9.055 ± 0.08	1.719ArgMet: 1.719 ± 0.026	1.297ArgAsn: 1.297 ± 0.027	5.45ArgPro: 5.45 ± 0.054	2.109ArgGln: 2.109 ± 0.034	7.816ArgArg: 7.816 ± 0.079	4.001ArgSer: 4.001 ± 0.041	5.559ArgThr: 5.559 ± 0.057	5.801ArgVal: 5.801 ± 0.056	1.364ArgTrp: 1.364 ± 0.025	1.76ArgTyr: 1.76 ± 0.028	0.0ArgXaa: 0.0 ± 0.0
Ser	6.854SerAla: 6.854 ± 0.07	0.42SerCys: 0.42 ± 0.013	2.407SerAsp: 2.407 ± 0.035	2.229SerGlu: 2.229 ± 0.032	1.506SerPhe: 1.506 ± 0.025	5.95SerGly: 5.95 ± 0.055	0.964SerHis: 0.964 ± 0.024	1.277SerIle: 1.277 ± 0.027	0.933SerLys: 0.933 ± 0.021	4.735SerLeu: 4.735 ± 0.05	0.994SerMet: 0.994 ± 0.018	0.797SerAsn: 0.797 ± 0.019	3.238SerPro: 3.238 ± 0.038	1.121SerGln: 1.121 ± 0.022	3.59SerArg: 3.59 ± 0.038	2.567SerSer: 2.567 ± 0.041	2.794SerThr: 2.794 ± 0.037	4.134SerVal: 4.134 ± 0.044	0.899SerTrp: 0.899 ± 0.019	1.145SerTyr: 1.145 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	9.434ThrAla: 9.434 ± 0.065	0.423ThrCys: 0.423 ± 0.013	3.382ThrAsp: 3.382 ± 0.043	3.074ThrGlu: 3.074 ± 0.037	1.479ThrPhe: 1.479 ± 0.025	7.077ThrGly: 7.077 ± 0.062	1.144ThrHis: 1.144 ± 0.025	1.479ThrIle: 1.479 ± 0.026	1.078ThrLys: 1.078 ± 0.024	5.67ThrLeu: 5.67 ± 0.05	0.851ThrMet: 0.851 ± 0.02	0.88ThrAsn: 0.88 ± 0.02	4.338ThrPro: 4.338 ± 0.057	1.232ThrGln: 1.232 ± 0.023	3.889ThrArg: 3.889 ± 0.042	2.782ThrSer: 2.782 ± 0.034	3.666ThrThr: 3.666 ± 0.049	5.899ThrVal: 5.899 ± 0.061	0.859ThrTrp: 0.859 ± 0.021	1.242ThrTyr: 1.242 ± 0.024	0.0ThrXaa: 0.0 ± 0.0
Val	10.619ValAla: 10.619 ± 0.08	0.771ValCys: 0.771 ± 0.019	4.663ValAsp: 4.663 ± 0.047	4.629ValGlu: 4.629 ± 0.05	2.39ValPhe: 2.39 ± 0.036	6.2ValGly: 6.2 ± 0.06	1.945ValHis: 1.945 ± 0.03	2.687ValIle: 2.687 ± 0.035	1.691ValLys: 1.691 ± 0.032	9.797ValLeu: 9.797 ± 0.081	1.38ValMet: 1.38 ± 0.025	1.589ValAsn: 1.589 ± 0.027	5.529ValPro: 5.529 ± 0.052	1.922ValGln: 1.922 ± 0.028	7.378ValArg: 7.378 ± 0.062	4.277ValSer: 4.277 ± 0.045	5.512ValThr: 5.512 ± 0.06	7.507ValVal: 7.507 ± 0.068	1.144ValTrp: 1.144 ± 0.021	1.503ValTyr: 1.503 ± 0.026	0.0ValXaa: 0.0 ± 0.0
Trp	1.715TrpAla: 1.715 ± 0.027	0.166TrpCys: 0.166 ± 0.008	0.819TrpAsp: 0.819 ± 0.021	0.766TrpGlu: 0.766 ± 0.017	0.505TrpPhe: 0.505 ± 0.014	1.086TrpGly: 1.086 ± 0.025	0.367TrpHis: 0.367 ± 0.014	0.549TrpIle: 0.549 ± 0.015	0.373TrpLys: 0.373 ± 0.012	1.773TrpLeu: 1.773 ± 0.03	0.289TrpMet: 0.289 ± 0.011	0.411TrpAsn: 0.411 ± 0.013	0.805TrpPro: 0.805 ± 0.02	0.598TrpGln: 0.598 ± 0.016	1.298TrpArg: 1.298 ± 0.023	0.956TrpSer: 0.956 ± 0.022	1.078TrpThr: 1.078 ± 0.021	0.991TrpVal: 0.991 ± 0.018	0.351TrpTrp: 0.351 ± 0.013	0.35TrpTyr: 0.35 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.861TyrAla: 2.861 ± 0.031	0.169TyrCys: 0.169 ± 0.007	1.331TyrAsp: 1.331 ± 0.027	1.265TyrGlu: 1.265 ± 0.021	0.612TyrPhe: 0.612 ± 0.016	2.27TyrGly: 2.27 ± 0.032	0.372TyrHis: 0.372 ± 0.013	0.387TyrIle: 0.387 ± 0.012	0.363TyrLys: 0.363 ± 0.013	2.032TyrLeu: 2.032 ± 0.03	0.236TyrMet: 0.236 ± 0.01	0.339TyrAsn: 0.339 ± 0.012	1.059TyrPro: 1.059 ± 0.023	0.533TyrGln: 0.533 ± 0.016	1.847TyrArg: 1.847 ± 0.032	0.864TyrSer: 0.864 ± 0.022	1.103TyrThr: 1.103 ± 0.02	1.59TyrVal: 1.59 ± 0.027	0.368TyrTrp: 0.368 ± 0.012	0.406TyrTyr: 0.406 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7724 proteins (2527622 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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