Amino acid dipepetide frequency for Moraxella phage Mcat8

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.042AlaAla: 3.042 ± 0.844
0.576AlaCys: 0.576 ± 0.287
4.522AlaAsp: 4.522 ± 0.7
4.111AlaGlu: 4.111 ± 0.585
4.358AlaPhe: 4.358 ± 0.737
4.687AlaGly: 4.687 ± 0.705
2.384AlaHis: 2.384 ± 0.46
6.496AlaIle: 6.496 ± 0.692
8.962AlaLys: 8.962 ± 1.125
6.66AlaLeu: 6.66 ± 0.758
2.467AlaMet: 2.467 ± 0.588
5.591AlaAsn: 5.591 ± 0.803
1.973AlaPro: 1.973 ± 0.385
4.276AlaGln: 4.276 ± 0.647
3.618AlaArg: 3.618 ± 0.507
4.605AlaSer: 4.605 ± 0.968
4.769AlaThr: 4.769 ± 1.112
4.358AlaVal: 4.358 ± 0.673
1.316AlaTrp: 1.316 ± 0.35
3.289AlaTyr: 3.289 ± 0.51
0.0AlaXaa: 0.0 ± 0.0
Cys
0.74CysAla: 0.74 ± 0.392
0.247CysCys: 0.247 ± 0.165
0.493CysAsp: 0.493 ± 0.176
0.493CysGlu: 0.493 ± 0.201
0.082CysPhe: 0.082 ± 0.09
1.233CysGly: 1.233 ± 0.403
0.329CysHis: 0.329 ± 0.223
0.329CysIle: 0.329 ± 0.174
1.069CysLys: 1.069 ± 0.42
0.658CysLeu: 0.658 ± 0.261
0.0CysMet: 0.0 ± 0.0
0.576CysAsn: 0.576 ± 0.24
0.329CysPro: 0.329 ± 0.18
0.411CysGln: 0.411 ± 0.175
0.576CysArg: 0.576 ± 0.247
0.74CysSer: 0.74 ± 0.271
0.411CysThr: 0.411 ± 0.229
0.247CysVal: 0.247 ± 0.163
0.0CysTrp: 0.0 ± 0.0
0.411CysTyr: 0.411 ± 0.18
0.0CysXaa: 0.0 ± 0.0
Asp
4.111AspAla: 4.111 ± 0.626
0.576AspCys: 0.576 ± 0.269
5.92AspAsp: 5.92 ± 0.802
4.933AspGlu: 4.933 ± 0.883
3.289AspPhe: 3.289 ± 0.605
6.66AspGly: 6.66 ± 0.8
0.411AspHis: 0.411 ± 0.26
3.947AspIle: 3.947 ± 0.625
5.92AspLys: 5.92 ± 0.477
5.098AspLeu: 5.098 ± 0.661
0.904AspMet: 0.904 ± 0.233
3.864AspAsn: 3.864 ± 0.528
1.562AspPro: 1.562 ± 0.467
0.904AspGln: 0.904 ± 0.19
1.809AspArg: 1.809 ± 0.375
2.796AspSer: 2.796 ± 0.478
2.878AspThr: 2.878 ± 0.477
2.713AspVal: 2.713 ± 0.358
1.48AspTrp: 1.48 ± 0.348
2.302AspTyr: 2.302 ± 0.457
0.0AspXaa: 0.0 ± 0.0
Glu
2.878GluAla: 2.878 ± 0.533
0.576GluCys: 0.576 ± 0.253
1.809GluAsp: 1.809 ± 0.51
1.809GluGlu: 1.809 ± 0.469
2.384GluPhe: 2.384 ± 0.516
1.644GluGly: 1.644 ± 0.384
1.069GluHis: 1.069 ± 0.291
5.18GluIle: 5.18 ± 0.819
3.618GluLys: 3.618 ± 0.828
4.769GluLeu: 4.769 ± 0.566
2.713GluMet: 2.713 ± 0.353
2.878GluAsn: 2.878 ± 0.523
1.973GluPro: 1.973 ± 0.406
5.345GluGln: 5.345 ± 0.634
3.371GluArg: 3.371 ± 0.543
3.536GluSer: 3.536 ± 0.497
2.302GluThr: 2.302 ± 0.406
2.713GluVal: 2.713 ± 0.657
0.987GluTrp: 0.987 ± 0.29
1.973GluTyr: 1.973 ± 0.391
0.0GluXaa: 0.0 ± 0.0
Phe
3.536PheAla: 3.536 ± 0.476
0.247PheCys: 0.247 ± 0.129
3.947PheAsp: 3.947 ± 0.526
2.796PheGlu: 2.796 ± 0.547
1.151PhePhe: 1.151 ± 0.41
2.96PheGly: 2.96 ± 0.353
0.74PheHis: 0.74 ± 0.252
3.864PheIle: 3.864 ± 0.66
2.22PheLys: 2.22 ± 0.513
2.22PheLeu: 2.22 ± 0.56
1.316PheMet: 1.316 ± 0.278
2.138PheAsn: 2.138 ± 0.434
0.658PhePro: 0.658 ± 0.21
0.411PheGln: 0.411 ± 0.215
1.809PheArg: 1.809 ± 0.409
2.631PheSer: 2.631 ± 0.455
2.713PheThr: 2.713 ± 0.546
2.302PheVal: 2.302 ± 0.542
0.493PheTrp: 0.493 ± 0.189
0.904PheTyr: 0.904 ± 0.309
0.0PheXaa: 0.0 ± 0.0
Gly
4.522GlyAla: 4.522 ± 0.674
0.576GlyCys: 0.576 ± 0.326
4.522GlyAsp: 4.522 ± 0.605
3.947GlyGlu: 3.947 ± 0.468
3.453GlyPhe: 3.453 ± 0.482
4.851GlyGly: 4.851 ± 0.667
1.069GlyHis: 1.069 ± 0.265
5.345GlyIle: 5.345 ± 0.795
5.427GlyLys: 5.427 ± 0.756
5.016GlyLeu: 5.016 ± 0.611
1.562GlyMet: 1.562 ± 0.323
3.371GlyAsn: 3.371 ± 0.626
0.0GlyPro: 0.0 ± 0.0
4.111GlyGln: 4.111 ± 0.638
3.453GlyArg: 3.453 ± 0.418
3.371GlySer: 3.371 ± 0.615
4.029GlyThr: 4.029 ± 0.739
5.673GlyVal: 5.673 ± 0.654
0.987GlyTrp: 0.987 ± 0.244
2.631GlyTyr: 2.631 ± 0.568
0.0GlyXaa: 0.0 ± 0.0
His
2.138HisAla: 2.138 ± 0.524
0.247HisCys: 0.247 ± 0.149
1.562HisAsp: 1.562 ± 0.308
1.233HisGlu: 1.233 ± 0.439
0.658HisPhe: 0.658 ± 0.242
1.973HisGly: 1.973 ± 0.359
1.151HisHis: 1.151 ± 0.484
1.398HisIle: 1.398 ± 0.317
1.233HisLys: 1.233 ± 0.328
1.48HisLeu: 1.48 ± 0.46
0.411HisMet: 0.411 ± 0.243
0.658HisAsn: 0.658 ± 0.247
1.233HisPro: 1.233 ± 0.37
0.658HisGln: 0.658 ± 0.22
0.987HisArg: 0.987 ± 0.278
1.233HisSer: 1.233 ± 0.346
1.727HisThr: 1.727 ± 0.259
0.904HisVal: 0.904 ± 0.278
0.164HisTrp: 0.164 ± 0.133
0.904HisTyr: 0.904 ± 0.254
0.0HisXaa: 0.0 ± 0.0
Ile
6.085IleAla: 6.085 ± 0.685
1.151IleCys: 1.151 ± 0.267
6.167IleAsp: 6.167 ± 0.704
4.111IleGlu: 4.111 ± 0.511
2.138IlePhe: 2.138 ± 0.438
4.358IleGly: 4.358 ± 0.67
1.151IleHis: 1.151 ± 0.336
3.782IleIle: 3.782 ± 0.701
6.002IleLys: 6.002 ± 0.697
5.098IleLeu: 5.098 ± 1.156
1.398IleMet: 1.398 ± 0.37
4.605IleAsn: 4.605 ± 0.859
2.384IlePro: 2.384 ± 0.446
3.042IleGln: 3.042 ± 0.495
2.878IleArg: 2.878 ± 0.535
4.605IleSer: 4.605 ± 0.897
5.509IleThr: 5.509 ± 0.744
3.536IleVal: 3.536 ± 0.609
0.904IleTrp: 0.904 ± 0.288
1.727IleTyr: 1.727 ± 0.333
0.0IleXaa: 0.0 ± 0.0
Lys
7.729LysAla: 7.729 ± 1.003
0.822LysCys: 0.822 ± 0.383
3.371LysAsp: 3.371 ± 0.516
4.276LysGlu: 4.276 ± 0.664
1.973LysPhe: 1.973 ± 0.341
4.769LysGly: 4.769 ± 0.793
2.138LysHis: 2.138 ± 0.44
5.016LysIle: 5.016 ± 0.581
5.756LysLys: 5.756 ± 0.874
6.002LysLeu: 6.002 ± 0.619
1.233LysMet: 1.233 ± 0.312
4.029LysAsn: 4.029 ± 0.745
2.467LysPro: 2.467 ± 0.501
4.933LysGln: 4.933 ± 0.679
3.782LysArg: 3.782 ± 0.616
4.933LysSer: 4.933 ± 0.855
5.673LysThr: 5.673 ± 0.809
4.44LysVal: 4.44 ± 0.576
0.576LysTrp: 0.576 ± 0.201
2.384LysTyr: 2.384 ± 0.436
0.0LysXaa: 0.0 ± 0.0
Leu
8.716LeuAla: 8.716 ± 1.191
0.658LeuCys: 0.658 ± 0.285
5.345LeuAsp: 5.345 ± 0.849
3.453LeuGlu: 3.453 ± 0.474
3.042LeuPhe: 3.042 ± 0.712
6.413LeuGly: 6.413 ± 0.743
1.973LeuHis: 1.973 ± 0.547
5.345LeuIle: 5.345 ± 0.684
6.085LeuLys: 6.085 ± 0.733
4.605LeuLeu: 4.605 ± 0.875
2.22LeuMet: 2.22 ± 0.51
5.098LeuAsn: 5.098 ± 0.711
3.207LeuPro: 3.207 ± 0.693
4.44LeuGln: 4.44 ± 0.428
3.207LeuArg: 3.207 ± 0.539
6.66LeuSer: 6.66 ± 0.675
5.345LeuThr: 5.345 ± 0.637
3.207LeuVal: 3.207 ± 0.625
1.151LeuTrp: 1.151 ± 0.271
2.384LeuTyr: 2.384 ± 0.423
0.0LeuXaa: 0.0 ± 0.0
Met
2.22MetAla: 2.22 ± 0.478
0.164MetCys: 0.164 ± 0.124
0.822MetAsp: 0.822 ± 0.254
0.329MetGlu: 0.329 ± 0.16
0.904MetPhe: 0.904 ± 0.276
1.727MetGly: 1.727 ± 0.391
0.082MetHis: 0.082 ± 0.087
1.562MetIle: 1.562 ± 0.397
1.809MetLys: 1.809 ± 0.574
1.644MetLeu: 1.644 ± 0.358
0.576MetMet: 0.576 ± 0.231
1.233MetAsn: 1.233 ± 0.253
0.822MetPro: 0.822 ± 0.287
1.562MetGln: 1.562 ± 0.361
1.151MetArg: 1.151 ± 0.318
2.22MetSer: 2.22 ± 0.556
1.973MetThr: 1.973 ± 0.482
1.891MetVal: 1.891 ± 0.374
0.0MetTrp: 0.0 ± 0.0
0.329MetTyr: 0.329 ± 0.148
0.0MetXaa: 0.0 ± 0.0
Asn
4.769AsnAla: 4.769 ± 0.833
0.247AsnCys: 0.247 ± 0.149
2.631AsnAsp: 2.631 ± 0.496
3.371AsnGlu: 3.371 ± 0.389
2.384AsnPhe: 2.384 ± 0.42
4.276AsnGly: 4.276 ± 0.682
1.151AsnHis: 1.151 ± 0.287
3.536AsnIle: 3.536 ± 0.678
2.96AsnLys: 2.96 ± 0.455
4.522AsnLeu: 4.522 ± 0.641
0.74AsnMet: 0.74 ± 0.243
3.453AsnAsn: 3.453 ± 0.579
1.973AsnPro: 1.973 ± 0.48
2.96AsnGln: 2.96 ± 0.505
2.713AsnArg: 2.713 ± 0.456
4.851AsnSer: 4.851 ± 1.163
3.536AsnThr: 3.536 ± 0.657
2.138AsnVal: 2.138 ± 0.355
0.576AsnTrp: 0.576 ± 0.219
2.384AsnTyr: 2.384 ± 0.507
0.0AsnXaa: 0.0 ± 0.0
Pro
1.48ProAla: 1.48 ± 0.383
0.658ProCys: 0.658 ± 0.258
1.891ProAsp: 1.891 ± 0.37
1.644ProGlu: 1.644 ± 0.437
1.727ProPhe: 1.727 ± 0.378
0.082ProGly: 0.082 ± 0.083
0.658ProHis: 0.658 ± 0.274
2.96ProIle: 2.96 ± 0.494
3.289ProLys: 3.289 ± 0.535
2.713ProLeu: 2.713 ± 0.542
0.74ProMet: 0.74 ± 0.217
2.302ProAsn: 2.302 ± 0.426
0.987ProPro: 0.987 ± 0.285
1.151ProGln: 1.151 ± 0.256
0.987ProArg: 0.987 ± 0.263
2.138ProSer: 2.138 ± 0.47
1.809ProThr: 1.809 ± 0.439
1.316ProVal: 1.316 ± 0.399
0.082ProTrp: 0.082 ± 0.09
0.987ProTyr: 0.987 ± 0.298
0.0ProXaa: 0.0 ± 0.0
Gln
6.907GlnAla: 6.907 ± 0.658
0.411GlnCys: 0.411 ± 0.187
2.796GlnAsp: 2.796 ± 0.697
2.384GlnGlu: 2.384 ± 0.476
1.398GlnPhe: 1.398 ± 0.29
3.7GlnGly: 3.7 ± 0.696
0.74GlnHis: 0.74 ± 0.226
4.522GlnIle: 4.522 ± 0.568
3.618GlnLys: 3.618 ± 0.446
4.111GlnLeu: 4.111 ± 0.785
1.48GlnMet: 1.48 ± 0.382
2.796GlnAsn: 2.796 ± 0.4
1.316GlnPro: 1.316 ± 0.334
2.384GlnGln: 2.384 ± 0.553
1.891GlnArg: 1.891 ± 0.294
3.864GlnSer: 3.864 ± 0.743
3.371GlnThr: 3.371 ± 0.623
2.713GlnVal: 2.713 ± 0.493
0.329GlnTrp: 0.329 ± 0.164
1.891GlnTyr: 1.891 ± 0.363
0.0GlnXaa: 0.0 ± 0.0
Arg
4.358ArgAla: 4.358 ± 0.81
0.329ArgCys: 0.329 ± 0.178
2.22ArgAsp: 2.22 ± 0.46
2.056ArgGlu: 2.056 ± 0.603
1.48ArgPhe: 1.48 ± 0.328
2.631ArgGly: 2.631 ± 0.442
0.904ArgHis: 0.904 ± 0.221
2.631ArgIle: 2.631 ± 0.736
2.549ArgLys: 2.549 ± 0.49
6.742ArgLeu: 6.742 ± 0.787
1.069ArgMet: 1.069 ± 0.338
1.233ArgAsn: 1.233 ± 0.257
1.316ArgPro: 1.316 ± 0.311
3.618ArgGln: 3.618 ± 0.631
1.809ArgArg: 1.809 ± 0.347
2.138ArgSer: 2.138 ± 0.408
3.042ArgThr: 3.042 ± 0.386
2.384ArgVal: 2.384 ± 0.404
0.411ArgTrp: 0.411 ± 0.228
1.809ArgTyr: 1.809 ± 0.48
0.0ArgXaa: 0.0 ± 0.0
Ser
4.769SerAla: 4.769 ± 0.76
0.329SerCys: 0.329 ± 0.19
4.193SerAsp: 4.193 ± 0.594
4.358SerGlu: 4.358 ± 0.753
2.796SerPhe: 2.796 ± 0.364
5.18SerGly: 5.18 ± 0.932
2.056SerHis: 2.056 ± 0.341
4.605SerIle: 4.605 ± 0.786
4.851SerLys: 4.851 ± 0.705
5.262SerLeu: 5.262 ± 0.793
1.562SerMet: 1.562 ± 0.429
3.618SerAsn: 3.618 ± 0.788
1.316SerPro: 1.316 ± 0.354
2.878SerGln: 2.878 ± 0.499
2.467SerArg: 2.467 ± 0.388
4.44SerSer: 4.44 ± 0.917
2.96SerThr: 2.96 ± 0.623
4.605SerVal: 4.605 ± 0.993
0.658SerTrp: 0.658 ± 0.222
1.973SerTyr: 1.973 ± 0.421
0.0SerXaa: 0.0 ± 0.0
Thr
6.907ThrAla: 6.907 ± 1.304
0.493ThrCys: 0.493 ± 0.28
3.947ThrAsp: 3.947 ± 0.631
3.042ThrGlu: 3.042 ± 0.482
1.316ThrPhe: 1.316 ± 0.293
4.111ThrGly: 4.111 ± 0.487
1.48ThrHis: 1.48 ± 0.306
4.276ThrIle: 4.276 ± 0.648
5.18ThrLys: 5.18 ± 1.171
6.989ThrLeu: 6.989 ± 0.757
0.74ThrMet: 0.74 ± 0.221
2.056ThrAsn: 2.056 ± 0.477
2.549ThrPro: 2.549 ± 0.504
3.371ThrGln: 3.371 ± 0.614
2.302ThrArg: 2.302 ± 0.366
2.467ThrSer: 2.467 ± 0.45
4.769ThrThr: 4.769 ± 0.641
3.7ThrVal: 3.7 ± 0.613
0.329ThrTrp: 0.329 ± 0.15
2.056ThrTyr: 2.056 ± 0.463
0.0ThrXaa: 0.0 ± 0.0
Val
3.618ValAla: 3.618 ± 0.589
0.658ValCys: 0.658 ± 0.242
2.878ValAsp: 2.878 ± 0.402
2.384ValGlu: 2.384 ± 0.475
2.878ValPhe: 2.878 ± 0.575
3.864ValGly: 3.864 ± 0.767
0.822ValHis: 0.822 ± 0.214
3.536ValIle: 3.536 ± 0.608
3.453ValLys: 3.453 ± 0.722
5.016ValLeu: 5.016 ± 0.589
1.069ValMet: 1.069 ± 0.305
3.124ValAsn: 3.124 ± 0.555
1.48ValPro: 1.48 ± 0.328
2.631ValGln: 2.631 ± 0.477
2.467ValArg: 2.467 ± 0.497
5.427ValSer: 5.427 ± 0.767
3.042ValThr: 3.042 ± 0.571
3.7ValVal: 3.7 ± 0.554
0.576ValTrp: 0.576 ± 0.214
2.631ValTyr: 2.631 ± 0.449
0.0ValXaa: 0.0 ± 0.0
Trp
1.151TrpAla: 1.151 ± 0.218
0.0TrpCys: 0.0 ± 0.0
0.658TrpAsp: 0.658 ± 0.233
0.411TrpGlu: 0.411 ± 0.17
0.411TrpPhe: 0.411 ± 0.217
0.74TrpGly: 0.74 ± 0.24
0.329TrpHis: 0.329 ± 0.183
0.164TrpIle: 0.164 ± 0.119
0.247TrpLys: 0.247 ± 0.137
0.987TrpLeu: 0.987 ± 0.259
0.0TrpMet: 0.0 ± 0.0
0.658TrpAsn: 0.658 ± 0.18
0.082TrpPro: 0.082 ± 0.083
1.151TrpGln: 1.151 ± 0.304
1.069TrpArg: 1.069 ± 0.344
0.904TrpSer: 0.904 ± 0.284
0.74TrpThr: 0.74 ± 0.235
1.151TrpVal: 1.151 ± 0.325
0.247TrpTrp: 0.247 ± 0.126
0.493TrpTyr: 0.493 ± 0.213
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.384TyrAla: 2.384 ± 0.586
0.411TyrCys: 0.411 ± 0.192
2.384TyrAsp: 2.384 ± 0.493
2.384TyrGlu: 2.384 ± 0.444
1.233TyrPhe: 1.233 ± 0.468
2.056TyrGly: 2.056 ± 0.434
1.316TyrHis: 1.316 ± 0.312
2.138TyrIle: 2.138 ± 0.423
2.056TyrLys: 2.056 ± 0.582
3.042TyrLeu: 3.042 ± 0.499
0.74TyrMet: 0.74 ± 0.236
1.891TyrAsn: 1.891 ± 0.297
1.973TyrPro: 1.973 ± 0.397
2.384TyrGln: 2.384 ± 0.393
2.384TyrArg: 2.384 ± 0.444
1.316TyrSer: 1.316 ± 0.358
1.48TyrThr: 1.48 ± 0.369
1.562TyrVal: 1.562 ± 0.337
0.329TyrTrp: 0.329 ± 0.157
2.138TyrTyr: 2.138 ± 0.659
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 56 proteins (12163 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski