Amino acid dipepetide frequency for Desulfovibrio sp. OH1186_COT-070

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.716AlaAla: 14.716 ± 0.222	2.087AlaCys: 2.087 ± 0.055	5.746AlaAsp: 5.746 ± 0.107	6.666AlaGlu: 6.666 ± 0.108	3.86AlaPhe: 3.86 ± 0.083	9.519AlaGly: 9.519 ± 0.127	2.73AlaHis: 2.73 ± 0.064	3.879AlaIle: 3.879 ± 0.078	3.335AlaLys: 3.335 ± 0.08	13.876AlaLeu: 13.876 ± 0.187	2.768AlaMet: 2.768 ± 0.065	2.353AlaAsn: 2.353 ± 0.061	5.424AlaPro: 5.424 ± 0.097	4.339AlaGln: 4.339 ± 0.082	8.65AlaArg: 8.65 ± 0.133	5.75AlaSer: 5.75 ± 0.097	4.175AlaThr: 4.175 ± 0.079	8.31AlaVal: 8.31 ± 0.133	1.571AlaTrp: 1.571 ± 0.054	2.283AlaTyr: 2.283 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	1.834CysAla: 1.834 ± 0.054	0.34CysCys: 0.34 ± 0.021	0.671CysAsp: 0.671 ± 0.032	0.678CysGlu: 0.678 ± 0.027	0.579CysPhe: 0.579 ± 0.031	1.751CysGly: 1.751 ± 0.052	0.463CysHis: 0.463 ± 0.03	0.742CysIle: 0.742 ± 0.033	0.478CysLys: 0.478 ± 0.03	1.925CysLeu: 1.925 ± 0.056	0.447CysMet: 0.447 ± 0.026	0.461CysAsn: 0.461 ± 0.026	1.085CysPro: 1.085 ± 0.041	0.388CysGln: 0.388 ± 0.024	1.323CysArg: 1.323 ± 0.037	0.915CysSer: 0.915 ± 0.037	0.782CysThr: 0.782 ± 0.029	1.155CysVal: 1.155 ± 0.042	0.202CysTrp: 0.202 ± 0.016	0.349CysTyr: 0.349 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	6.198AspAla: 6.198 ± 0.091	0.779AspCys: 0.779 ± 0.034	2.255AspAsp: 2.255 ± 0.064	2.642AspGlu: 2.642 ± 0.065	2.435AspPhe: 2.435 ± 0.068	4.057AspGly: 4.057 ± 0.112	0.936AspHis: 0.936 ± 0.033	3.081AspIle: 3.081 ± 0.067	2.088AspLys: 2.088 ± 0.062	5.145AspLeu: 5.145 ± 0.081	1.95AspMet: 1.95 ± 0.053	1.55AspAsn: 1.55 ± 0.048	2.524AspPro: 2.524 ± 0.056	1.222AspGln: 1.222 ± 0.04	2.76AspArg: 2.76 ± 0.06	2.734AspSer: 2.734 ± 0.063	2.51AspThr: 2.51 ± 0.068	3.778AspVal: 3.778 ± 0.073	0.783AspTrp: 0.783 ± 0.034	1.284AspTyr: 1.284 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	6.903GluAla: 6.903 ± 0.117	0.664GluCys: 0.664 ± 0.028	3.284GluAsp: 3.284 ± 0.068	4.371GluGlu: 4.371 ± 0.099	1.716GluPhe: 1.716 ± 0.054	4.446GluGly: 4.446 ± 0.086	1.418GluHis: 1.418 ± 0.048	3.042GluIle: 3.042 ± 0.066	3.891GluLys: 3.891 ± 0.091	5.395GluLeu: 5.395 ± 0.096	1.699GluMet: 1.699 ± 0.042	2.508GluAsn: 2.508 ± 0.058	2.225GluPro: 2.225 ± 0.052	2.474GluGln: 2.474 ± 0.063	4.3GluArg: 4.3 ± 0.078	3.107GluSer: 3.107 ± 0.071	2.465GluThr: 2.465 ± 0.067	3.69GluVal: 3.69 ± 0.074	0.551GluTrp: 0.551 ± 0.029	1.519GluTyr: 1.519 ± 0.05	0.0GluXaa: 0.0 ± 0.0
Phe	4.167PheAla: 4.167 ± 0.072	0.944PheCys: 0.944 ± 0.038	1.986PheAsp: 1.986 ± 0.055	1.725PheGlu: 1.725 ± 0.053	2.075PhePhe: 2.075 ± 0.058	2.972PheGly: 2.972 ± 0.074	0.807PheHis: 0.807 ± 0.037	1.333PheIle: 1.333 ± 0.046	1.078PheLys: 1.078 ± 0.042	4.59PheLeu: 4.59 ± 0.085	0.94PheMet: 0.94 ± 0.041	0.916PheAsn: 0.916 ± 0.047	1.805PhePro: 1.805 ± 0.048	1.01PheGln: 1.01 ± 0.034	2.499PheArg: 2.499 ± 0.052	2.987PheSer: 2.987 ± 0.063	1.919PheThr: 1.919 ± 0.066	2.742PheVal: 2.742 ± 0.055	0.794PheTrp: 0.794 ± 0.032	0.982PheTyr: 0.982 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	7.507GlyAla: 7.507 ± 0.124	1.4GlyCys: 1.4 ± 0.048	3.732GlyAsp: 3.732 ± 0.07	4.579GlyGlu: 4.579 ± 0.081	3.226GlyPhe: 3.226 ± 0.078	6.932GlyGly: 6.932 ± 0.141	2.008GlyHis: 2.008 ± 0.048	4.565GlyIle: 4.565 ± 0.086	4.139GlyLys: 4.139 ± 0.083	8.747GlyLeu: 8.747 ± 0.129	2.81GlyMet: 2.81 ± 0.057	2.452GlyAsn: 2.452 ± 0.071	2.929GlyPro: 2.929 ± 0.061	3.306GlyGln: 3.306 ± 0.065	5.68GlyArg: 5.68 ± 0.086	4.438GlySer: 4.438 ± 0.09	4.189GlyThr: 4.189 ± 0.121	5.68GlyVal: 5.68 ± 0.098	0.999GlyTrp: 0.999 ± 0.046	2.203GlyTyr: 2.203 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	2.602HisAla: 2.602 ± 0.058	0.475HisCys: 0.475 ± 0.028	1.182HisAsp: 1.182 ± 0.04	1.275HisGlu: 1.275 ± 0.04	0.994HisPhe: 0.994 ± 0.037	1.91HisGly: 1.91 ± 0.053	0.523HisHis: 0.523 ± 0.032	1.317HisIle: 1.317 ± 0.051	0.859HisLys: 0.859 ± 0.034	2.49HisLeu: 2.49 ± 0.059	0.71HisMet: 0.71 ± 0.032	0.679HisAsn: 0.679 ± 0.029	1.338HisPro: 1.338 ± 0.048	0.581HisGln: 0.581 ± 0.029	1.24HisArg: 1.24 ± 0.046	1.304HisSer: 1.304 ± 0.038	1.232HisThr: 1.232 ± 0.045	1.737HisVal: 1.737 ± 0.051	0.361HisTrp: 0.361 ± 0.022	0.558HisTyr: 0.558 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	4.403IleAla: 4.403 ± 0.094	0.804IleCys: 0.804 ± 0.03	2.13IleAsp: 2.13 ± 0.063	2.105IleGlu: 2.105 ± 0.06	2.121IlePhe: 2.121 ± 0.055	3.095IleGly: 3.095 ± 0.079	0.942IleHis: 0.942 ± 0.033	2.172IleIle: 2.172 ± 0.069	1.533IleLys: 1.533 ± 0.055	4.992IleLeu: 4.992 ± 0.084	1.219IleMet: 1.219 ± 0.048	1.457IleAsn: 1.457 ± 0.042	2.53IlePro: 2.53 ± 0.063	1.223IleGln: 1.223 ± 0.043	3.124IleArg: 3.124 ± 0.069	3.012IleSer: 3.012 ± 0.063	2.433IleThr: 2.433 ± 0.064	3.394IleVal: 3.394 ± 0.075	0.506IleTrp: 0.506 ± 0.028	1.109IleTyr: 1.109 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	4.197LysAla: 4.197 ± 0.091	0.382LysCys: 0.382 ± 0.024	2.059LysAsp: 2.059 ± 0.06	2.498LysGlu: 2.498 ± 0.075	1.033LysPhe: 1.033 ± 0.041	2.97LysGly: 2.97 ± 0.081	0.757LysHis: 0.757 ± 0.033	2.204LysIle: 2.204 ± 0.057	2.676LysLys: 2.676 ± 0.076	3.418LysLeu: 3.418 ± 0.086	1.069LysMet: 1.069 ± 0.039	1.901LysAsn: 1.901 ± 0.056	1.81LysPro: 1.81 ± 0.048	1.169LysGln: 1.169 ± 0.05	2.244LysArg: 2.244 ± 0.059	2.251LysSer: 2.251 ± 0.052	2.257LysThr: 2.257 ± 0.063	2.357LysVal: 2.357 ± 0.066	0.316LysTrp: 0.316 ± 0.021	1.049LysTyr: 1.049 ± 0.043	0.0LysXaa: 0.0 ± 0.0
Leu	13.688LeuAla: 13.688 ± 0.189	2.116LeuCys: 2.116 ± 0.06	6.014LeuAsp: 6.014 ± 0.088	7.069LeuGlu: 7.069 ± 0.108	4.063LeuPhe: 4.063 ± 0.08	8.601LeuGly: 8.601 ± 0.12	2.787LeuHis: 2.787 ± 0.074	3.309LeuIle: 3.309 ± 0.079	3.742LeuLys: 3.742 ± 0.078	13.064LeuLeu: 13.064 ± 0.19	2.292LeuMet: 2.292 ± 0.057	2.643LeuAsn: 2.643 ± 0.059	7.098LeuPro: 7.098 ± 0.122	3.24LeuGln: 3.24 ± 0.069	8.51LeuArg: 8.51 ± 0.134	6.408LeuSer: 6.408 ± 0.094	5.538LeuThr: 5.538 ± 0.092	7.427LeuVal: 7.427 ± 0.102	1.416LeuTrp: 1.416 ± 0.05	2.443LeuTyr: 2.443 ± 0.058	0.0LeuXaa: 0.0 ± 0.0
Met	3.139MetAla: 3.139 ± 0.078	0.27MetCys: 0.27 ± 0.018	1.462MetAsp: 1.462 ± 0.045	1.728MetGlu: 1.728 ± 0.044	0.729MetPhe: 0.729 ± 0.028	2.216MetGly: 2.216 ± 0.056	0.608MetHis: 0.608 ± 0.03	0.969MetIle: 0.969 ± 0.036	1.066MetLys: 1.066 ± 0.034	2.97MetLeu: 2.97 ± 0.062	0.5MetMet: 0.5 ± 0.026	0.804MetAsn: 0.804 ± 0.039	1.711MetPro: 1.711 ± 0.045	1.029MetGln: 1.029 ± 0.036	1.992MetArg: 1.992 ± 0.053	1.587MetSer: 1.587 ± 0.042	1.417MetThr: 1.417 ± 0.049	1.686MetVal: 1.686 ± 0.047	0.185MetTrp: 0.185 ± 0.015	0.514MetTyr: 0.514 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	3.174AsnAla: 3.174 ± 0.073	0.411AsnCys: 0.411 ± 0.024	1.294AsnAsp: 1.294 ± 0.053	1.354AsnGlu: 1.354 ± 0.048	1.218AsnPhe: 1.218 ± 0.036	2.215AsnGly: 2.215 ± 0.065	0.552AsnHis: 0.552 ± 0.03	1.794AsnIle: 1.794 ± 0.06	0.973AsnLys: 0.973 ± 0.041	3.085AsnLeu: 3.085 ± 0.067	0.896AsnMet: 0.896 ± 0.035	0.863AsnAsn: 0.863 ± 0.04	1.87AsnPro: 1.87 ± 0.044	0.734AsnGln: 0.734 ± 0.036	1.778AsnArg: 1.778 ± 0.056	1.561AsnSer: 1.561 ± 0.057	1.59AsnThr: 1.59 ± 0.051	2.034AsnVal: 2.034 ± 0.056	0.382AsnTrp: 0.382 ± 0.022	0.751AsnTyr: 0.751 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	6.041ProAla: 6.041 ± 0.11	0.813ProCys: 0.813 ± 0.031	3.368ProAsp: 3.368 ± 0.069	4.187ProGlu: 4.187 ± 0.078	1.931ProPhe: 1.931 ± 0.047	4.629ProGly: 4.629 ± 0.087	1.359ProHis: 1.359 ± 0.044	1.339ProIle: 1.339 ± 0.05	1.42ProLys: 1.42 ± 0.05	5.859ProLeu: 5.859 ± 0.103	1.014ProMet: 1.014 ± 0.03	1.019ProAsn: 1.019 ± 0.044	3.112ProPro: 3.112 ± 0.089	2.392ProGln: 2.392 ± 0.058	3.059ProArg: 3.059 ± 0.066	2.609ProSer: 2.609 ± 0.062	1.873ProThr: 1.873 ± 0.054	4.358ProVal: 4.358 ± 0.08	0.813ProTrp: 0.813 ± 0.033	1.255ProTyr: 1.255 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	4.399GlnAla: 4.399 ± 0.087	0.551GlnCys: 0.551 ± 0.026	1.724GlnAsp: 1.724 ± 0.044	2.425GlnGlu: 2.425 ± 0.069	0.923GlnPhe: 0.923 ± 0.035	3.11GlnGly: 3.11 ± 0.074	0.713GlnHis: 0.713 ± 0.03	1.612GlnIle: 1.612 ± 0.049	1.91GlnLys: 1.91 ± 0.053	2.588GlnLeu: 2.588 ± 0.065	0.979GlnMet: 0.979 ± 0.033	1.143GlnAsn: 1.143 ± 0.043	1.566GlnPro: 1.566 ± 0.051	1.326GlnGln: 1.326 ± 0.047	2.551GlnArg: 2.551 ± 0.056	1.838GlnSer: 1.838 ± 0.052	1.781GlnThr: 1.781 ± 0.054	2.083GlnVal: 2.083 ± 0.057	0.559GlnTrp: 0.559 ± 0.027	0.854GlnTyr: 0.854 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	7.027ArgAla: 7.027 ± 0.127	0.999ArgCys: 0.999 ± 0.039	3.485ArgAsp: 3.485 ± 0.079	5.173ArgGlu: 5.173 ± 0.094	2.614ArgPhe: 2.614 ± 0.067	4.392ArgGly: 4.392 ± 0.08	2.067ArgHis: 2.067 ± 0.065	3.749ArgIle: 3.749 ± 0.073	3.079ArgLys: 3.079 ± 0.084	8.134ArgLeu: 8.134 ± 0.126	2.174ArgMet: 2.174 ± 0.049	2.055ArgAsn: 2.055 ± 0.049	3.253ArgPro: 3.253 ± 0.081	3.346ArgGln: 3.346 ± 0.075	5.203ArgArg: 5.203 ± 0.093	3.452ArgSer: 3.452 ± 0.079	3.145ArgThr: 3.145 ± 0.073	4.392ArgVal: 4.392 ± 0.085	0.894ArgTrp: 0.894 ± 0.039	1.82ArgTyr: 1.82 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	5.899SerAla: 5.899 ± 0.085	0.89SerCys: 0.89 ± 0.036	2.217SerAsp: 2.217 ± 0.052	2.418SerGlu: 2.418 ± 0.057	2.427SerPhe: 2.427 ± 0.059	5.77SerGly: 5.77 ± 0.105	1.255SerHis: 1.255 ± 0.041	2.483SerIle: 2.483 ± 0.061	1.553SerLys: 1.553 ± 0.053	7.117SerLeu: 7.117 ± 0.111	1.497SerMet: 1.497 ± 0.047	1.267SerAsn: 1.267 ± 0.048	3.442SerPro: 3.442 ± 0.07	1.636SerGln: 1.636 ± 0.049	4.105SerArg: 4.105 ± 0.075	3.191SerSer: 3.191 ± 0.072	2.551SerThr: 2.551 ± 0.065	4.316SerVal: 4.316 ± 0.072	0.725SerTrp: 0.725 ± 0.029	1.16SerTyr: 1.16 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	5.387ThrAla: 5.387 ± 0.089	0.659ThrCys: 0.659 ± 0.027	2.487ThrAsp: 2.487 ± 0.072	2.586ThrGlu: 2.586 ± 0.068	1.835ThrPhe: 1.835 ± 0.06	4.672ThrGly: 4.672 ± 0.104	1.007ThrHis: 1.007 ± 0.034	2.055ThrIle: 2.055 ± 0.063	1.279ThrLys: 1.279 ± 0.047	5.476ThrLeu: 5.476 ± 0.103	0.911ThrMet: 0.911 ± 0.033	1.19ThrAsn: 1.19 ± 0.048	3.344ThrPro: 3.344 ± 0.074	1.354ThrGln: 1.354 ± 0.045	2.954ThrArg: 2.954 ± 0.064	2.565ThrSer: 2.565 ± 0.058	2.182ThrThr: 2.182 ± 0.069	3.926ThrVal: 3.926 ± 0.089	0.544ThrTrp: 0.544 ± 0.027	1.105ThrTyr: 1.105 ± 0.048	0.0ThrXaa: 0.0 ± 0.0
Val	6.881ValAla: 6.881 ± 0.111	1.363ValCys: 1.363 ± 0.046	3.765ValAsp: 3.765 ± 0.073	4.238ValGlu: 4.238 ± 0.078	3.003ValPhe: 3.003 ± 0.071	5.031ValGly: 5.031 ± 0.085	1.528ValHis: 1.528 ± 0.04	3.071ValIle: 3.071 ± 0.067	2.079ValLys: 2.079 ± 0.064	8.423ValLeu: 8.423 ± 0.117	1.843ValMet: 1.843 ± 0.052	2.056ValAsn: 2.056 ± 0.061	3.55ValPro: 3.55 ± 0.068	2.423ValGln: 2.423 ± 0.05	5.651ValArg: 5.651 ± 0.108	4.2ValSer: 4.2 ± 0.083	3.555ValThr: 3.555 ± 0.089	5.075ValVal: 5.075 ± 0.094	0.995ValTrp: 0.995 ± 0.035	1.599ValTyr: 1.599 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	1.144TrpAla: 1.144 ± 0.04	0.196TrpCys: 0.196 ± 0.017	0.591TrpAsp: 0.591 ± 0.028	0.739TrpGlu: 0.739 ± 0.027	0.473TrpPhe: 0.473 ± 0.028	1.015TrpGly: 1.015 ± 0.033	0.357TrpHis: 0.357 ± 0.023	0.554TrpIle: 0.554 ± 0.032	0.61TrpLys: 0.61 ± 0.03	1.807TrpLeu: 1.807 ± 0.056	0.324TrpMet: 0.324 ± 0.024	0.442TrpAsn: 0.442 ± 0.024	0.687TrpPro: 0.687 ± 0.03	0.733TrpGln: 0.733 ± 0.031	1.109TrpArg: 1.109 ± 0.038	0.639TrpSer: 0.639 ± 0.025	0.569TrpThr: 0.569 ± 0.028	0.639TrpVal: 0.639 ± 0.032	0.216TrpTrp: 0.216 ± 0.017	0.322TrpTyr: 0.322 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.731TyrAla: 2.731 ± 0.06	0.422TyrCys: 0.422 ± 0.025	1.258TyrAsp: 1.258 ± 0.041	1.214TyrGlu: 1.214 ± 0.039	1.018TyrPhe: 1.018 ± 0.04	2.218TyrGly: 2.218 ± 0.061	0.552TyrHis: 0.552 ± 0.028	1.035TyrIle: 1.035 ± 0.039	0.828TyrLys: 0.828 ± 0.036	2.365TyrLeu: 2.365 ± 0.06	0.536TyrMet: 0.536 ± 0.025	0.771TyrAsn: 0.771 ± 0.033	1.148TyrPro: 1.148 ± 0.038	0.708TyrGln: 0.708 ± 0.033	1.723TyrArg: 1.723 ± 0.049	1.37TyrSer: 1.37 ± 0.044	1.355TyrThr: 1.355 ± 0.057	1.551TyrVal: 1.551 ± 0.042	0.355TyrTrp: 0.355 ± 0.023	0.73TyrTyr: 0.73 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2373 proteins (758626 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---