Amino acid dipepetide frequency for Thermobacillus composti (strain DSM 18247 / JCM 13945 / KWC4)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.315AlaAla: 14.315 ± 0.203
0.909AlaCys: 0.909 ± 0.03
5.773AlaAsp: 5.773 ± 0.084
7.946AlaGlu: 7.946 ± 0.105
3.712AlaPhe: 3.712 ± 0.062
9.635AlaGly: 9.635 ± 0.117
1.697AlaHis: 1.697 ± 0.045
5.306AlaIle: 5.306 ± 0.065
3.886AlaLys: 3.886 ± 0.059
10.059AlaLeu: 10.059 ± 0.113
2.72AlaMet: 2.72 ± 0.046
2.409AlaAsn: 2.409 ± 0.047
3.421AlaPro: 3.421 ± 0.069
2.6AlaGln: 2.6 ± 0.044
6.097AlaArg: 6.097 ± 0.076
5.066AlaSer: 5.066 ± 0.077
3.21AlaThr: 3.21 ± 0.062
8.426AlaVal: 8.426 ± 0.12
1.303AlaTrp: 1.303 ± 0.034
2.838AlaTyr: 2.838 ± 0.051
0.0AlaXaa: 0.0 ± 0.0
Cys
0.745CysAla: 0.745 ± 0.028
0.134CysCys: 0.134 ± 0.011
0.403CysAsp: 0.403 ± 0.019
0.471CysGlu: 0.471 ± 0.022
0.277CysPhe: 0.277 ± 0.015
0.949CysGly: 0.949 ± 0.034
0.183CysHis: 0.183 ± 0.012
0.425CysIle: 0.425 ± 0.017
0.24CysLys: 0.24 ± 0.014
0.772CysLeu: 0.772 ± 0.027
0.218CysMet: 0.218 ± 0.012
0.249CysAsn: 0.249 ± 0.015
0.425CysPro: 0.425 ± 0.02
0.179CysGln: 0.179 ± 0.012
0.673CysArg: 0.673 ± 0.025
0.468CysSer: 0.468 ± 0.018
0.412CysThr: 0.412 ± 0.021
0.498CysVal: 0.498 ± 0.02
0.103CysTrp: 0.103 ± 0.009
0.232CysTyr: 0.232 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
5.315AspAla: 5.315 ± 0.079
0.396AspCys: 0.396 ± 0.021
2.846AspAsp: 2.846 ± 0.054
4.282AspGlu: 4.282 ± 0.071
1.932AspPhe: 1.932 ± 0.041
5.034AspGly: 5.034 ± 0.081
1.061AspHis: 1.061 ± 0.03
3.215AspIle: 3.215 ± 0.055
2.095AspLys: 2.095 ± 0.048
4.989AspLeu: 4.989 ± 0.067
1.21AspMet: 1.21 ± 0.032
1.46AspAsn: 1.46 ± 0.039
2.99AspPro: 2.99 ± 0.046
1.431AspGln: 1.431 ± 0.04
4.117AspArg: 4.117 ± 0.071
2.361AspSer: 2.361 ± 0.049
2.196AspThr: 2.196 ± 0.051
3.675AspVal: 3.675 ± 0.052
0.974AspTrp: 0.974 ± 0.03
1.872AspTyr: 1.872 ± 0.041
0.0AspXaa: 0.0 ± 0.0
Glu
8.065GluAla: 8.065 ± 0.113
0.398GluCys: 0.398 ± 0.018
3.284GluAsp: 3.284 ± 0.051
5.296GluGlu: 5.296 ± 0.088
1.996GluPhe: 1.996 ± 0.039
4.692GluGly: 4.692 ± 0.069
1.405GluHis: 1.405 ± 0.038
4.099GluIle: 4.099 ± 0.06
3.131GluLys: 3.131 ± 0.069
7.496GluLeu: 7.496 ± 0.103
1.858GluMet: 1.858 ± 0.04
2.047GluAsn: 2.047 ± 0.044
3.097GluPro: 3.097 ± 0.058
3.09GluGln: 3.09 ± 0.062
6.163GluArg: 6.163 ± 0.094
3.297GluSer: 3.297 ± 0.045
3.783GluThr: 3.783 ± 0.062
4.082GluVal: 4.082 ± 0.067
1.123GluTrp: 1.123 ± 0.036
1.969GluTyr: 1.969 ± 0.047
0.0GluXaa: 0.0 ± 0.0
Phe
3.769PheAla: 3.769 ± 0.058
0.349PheCys: 0.349 ± 0.018
2.37PheAsp: 2.37 ± 0.05
2.51PheGlu: 2.51 ± 0.046
1.679PhePhe: 1.679 ± 0.045
3.413PheGly: 3.413 ± 0.055
0.829PheHis: 0.829 ± 0.028
2.331PheIle: 2.331 ± 0.052
1.505PheLys: 1.505 ± 0.035
3.589PheLeu: 3.589 ± 0.065
0.961PheMet: 0.961 ± 0.026
1.182PheAsn: 1.182 ± 0.034
1.535PhePro: 1.535 ± 0.033
0.992PheGln: 0.992 ± 0.032
2.802PheArg: 2.802 ± 0.045
2.074PheSer: 2.074 ± 0.043
2.062PheThr: 2.062 ± 0.044
2.935PheVal: 2.935 ± 0.051
0.578PheTrp: 0.578 ± 0.02
1.275PheTyr: 1.275 ± 0.031
0.0PheXaa: 0.0 ± 0.0
Gly
7.013GlyAla: 7.013 ± 0.097
0.844GlyCys: 0.844 ± 0.027
3.807GlyAsp: 3.807 ± 0.066
5.378GlyGlu: 5.378 ± 0.078
3.272GlyPhe: 3.272 ± 0.058
7.051GlyGly: 7.051 ± 0.104
1.575GlyHis: 1.575 ± 0.04
5.461GlyIle: 5.461 ± 0.076
4.137GlyLys: 4.137 ± 0.06
7.663GlyLeu: 7.663 ± 0.093
2.562GlyMet: 2.562 ± 0.054
2.371GlyAsn: 2.371 ± 0.053
2.634GlyPro: 2.634 ± 0.05
2.32GlyGln: 2.32 ± 0.048
5.884GlyArg: 5.884 ± 0.086
4.605GlySer: 4.605 ± 0.075
4.335GlyThr: 4.335 ± 0.062
5.6GlyVal: 5.6 ± 0.076
1.366GlyTrp: 1.366 ± 0.036
2.867GlyTyr: 2.867 ± 0.047
0.0GlyXaa: 0.0 ± 0.0
His
1.987HisAla: 1.987 ± 0.039
0.206HisCys: 0.206 ± 0.012
1.069HisAsp: 1.069 ± 0.029
1.307HisGlu: 1.307 ± 0.033
0.916HisPhe: 0.916 ± 0.027
1.622HisGly: 1.622 ± 0.039
0.584HisHis: 0.584 ± 0.026
1.1HisIle: 1.1 ± 0.029
0.68HisLys: 0.68 ± 0.024
2.072HisLeu: 2.072 ± 0.056
0.454HisMet: 0.454 ± 0.02
0.545HisAsn: 0.545 ± 0.022
1.427HisPro: 1.427 ± 0.038
0.623HisGln: 0.623 ± 0.022
1.385HisArg: 1.385 ± 0.037
0.936HisSer: 0.936 ± 0.029
0.911HisThr: 0.911 ± 0.028
1.539HisVal: 1.539 ± 0.034
0.308HisTrp: 0.308 ± 0.016
0.826HisTyr: 0.826 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
6.44IleAla: 6.44 ± 0.074
0.511IleCys: 0.511 ± 0.021
3.611IleAsp: 3.611 ± 0.056
4.398IleGlu: 4.398 ± 0.065
1.987IlePhe: 1.987 ± 0.05
5.379IleGly: 5.379 ± 0.075
1.181IleHis: 1.181 ± 0.032
3.183IleIle: 3.183 ± 0.061
2.012IleLys: 2.012 ± 0.049
4.816IleLeu: 4.816 ± 0.07
1.32IleMet: 1.32 ± 0.036
1.674IleAsn: 1.674 ± 0.045
2.772IlePro: 2.772 ± 0.055
1.666IleGln: 1.666 ± 0.041
5.277IleArg: 5.277 ± 0.064
2.977IleSer: 2.977 ± 0.053
2.806IleThr: 2.806 ± 0.054
5.136IleVal: 5.136 ± 0.064
0.646IleTrp: 0.646 ± 0.023
1.776IleTyr: 1.776 ± 0.042
0.0IleXaa: 0.0 ± 0.0
Lys
4.071LysAla: 4.071 ± 0.07
0.236LysCys: 0.236 ± 0.015
2.087LysAsp: 2.087 ± 0.045
3.131LysGlu: 3.131 ± 0.06
1.322LysPhe: 1.322 ± 0.033
2.846LysGly: 2.846 ± 0.052
0.932LysHis: 0.932 ± 0.028
2.402LysIle: 2.402 ± 0.056
2.164LysLys: 2.164 ± 0.049
4.461LysLeu: 4.461 ± 0.063
1.14LysMet: 1.14 ± 0.034
1.397LysAsn: 1.397 ± 0.039
2.285LysPro: 2.285 ± 0.043
1.682LysGln: 1.682 ± 0.044
3.358LysArg: 3.358 ± 0.06
2.052LysSer: 2.052 ± 0.045
2.394LysThr: 2.394 ± 0.053
2.812LysVal: 2.812 ± 0.047
0.571LysTrp: 0.571 ± 0.022
1.316LysTyr: 1.316 ± 0.031
0.0LysXaa: 0.0 ± 0.0
Leu
10.644LeuAla: 10.644 ± 0.113
0.767LeuCys: 0.767 ± 0.025
5.521LeuAsp: 5.521 ± 0.075
6.652LeuGlu: 6.652 ± 0.083
4.256LeuPhe: 4.256 ± 0.069
6.946LeuGly: 6.946 ± 0.083
2.131LeuHis: 2.131 ± 0.043
5.95LeuIle: 5.95 ± 0.089
4.651LeuLys: 4.651 ± 0.064
11.236LeuLeu: 11.236 ± 0.135
2.418LeuMet: 2.418 ± 0.047
3.154LeuAsn: 3.154 ± 0.052
4.952LeuPro: 4.952 ± 0.063
3.289LeuGln: 3.289 ± 0.058
6.8LeuArg: 6.8 ± 0.089
5.797LeuSer: 5.797 ± 0.082
5.349LeuThr: 5.349 ± 0.072
6.361LeuVal: 6.361 ± 0.081
1.087LeuTrp: 1.087 ± 0.034
3.055LeuTyr: 3.055 ± 0.052
0.0LeuXaa: 0.0 ± 0.0
Met
2.599MetAla: 2.599 ± 0.047
0.151MetCys: 0.151 ± 0.01
1.352MetAsp: 1.352 ± 0.035
1.744MetGlu: 1.744 ± 0.036
0.955MetPhe: 0.955 ± 0.025
1.448MetGly: 1.448 ± 0.038
0.475MetHis: 0.475 ± 0.018
1.6MetIle: 1.6 ± 0.039
1.555MetLys: 1.555 ± 0.037
3.029MetLeu: 3.029 ± 0.054
0.764MetMet: 0.764 ± 0.023
1.096MetAsn: 1.096 ± 0.031
1.318MetPro: 1.318 ± 0.033
0.863MetGln: 0.863 ± 0.029
1.955MetArg: 1.955 ± 0.047
1.511MetSer: 1.511 ± 0.037
1.689MetThr: 1.689 ± 0.037
1.585MetVal: 1.585 ± 0.038
0.201MetTrp: 0.201 ± 0.012
0.641MetTyr: 0.641 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
2.878AsnAla: 2.878 ± 0.052
0.214AsnCys: 0.214 ± 0.014
1.448AsnAsp: 1.448 ± 0.034
1.869AsnGlu: 1.869 ± 0.044
1.035AsnPhe: 1.035 ± 0.026
2.739AsnGly: 2.739 ± 0.06
0.614AsnHis: 0.614 ± 0.026
1.84AsnIle: 1.84 ± 0.045
1.177AsnLys: 1.177 ± 0.033
2.844AsnLeu: 2.844 ± 0.056
0.794AsnMet: 0.794 ± 0.027
0.972AsnAsn: 0.972 ± 0.033
1.903AsnPro: 1.903 ± 0.037
0.909AsnGln: 0.909 ± 0.029
2.36AsnArg: 2.36 ± 0.043
1.271AsnSer: 1.271 ± 0.042
1.481AsnThr: 1.481 ± 0.037
2.332AsnVal: 2.332 ± 0.047
0.434AsnTrp: 0.434 ± 0.019
0.979AsnTyr: 0.979 ± 0.032
0.0AsnXaa: 0.0 ± 0.0
Pro
4.791ProAla: 4.791 ± 0.084
0.313ProCys: 0.313 ± 0.015
3.53ProAsp: 3.53 ± 0.061
4.144ProGlu: 4.144 ± 0.061
1.892ProPhe: 1.892 ± 0.047
4.053ProGly: 4.053 ± 0.07
1.063ProHis: 1.063 ± 0.033
2.284ProIle: 2.284 ± 0.038
1.705ProLys: 1.705 ± 0.035
4.225ProLeu: 4.225 ± 0.061
0.983ProMet: 0.983 ± 0.029
1.405ProAsn: 1.405 ± 0.036
1.728ProPro: 1.728 ± 0.045
1.355ProGln: 1.355 ± 0.042
2.158ProArg: 2.158 ± 0.045
2.326ProSer: 2.326 ± 0.045
1.693ProThr: 1.693 ± 0.038
3.688ProVal: 3.688 ± 0.054
0.641ProTrp: 0.641 ± 0.023
1.55ProTyr: 1.55 ± 0.039
0.0ProXaa: 0.0 ± 0.0
Gln
3.433GlnAla: 3.433 ± 0.054
0.179GlnCys: 0.179 ± 0.012
1.384GlnAsp: 1.384 ± 0.032
1.959GlnGlu: 1.959 ± 0.042
1.233GlnPhe: 1.233 ± 0.032
2.082GlnGly: 2.082 ± 0.038
0.689GlnHis: 0.689 ± 0.024
1.852GlnIle: 1.852 ± 0.043
1.266GlnLys: 1.266 ± 0.036
3.283GlnLeu: 3.283 ± 0.059
0.904GlnMet: 0.904 ± 0.027
0.925GlnAsn: 0.925 ± 0.03
1.557GlnPro: 1.557 ± 0.034
1.36GlnGln: 1.36 ± 0.045
2.115GlnArg: 2.115 ± 0.045
1.604GlnSer: 1.604 ± 0.038
1.716GlnThr: 1.716 ± 0.047
1.987GlnVal: 1.987 ± 0.042
0.457GlnTrp: 0.457 ± 0.017
1.063GlnTyr: 1.063 ± 0.029
0.0GlnXaa: 0.0 ± 0.0
Arg
5.555ArgAla: 5.555 ± 0.09
0.549ArgCys: 0.549 ± 0.024
3.475ArgAsp: 3.475 ± 0.054
5.763ArgGlu: 5.763 ± 0.077
2.961ArgPhe: 2.961 ± 0.054
4.444ArgGly: 4.444 ± 0.071
1.739ArgHis: 1.739 ± 0.043
4.947ArgIle: 4.947 ± 0.061
3.517ArgLys: 3.517 ± 0.053
8.125ArgLeu: 8.125 ± 0.099
2.297ArgMet: 2.297 ± 0.043
2.169ArgAsn: 2.169 ± 0.041
3.058ArgPro: 3.058 ± 0.055
2.657ArgGln: 2.657 ± 0.053
5.803ArgArg: 5.803 ± 0.106
3.814ArgSer: 3.814 ± 0.065
3.719ArgThr: 3.719 ± 0.059
4.303ArgVal: 4.303 ± 0.068
0.969ArgTrp: 0.969 ± 0.03
2.47ArgTyr: 2.47 ± 0.043
0.0ArgXaa: 0.0 ± 0.0
Ser
4.954SerAla: 4.954 ± 0.071
0.426SerCys: 0.426 ± 0.02
2.621SerAsp: 2.621 ± 0.05
3.069SerGlu: 3.069 ± 0.051
2.266SerPhe: 2.266 ± 0.048
5.701SerGly: 5.701 ± 0.078
0.947SerHis: 0.947 ± 0.028
3.022SerIle: 3.022 ± 0.068
1.96SerLys: 1.96 ± 0.039
5.072SerLeu: 5.072 ± 0.066
1.38SerMet: 1.38 ± 0.038
1.48SerAsn: 1.48 ± 0.042
2.412SerPro: 2.412 ± 0.05
1.271SerGln: 1.271 ± 0.032
3.696SerArg: 3.696 ± 0.059
2.9SerSer: 2.9 ± 0.06
2.343SerThr: 2.343 ± 0.051
4.004SerVal: 4.004 ± 0.063
0.713SerTrp: 0.713 ± 0.027
1.621SerTyr: 1.621 ± 0.037
0.0SerXaa: 0.0 ± 0.0
Thr
5.155ThrAla: 5.155 ± 0.07
0.343ThrCys: 0.343 ± 0.017
2.775ThrAsp: 2.775 ± 0.049
2.903ThrGlu: 2.903 ± 0.051
2.178ThrPhe: 2.178 ± 0.05
4.718ThrGly: 4.718 ± 0.076
0.917ThrHis: 0.917 ± 0.027
3.238ThrIle: 3.238 ± 0.053
1.758ThrLys: 1.758 ± 0.04
4.854ThrLeu: 4.854 ± 0.064
1.289ThrMet: 1.289 ± 0.035
1.482ThrAsn: 1.482 ± 0.038
2.441ThrPro: 2.441 ± 0.048
1.109ThrGln: 1.109 ± 0.033
2.653ThrArg: 2.653 ± 0.045
2.477ThrSer: 2.477 ± 0.053
2.297ThrThr: 2.297 ± 0.056
4.328ThrVal: 4.328 ± 0.067
0.587ThrTrp: 0.587 ± 0.023
1.511ThrTyr: 1.511 ± 0.043
0.0ThrXaa: 0.0 ± 0.0
Val
5.543ValAla: 5.543 ± 0.078
0.736ValCys: 0.736 ± 0.027
3.658ValAsp: 3.658 ± 0.058
4.479ValGlu: 4.479 ± 0.064
2.934ValPhe: 2.934 ± 0.057
4.526ValGly: 4.526 ± 0.066
1.465ValHis: 1.465 ± 0.041
4.572ValIle: 4.572 ± 0.068
3.343ValLys: 3.343 ± 0.051
7.631ValLeu: 7.631 ± 0.088
2.026ValMet: 2.026 ± 0.045
2.355ValAsn: 2.355 ± 0.046
3.621ValPro: 3.621 ± 0.06
2.193ValGln: 2.193 ± 0.044
5.481ValArg: 5.481 ± 0.067
4.107ValSer: 4.107 ± 0.065
4.252ValThr: 4.252 ± 0.074
5.313ValVal: 5.313 ± 0.067
0.97ValTrp: 0.97 ± 0.027
2.382ValTyr: 2.382 ± 0.04
0.0ValXaa: 0.0 ± 0.0
Trp
1.024TrpAla: 1.024 ± 0.036
0.111TrpCys: 0.111 ± 0.011
0.68TrpAsp: 0.68 ± 0.026
0.867TrpGlu: 0.867 ± 0.027
0.608TrpPhe: 0.608 ± 0.023
0.812TrpGly: 0.812 ± 0.026
0.326TrpHis: 0.326 ± 0.019
0.939TrpIle: 0.939 ± 0.026
0.628TrpLys: 0.628 ± 0.022
1.719TrpLeu: 1.719 ± 0.044
0.484TrpMet: 0.484 ± 0.021
0.619TrpAsn: 0.619 ± 0.023
0.516TrpPro: 0.516 ± 0.02
0.511TrpGln: 0.511 ± 0.02
0.986TrpArg: 0.986 ± 0.03
0.751TrpSer: 0.751 ± 0.03
0.785TrpThr: 0.785 ± 0.026
0.74TrpVal: 0.74 ± 0.026
0.204TrpTrp: 0.204 ± 0.012
0.416TrpTyr: 0.416 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.032TyrAla: 3.032 ± 0.054
0.283TyrCys: 0.283 ± 0.017
1.756TyrAsp: 1.756 ± 0.04
2.203TyrGlu: 2.203 ± 0.046
1.33TyrPhe: 1.33 ± 0.034
2.653TyrGly: 2.653 ± 0.046
0.686TyrHis: 0.686 ± 0.023
1.799TyrIle: 1.799 ± 0.041
1.249TyrLys: 1.249 ± 0.039
3.078TyrLeu: 3.078 ± 0.052
0.748TyrMet: 0.748 ± 0.024
1.103TyrAsn: 1.103 ± 0.031
1.437TyrPro: 1.437 ± 0.033
0.948TyrGln: 0.948 ± 0.033
2.567TyrArg: 2.567 ± 0.047
1.467TyrSer: 1.467 ± 0.037
1.582TyrThr: 1.582 ± 0.039
2.243TyrVal: 2.243 ± 0.043
0.493TyrTrp: 0.493 ± 0.021
1.187TyrTyr: 1.187 ± 0.036
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3802 proteins (1222205 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski