Amino acid dipepetide frequency for Kroppenstedtia eburnea

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.479AlaAla: 7.479 ± 0.119	0.669AlaCys: 0.669 ± 0.027	4.135AlaAsp: 4.135 ± 0.061	5.643AlaGlu: 5.643 ± 0.085	3.027AlaPhe: 3.027 ± 0.049	7.435AlaGly: 7.435 ± 0.103	1.578AlaHis: 1.578 ± 0.038	4.413AlaIle: 4.413 ± 0.063	3.592AlaLys: 3.592 ± 0.073	8.193AlaLeu: 8.193 ± 0.095	2.012AlaMet: 2.012 ± 0.047	1.919AlaAsn: 1.919 ± 0.048	2.729AlaPro: 2.729 ± 0.053	2.416AlaGln: 2.416 ± 0.046	4.952AlaArg: 4.952 ± 0.072	3.782AlaSer: 3.782 ± 0.066	3.52AlaThr: 3.52 ± 0.058	6.907AlaVal: 6.907 ± 0.087	0.996AlaTrp: 0.996 ± 0.033	2.045AlaTyr: 2.045 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	0.509CysAla: 0.509 ± 0.024	0.106CysCys: 0.106 ± 0.012	0.421CysAsp: 0.421 ± 0.02	0.42CysGlu: 0.42 ± 0.022	0.335CysPhe: 0.335 ± 0.018	0.82CysGly: 0.82 ± 0.034	0.232CysHis: 0.232 ± 0.014	0.444CysIle: 0.444 ± 0.019	0.275CysLys: 0.275 ± 0.016	0.768CysLeu: 0.768 ± 0.026	0.176CysMet: 0.176 ± 0.011	0.238CysAsn: 0.238 ± 0.017	0.431CysPro: 0.431 ± 0.022	0.247CysGln: 0.247 ± 0.016	0.622CysArg: 0.622 ± 0.027	0.48CysSer: 0.48 ± 0.021	0.413CysThr: 0.413 ± 0.023	0.421CysVal: 0.421 ± 0.023	0.108CysTrp: 0.108 ± 0.01	0.232CysTyr: 0.232 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	3.456AspAla: 3.456 ± 0.055	0.408AspCys: 0.408 ± 0.021	2.116AspAsp: 2.116 ± 0.06	3.742AspGlu: 3.742 ± 0.062	1.995AspPhe: 1.995 ± 0.044	4.129AspGly: 4.129 ± 0.077	1.479AspHis: 1.479 ± 0.035	2.36AspIle: 2.36 ± 0.057	1.92AspLys: 1.92 ± 0.048	5.65AspLeu: 5.65 ± 0.079	1.06AspMet: 1.06 ± 0.037	1.033AspAsn: 1.033 ± 0.031	3.385AspPro: 3.385 ± 0.063	2.158AspGln: 2.158 ± 0.053	4.437AspArg: 4.437 ± 0.068	2.477AspSer: 2.477 ± 0.05	2.247AspThr: 2.247 ± 0.049	3.618AspVal: 3.618 ± 0.062	0.923AspTrp: 0.923 ± 0.027	1.556AspTyr: 1.556 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	6.415GluAla: 6.415 ± 0.108	0.429GluCys: 0.429 ± 0.022	3.345GluAsp: 3.345 ± 0.062	7.924GluGlu: 7.924 ± 0.116	1.837GluPhe: 1.837 ± 0.048	5.829GluGly: 5.829 ± 0.083	1.405GluHis: 1.405 ± 0.034	4.488GluIle: 4.488 ± 0.065	5.333GluLys: 5.333 ± 0.083	6.843GluLeu: 6.843 ± 0.105	2.257GluMet: 2.257 ± 0.048	2.309GluAsn: 2.309 ± 0.054	2.674GluPro: 2.674 ± 0.055	3.467GluGln: 3.467 ± 0.079	5.132GluArg: 5.132 ± 0.104	3.402GluSer: 3.402 ± 0.068	3.957GluThr: 3.957 ± 0.064	5.7GluVal: 5.7 ± 0.085	1.099GluTrp: 1.099 ± 0.038	1.732GluTyr: 1.732 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	3.008PheAla: 3.008 ± 0.06	0.375PheCys: 0.375 ± 0.021	2.027PheAsp: 2.027 ± 0.047	2.041PheGlu: 2.041 ± 0.045	1.96PhePhe: 1.96 ± 0.056	3.19PheGly: 3.19 ± 0.066	1.05PheHis: 1.05 ± 0.034	2.221PheIle: 2.221 ± 0.055	1.328PheLys: 1.328 ± 0.035	4.387PheLeu: 4.387 ± 0.073	0.847PheMet: 0.847 ± 0.027	1.198PheAsn: 1.198 ± 0.036	1.89PhePro: 1.89 ± 0.048	1.487PheGln: 1.487 ± 0.038	2.53PheArg: 2.53 ± 0.052	2.651PheSer: 2.651 ± 0.051	2.195PheThr: 2.195 ± 0.052	2.497PheVal: 2.497 ± 0.054	0.519PheTrp: 0.519 ± 0.024	1.18PheTyr: 1.18 ± 0.04	0.0PheXaa: 0.0 ± 0.0
Gly	5.923GlyAla: 5.923 ± 0.083	0.797GlyCys: 0.797 ± 0.03	3.91GlyAsp: 3.91 ± 0.069	6.414GlyGlu: 6.414 ± 0.081	3.334GlyPhe: 3.334 ± 0.061	6.687GlyGly: 6.687 ± 0.094	1.672GlyHis: 1.672 ± 0.044	5.702GlyIle: 5.702 ± 0.084	5.294GlyLys: 5.294 ± 0.07	8.02GlyLeu: 8.02 ± 0.102	2.737GlyMet: 2.737 ± 0.062	2.468GlyAsn: 2.468 ± 0.052	2.545GlyPro: 2.545 ± 0.046	2.54GlyGln: 2.54 ± 0.053	4.856GlyArg: 4.856 ± 0.072	4.488GlySer: 4.488 ± 0.068	4.358GlyThr: 4.358 ± 0.072	6.527GlyVal: 6.527 ± 0.098	1.448GlyTrp: 1.448 ± 0.038	2.665GlyTyr: 2.665 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	1.477HisAla: 1.477 ± 0.037	0.225HisCys: 0.225 ± 0.015	0.959HisAsp: 0.959 ± 0.032	1.237HisGlu: 1.237 ± 0.04	1.031HisPhe: 1.031 ± 0.032	1.823HisGly: 1.823 ± 0.048	0.835HisHis: 0.835 ± 0.042	1.197HisIle: 1.197 ± 0.039	0.687HisLys: 0.687 ± 0.026	2.896HisLeu: 2.896 ± 0.064	0.544HisMet: 0.544 ± 0.022	0.549HisAsn: 0.549 ± 0.021	1.87HisPro: 1.87 ± 0.043	0.986HisGln: 0.986 ± 0.036	1.974HisArg: 1.974 ± 0.05	1.225HisSer: 1.225 ± 0.031	1.109HisThr: 1.109 ± 0.038	1.461HisVal: 1.461 ± 0.039	0.359HisTrp: 0.359 ± 0.019	0.743HisTyr: 0.743 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	4.821IleAla: 4.821 ± 0.073	0.562IleCys: 0.562 ± 0.025	2.954IleAsp: 2.954 ± 0.061	3.165IleGlu: 3.165 ± 0.065	2.091IlePhe: 2.091 ± 0.057	4.965IleGly: 4.965 ± 0.073	1.795IleHis: 1.795 ± 0.046	2.901IleIle: 2.901 ± 0.063	2.137IleLys: 2.137 ± 0.054	6.441IleLeu: 6.441 ± 0.087	1.135IleMet: 1.135 ± 0.039	1.643IleAsn: 1.643 ± 0.04	3.422IlePro: 3.422 ± 0.064	2.668IleGln: 2.668 ± 0.053	5.095IleArg: 5.095 ± 0.075	3.584IleSer: 3.584 ± 0.068	3.168IleThr: 3.168 ± 0.061	3.663IleVal: 3.663 ± 0.067	0.668IleTrp: 0.668 ± 0.025	1.599IleTyr: 1.599 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	3.698LysAla: 3.698 ± 0.066	0.228LysCys: 0.228 ± 0.015	2.479LysAsp: 2.479 ± 0.056	5.203LysGlu: 5.203 ± 0.081	1.162LysPhe: 1.162 ± 0.033	4.494LysGly: 4.494 ± 0.078	0.989LysHis: 0.989 ± 0.034	2.633LysIle: 2.633 ± 0.052	4.018LysLys: 4.018 ± 0.079	4.183LysLeu: 4.183 ± 0.067	1.498LysMet: 1.498 ± 0.037	1.778LysAsn: 1.778 ± 0.049	2.223LysPro: 2.223 ± 0.045	2.212LysGln: 2.212 ± 0.055	3.392LysArg: 3.392 ± 0.069	2.54LysSer: 2.54 ± 0.063	2.778LysThr: 2.778 ± 0.051	3.748LysVal: 3.748 ± 0.059	0.76LysTrp: 0.76 ± 0.029	1.364LysTyr: 1.364 ± 0.044	0.0LysXaa: 0.0 ± 0.0
Leu	8.658LeuAla: 8.658 ± 0.108	0.797LeuCys: 0.797 ± 0.028	5.344LeuAsp: 5.344 ± 0.065	7.325LeuGlu: 7.325 ± 0.121	4.712LeuPhe: 4.712 ± 0.081	7.621LeuGly: 7.621 ± 0.1	2.322LeuHis: 2.322 ± 0.055	6.202LeuIle: 6.202 ± 0.084	5.513LeuLys: 5.513 ± 0.08	11.213LeuLeu: 11.213 ± 0.151	2.629LeuMet: 2.629 ± 0.056	3.254LeuAsn: 3.254 ± 0.058	5.104LeuPro: 5.104 ± 0.09	3.686LeuGln: 3.686 ± 0.063	5.968LeuArg: 5.968 ± 0.087	6.66LeuSer: 6.66 ± 0.087	5.835LeuThr: 5.835 ± 0.079	7.163LeuVal: 7.163 ± 0.086	1.193LeuTrp: 1.193 ± 0.035	2.838LeuTyr: 2.838 ± 0.064	0.0LeuXaa: 0.0 ± 0.0
Met	2.311MetAla: 2.311 ± 0.05	0.148MetCys: 0.148 ± 0.01	1.679MetAsp: 1.679 ± 0.046	2.416MetGlu: 2.416 ± 0.048	0.845MetPhe: 0.845 ± 0.031	2.245MetGly: 2.245 ± 0.058	0.395MetHis: 0.395 ± 0.02	1.758MetIle: 1.758 ± 0.04	2.005MetLys: 2.005 ± 0.042	2.26MetLeu: 2.26 ± 0.045	0.871MetMet: 0.871 ± 0.031	1.11MetAsn: 1.11 ± 0.029	1.016MetPro: 1.016 ± 0.035	0.825MetGln: 0.825 ± 0.03	1.323MetArg: 1.323 ± 0.032	1.418MetSer: 1.418 ± 0.044	1.469MetThr: 1.469 ± 0.037	2.078MetVal: 2.078 ± 0.047	0.241MetTrp: 0.241 ± 0.015	0.584MetTyr: 0.584 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	1.84AsnAla: 1.84 ± 0.04	0.22AsnCys: 0.22 ± 0.015	1.192AsnAsp: 1.192 ± 0.036	1.678AsnGlu: 1.678 ± 0.048	0.892AsnPhe: 0.892 ± 0.032	2.299AsnGly: 2.299 ± 0.059	0.878AsnHis: 0.878 ± 0.029	1.754AsnIle: 1.754 ± 0.041	1.308AsnLys: 1.308 ± 0.04	3.088AsnLeu: 3.088 ± 0.049	0.756AsnMet: 0.756 ± 0.03	0.944AsnAsn: 0.944 ± 0.038	2.072AsnPro: 2.072 ± 0.051	1.397AsnGln: 1.397 ± 0.036	2.853AsnArg: 2.853 ± 0.05	1.427AsnSer: 1.427 ± 0.041	1.366AsnThr: 1.366 ± 0.037	1.803AsnVal: 1.803 ± 0.041	0.425AsnTrp: 0.425 ± 0.023	0.833AsnTyr: 0.833 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	3.51ProAla: 3.51 ± 0.064	0.294ProCys: 0.294 ± 0.017	3.153ProAsp: 3.153 ± 0.051	4.294ProGlu: 4.294 ± 0.074	2.07ProPhe: 2.07 ± 0.047	4.254ProGly: 4.254 ± 0.08	1.14ProHis: 1.14 ± 0.029	2.272ProIle: 2.272 ± 0.046	1.917ProLys: 1.917 ± 0.048	4.638ProLeu: 4.638 ± 0.086	1.048ProMet: 1.048 ± 0.037	1.077ProAsn: 1.077 ± 0.035	1.972ProPro: 1.972 ± 0.06	1.484ProGln: 1.484 ± 0.037	2.605ProArg: 2.605 ± 0.055	2.567ProSer: 2.567 ± 0.052	2.046ProThr: 2.046 ± 0.043	4.336ProVal: 4.336 ± 0.08	0.649ProTrp: 0.649 ± 0.029	1.388ProTyr: 1.388 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	3.351GlnAla: 3.351 ± 0.053	0.206GlnCys: 0.206 ± 0.017	1.455GlnAsp: 1.455 ± 0.04	2.734GlnGlu: 2.734 ± 0.074	1.241GlnPhe: 1.241 ± 0.035	2.756GlnGly: 2.756 ± 0.056	0.71GlnHis: 0.71 ± 0.026	2.108GlnIle: 2.108 ± 0.049	2.071GlnLys: 2.071 ± 0.049	3.761GlnLeu: 3.761 ± 0.067	1.145GlnMet: 1.145 ± 0.037	1.05GlnAsn: 1.05 ± 0.036	1.783GlnPro: 1.783 ± 0.059	1.723GlnGln: 1.723 ± 0.048	2.263GlnArg: 2.263 ± 0.047	1.897GlnSer: 1.897 ± 0.043	1.983GlnThr: 1.983 ± 0.043	3.363GlnVal: 3.363 ± 0.057	0.561GlnTrp: 0.561 ± 0.024	0.985GlnTyr: 0.985 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	4.009ArgAla: 4.009 ± 0.067	0.496ArgCys: 0.496 ± 0.024	3.185ArgAsp: 3.185 ± 0.06	6.554ArgGlu: 6.554 ± 0.115	2.814ArgPhe: 2.814 ± 0.059	4.498ArgGly: 4.498 ± 0.069	1.49ArgHis: 1.49 ± 0.04	4.369ArgIle: 4.369 ± 0.07	3.869ArgLys: 3.869 ± 0.063	7.43ArgLeu: 7.43 ± 0.11	2.217ArgMet: 2.217 ± 0.047	1.989ArgAsn: 1.989 ± 0.047	2.626ArgPro: 2.626 ± 0.054	2.596ArgGln: 2.596 ± 0.058	4.951ArgArg: 4.951 ± 0.087	3.369ArgSer: 3.369 ± 0.059	2.821ArgThr: 2.821 ± 0.05	5.039ArgVal: 5.039 ± 0.083	1.157ArgTrp: 1.157 ± 0.04	2.043ArgTyr: 2.043 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	3.715SerAla: 3.715 ± 0.062	0.395SerCys: 0.395 ± 0.023	2.553SerAsp: 2.553 ± 0.052	3.068SerGlu: 3.068 ± 0.055	2.555SerPhe: 2.555 ± 0.049	5.102SerGly: 5.102 ± 0.072	1.297SerHis: 1.297 ± 0.042	3.155SerIle: 3.155 ± 0.06	2.286SerLys: 2.286 ± 0.051	6.367SerLeu: 6.367 ± 0.083	1.606SerMet: 1.606 ± 0.04	1.48SerAsn: 1.48 ± 0.039	2.915SerPro: 2.915 ± 0.054	1.699SerGln: 1.699 ± 0.044	3.866SerArg: 3.866 ± 0.069	3.117SerSer: 3.117 ± 0.069	2.715SerThr: 2.715 ± 0.055	4.058SerVal: 4.058 ± 0.068	0.76SerTrp: 0.76 ± 0.03	1.555SerTyr: 1.555 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	4.461ThrAla: 4.461 ± 0.058	0.404ThrCys: 0.404 ± 0.019	2.842ThrAsp: 2.842 ± 0.062	3.36ThrGlu: 3.36 ± 0.062	2.038ThrPhe: 2.038 ± 0.049	5.332ThrGly: 5.332 ± 0.073	1.222ThrHis: 1.222 ± 0.036	2.787ThrIle: 2.787 ± 0.054	1.786ThrLys: 1.786 ± 0.046	5.524ThrLeu: 5.524 ± 0.076	1.182ThrMet: 1.182 ± 0.032	1.222ThrAsn: 1.222 ± 0.036	2.797ThrPro: 2.797 ± 0.056	1.464ThrGln: 1.464 ± 0.039	3.071ThrArg: 3.071 ± 0.059	2.608ThrSer: 2.608 ± 0.058	2.513ThrThr: 2.513 ± 0.065	4.514ThrVal: 4.514 ± 0.07	0.662ThrTrp: 0.662 ± 0.027	1.556ThrTyr: 1.556 ± 0.056	0.0ThrXaa: 0.0 ± 0.0
Val	6.088ValAla: 6.088 ± 0.083	0.608ValCys: 0.608 ± 0.027	4.186ValAsp: 4.186 ± 0.074	5.714ValGlu: 5.714 ± 0.076	2.766ValPhe: 2.766 ± 0.053	5.507ValGly: 5.507 ± 0.098	1.69ValHis: 1.69 ± 0.038	5.103ValIle: 5.103 ± 0.073	4.055ValLys: 4.055 ± 0.067	7.532ValLeu: 7.532 ± 0.095	2.025ValMet: 2.025 ± 0.048	2.371ValAsn: 2.371 ± 0.051	3.431ValPro: 3.431 ± 0.058	2.439ValGln: 2.439 ± 0.048	4.49ValArg: 4.49 ± 0.068	4.375ValSer: 4.375 ± 0.065	4.574ValThr: 4.574 ± 0.076	5.737ValVal: 5.737 ± 0.092	0.943ValTrp: 0.943 ± 0.028	2.007ValTyr: 2.007 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	0.876TrpAla: 0.876 ± 0.029	0.095TrpCys: 0.095 ± 0.01	0.652TrpAsp: 0.652 ± 0.026	0.928TrpGlu: 0.928 ± 0.031	0.646TrpPhe: 0.646 ± 0.027	1.009TrpGly: 1.009 ± 0.035	0.215TrpHis: 0.215 ± 0.018	1.056TrpIle: 1.056 ± 0.037	0.876TrpLys: 0.876 ± 0.03	1.728TrpLeu: 1.728 ± 0.045	0.56TrpMet: 0.56 ± 0.024	0.539TrpAsn: 0.539 ± 0.022	0.399TrpPro: 0.399 ± 0.019	0.46TrpGln: 0.46 ± 0.023	0.735TrpArg: 0.735 ± 0.027	0.761TrpSer: 0.761 ± 0.029	0.727TrpThr: 0.727 ± 0.028	1.197TrpVal: 1.197 ± 0.035	0.239TrpTrp: 0.239 ± 0.018	0.394TrpTyr: 0.394 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.836TyrAla: 1.836 ± 0.042	0.236TyrCys: 0.236 ± 0.016	1.565TyrAsp: 1.565 ± 0.053	1.72TyrGlu: 1.72 ± 0.04	1.227TyrPhe: 1.227 ± 0.037	2.387TyrGly: 2.387 ± 0.048	0.791TyrHis: 0.791 ± 0.033	1.555TyrIle: 1.555 ± 0.042	1.111TyrLys: 1.111 ± 0.039	3.116TyrLeu: 3.116 ± 0.062	0.693TyrMet: 0.693 ± 0.023	0.855TyrAsn: 0.855 ± 0.04	1.429TyrPro: 1.429 ± 0.036	1.191TyrGln: 1.191 ± 0.032	2.409TyrArg: 2.409 ± 0.051	1.435TyrSer: 1.435 ± 0.038	1.55TyrThr: 1.55 ± 0.041	1.811TyrVal: 1.811 ± 0.049	0.381TyrTrp: 0.381 ± 0.018	1.035TyrTyr: 1.035 ± 0.036	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3484 proteins (997009 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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