Amino acid dipepetide frequency for Tenacibaculum sp. MAR_2010_89

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	2.94AlaAla: 2.94 ± 0.084	0.488AlaCys: 0.488 ± 0.025	2.514AlaAsp: 2.514 ± 0.053	2.892AlaGlu: 2.892 ± 0.056	2.885AlaPhe: 2.885 ± 0.052	3.482AlaGly: 3.482 ± 0.109	0.894AlaHis: 0.894 ± 0.029	5.089AlaIle: 5.089 ± 0.079	4.669AlaLys: 4.669 ± 0.09	5.046AlaLeu: 5.046 ± 0.077	1.16AlaMet: 1.16 ± 0.035	3.261AlaAsn: 3.261 ± 0.06	1.611AlaPro: 1.611 ± 0.046	1.818AlaGln: 1.818 ± 0.044	1.617AlaArg: 1.617 ± 0.045	4.02AlaSer: 4.02 ± 0.09	3.482AlaThr: 3.482 ± 0.104	3.406AlaVal: 3.406 ± 0.084	0.471AlaTrp: 0.471 ± 0.02	2.113AlaTyr: 2.113 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.388CysAla: 0.388 ± 0.016	0.105CysCys: 0.105 ± 0.01	0.417CysAsp: 0.417 ± 0.036	0.433CysGlu: 0.433 ± 0.021	0.43CysPhe: 0.43 ± 0.019	0.589CysGly: 0.589 ± 0.026	0.153CysHis: 0.153 ± 0.013	0.617CysIle: 0.617 ± 0.021	0.598CysLys: 0.598 ± 0.026	0.602CysLeu: 0.602 ± 0.02	0.143CysMet: 0.143 ± 0.011	0.551CysAsn: 0.551 ± 0.034	0.31CysPro: 0.31 ± 0.028	0.191CysGln: 0.191 ± 0.017	0.179CysArg: 0.179 ± 0.012	0.646CysSer: 0.646 ± 0.046	0.413CysThr: 0.413 ± 0.027	0.429CysVal: 0.429 ± 0.019	0.071CysTrp: 0.071 ± 0.008	0.326CysTyr: 0.326 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	3.015AspAla: 3.015 ± 0.062	0.395AspCys: 0.395 ± 0.021	2.508AspAsp: 2.508 ± 0.055	3.296AspGlu: 3.296 ± 0.062	3.352AspPhe: 3.352 ± 0.054	3.339AspGly: 3.339 ± 0.136	0.661AspHis: 0.661 ± 0.023	4.326AspIle: 4.326 ± 0.068	4.37AspLys: 4.37 ± 0.072	4.716AspLeu: 4.716 ± 0.085	0.858AspMet: 0.858 ± 0.027	3.171AspAsn: 3.171 ± 0.065	1.27AspPro: 1.27 ± 0.039	1.093AspGln: 1.093 ± 0.026	1.492AspArg: 1.492 ± 0.04	3.256AspSer: 3.256 ± 0.098	2.837AspThr: 2.837 ± 0.087	3.506AspVal: 3.506 ± 0.064	0.588AspTrp: 0.588 ± 0.022	2.501AspTyr: 2.501 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	3.668GluAla: 3.668 ± 0.075	0.358GluCys: 0.358 ± 0.016	3.06GluAsp: 3.06 ± 0.059	4.917GluGlu: 4.917 ± 0.093	2.944GluPhe: 2.944 ± 0.055	3.51GluGly: 3.51 ± 0.055	1.0GluHis: 1.0 ± 0.033	5.643GluIle: 5.643 ± 0.077	6.547GluLys: 6.547 ± 0.1	6.431GluLeu: 6.431 ± 0.102	1.358GluMet: 1.358 ± 0.043	5.024GluAsn: 5.024 ± 0.064	1.298GluPro: 1.298 ± 0.04	1.972GluGln: 1.972 ± 0.047	2.11GluArg: 2.11 ± 0.051	3.213GluSer: 3.213 ± 0.059	3.315GluThr: 3.315 ± 0.055	4.406GluVal: 4.406 ± 0.071	0.534GluTrp: 0.534 ± 0.02	2.539GluTyr: 2.539 ± 0.044	0.0GluXaa: 0.0 ± 0.0
Phe	2.365PheAla: 2.365 ± 0.054	0.449PheCys: 0.449 ± 0.02	2.96PheAsp: 2.96 ± 0.05	3.149PheGlu: 3.149 ± 0.047	3.053PhePhe: 3.053 ± 0.064	3.341PheGly: 3.341 ± 0.064	0.797PheHis: 0.797 ± 0.025	4.502PheIle: 4.502 ± 0.075	4.478PheLys: 4.478 ± 0.076	5.097PheLeu: 5.097 ± 0.097	1.003PheMet: 1.003 ± 0.033	3.845PheAsn: 3.845 ± 0.062	1.528PhePro: 1.528 ± 0.039	1.408PheGln: 1.408 ± 0.036	1.411PheArg: 1.411 ± 0.032	4.38PheSer: 4.38 ± 0.064	3.311PheThr: 3.311 ± 0.064	2.807PheVal: 2.807 ± 0.052	0.603PheTrp: 0.603 ± 0.024	2.276PheTyr: 2.276 ± 0.05	0.0PheXaa: 0.0 ± 0.0
Gly	3.625GlyAla: 3.625 ± 0.072	0.579GlyCys: 0.579 ± 0.041	3.048GlyAsp: 3.048 ± 0.081	3.3GlyGlu: 3.3 ± 0.061	3.418GlyPhe: 3.418 ± 0.059	4.479GlyGly: 4.479 ± 0.132	0.978GlyHis: 0.978 ± 0.034	5.314GlyIle: 5.314 ± 0.066	5.224GlyLys: 5.224 ± 0.071	5.217GlyLeu: 5.217 ± 0.074	1.337GlyMet: 1.337 ± 0.034	3.976GlyAsn: 3.976 ± 0.086	1.075GlyPro: 1.075 ± 0.031	1.521GlyGln: 1.521 ± 0.044	1.875GlyArg: 1.875 ± 0.048	3.881GlySer: 3.881 ± 0.12	4.152GlyThr: 4.152 ± 0.194	4.512GlyVal: 4.512 ± 0.099	0.678GlyTrp: 0.678 ± 0.027	2.773GlyTyr: 2.773 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	0.809HisAla: 0.809 ± 0.027	0.158HisCys: 0.158 ± 0.012	0.728HisAsp: 0.728 ± 0.025	0.924HisGlu: 0.924 ± 0.032	1.037HisPhe: 1.037 ± 0.033	0.897HisGly: 0.897 ± 0.033	0.444HisHis: 0.444 ± 0.022	1.387HisIle: 1.387 ± 0.036	1.405HisLys: 1.405 ± 0.034	1.703HisLeu: 1.703 ± 0.045	0.259HisMet: 0.259 ± 0.015	0.992HisAsn: 0.992 ± 0.029	0.767HisPro: 0.767 ± 0.031	0.689HisGln: 0.689 ± 0.025	0.574HisArg: 0.574 ± 0.024	1.065HisSer: 1.065 ± 0.034	0.963HisThr: 0.963 ± 0.031	0.833HisVal: 0.833 ± 0.025	0.186HisTrp: 0.186 ± 0.013	0.759HisTyr: 0.759 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.184IleAla: 5.184 ± 0.081	0.634IleCys: 0.634 ± 0.025	5.127IleAsp: 5.127 ± 0.078	6.008IleGlu: 6.008 ± 0.087	3.769IlePhe: 3.769 ± 0.068	5.127IleGly: 5.127 ± 0.082	1.423IleHis: 1.423 ± 0.038	7.058IleIle: 7.058 ± 0.112	7.557IleLys: 7.557 ± 0.111	7.292IleLeu: 7.292 ± 0.117	1.308IleMet: 1.308 ± 0.043	6.177IleAsn: 6.177 ± 0.077	3.214IlePro: 3.214 ± 0.062	2.692IleGln: 2.692 ± 0.047	2.397IleArg: 2.397 ± 0.047	6.377IleSer: 6.377 ± 0.078	5.573IleThr: 5.573 ± 0.105	4.81IleVal: 4.81 ± 0.069	0.711IleTrp: 0.711 ± 0.028	3.005IleTyr: 3.005 ± 0.056	0.0IleXaa: 0.0 ± 0.0
Lys	4.918LysAla: 4.918 ± 0.086	0.412LysCys: 0.412 ± 0.02	4.439LysAsp: 4.439 ± 0.083	7.811LysGlu: 7.811 ± 0.116	3.271LysPhe: 3.271 ± 0.067	5.163LysGly: 5.163 ± 0.07	1.624LysHis: 1.624 ± 0.039	7.695LysIle: 7.695 ± 0.112	9.919LysLys: 9.919 ± 0.161	7.758LysLeu: 7.758 ± 0.101	2.092LysMet: 2.092 ± 0.05	7.192LysAsn: 7.192 ± 0.095	2.365LysPro: 2.365 ± 0.053	3.138LysGln: 3.138 ± 0.061	3.121LysArg: 3.121 ± 0.067	5.472LysSer: 5.472 ± 0.085	5.391LysThr: 5.391 ± 0.075	5.343LysVal: 5.343 ± 0.077	0.887LysTrp: 0.887 ± 0.028	3.646LysTyr: 3.646 ± 0.057	0.0LysXaa: 0.0 ± 0.0
Leu	4.928LeuAla: 4.928 ± 0.069	0.666LeuCys: 0.666 ± 0.026	4.56LeuAsp: 4.56 ± 0.08	5.875LeuGlu: 5.875 ± 0.099	5.113LeuPhe: 5.113 ± 0.092	5.583LeuGly: 5.583 ± 0.071	1.543LeuHis: 1.543 ± 0.042	7.551LeuIle: 7.551 ± 0.12	8.88LeuLys: 8.88 ± 0.116	9.012LeuLeu: 9.012 ± 0.134	1.759LeuMet: 1.759 ± 0.042	6.302LeuAsn: 6.302 ± 0.086	3.303LeuPro: 3.303 ± 0.055	3.076LeuGln: 3.076 ± 0.062	2.701LeuArg: 2.701 ± 0.056	6.757LeuSer: 6.757 ± 0.109	5.463LeuThr: 5.463 ± 0.098	5.132LeuVal: 5.132 ± 0.087	0.735LeuTrp: 0.735 ± 0.024	3.216LeuTyr: 3.216 ± 0.061	0.0LeuXaa: 0.0 ± 0.0
Met	1.196MetAla: 1.196 ± 0.04	0.142MetCys: 0.142 ± 0.011	0.866MetAsp: 0.866 ± 0.03	1.027MetGlu: 1.027 ± 0.031	0.872MetPhe: 0.872 ± 0.029	1.1MetGly: 1.1 ± 0.036	0.351MetHis: 0.351 ± 0.018	1.504MetIle: 1.504 ± 0.045	2.142MetLys: 2.142 ± 0.044	1.779MetLeu: 1.779 ± 0.045	0.511MetMet: 0.511 ± 0.023	1.417MetAsn: 1.417 ± 0.038	0.686MetPro: 0.686 ± 0.026	0.645MetGln: 0.645 ± 0.025	0.758MetArg: 0.758 ± 0.025	1.29MetSer: 1.29 ± 0.036	0.957MetThr: 0.957 ± 0.035	1.128MetVal: 1.128 ± 0.035	0.154MetTrp: 0.154 ± 0.012	0.699MetTyr: 0.699 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	3.428AsnAla: 3.428 ± 0.061	0.518AsnCys: 0.518 ± 0.026	3.68AsnAsp: 3.68 ± 0.097	4.344AsnGlu: 4.344 ± 0.071	3.481AsnPhe: 3.481 ± 0.065	4.383AsnGly: 4.383 ± 0.131	1.154AsnHis: 1.154 ± 0.032	5.819AsnIle: 5.819 ± 0.081	6.337AsnLys: 6.337 ± 0.093	6.019AsnLeu: 6.019 ± 0.083	1.248AsnMet: 1.248 ± 0.028	5.344AsnAsn: 5.344 ± 0.093	2.618AsnPro: 2.618 ± 0.055	2.411AsnGln: 2.411 ± 0.049	2.156AsnArg: 2.156 ± 0.05	4.878AsnSer: 4.878 ± 0.087	4.484AsnThr: 4.484 ± 0.095	3.902AsnVal: 3.902 ± 0.08	0.828AsnTrp: 0.828 ± 0.028	3.477AsnTyr: 3.477 ± 0.062	0.0AsnXaa: 0.0 ± 0.0
Pro	1.472ProAla: 1.472 ± 0.06	0.213ProCys: 0.213 ± 0.014	1.633ProAsp: 1.633 ± 0.044	2.19ProGlu: 2.19 ± 0.048	1.773ProPhe: 1.773 ± 0.031	1.506ProGly: 1.506 ± 0.043	0.557ProHis: 0.557 ± 0.023	2.714ProIle: 2.714 ± 0.057	2.711ProLys: 2.711 ± 0.059	2.61ProLeu: 2.61 ± 0.052	0.596ProMet: 0.596 ± 0.025	2.289ProAsn: 2.289 ± 0.05	0.719ProPro: 0.719 ± 0.028	0.93ProGln: 0.93 ± 0.028	0.757ProArg: 0.757 ± 0.024	2.26ProSer: 2.26 ± 0.067	1.938ProThr: 1.938 ± 0.047	2.05ProVal: 2.05 ± 0.072	0.3ProTrp: 0.3 ± 0.018	1.291ProTyr: 1.291 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	1.527GlnAla: 1.527 ± 0.04	0.177GlnCys: 0.177 ± 0.012	1.241GlnAsp: 1.241 ± 0.038	2.184GlnGlu: 2.184 ± 0.046	1.6GlnPhe: 1.6 ± 0.036	1.579GlnGly: 1.579 ± 0.041	0.553GlnHis: 0.553 ± 0.023	2.558GlnIle: 2.558 ± 0.054	3.168GlnLys: 3.168 ± 0.066	3.292GlnLeu: 3.292 ± 0.063	0.659GlnMet: 0.659 ± 0.024	2.163GlnAsn: 2.163 ± 0.048	0.908GlnPro: 0.908 ± 0.028	1.35GlnGln: 1.35 ± 0.036	1.077GlnArg: 1.077 ± 0.031	1.826GlnSer: 1.826 ± 0.041	1.768GlnThr: 1.768 ± 0.046	1.8GlnVal: 1.8 ± 0.033	0.294GlnTrp: 0.294 ± 0.015	1.29GlnTyr: 1.29 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	1.622ArgAla: 1.622 ± 0.042	0.174ArgCys: 0.174 ± 0.016	1.437ArgAsp: 1.437 ± 0.033	1.907ArgGlu: 1.907 ± 0.044	1.754ArgPhe: 1.754 ± 0.04	1.746ArgGly: 1.746 ± 0.043	0.519ArgHis: 0.519 ± 0.022	2.727ArgIle: 2.727 ± 0.052	2.989ArgLys: 2.989 ± 0.062	2.771ArgLeu: 2.771 ± 0.056	0.76ArgMet: 0.76 ± 0.024	2.067ArgAsn: 2.067 ± 0.051	0.842ArgPro: 0.842 ± 0.027	0.863ArgGln: 0.863 ± 0.027	1.137ArgArg: 1.137 ± 0.04	1.768ArgSer: 1.768 ± 0.047	1.619ArgThr: 1.619 ± 0.037	2.022ArgVal: 2.022 ± 0.037	0.316ArgTrp: 0.316 ± 0.016	1.333ArgTyr: 1.333 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	3.186SerAla: 3.186 ± 0.081	0.732SerCys: 0.732 ± 0.048	3.376SerAsp: 3.376 ± 0.06	3.96SerGlu: 3.96 ± 0.071	4.432SerPhe: 4.432 ± 0.067	4.469SerGly: 4.469 ± 0.11	1.02SerHis: 1.02 ± 0.035	6.363SerIle: 6.363 ± 0.096	6.191SerLys: 6.191 ± 0.092	6.698SerLeu: 6.698 ± 0.098	1.24SerMet: 1.24 ± 0.036	4.693SerAsn: 4.693 ± 0.096	2.017SerPro: 2.017 ± 0.05	1.989SerGln: 1.989 ± 0.041	1.849SerArg: 1.849 ± 0.036	5.196SerSer: 5.196 ± 0.127	4.106SerThr: 4.106 ± 0.119	4.095SerVal: 4.095 ± 0.073	0.756SerTrp: 0.756 ± 0.029	3.067SerTyr: 3.067 ± 0.064	0.0SerXaa: 0.0 ± 0.0
Thr	3.293ThrAla: 3.293 ± 0.125	0.399ThrCys: 0.399 ± 0.027	3.071ThrAsp: 3.071 ± 0.073	3.245ThrGlu: 3.245 ± 0.053	3.072ThrPhe: 3.072 ± 0.059	4.034ThrGly: 4.034 ± 0.147	1.035ThrHis: 1.035 ± 0.032	5.817ThrIle: 5.817 ± 0.098	4.877ThrLys: 4.877 ± 0.078	5.302ThrLeu: 5.302 ± 0.08	0.891ThrMet: 0.891 ± 0.031	4.309ThrAsn: 4.309 ± 0.119	2.479ThrPro: 2.479 ± 0.079	1.874ThrGln: 1.874 ± 0.05	1.571ThrArg: 1.571 ± 0.043	4.713ThrSer: 4.713 ± 0.117	4.05ThrThr: 4.05 ± 0.158	3.918ThrVal: 3.918 ± 0.164	0.558ThrTrp: 0.558 ± 0.021	2.578ThrTyr: 2.578 ± 0.087	0.0ThrXaa: 0.0 ± 0.0
Val	3.649ValAla: 3.649 ± 0.058	0.511ValCys: 0.511 ± 0.028	3.306ValAsp: 3.306 ± 0.085	3.562ValGlu: 3.562 ± 0.057	3.481ValPhe: 3.481 ± 0.063	3.617ValGly: 3.617 ± 0.073	0.916ValHis: 0.916 ± 0.028	4.932ValIle: 4.932 ± 0.066	4.813ValLys: 4.813 ± 0.077	6.051ValLeu: 6.051 ± 0.092	1.112ValMet: 1.112 ± 0.032	3.997ValAsn: 3.997 ± 0.079	1.915ValPro: 1.915 ± 0.045	1.535ValGln: 1.535 ± 0.038	1.789ValArg: 1.789 ± 0.041	4.775ValSer: 4.775 ± 0.093	4.014ValThr: 4.014 ± 0.165	4.099ValVal: 4.099 ± 0.114	0.577ValTrp: 0.577 ± 0.022	2.362ValTyr: 2.362 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	0.527TrpAla: 0.527 ± 0.023	0.088TrpCys: 0.088 ± 0.008	0.491TrpAsp: 0.491 ± 0.019	0.602TrpGlu: 0.602 ± 0.025	0.575TrpPhe: 0.575 ± 0.025	0.604TrpGly: 0.604 ± 0.024	0.204TrpHis: 0.204 ± 0.013	0.734TrpIle: 0.734 ± 0.028	0.886TrpLys: 0.886 ± 0.028	0.974TrpLeu: 0.974 ± 0.031	0.256TrpMet: 0.256 ± 0.015	0.737TrpAsn: 0.737 ± 0.025	0.164TrpPro: 0.164 ± 0.014	0.344TrpGln: 0.344 ± 0.016	0.355TrpArg: 0.355 ± 0.019	0.701TrpSer: 0.701 ± 0.027	0.479TrpThr: 0.479 ± 0.021	0.581TrpVal: 0.581 ± 0.022	0.131TrpTrp: 0.131 ± 0.011	0.413TrpTyr: 0.413 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.117TyrAla: 2.117 ± 0.045	0.391TyrCys: 0.391 ± 0.02	2.091TyrAsp: 2.091 ± 0.046	2.222TyrGlu: 2.222 ± 0.043	2.454TyrPhe: 2.454 ± 0.053	2.414TyrGly: 2.414 ± 0.047	0.753TyrHis: 0.753 ± 0.024	3.094TyrIle: 3.094 ± 0.057	3.895TyrLys: 3.895 ± 0.071	3.785TyrLeu: 3.785 ± 0.062	0.674TyrMet: 0.674 ± 0.027	2.999TyrAsn: 2.999 ± 0.058	1.419TyrPro: 1.419 ± 0.039	1.473TyrGln: 1.473 ± 0.038	1.45TyrArg: 1.45 ± 0.037	2.961TyrSer: 2.961 ± 0.071	2.77TyrThr: 2.77 ± 0.111	2.234TyrVal: 2.234 ± 0.053	0.469TyrTrp: 0.469 ± 0.019	1.913TyrTyr: 1.913 ± 0.039	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3597 proteins (1239690 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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