Amino acid dipepetide frequency for Cellulomonas soli

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
22.673AlaAla: 22.673 ± 0.215
0.913AlaCys: 0.913 ± 0.029
9.247AlaAsp: 9.247 ± 0.101
7.417AlaGlu: 7.417 ± 0.094
3.45AlaPhe: 3.45 ± 0.06
13.93AlaGly: 13.93 ± 0.122
2.838AlaHis: 2.838 ± 0.046
4.048AlaIle: 4.048 ± 0.065
1.748AlaLys: 1.748 ± 0.049
15.475AlaLeu: 15.475 ± 0.131
2.432AlaMet: 2.432 ± 0.046
1.771AlaAsn: 1.771 ± 0.04
7.862AlaPro: 7.862 ± 0.111
4.54AlaGln: 4.54 ± 0.064
11.012AlaArg: 11.012 ± 0.12
7.222AlaSer: 7.222 ± 0.092
8.969AlaThr: 8.969 ± 0.11
14.131AlaVal: 14.131 ± 0.134
2.227AlaTrp: 2.227 ± 0.046
2.434AlaTyr: 2.434 ± 0.049
0.0AlaXaa: 0.0 ± 0.0
Cys
0.785CysAla: 0.785 ± 0.026
0.062CysCys: 0.062 ± 0.007
0.33CysAsp: 0.33 ± 0.018
0.288CysGlu: 0.288 ± 0.013
0.155CysPhe: 0.155 ± 0.011
0.658CysGly: 0.658 ± 0.027
0.117CysHis: 0.117 ± 0.01
0.122CysIle: 0.122 ± 0.01
0.055CysLys: 0.055 ± 0.006
0.513CysLeu: 0.513 ± 0.019
0.072CysMet: 0.072 ± 0.008
0.087CysAsn: 0.087 ± 0.008
0.373CysPro: 0.373 ± 0.018
0.14CysGln: 0.14 ± 0.011
0.383CysArg: 0.383 ± 0.019
0.359CysSer: 0.359 ± 0.015
0.457CysThr: 0.457 ± 0.02
0.542CysVal: 0.542 ± 0.022
0.082CysTrp: 0.082 ± 0.007
0.104CysTyr: 0.104 ± 0.007
0.0CysXaa: 0.0 ± 0.0
Asp
9.364AspAla: 9.364 ± 0.095
0.31AspCys: 0.31 ± 0.016
4.422AspAsp: 4.422 ± 0.07
4.273AspGlu: 4.273 ± 0.075
1.27AspPhe: 1.27 ± 0.037
7.056AspGly: 7.056 ± 0.091
1.241AspHis: 1.241 ± 0.03
1.45AspIle: 1.45 ± 0.037
0.716AspLys: 0.716 ± 0.03
7.352AspLeu: 7.352 ± 0.085
0.713AspMet: 0.713 ± 0.023
0.699AspAsn: 0.699 ± 0.03
4.9AspPro: 4.9 ± 0.07
1.697AspGln: 1.697 ± 0.039
4.755AspArg: 4.755 ± 0.072
2.161AspSer: 2.161 ± 0.04
3.008AspThr: 3.008 ± 0.051
6.782AspVal: 6.782 ± 0.081
0.872AspTrp: 0.872 ± 0.026
0.982AspTyr: 0.982 ± 0.029
0.0AspXaa: 0.0 ± 0.0
Glu
6.711GluAla: 6.711 ± 0.085
0.232GluCys: 0.232 ± 0.012
2.874GluAsp: 2.874 ± 0.057
2.458GluGlu: 2.458 ± 0.049
1.091GluPhe: 1.091 ± 0.029
3.857GluGly: 3.857 ± 0.053
1.726GluHis: 1.726 ± 0.046
1.991GluIle: 1.991 ± 0.045
0.818GluLys: 0.818 ± 0.03
6.16GluLeu: 6.16 ± 0.077
0.68GluMet: 0.68 ± 0.024
0.78GluAsn: 0.78 ± 0.024
3.213GluPro: 3.213 ± 0.049
2.469GluGln: 2.469 ± 0.055
4.749GluArg: 4.749 ± 0.069
2.207GluSer: 2.207 ± 0.046
2.415GluThr: 2.415 ± 0.048
5.025GluVal: 5.025 ± 0.073
0.605GluTrp: 0.605 ± 0.019
0.838GluTyr: 0.838 ± 0.028
0.0GluXaa: 0.0 ± 0.0
Phe
3.552PheAla: 3.552 ± 0.06
0.178PheCys: 0.178 ± 0.013
1.828PheAsp: 1.828 ± 0.036
1.277PheGlu: 1.277 ± 0.033
0.694PhePhe: 0.694 ± 0.028
2.782PheGly: 2.782 ± 0.052
0.457PheHis: 0.457 ± 0.02
0.575PheIle: 0.575 ± 0.025
0.32PheLys: 0.32 ± 0.017
2.309PheLeu: 2.309 ± 0.046
0.321PheMet: 0.321 ± 0.015
0.416PheAsn: 0.416 ± 0.017
1.137PhePro: 1.137 ± 0.031
0.568PheGln: 0.568 ± 0.023
1.485PheArg: 1.485 ± 0.037
1.343PheSer: 1.343 ± 0.04
1.768PheThr: 1.768 ± 0.041
2.676PheVal: 2.676 ± 0.049
0.407PheTrp: 0.407 ± 0.017
0.507PheTyr: 0.507 ± 0.025
0.0PheXaa: 0.0 ± 0.0
Gly
12.346GlyAla: 12.346 ± 0.114
0.589GlyCys: 0.589 ± 0.023
5.237GlyAsp: 5.237 ± 0.068
4.482GlyGlu: 4.482 ± 0.066
2.756GlyPhe: 2.756 ± 0.053
8.059GlyGly: 8.059 ± 0.122
2.019GlyHis: 2.019 ± 0.04
3.114GlyIle: 3.114 ± 0.051
1.549GlyLys: 1.549 ± 0.035
9.865GlyLeu: 9.865 ± 0.092
1.807GlyMet: 1.807 ± 0.041
1.284GlyAsn: 1.284 ± 0.037
5.214GlyPro: 5.214 ± 0.083
2.58GlyGln: 2.58 ± 0.046
7.29GlyArg: 7.29 ± 0.096
5.669GlySer: 5.669 ± 0.072
7.275GlyThr: 7.275 ± 0.102
8.632GlyVal: 8.632 ± 0.096
1.855GlyTrp: 1.855 ± 0.041
2.174GlyTyr: 2.174 ± 0.047
0.0GlyXaa: 0.0 ± 0.0
His
2.898HisAla: 2.898 ± 0.048
0.121HisCys: 0.121 ± 0.01
1.45HisAsp: 1.45 ± 0.036
1.265HisGlu: 1.265 ± 0.034
0.386HisPhe: 0.386 ± 0.017
2.299HisGly: 2.299 ± 0.047
0.584HisHis: 0.584 ± 0.022
0.419HisIle: 0.419 ± 0.017
0.232HisLys: 0.232 ± 0.015
2.457HisLeu: 2.457 ± 0.045
0.247HisMet: 0.247 ± 0.013
0.277HisAsn: 0.277 ± 0.014
1.595HisPro: 1.595 ± 0.039
0.539HisGln: 0.539 ± 0.021
1.789HisArg: 1.789 ± 0.037
0.729HisSer: 0.729 ± 0.025
1.047HisThr: 1.047 ± 0.031
2.248HisVal: 2.248 ± 0.045
0.294HisTrp: 0.294 ± 0.013
0.351HisTyr: 0.351 ± 0.019
0.0HisXaa: 0.0 ± 0.0
Ile
4.633IleAla: 4.633 ± 0.063
0.183IleCys: 0.183 ± 0.012
2.435IleAsp: 2.435 ± 0.047
1.818IleGlu: 1.818 ± 0.043
0.606IlePhe: 0.606 ± 0.025
3.407IleGly: 3.407 ± 0.063
0.455IleHis: 0.455 ± 0.019
0.782IleIle: 0.782 ± 0.033
0.476IleLys: 0.476 ± 0.023
2.104IleLeu: 2.104 ± 0.046
0.383IleMet: 0.383 ± 0.019
0.535IleAsn: 0.535 ± 0.025
1.455IlePro: 1.455 ± 0.034
0.579IleGln: 0.579 ± 0.027
1.748IleArg: 1.748 ± 0.043
1.478IleSer: 1.478 ± 0.041
2.028IleThr: 2.028 ± 0.04
2.842IleVal: 2.842 ± 0.051
0.333IleTrp: 0.333 ± 0.015
0.473IleTyr: 0.473 ± 0.019
0.0IleXaa: 0.0 ± 0.0
Lys
1.821LysAla: 1.821 ± 0.046
0.05LysCys: 0.05 ± 0.006
0.849LysAsp: 0.849 ± 0.032
0.623LysGlu: 0.623 ± 0.027
0.312LysPhe: 0.312 ± 0.016
1.066LysGly: 1.066 ± 0.031
0.292LysHis: 0.292 ± 0.016
0.6LysIle: 0.6 ± 0.027
0.369LysLys: 0.369 ± 0.021
1.105LysLeu: 1.105 ± 0.037
0.22LysMet: 0.22 ± 0.014
0.317LysAsn: 0.317 ± 0.017
0.72LysPro: 0.72 ± 0.028
0.408LysGln: 0.408 ± 0.019
0.859LysArg: 0.859 ± 0.029
0.701LysSer: 0.701 ± 0.022
0.787LysThr: 0.787 ± 0.027
1.388LysVal: 1.388 ± 0.037
0.147LysTrp: 0.147 ± 0.011
0.284LysTyr: 0.284 ± 0.017
0.0LysXaa: 0.0 ± 0.0
Leu
16.588LeuAla: 16.588 ± 0.137
0.553LeuCys: 0.553 ± 0.021
7.447LeuAsp: 7.447 ± 0.089
4.915LeuGlu: 4.915 ± 0.064
2.264LeuPhe: 2.264 ± 0.048
9.739LeuGly: 9.739 ± 0.101
2.142LeuHis: 2.142 ± 0.044
2.383LeuIle: 2.383 ± 0.053
1.152LeuLys: 1.152 ± 0.033
11.256LeuLeu: 11.256 ± 0.14
1.415LeuMet: 1.415 ± 0.03
1.282LeuAsn: 1.282 ± 0.034
5.99LeuPro: 5.99 ± 0.069
2.446LeuGln: 2.446 ± 0.047
8.141LeuArg: 8.141 ± 0.092
4.97LeuSer: 4.97 ± 0.071
7.314LeuThr: 7.314 ± 0.084
12.212LeuVal: 12.212 ± 0.123
1.251LeuTrp: 1.251 ± 0.035
1.49LeuTyr: 1.49 ± 0.036
0.0LeuXaa: 0.0 ± 0.0
Met
2.007MetAla: 2.007 ± 0.042
0.101MetCys: 0.101 ± 0.008
0.776MetAsp: 0.776 ± 0.026
0.499MetGlu: 0.499 ± 0.023
0.376MetPhe: 0.376 ± 0.018
1.093MetGly: 1.093 ± 0.033
0.325MetHis: 0.325 ± 0.015
0.56MetIle: 0.56 ± 0.023
0.239MetLys: 0.239 ± 0.014
1.62MetLeu: 1.62 ± 0.033
0.193MetMet: 0.193 ± 0.012
0.316MetAsn: 0.316 ± 0.015
1.028MetPro: 1.028 ± 0.027
0.431MetGln: 0.431 ± 0.017
1.194MetArg: 1.194 ± 0.031
1.328MetSer: 1.328 ± 0.038
1.588MetThr: 1.588 ± 0.032
1.279MetVal: 1.279 ± 0.033
0.154MetTrp: 0.154 ± 0.011
0.221MetTyr: 0.221 ± 0.013
0.0MetXaa: 0.0 ± 0.0
Asn
1.793AsnAla: 1.793 ± 0.043
0.085AsnCys: 0.085 ± 0.009
0.835AsnAsp: 0.835 ± 0.025
0.638AsnGlu: 0.638 ± 0.023
0.399AsnPhe: 0.399 ± 0.019
1.467AsnGly: 1.467 ± 0.039
0.314AsnHis: 0.314 ± 0.016
0.432AsnIle: 0.432 ± 0.022
0.239AsnLys: 0.239 ± 0.015
1.475AsnLeu: 1.475 ± 0.033
0.197AsnMet: 0.197 ± 0.011
0.258AsnAsn: 0.258 ± 0.015
1.142AsnPro: 1.142 ± 0.034
0.404AsnGln: 0.404 ± 0.018
0.92AsnArg: 0.92 ± 0.027
0.643AsnSer: 0.643 ± 0.031
0.79AsnThr: 0.79 ± 0.026
1.299AsnVal: 1.299 ± 0.036
0.176AsnTrp: 0.176 ± 0.012
0.322AsnTyr: 0.322 ± 0.021
0.0AsnXaa: 0.0 ± 0.0
Pro
9.02ProAla: 9.02 ± 0.126
0.238ProCys: 0.238 ± 0.012
4.58ProAsp: 4.58 ± 0.068
3.417ProGlu: 3.417 ± 0.053
1.499ProPhe: 1.499 ± 0.034
6.203ProGly: 6.203 ± 0.079
1.217ProHis: 1.217 ± 0.029
1.293ProIle: 1.293 ± 0.031
0.617ProLys: 0.617 ± 0.025
5.039ProLeu: 5.039 ± 0.063
0.928ProMet: 0.928 ± 0.024
0.689ProAsn: 0.689 ± 0.026
2.879ProPro: 2.879 ± 0.059
1.685ProGln: 1.685 ± 0.043
3.729ProArg: 3.729 ± 0.063
3.498ProSer: 3.498 ± 0.059
4.542ProThr: 4.542 ± 0.062
6.286ProVal: 6.286 ± 0.079
0.951ProTrp: 0.951 ± 0.032
1.011ProTyr: 1.011 ± 0.031
0.0ProXaa: 0.0 ± 0.0
Gln
4.215GlnAla: 4.215 ± 0.066
0.125GlnCys: 0.125 ± 0.009
1.637GlnAsp: 1.637 ± 0.037
1.302GlnGlu: 1.302 ± 0.033
0.729GlnPhe: 0.729 ± 0.024
2.234GlnGly: 2.234 ± 0.043
0.645GlnHis: 0.645 ± 0.022
1.106GlnIle: 1.106 ± 0.033
0.369GlnLys: 0.369 ± 0.019
2.867GlnLeu: 2.867 ± 0.055
0.467GlnMet: 0.467 ± 0.021
0.433GlnAsn: 0.433 ± 0.022
1.562GlnPro: 1.562 ± 0.041
1.138GlnGln: 1.138 ± 0.033
2.192GlnArg: 2.192 ± 0.04
1.226GlnSer: 1.226 ± 0.032
1.517GlnThr: 1.517 ± 0.038
3.698GlnVal: 3.698 ± 0.051
0.449GlnTrp: 0.449 ± 0.02
0.554GlnTyr: 0.554 ± 0.022
0.0GlnXaa: 0.0 ± 0.0
Arg
10.49ArgAla: 10.49 ± 0.109
0.395ArgCys: 0.395 ± 0.02
4.107ArgAsp: 4.107 ± 0.054
4.016ArgGlu: 4.016 ± 0.064
2.001ArgPhe: 2.001 ± 0.047
5.674ArgGly: 5.674 ± 0.075
1.765ArgHis: 1.765 ± 0.041
2.572ArgIle: 2.572 ± 0.046
0.908ArgLys: 0.908 ± 0.029
8.159ArgLeu: 8.159 ± 0.092
1.555ArgMet: 1.555 ± 0.033
0.91ArgAsn: 0.91 ± 0.023
4.568ArgPro: 4.568 ± 0.079
2.011ArgGln: 2.011 ± 0.039
7.64ArgArg: 7.64 ± 0.096
4.119ArgSer: 4.119 ± 0.055
5.756ArgThr: 5.756 ± 0.075
6.696ArgVal: 6.696 ± 0.087
1.486ArgTrp: 1.486 ± 0.036
1.594ArgTyr: 1.594 ± 0.039
0.0ArgXaa: 0.0 ± 0.0
Ser
7.356SerAla: 7.356 ± 0.095
0.303SerCys: 0.303 ± 0.017
2.877SerAsp: 2.877 ± 0.051
2.188SerGlu: 2.188 ± 0.041
1.376SerPhe: 1.376 ± 0.038
5.766SerGly: 5.766 ± 0.081
0.882SerHis: 0.882 ± 0.027
1.631SerIle: 1.631 ± 0.033
0.645SerLys: 0.645 ± 0.025
4.759SerLeu: 4.759 ± 0.068
0.978SerMet: 0.978 ± 0.025
0.766SerAsn: 0.766 ± 0.023
3.154SerPro: 3.154 ± 0.051
1.316SerGln: 1.316 ± 0.031
3.522SerArg: 3.522 ± 0.055
3.176SerSer: 3.176 ± 0.072
4.234SerThr: 4.234 ± 0.073
4.824SerVal: 4.824 ± 0.069
0.945SerTrp: 0.945 ± 0.024
1.028SerTyr: 1.028 ± 0.035
0.0SerXaa: 0.0 ± 0.0
Thr
9.335ThrAla: 9.335 ± 0.115
0.404ThrCys: 0.404 ± 0.02
4.006ThrAsp: 4.006 ± 0.057
2.848ThrGlu: 2.848 ± 0.052
1.954ThrPhe: 1.954 ± 0.044
7.007ThrGly: 7.007 ± 0.078
1.305ThrHis: 1.305 ± 0.029
2.17ThrIle: 2.17 ± 0.043
0.856ThrLys: 0.856 ± 0.028
6.604ThrLeu: 6.604 ± 0.08
0.912ThrMet: 0.912 ± 0.03
0.98ThrAsn: 0.98 ± 0.034
4.464ThrPro: 4.464 ± 0.074
1.706ThrGln: 1.706 ± 0.036
4.224ThrArg: 4.224 ± 0.059
4.085ThrSer: 4.085 ± 0.064
5.025ThrThr: 5.025 ± 0.092
7.059ThrVal: 7.059 ± 0.1
1.204ThrTrp: 1.204 ± 0.036
1.358ThrTyr: 1.358 ± 0.036
0.0ThrXaa: 0.0 ± 0.0
Val
14.519ValAla: 14.519 ± 0.139
0.559ValCys: 0.559 ± 0.024
6.948ValAsp: 6.948 ± 0.079
5.615ValGlu: 5.615 ± 0.07
2.264ValPhe: 2.264 ± 0.051
8.597ValGly: 8.597 ± 0.087
2.267ValHis: 2.267 ± 0.045
2.711ValIle: 2.711 ± 0.054
1.146ValLys: 1.146 ± 0.026
12.097ValLeu: 12.097 ± 0.118
1.351ValMet: 1.351 ± 0.032
1.393ValAsn: 1.393 ± 0.036
6.343ValPro: 6.343 ± 0.075
2.685ValGln: 2.685 ± 0.047
7.956ValArg: 7.956 ± 0.095
4.756ValSer: 4.756 ± 0.064
6.787ValThr: 6.787 ± 0.102
12.223ValVal: 12.223 ± 0.119
1.231ValTrp: 1.231 ± 0.032
1.494ValTyr: 1.494 ± 0.039
0.0ValXaa: 0.0 ± 0.0
Trp
1.816TrpAla: 1.816 ± 0.047
0.15TrpCys: 0.15 ± 0.01
0.896TrpAsp: 0.896 ± 0.029
0.619TrpGlu: 0.619 ± 0.023
0.532TrpPhe: 0.532 ± 0.02
1.119TrpGly: 1.119 ± 0.033
0.344TrpHis: 0.344 ± 0.014
0.436TrpIle: 0.436 ± 0.018
0.217TrpLys: 0.217 ± 0.012
1.673TrpLeu: 1.673 ± 0.04
0.268TrpMet: 0.268 ± 0.014
0.323TrpAsn: 0.323 ± 0.017
0.758TrpPro: 0.758 ± 0.024
0.59TrpGln: 0.59 ± 0.023
1.294TrpArg: 1.294 ± 0.033
1.164TrpSer: 1.164 ± 0.037
1.085TrpThr: 1.085 ± 0.027
1.366TrpVal: 1.366 ± 0.029
0.404TrpTrp: 0.404 ± 0.019
0.305TrpTyr: 0.305 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.417TyrAla: 2.417 ± 0.045
0.129TyrCys: 0.129 ± 0.01
1.243TyrAsp: 1.243 ± 0.035
0.942TyrGlu: 0.942 ± 0.029
0.488TyrPhe: 0.488 ± 0.021
1.781TyrGly: 1.781 ± 0.042
0.295TyrHis: 0.295 ± 0.017
0.355TyrIle: 0.355 ± 0.018
0.246TyrLys: 0.246 ± 0.015
2.061TyrLeu: 2.061 ± 0.043
0.189TyrMet: 0.189 ± 0.012
0.315TyrAsn: 0.315 ± 0.014
0.964TyrPro: 0.964 ± 0.03
0.535TyrGln: 0.535 ± 0.022
1.538TyrArg: 1.538 ± 0.038
0.892TyrSer: 0.892 ± 0.032
1.113TyrThr: 1.113 ± 0.031
1.731TyrVal: 1.731 ± 0.042
0.288TyrTrp: 0.288 ± 0.014
0.387TyrTyr: 0.387 ± 0.021
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3847 proteins (1283081 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski