Amino acid dipepetide frequency for Aestuariivirga litoralis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.194AlaAla: 18.194 ± 0.195
1.176AlaCys: 1.176 ± 0.034
6.286AlaAsp: 6.286 ± 0.072
7.678AlaGlu: 7.678 ± 0.092
4.358AlaPhe: 4.358 ± 0.066
10.82AlaGly: 10.82 ± 0.102
2.31AlaHis: 2.31 ± 0.045
6.28AlaIle: 6.28 ± 0.072
4.642AlaLys: 4.642 ± 0.069
13.175AlaLeu: 13.175 ± 0.129
3.807AlaMet: 3.807 ± 0.061
2.848AlaAsn: 2.848 ± 0.052
5.532AlaPro: 5.532 ± 0.075
4.135AlaGln: 4.135 ± 0.067
8.653AlaArg: 8.653 ± 0.106
6.252AlaSer: 6.252 ± 0.076
6.005AlaThr: 6.005 ± 0.078
8.918AlaVal: 8.918 ± 0.099
1.603AlaTrp: 1.603 ± 0.035
2.641AlaTyr: 2.641 ± 0.046
0.0AlaXaa: 0.0 ± 0.0
Cys
1.004CysAla: 1.004 ± 0.03
0.129CysCys: 0.129 ± 0.012
0.581CysAsp: 0.581 ± 0.019
0.481CysGlu: 0.481 ± 0.018
0.393CysPhe: 0.393 ± 0.017
1.007CysGly: 1.007 ± 0.032
0.272CysHis: 0.272 ± 0.017
0.436CysIle: 0.436 ± 0.018
0.223CysLys: 0.223 ± 0.014
0.871CysLeu: 0.871 ± 0.028
0.179CysMet: 0.179 ± 0.012
0.282CysAsn: 0.282 ± 0.015
0.514CysPro: 0.514 ± 0.029
0.227CysGln: 0.227 ± 0.013
0.667CysArg: 0.667 ± 0.022
0.506CysSer: 0.506 ± 0.018
0.525CysThr: 0.525 ± 0.02
0.657CysVal: 0.657 ± 0.029
0.138CysTrp: 0.138 ± 0.01
0.248CysTyr: 0.248 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
6.252AspAla: 6.252 ± 0.076
0.547AspCys: 0.547 ± 0.021
2.781AspAsp: 2.781 ± 0.05
3.236AspGlu: 3.236 ± 0.055
2.114AspPhe: 2.114 ± 0.036
5.07AspGly: 5.07 ± 0.068
1.189AspHis: 1.189 ± 0.026
2.93AspIle: 2.93 ± 0.047
1.836AspLys: 1.836 ± 0.046
5.337AspLeu: 5.337 ± 0.066
1.478AspMet: 1.478 ± 0.033
1.31AspAsn: 1.31 ± 0.035
3.267AspPro: 3.267 ± 0.053
1.664AspGln: 1.664 ± 0.032
3.652AspArg: 3.652 ± 0.059
2.1AspSer: 2.1 ± 0.039
2.599AspThr: 2.599 ± 0.047
4.279AspVal: 4.279 ± 0.062
1.036AspTrp: 1.036 ± 0.03
1.612AspTyr: 1.612 ± 0.036
0.0AspXaa: 0.0 ± 0.0
Glu
7.564GluAla: 7.564 ± 0.083
0.369GluCys: 0.369 ± 0.018
2.719GluAsp: 2.719 ± 0.045
3.107GluGlu: 3.107 ± 0.062
1.65GluPhe: 1.65 ± 0.032
4.328GluGly: 4.328 ± 0.065
1.209GluHis: 1.209 ± 0.031
3.177GluIle: 3.177 ± 0.057
2.472GluLys: 2.472 ± 0.052
5.344GluLeu: 5.344 ± 0.07
1.508GluMet: 1.508 ± 0.035
1.462GluAsn: 1.462 ± 0.031
2.645GluPro: 2.645 ± 0.049
2.184GluGln: 2.184 ± 0.041
4.234GluArg: 4.234 ± 0.069
2.076GluSer: 2.076 ± 0.041
3.294GluThr: 3.294 ± 0.059
3.919GluVal: 3.919 ± 0.072
0.678GluTrp: 0.678 ± 0.025
0.902GluTyr: 0.902 ± 0.029
0.0GluXaa: 0.0 ± 0.0
Phe
4.596PheAla: 4.596 ± 0.072
0.422PheCys: 0.422 ± 0.018
2.522PheAsp: 2.522 ± 0.047
2.016PheGlu: 2.016 ± 0.039
1.424PhePhe: 1.424 ± 0.04
3.593PheGly: 3.593 ± 0.062
0.769PheHis: 0.769 ± 0.024
1.876PheIle: 1.876 ± 0.042
1.114PheLys: 1.114 ± 0.027
3.521PheLeu: 3.521 ± 0.063
0.887PheMet: 0.887 ± 0.028
1.154PheAsn: 1.154 ± 0.031
1.629PhePro: 1.629 ± 0.034
0.965PheGln: 0.965 ± 0.031
2.238PheArg: 2.238 ± 0.045
2.094PheSer: 2.094 ± 0.042
2.264PheThr: 2.264 ± 0.04
2.705PheVal: 2.705 ± 0.054
0.572PheTrp: 0.572 ± 0.025
0.948PheTyr: 0.948 ± 0.025
0.0PheXaa: 0.0 ± 0.0
Gly
9.302GlyAla: 9.302 ± 0.152
0.902GlyCys: 0.902 ± 0.03
4.279GlyAsp: 4.279 ± 0.068
4.886GlyGlu: 4.886 ± 0.075
3.806GlyPhe: 3.806 ± 0.057
7.422GlyGly: 7.422 ± 0.099
2.036GlyHis: 2.036 ± 0.038
4.675GlyIle: 4.675 ± 0.057
3.797GlyLys: 3.797 ± 0.059
9.26GlyLeu: 9.26 ± 0.102
2.403GlyMet: 2.403 ± 0.044
2.298GlyAsn: 2.298 ± 0.048
3.656GlyPro: 3.656 ± 0.06
2.922GlyGln: 2.922 ± 0.049
5.813GlyArg: 5.813 ± 0.072
4.773GlySer: 4.773 ± 0.069
4.766GlyThr: 4.766 ± 0.074
6.177GlyVal: 6.177 ± 0.082
1.48GlyTrp: 1.48 ± 0.04
2.384GlyTyr: 2.384 ± 0.048
0.0GlyXaa: 0.0 ± 0.0
His
2.491HisAla: 2.491 ± 0.046
0.296HisCys: 0.296 ± 0.015
1.295HisAsp: 1.295 ± 0.031
1.112HisGlu: 1.112 ± 0.032
0.913HisPhe: 0.913 ± 0.029
2.117HisGly: 2.117 ± 0.037
0.632HisHis: 0.632 ± 0.027
0.979HisIle: 0.979 ± 0.025
0.582HisLys: 0.582 ± 0.025
2.041HisLeu: 2.041 ± 0.043
0.566HisMet: 0.566 ± 0.021
0.51HisAsn: 0.51 ± 0.02
1.393HisPro: 1.393 ± 0.033
0.583HisGln: 0.583 ± 0.022
1.393HisArg: 1.393 ± 0.036
0.867HisSer: 0.867 ± 0.025
0.801HisThr: 0.801 ± 0.027
1.646HisVal: 1.646 ± 0.035
0.365HisTrp: 0.365 ± 0.015
0.615HisTyr: 0.615 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
7.23IleAla: 7.23 ± 0.077
0.54IleCys: 0.54 ± 0.02
3.438IleAsp: 3.438 ± 0.052
3.137IleGlu: 3.137 ± 0.057
1.635IlePhe: 1.635 ± 0.038
4.79IleGly: 4.79 ± 0.069
0.958IleHis: 0.958 ± 0.028
2.526IleIle: 2.526 ± 0.053
1.536IleLys: 1.536 ± 0.039
4.437IleLeu: 4.437 ± 0.065
1.121IleMet: 1.121 ± 0.031
1.436IleAsn: 1.436 ± 0.037
2.458IlePro: 2.458 ± 0.045
1.054IleGln: 1.054 ± 0.031
3.232IleArg: 3.232 ± 0.05
2.815IleSer: 2.815 ± 0.045
2.945IleThr: 2.945 ± 0.045
3.956IleVal: 3.956 ± 0.057
0.586IleTrp: 0.586 ± 0.023
1.122IleTyr: 1.122 ± 0.028
0.0IleXaa: 0.0 ± 0.0
Lys
4.842LysAla: 4.842 ± 0.068
0.205LysCys: 0.205 ± 0.013
2.226LysAsp: 2.226 ± 0.051
1.822LysGlu: 1.822 ± 0.047
0.921LysPhe: 0.921 ± 0.027
3.429LysGly: 3.429 ± 0.056
0.723LysHis: 0.723 ± 0.023
1.781LysIle: 1.781 ± 0.042
1.674LysLys: 1.674 ± 0.053
3.964LysLeu: 3.964 ± 0.064
0.885LysMet: 0.885 ± 0.026
1.021LysAsn: 1.021 ± 0.031
2.496LysPro: 2.496 ± 0.053
1.208LysGln: 1.208 ± 0.03
2.402LysArg: 2.402 ± 0.055
2.001LysSer: 2.001 ± 0.039
2.065LysThr: 2.065 ± 0.04
2.924LysVal: 2.924 ± 0.048
0.43LysTrp: 0.43 ± 0.019
0.724LysTyr: 0.724 ± 0.024
0.0LysXaa: 0.0 ± 0.0
Leu
14.043LeuAla: 14.043 ± 0.142
0.95LeuCys: 0.95 ± 0.025
5.628LeuAsp: 5.628 ± 0.07
4.947LeuGlu: 4.947 ± 0.061
3.628LeuPhe: 3.628 ± 0.059
8.469LeuGly: 8.469 ± 0.089
1.969LeuHis: 1.969 ± 0.049
4.797LeuIle: 4.797 ± 0.068
4.46LeuLys: 4.46 ± 0.067
9.712LeuLeu: 9.712 ± 0.131
2.574LeuMet: 2.574 ± 0.044
2.542LeuAsn: 2.542 ± 0.048
5.602LeuPro: 5.602 ± 0.072
2.728LeuGln: 2.728 ± 0.045
6.597LeuArg: 6.597 ± 0.084
6.22LeuSer: 6.22 ± 0.08
5.377LeuThr: 5.377 ± 0.082
7.255LeuVal: 7.255 ± 0.071
1.325LeuTrp: 1.325 ± 0.038
2.072LeuTyr: 2.072 ± 0.043
0.0LeuXaa: 0.0 ± 0.0
Met
3.54MetAla: 3.54 ± 0.055
0.199MetCys: 0.199 ± 0.012
1.216MetAsp: 1.216 ± 0.03
1.159MetGlu: 1.159 ± 0.028
0.735MetPhe: 0.735 ± 0.025
2.127MetGly: 2.127 ± 0.041
0.456MetHis: 0.456 ± 0.016
1.415MetIle: 1.415 ± 0.036
1.298MetLys: 1.298 ± 0.031
2.697MetLeu: 2.697 ± 0.046
0.811MetMet: 0.811 ± 0.026
0.818MetAsn: 0.818 ± 0.024
1.53MetPro: 1.53 ± 0.037
0.868MetGln: 0.868 ± 0.025
1.733MetArg: 1.733 ± 0.034
1.696MetSer: 1.696 ± 0.035
1.84MetThr: 1.84 ± 0.035
1.844MetVal: 1.844 ± 0.038
0.286MetTrp: 0.286 ± 0.015
0.356MetTyr: 0.356 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
3.158AsnAla: 3.158 ± 0.055
0.293AsnCys: 0.293 ± 0.015
1.351AsnAsp: 1.351 ± 0.036
1.222AsnGlu: 1.222 ± 0.033
1.022AsnPhe: 1.022 ± 0.028
2.383AsnGly: 2.383 ± 0.047
0.531AsnHis: 0.531 ± 0.02
1.36AsnIle: 1.36 ± 0.035
0.797AsnLys: 0.797 ± 0.024
2.503AsnLeu: 2.503 ± 0.039
0.707AsnMet: 0.707 ± 0.024
0.762AsnAsn: 0.762 ± 0.029
1.992AsnPro: 1.992 ± 0.046
0.742AsnGln: 0.742 ± 0.025
1.778AsnArg: 1.778 ± 0.037
1.291AsnSer: 1.291 ± 0.031
1.365AsnThr: 1.365 ± 0.043
2.013AsnVal: 2.013 ± 0.043
0.507AsnTrp: 0.507 ± 0.02
0.764AsnTyr: 0.764 ± 0.028
0.0AsnXaa: 0.0 ± 0.0
Pro
6.546ProAla: 6.546 ± 0.09
0.377ProCys: 0.377 ± 0.019
3.463ProAsp: 3.463 ± 0.059
3.809ProGlu: 3.809 ± 0.056
2.078ProPhe: 2.078 ± 0.043
4.815ProGly: 4.815 ± 0.063
1.181ProHis: 1.181 ± 0.029
2.057ProIle: 2.057 ± 0.048
2.019ProLys: 2.019 ± 0.046
4.822ProLeu: 4.822 ± 0.066
1.33ProMet: 1.33 ± 0.031
1.304ProAsn: 1.304 ± 0.037
2.825ProPro: 2.825 ± 0.076
1.764ProGln: 1.764 ± 0.037
3.111ProArg: 3.111 ± 0.049
2.706ProSer: 2.706 ± 0.052
2.264ProThr: 2.264 ± 0.046
4.38ProVal: 4.38 ± 0.057
0.795ProTrp: 0.795 ± 0.025
1.268ProTyr: 1.268 ± 0.03
0.0ProXaa: 0.0 ± 0.0
Gln
3.992GlnAla: 3.992 ± 0.068
0.248GlnCys: 0.248 ± 0.014
1.512GlnAsp: 1.512 ± 0.039
1.375GlnGlu: 1.375 ± 0.035
1.072GlnPhe: 1.072 ± 0.032
2.679GlnGly: 2.679 ± 0.055
0.678GlnHis: 0.678 ± 0.023
1.574GlnIle: 1.574 ± 0.036
1.226GlnLys: 1.226 ± 0.031
3.037GlnLeu: 3.037 ± 0.051
0.933GlnMet: 0.933 ± 0.025
0.811GlnAsn: 0.811 ± 0.032
1.767GlnPro: 1.767 ± 0.039
1.304GlnGln: 1.304 ± 0.034
2.368GlnArg: 2.368 ± 0.045
1.654GlnSer: 1.654 ± 0.037
1.451GlnThr: 1.451 ± 0.033
2.317GlnVal: 2.317 ± 0.043
0.485GlnTrp: 0.485 ± 0.022
0.656GlnTyr: 0.656 ± 0.024
0.0GlnXaa: 0.0 ± 0.0
Arg
7.311ArgAla: 7.311 ± 0.089
0.56ArgCys: 0.56 ± 0.026
3.705ArgAsp: 3.705 ± 0.047
3.86ArgGlu: 3.86 ± 0.056
2.729ArgPhe: 2.729 ± 0.047
4.671ArgGly: 4.671 ± 0.061
1.804ArgHis: 1.804 ± 0.042
3.782ArgIle: 3.782 ± 0.06
2.556ArgLys: 2.556 ± 0.05
7.454ArgLeu: 7.454 ± 0.096
1.876ArgMet: 1.876 ± 0.039
2.008ArgAsn: 2.008 ± 0.037
3.509ArgPro: 3.509 ± 0.049
2.484ArgGln: 2.484 ± 0.05
5.348ArgArg: 5.348 ± 0.088
3.407ArgSer: 3.407 ± 0.054
3.053ArgThr: 3.053 ± 0.049
4.365ArgVal: 4.365 ± 0.061
0.965ArgTrp: 0.965 ± 0.027
1.632ArgTyr: 1.632 ± 0.036
0.0ArgXaa: 0.0 ± 0.0
Ser
5.793SerAla: 5.793 ± 0.071
0.571SerCys: 0.571 ± 0.024
2.616SerAsp: 2.616 ± 0.048
2.539SerGlu: 2.539 ± 0.045
2.552SerPhe: 2.552 ± 0.049
5.43SerGly: 5.43 ± 0.077
1.152SerHis: 1.152 ± 0.032
2.598SerIle: 2.598 ± 0.046
1.688SerLys: 1.688 ± 0.035
5.634SerLeu: 5.634 ± 0.068
1.312SerMet: 1.312 ± 0.03
1.375SerAsn: 1.375 ± 0.039
2.829SerPro: 2.829 ± 0.054
1.506SerGln: 1.506 ± 0.038
3.476SerArg: 3.476 ± 0.053
2.829SerSer: 2.829 ± 0.056
2.661SerThr: 2.661 ± 0.062
3.667SerVal: 3.667 ± 0.058
0.844SerTrp: 0.844 ± 0.026
1.414SerTyr: 1.414 ± 0.037
0.0SerXaa: 0.0 ± 0.0
Thr
6.497ThrAla: 6.497 ± 0.085
0.487ThrCys: 0.487 ± 0.023
2.634ThrAsp: 2.634 ± 0.05
2.537ThrGlu: 2.537 ± 0.043
1.9ThrPhe: 1.9 ± 0.04
5.488ThrGly: 5.488 ± 0.14
1.059ThrHis: 1.059 ± 0.032
2.836ThrIle: 2.836 ± 0.048
1.505ThrLys: 1.505 ± 0.038
5.553ThrLeu: 5.553 ± 0.077
1.197ThrMet: 1.197 ± 0.029
1.245ThrAsn: 1.245 ± 0.038
3.407ThrPro: 3.407 ± 0.059
1.441ThrGln: 1.441 ± 0.049
3.42ThrArg: 3.42 ± 0.047
2.861ThrSer: 2.861 ± 0.051
2.77ThrThr: 2.77 ± 0.081
4.258ThrVal: 4.258 ± 0.057
0.714ThrTrp: 0.714 ± 0.026
1.259ThrTyr: 1.259 ± 0.032
0.0ThrXaa: 0.0 ± 0.0
Val
8.933ValAla: 8.933 ± 0.087
0.653ValCys: 0.653 ± 0.022
3.82ValAsp: 3.82 ± 0.057
4.077ValGlu: 4.077 ± 0.063
2.838ValPhe: 2.838 ± 0.055
5.194ValGly: 5.194 ± 0.077
1.368ValHis: 1.368 ± 0.033
4.262ValIle: 4.262 ± 0.06
3.021ValLys: 3.021 ± 0.053
7.54ValLeu: 7.54 ± 0.09
2.101ValMet: 2.101 ± 0.046
2.161ValAsn: 2.161 ± 0.042
3.911ValPro: 3.911 ± 0.057
2.009ValGln: 2.009 ± 0.043
4.152ValArg: 4.152 ± 0.067
4.315ValSer: 4.315 ± 0.056
5.022ValThr: 5.022 ± 0.059
5.632ValVal: 5.632 ± 0.081
0.99ValTrp: 0.99 ± 0.031
1.548ValTyr: 1.548 ± 0.035
0.0ValXaa: 0.0 ± 0.0
Trp
1.395TrpAla: 1.395 ± 0.032
0.15TrpCys: 0.15 ± 0.011
0.707TrpAsp: 0.707 ± 0.022
0.597TrpGlu: 0.597 ± 0.023
0.604TrpPhe: 0.604 ± 0.027
1.027TrpGly: 1.027 ± 0.032
0.349TrpHis: 0.349 ± 0.017
0.688TrpIle: 0.688 ± 0.024
0.581TrpLys: 0.581 ± 0.021
1.697TrpLeu: 1.697 ± 0.042
0.415TrpMet: 0.415 ± 0.017
0.537TrpAsn: 0.537 ± 0.022
0.785TrpPro: 0.785 ± 0.025
0.613TrpGln: 0.613 ± 0.024
1.073TrpArg: 1.073 ± 0.028
0.853TrpSer: 0.853 ± 0.026
0.85TrpThr: 0.85 ± 0.027
0.9TrpVal: 0.9 ± 0.024
0.284TrpTrp: 0.284 ± 0.018
0.383TrpTyr: 0.383 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.633TyrAla: 2.633 ± 0.052
0.265TyrCys: 0.265 ± 0.014
1.511TyrAsp: 1.511 ± 0.032
1.24TyrGlu: 1.24 ± 0.029
0.94TyrPhe: 0.94 ± 0.027
2.177TyrGly: 2.177 ± 0.04
0.551TyrHis: 0.551 ± 0.023
0.928TyrIle: 0.928 ± 0.031
0.715TyrLys: 0.715 ± 0.023
2.296TyrLeu: 2.296 ± 0.044
0.534TyrMet: 0.534 ± 0.021
0.657TyrAsn: 0.657 ± 0.027
1.164TyrPro: 1.164 ± 0.035
0.737TyrGln: 0.737 ± 0.025
1.742TyrArg: 1.742 ± 0.037
1.172TyrSer: 1.172 ± 0.035
1.151TyrThr: 1.151 ± 0.031
1.735TyrVal: 1.735 ± 0.033
0.403TyrTrp: 0.403 ± 0.018
0.653TyrTyr: 0.653 ± 0.028
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3996 proteins (1285438 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski