Amino acid dipepetide frequency for Cavenderia fasciculata (strain SH3) (Slime mold) (Dictyostelium fasciculatum)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.562AlaAla: 3.562 ± 0.045	0.715AlaCys: 0.715 ± 0.012	2.063AlaAsp: 2.063 ± 0.021	1.949AlaGlu: 1.949 ± 0.022	1.821AlaPhe: 1.821 ± 0.018	2.315AlaGly: 2.315 ± 0.027	0.832AlaHis: 0.832 ± 0.013	3.518AlaIle: 3.518 ± 0.027	2.878AlaLys: 2.878 ± 0.027	4.053AlaLeu: 4.053 ± 0.031	1.174AlaMet: 1.174 ± 0.018	2.601AlaAsn: 2.601 ± 0.024	2.197AlaPro: 2.197 ± 0.028	1.745AlaGln: 1.745 ± 0.022	1.599AlaArg: 1.599 ± 0.018	4.295AlaSer: 4.295 ± 0.035	3.648AlaThr: 3.648 ± 0.039	2.576AlaVal: 2.576 ± 0.027	0.361AlaTrp: 0.361 ± 0.007	1.329AlaTyr: 1.329 ± 0.017	0.0AlaXaa: 0.0 ± 0.0
Cys	0.658CysAla: 0.658 ± 0.011	0.313CysCys: 0.313 ± 0.01	0.844CysAsp: 0.844 ± 0.014	0.619CysGlu: 0.619 ± 0.011	0.705CysPhe: 0.705 ± 0.013	0.816CysGly: 0.816 ± 0.013	0.377CysHis: 0.377 ± 0.008	1.052CysIle: 1.052 ± 0.013	0.991CysLys: 0.991 ± 0.014	1.445CysLeu: 1.445 ± 0.019	0.255CysMet: 0.255 ± 0.006	0.931CysAsn: 0.931 ± 0.016	0.668CysPro: 0.668 ± 0.012	0.793CysGln: 0.793 ± 0.014	0.586CysArg: 0.586 ± 0.01	1.328CysSer: 1.328 ± 0.016	1.075CysThr: 1.075 ± 0.017	0.804CysVal: 0.804 ± 0.015	0.163CysTrp: 0.163 ± 0.005	0.552CysTyr: 0.552 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	2.239AspAla: 2.239 ± 0.025	0.862AspCys: 0.862 ± 0.013	4.747AspAsp: 4.747 ± 0.052	3.792AspGlu: 3.792 ± 0.037	2.294AspPhe: 2.294 ± 0.022	2.971AspGly: 2.971 ± 0.032	1.397AspHis: 1.397 ± 0.017	4.333AspIle: 4.333 ± 0.025	3.349AspLys: 3.349 ± 0.026	4.633AspLeu: 4.633 ± 0.032	1.14AspMet: 1.14 ± 0.014	3.729AspAsn: 3.729 ± 0.029	2.214AspPro: 2.214 ± 0.021	3.029AspGln: 3.029 ± 0.024	2.327AspArg: 2.327 ± 0.034	4.305AspSer: 4.305 ± 0.033	3.043AspThr: 3.043 ± 0.021	2.634AspVal: 2.634 ± 0.022	0.552AspTrp: 0.552 ± 0.01	2.235AspTyr: 2.235 ± 0.021	0.0AspXaa: 0.0 ± 0.0
Glu	2.225GluAla: 2.225 ± 0.025	0.827GluCys: 0.827 ± 0.014	3.263GluAsp: 3.263 ± 0.037	5.885GluGlu: 5.885 ± 0.084	2.201GluPhe: 2.201 ± 0.02	2.183GluGly: 2.183 ± 0.023	1.004GluHis: 1.004 ± 0.013	3.888GluIle: 3.888 ± 0.032	4.808GluLys: 4.808 ± 0.048	4.601GluLeu: 4.601 ± 0.031	1.529GluMet: 1.529 ± 0.017	3.001GluAsn: 3.001 ± 0.027	1.594GluPro: 1.594 ± 0.02	2.749GluGln: 2.749 ± 0.03	2.548GluArg: 2.548 ± 0.035	4.244GluSer: 4.244 ± 0.03	2.955GluThr: 2.955 ± 0.021	2.368GluVal: 2.368 ± 0.022	0.585GluTrp: 0.585 ± 0.01	2.138GluTyr: 2.138 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	1.86PheAla: 1.86 ± 0.02	0.612PheCys: 0.612 ± 0.011	2.609PheAsp: 2.609 ± 0.024	2.3PheGlu: 2.3 ± 0.021	1.808PhePhe: 1.808 ± 0.021	2.69PheGly: 2.69 ± 0.029	0.84PheHis: 0.84 ± 0.012	3.417PheIle: 3.417 ± 0.026	3.195PheLys: 3.195 ± 0.028	3.478PheLeu: 3.478 ± 0.029	0.838PheMet: 0.838 ± 0.011	3.129PheAsn: 3.129 ± 0.025	1.617PhePro: 1.617 ± 0.017	1.717PheGln: 1.717 ± 0.016	1.316PheArg: 1.316 ± 0.016	3.572PheSer: 3.572 ± 0.026	2.605PheThr: 2.605 ± 0.026	2.431PheVal: 2.431 ± 0.021	0.374PheTrp: 0.374 ± 0.008	1.646PheTyr: 1.646 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	2.671GlyAla: 2.671 ± 0.034	0.928GlyCys: 0.928 ± 0.016	2.902GlyAsp: 2.902 ± 0.027	2.354GlyGlu: 2.354 ± 0.021	2.073GlyPhe: 2.073 ± 0.019	4.855GlyGly: 4.855 ± 0.057	1.353GlyHis: 1.353 ± 0.023	3.227GlyIle: 3.227 ± 0.029	2.802GlyLys: 2.802 ± 0.025	3.813GlyLeu: 3.813 ± 0.028	1.016GlyMet: 1.016 ± 0.013	2.854GlyAsn: 2.854 ± 0.025	1.448GlyPro: 1.448 ± 0.019	2.066GlyGln: 2.066 ± 0.025	1.965GlyArg: 1.965 ± 0.021	4.759GlySer: 4.759 ± 0.042	2.893GlyThr: 2.893 ± 0.031	3.021GlyVal: 3.021 ± 0.033	0.575GlyTrp: 0.575 ± 0.011	1.953GlyTyr: 1.953 ± 0.021	0.0GlyXaa: 0.0 ± 0.0
His	0.789HisAla: 0.789 ± 0.011	0.414HisCys: 0.414 ± 0.01	0.942HisAsp: 0.942 ± 0.015	0.809HisGlu: 0.809 ± 0.013	1.192HisPhe: 1.192 ± 0.016	1.057HisGly: 1.057 ± 0.017	1.522HisHis: 1.522 ± 0.029	1.637HisIle: 1.637 ± 0.018	1.068HisLys: 1.068 ± 0.013	2.605HisLeu: 2.605 ± 0.024	0.403HisMet: 0.403 ± 0.008	1.35HisAsn: 1.35 ± 0.018	1.255HisPro: 1.255 ± 0.015	1.667HisGln: 1.667 ± 0.022	1.005HisArg: 1.005 ± 0.014	1.939HisSer: 1.939 ± 0.021	1.152HisThr: 1.152 ± 0.013	1.08HisVal: 1.08 ± 0.014	0.206HisTrp: 0.206 ± 0.006	1.003HisTyr: 1.003 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	3.296IleAla: 3.296 ± 0.031	1.059IleCys: 1.059 ± 0.012	4.915IleAsp: 4.915 ± 0.031	4.221IleGlu: 4.221 ± 0.031	2.921IlePhe: 2.921 ± 0.026	3.646IleGly: 3.646 ± 0.032	1.622IleHis: 1.622 ± 0.019	5.604IleIle: 5.604 ± 0.038	5.212IleLys: 5.212 ± 0.033	6.085IleLeu: 6.085 ± 0.035	1.261IleMet: 1.261 ± 0.013	5.093IleAsn: 5.093 ± 0.035	3.497IlePro: 3.497 ± 0.027	3.535IleGln: 3.535 ± 0.025	2.533IleArg: 2.533 ± 0.02	5.92IleSer: 5.92 ± 0.036	4.454IleThr: 4.454 ± 0.034	4.515IleVal: 4.515 ± 0.031	0.549IleTrp: 0.549 ± 0.01	2.586IleTyr: 2.586 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	2.565LysAla: 2.565 ± 0.031	0.959LysCys: 0.959 ± 0.016	3.917LysAsp: 3.917 ± 0.026	5.169LysGlu: 5.169 ± 0.043	2.259LysPhe: 2.259 ± 0.02	2.639LysGly: 2.639 ± 0.022	1.386LysHis: 1.386 ± 0.015	4.267LysIle: 4.267 ± 0.034	6.272LysLys: 6.272 ± 0.063	5.652LysLeu: 5.652 ± 0.035	1.559LysMet: 1.559 ± 0.017	3.623LysAsn: 3.623 ± 0.026	2.48LysPro: 2.48 ± 0.024	3.486LysGln: 3.486 ± 0.029	3.035LysArg: 3.035 ± 0.028	5.311LysSer: 5.311 ± 0.037	3.515LysThr: 3.515 ± 0.026	3.337LysVal: 3.337 ± 0.024	0.649LysTrp: 0.649 ± 0.01	2.562LysTyr: 2.562 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	4.425LeuAla: 4.425 ± 0.031	1.298LeuCys: 1.298 ± 0.016	5.243LeuAsp: 5.243 ± 0.032	5.561LeuGlu: 5.561 ± 0.046	4.332LeuPhe: 4.332 ± 0.036	3.872LeuGly: 3.872 ± 0.025	1.912LeuHis: 1.912 ± 0.022	5.78LeuIle: 5.78 ± 0.037	6.128LeuLys: 6.128 ± 0.041	8.842LeuLeu: 8.842 ± 0.057	1.669LeuMet: 1.669 ± 0.017	5.209LeuAsn: 5.209 ± 0.034	4.311LeuPro: 4.311 ± 0.038	4.044LeuGln: 4.044 ± 0.029	2.941LeuArg: 2.941 ± 0.026	8.255LeuSer: 8.255 ± 0.051	5.091LeuThr: 5.091 ± 0.034	5.664LeuVal: 5.664 ± 0.036	0.696LeuTrp: 0.696 ± 0.011	3.199LeuTyr: 3.199 ± 0.028	0.0LeuXaa: 0.0 ± 0.0
Met	1.199MetAla: 1.199 ± 0.014	0.266MetCys: 0.266 ± 0.006	1.468MetAsp: 1.468 ± 0.018	1.318MetGlu: 1.318 ± 0.018	0.839MetPhe: 0.839 ± 0.013	1.059MetGly: 1.059 ± 0.014	0.305MetHis: 0.305 ± 0.007	1.677MetIle: 1.677 ± 0.018	1.253MetLys: 1.253 ± 0.014	1.549MetLeu: 1.549 ± 0.017	0.69MetMet: 0.69 ± 0.012	1.323MetAsn: 1.323 ± 0.014	0.702MetPro: 0.702 ± 0.013	0.638MetGln: 0.638 ± 0.009	0.646MetArg: 0.646 ± 0.012	1.818MetSer: 1.818 ± 0.018	1.397MetThr: 1.397 ± 0.015	1.486MetVal: 1.486 ± 0.018	0.159MetTrp: 0.159 ± 0.005	0.626MetTyr: 0.626 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.515AsnAla: 2.515 ± 0.024	0.877AsnCys: 0.877 ± 0.013	3.525AsnAsp: 3.525 ± 0.025	2.904AsnGlu: 2.904 ± 0.021	2.081AsnPhe: 2.081 ± 0.019	3.68AsnGly: 3.68 ± 0.032	1.961AsnHis: 1.961 ± 0.019	5.28AsnIle: 5.28 ± 0.034	3.553AsnLys: 3.553 ± 0.026	5.07AsnLeu: 5.07 ± 0.029	1.186AsnMet: 1.186 ± 0.015	14.262AsnAsn: 14.262 ± 0.166	2.54AsnPro: 2.54 ± 0.022	4.126AsnGln: 4.126 ± 0.033	2.466AsnArg: 2.466 ± 0.023	5.793AsnSer: 5.793 ± 0.048	4.095AsnThr: 4.095 ± 0.03	3.249AsnVal: 3.249 ± 0.025	0.501AsnTrp: 0.501 ± 0.008	2.291AsnTyr: 2.291 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	1.984ProAla: 1.984 ± 0.025	0.464ProCys: 0.464 ± 0.011	1.755ProAsp: 1.755 ± 0.02	1.757ProGlu: 1.757 ± 0.021	2.009ProPhe: 2.009 ± 0.021	1.532ProGly: 1.532 ± 0.026	0.958ProHis: 0.958 ± 0.015	3.53ProIle: 3.53 ± 0.029	2.632ProLys: 2.632 ± 0.025	4.12ProLeu: 4.12 ± 0.031	0.81ProMet: 0.81 ± 0.013	2.89ProAsn: 2.89 ± 0.025	4.019ProPro: 4.019 ± 0.062	2.204ProGln: 2.204 ± 0.029	1.385ProArg: 1.385 ± 0.019	5.312ProSer: 5.312 ± 0.043	4.225ProThr: 4.225 ± 0.04	2.334ProVal: 2.334 ± 0.025	0.333ProTrp: 0.333 ± 0.007	1.395ProTyr: 1.395 ± 0.016	0.0ProXaa: 0.0 ± 0.0
Gln	1.843GlnAla: 1.843 ± 0.022	0.789GlnCys: 0.789 ± 0.012	2.428GlnAsp: 2.428 ± 0.021	2.786GlnGlu: 2.786 ± 0.033	2.127GlnPhe: 2.127 ± 0.02	1.682GlnGly: 1.682 ± 0.019	1.533GlnHis: 1.533 ± 0.019	2.841GlnIle: 2.841 ± 0.022	2.739GlnLys: 2.739 ± 0.022	4.92GlnLeu: 4.92 ± 0.033	1.022GlnMet: 1.022 ± 0.014	2.543GlnAsn: 2.543 ± 0.023	2.76GlnPro: 2.76 ± 0.037	8.692GlnGln: 8.692 ± 0.153	1.773GlnArg: 1.773 ± 0.019	4.553GlnSer: 4.553 ± 0.033	2.662GlnThr: 2.662 ± 0.024	2.426GlnVal: 2.426 ± 0.024	0.438GlnTrp: 0.438 ± 0.008	1.942GlnTyr: 1.942 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	1.68ArgAla: 1.68 ± 0.02	0.55ArgCys: 0.55 ± 0.009	2.33ArgAsp: 2.33 ± 0.035	2.2ArgGlu: 2.2 ± 0.024	1.776ArgPhe: 1.776 ± 0.015	1.874ArgGly: 1.874 ± 0.028	0.839ArgHis: 0.839 ± 0.012	2.572ArgIle: 2.572 ± 0.023	2.397ArgLys: 2.397 ± 0.026	3.716ArgLeu: 3.716 ± 0.035	0.853ArgMet: 0.853 ± 0.013	1.963ArgAsn: 1.963 ± 0.021	1.329ArgPro: 1.329 ± 0.014	1.56ArgGln: 1.56 ± 0.016	1.677ArgArg: 1.677 ± 0.02	2.937ArgSer: 2.937 ± 0.028	1.767ArgThr: 1.767 ± 0.018	2.247ArgVal: 2.247 ± 0.019	0.393ArgTrp: 0.393 ± 0.009	1.544ArgTyr: 1.544 ± 0.016	0.0ArgXaa: 0.0 ± 0.0
Ser	3.756SerAla: 3.756 ± 0.034	1.218SerCys: 1.218 ± 0.017	4.042SerAsp: 4.042 ± 0.025	3.194SerGlu: 3.194 ± 0.027	4.24SerPhe: 4.24 ± 0.03	4.296SerGly: 4.296 ± 0.045	1.834SerHis: 1.834 ± 0.022	7.521SerIle: 7.521 ± 0.044	5.294SerLys: 5.294 ± 0.034	8.664SerLeu: 8.664 ± 0.054	1.834SerMet: 1.834 ± 0.017	6.608SerAsn: 6.608 ± 0.045	4.878SerPro: 4.878 ± 0.05	3.578SerGln: 3.578 ± 0.029	2.859SerArg: 2.859 ± 0.026	15.349SerSer: 15.349 ± 0.143	8.2SerThr: 8.2 ± 0.075	4.489SerVal: 4.489 ± 0.032	0.659SerTrp: 0.659 ± 0.011	2.834SerTyr: 2.834 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	3.023ThrAla: 3.023 ± 0.035	1.008ThrCys: 1.008 ± 0.018	2.729ThrAsp: 2.729 ± 0.023	2.495ThrGlu: 2.495 ± 0.021	2.82ThrPhe: 2.82 ± 0.026	2.938ThrGly: 2.938 ± 0.049	1.146ThrHis: 1.146 ± 0.012	5.542ThrIle: 5.542 ± 0.042	3.978ThrLys: 3.978 ± 0.029	5.912ThrLeu: 5.912 ± 0.034	1.246ThrMet: 1.246 ± 0.016	4.6ThrAsn: 4.6 ± 0.034	3.829ThrPro: 3.829 ± 0.037	2.256ThrGln: 2.256 ± 0.021	1.964ThrArg: 1.964 ± 0.02	7.227ThrSer: 7.227 ± 0.064	9.632ThrThr: 9.632 ± 0.124	3.457ThrVal: 3.457 ± 0.031	0.464ThrTrp: 0.464 ± 0.008	1.936ThrTyr: 1.936 ± 0.02	0.0ThrXaa: 0.0 ± 0.0
Val	3.092ValAla: 3.092 ± 0.029	0.928ValCys: 0.928 ± 0.011	3.513ValAsp: 3.513 ± 0.024	3.302ValGlu: 3.302 ± 0.026	2.291ValPhe: 2.291 ± 0.021	3.14ValGly: 3.14 ± 0.03	1.113ValHis: 1.113 ± 0.015	3.673ValIle: 3.673 ± 0.027	3.448ValLys: 3.448 ± 0.029	4.695ValLeu: 4.695 ± 0.032	1.038ValMet: 1.038 ± 0.015	3.111ValAsn: 3.111 ± 0.024	2.458ValPro: 2.458 ± 0.026	2.359ValGln: 2.359 ± 0.023	1.766ValArg: 1.766 ± 0.016	4.605ValSer: 4.605 ± 0.034	3.281ValThr: 3.281 ± 0.035	4.029ValVal: 4.029 ± 0.038	0.525ValTrp: 0.525 ± 0.014	1.948ValTyr: 1.948 ± 0.018	0.0ValXaa: 0.0 ± 0.0
Trp	0.432TrpAla: 0.432 ± 0.009	0.173TrpCys: 0.173 ± 0.005	0.544TrpAsp: 0.544 ± 0.01	0.444TrpGlu: 0.444 ± 0.009	0.407TrpPhe: 0.407 ± 0.007	0.417TrpGly: 0.417 ± 0.01	0.144TrpHis: 0.144 ± 0.005	0.698TrpIle: 0.698 ± 0.011	0.657TrpLys: 0.657 ± 0.01	0.748TrpLeu: 0.748 ± 0.013	0.261TrpMet: 0.261 ± 0.006	0.602TrpAsn: 0.602 ± 0.01	0.222TrpPro: 0.222 ± 0.006	0.25TrpGln: 0.25 ± 0.006	0.416TrpArg: 0.416 ± 0.009	0.752TrpSer: 0.752 ± 0.012	0.537TrpThr: 0.537 ± 0.008	0.516TrpVal: 0.516 ± 0.009	0.128TrpTrp: 0.128 ± 0.005	0.303TrpTyr: 0.303 ± 0.007	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.419TyrAla: 1.419 ± 0.017	0.713TyrCys: 0.713 ± 0.014	2.047TyrAsp: 2.047 ± 0.021	1.537TyrGlu: 1.537 ± 0.013	1.857TyrPhe: 1.857 ± 0.02	1.863TyrGly: 1.863 ± 0.018	1.017TyrHis: 1.017 ± 0.014	2.468TyrIle: 2.468 ± 0.019	1.992TyrLys: 1.992 ± 0.021	3.869TyrLeu: 3.869 ± 0.033	0.634TyrMet: 0.634 ± 0.01	2.535TyrAsn: 2.535 ± 0.027	1.629TyrPro: 1.629 ± 0.02	2.004TyrGln: 2.004 ± 0.02	1.397TyrArg: 1.397 ± 0.015	3.071TyrSer: 3.071 ± 0.022	1.974TyrThr: 1.974 ± 0.02	1.654TyrVal: 1.654 ± 0.015	0.341TyrTrp: 0.341 ± 0.008	1.792TyrTyr: 1.792 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 12152 proteins (6765862 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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