Amino acid dipepetide frequency for Plesiocystis pacifica SIR-1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.001AlaAla: 16.001 ± 0.132
1.929AlaCys: 1.929 ± 0.031
6.965AlaAsp: 6.965 ± 0.046
9.481AlaGlu: 9.481 ± 0.075
3.691AlaPhe: 3.691 ± 0.046
10.712AlaGly: 10.712 ± 0.077
2.586AlaHis: 2.586 ± 0.03
4.442AlaIle: 4.442 ± 0.044
3.789AlaLys: 3.789 ± 0.063
15.235AlaLeu: 15.235 ± 0.116
2.669AlaMet: 2.669 ± 0.033
2.397AlaAsn: 2.397 ± 0.032
7.023AlaPro: 7.023 ± 0.072
4.128AlaGln: 4.128 ± 0.039
10.492AlaArg: 10.492 ± 0.087
6.998AlaSer: 6.998 ± 0.056
5.578AlaThr: 5.578 ± 0.046
8.357AlaVal: 8.357 ± 0.061
1.994AlaTrp: 1.994 ± 0.029
2.285AlaTyr: 2.285 ± 0.03
0.0AlaXaa: 0.0 ± 0.0
Cys
1.534CysAla: 1.534 ± 0.029
0.174CysCys: 0.174 ± 0.008
0.921CysAsp: 0.921 ± 0.024
0.954CysGlu: 0.954 ± 0.022
0.382CysPhe: 0.382 ± 0.011
1.236CysGly: 1.236 ± 0.028
0.277CysHis: 0.277 ± 0.012
0.343CysIle: 0.343 ± 0.01
0.241CysLys: 0.241 ± 0.009
1.019CysLeu: 1.019 ± 0.021
0.207CysMet: 0.207 ± 0.008
0.297CysAsn: 0.297 ± 0.011
0.745CysPro: 0.745 ± 0.017
0.343CysGln: 0.343 ± 0.011
0.656CysArg: 0.656 ± 0.015
0.789CysSer: 0.789 ± 0.021
0.687CysThr: 0.687 ± 0.02
1.018CysVal: 1.018 ± 0.021
0.199CysTrp: 0.199 ± 0.012
0.226CysTyr: 0.226 ± 0.008
0.0CysXaa: 0.0 ± 0.0
Asp
8.726AspAla: 8.726 ± 0.066
0.845AspCys: 0.845 ± 0.024
4.746AspAsp: 4.746 ± 0.058
5.407AspGlu: 5.407 ± 0.055
2.179AspPhe: 2.179 ± 0.029
6.585AspGly: 6.585 ± 0.067
1.326AspHis: 1.326 ± 0.025
1.968AspIle: 1.968 ± 0.024
1.205AspLys: 1.205 ± 0.022
5.937AspLeu: 5.937 ± 0.044
1.046AspMet: 1.046 ± 0.019
1.303AspAsn: 1.303 ± 0.026
5.02AspPro: 5.02 ± 0.048
1.758AspGln: 1.758 ± 0.023
4.007AspArg: 4.007 ± 0.039
3.036AspSer: 3.036 ± 0.031
3.22AspThr: 3.22 ± 0.047
3.612AspVal: 3.612 ± 0.039
1.007AspTrp: 1.007 ± 0.02
1.454AspTyr: 1.454 ± 0.02
0.0AspXaa: 0.0 ± 0.0
Glu
10.832GluAla: 10.832 ± 0.09
0.696GluCys: 0.696 ± 0.021
4.531GluAsp: 4.531 ± 0.05
3.832GluGlu: 3.832 ± 0.067
1.955GluPhe: 1.955 ± 0.028
7.102GluGly: 7.102 ± 0.053
1.801GluHis: 1.801 ± 0.022
2.342GluIle: 2.342 ± 0.034
1.118GluLys: 1.118 ± 0.028
10.18GluLeu: 10.18 ± 0.084
0.972GluMet: 0.972 ± 0.02
1.015GluAsn: 1.015 ± 0.019
4.594GluPro: 4.594 ± 0.051
2.779GluGln: 2.779 ± 0.033
6.938GluArg: 6.938 ± 0.059
3.731GluSer: 3.731 ± 0.046
3.679GluThr: 3.679 ± 0.056
5.536GluVal: 5.536 ± 0.046
0.831GluTrp: 0.831 ± 0.018
1.065GluTyr: 1.065 ± 0.021
0.0GluXaa: 0.0 ± 0.0
Phe
3.942PheAla: 3.942 ± 0.033
0.403PheCys: 0.403 ± 0.012
2.596PheAsp: 2.596 ± 0.03
2.847PheGlu: 2.847 ± 0.031
0.995PhePhe: 0.995 ± 0.02
3.212PheGly: 3.212 ± 0.037
0.655PheHis: 0.655 ± 0.013
1.011PheIle: 1.011 ± 0.018
0.59PheLys: 0.59 ± 0.015
2.349PheLeu: 2.349 ± 0.033
0.631PheMet: 0.631 ± 0.016
0.717PheAsn: 0.717 ± 0.015
1.416PhePro: 1.416 ± 0.022
0.736PheGln: 0.736 ± 0.015
1.74PheArg: 1.74 ± 0.026
1.712PheSer: 1.712 ± 0.021
1.567PheThr: 1.567 ± 0.026
2.628PheVal: 2.628 ± 0.032
0.418PheTrp: 0.418 ± 0.013
0.654PheTyr: 0.654 ± 0.014
0.0PheXaa: 0.0 ± 0.0
Gly
10.079GlyAla: 10.079 ± 0.07
1.305GlyCys: 1.305 ± 0.026
5.773GlyAsp: 5.773 ± 0.058
7.792GlyGlu: 7.792 ± 0.069
2.817GlyPhe: 2.817 ± 0.035
8.414GlyGly: 8.414 ± 0.09
1.808GlyHis: 1.808 ± 0.029
2.696GlyIle: 2.696 ± 0.035
2.43GlyLys: 2.43 ± 0.038
9.3GlyLeu: 9.3 ± 0.067
2.016GlyMet: 2.016 ± 0.027
1.795GlyAsn: 1.795 ± 0.034
4.809GlyPro: 4.809 ± 0.05
3.003GlyGln: 3.003 ± 0.033
6.369GlyArg: 6.369 ± 0.056
5.531GlySer: 5.531 ± 0.051
4.513GlyThr: 4.513 ± 0.047
6.753GlyVal: 6.753 ± 0.051
1.502GlyTrp: 1.502 ± 0.026
1.932GlyTyr: 1.932 ± 0.027
0.0GlyXaa: 0.0 ± 0.0
His
2.675HisAla: 2.675 ± 0.033
0.251HisCys: 0.251 ± 0.009
1.302HisAsp: 1.302 ± 0.024
1.467HisGlu: 1.467 ± 0.023
0.756HisPhe: 0.756 ± 0.016
2.122HisGly: 2.122 ± 0.029
0.593HisHis: 0.593 ± 0.016
0.641HisIle: 0.641 ± 0.015
0.341HisLys: 0.341 ± 0.01
2.14HisLeu: 2.14 ± 0.032
0.327HisMet: 0.327 ± 0.01
0.4HisAsn: 0.4 ± 0.012
1.508HisPro: 1.508 ± 0.022
0.557HisGln: 0.557 ± 0.015
1.761HisArg: 1.761 ± 0.026
0.929HisSer: 0.929 ± 0.019
0.882HisThr: 0.882 ± 0.018
1.532HisVal: 1.532 ± 0.023
0.317HisTrp: 0.317 ± 0.01
0.586HisTyr: 0.586 ± 0.014
0.0HisXaa: 0.0 ± 0.0
Ile
4.4IleAla: 4.4 ± 0.037
0.345IleCys: 0.345 ± 0.011
2.932IleAsp: 2.932 ± 0.033
3.141IleGlu: 3.141 ± 0.036
0.901IlePhe: 0.901 ± 0.019
2.985IleGly: 2.985 ± 0.034
0.883IleHis: 0.883 ± 0.016
1.095IleIle: 1.095 ± 0.018
0.72IleLys: 0.72 ± 0.018
2.814IleLeu: 2.814 ± 0.029
0.469IleMet: 0.469 ± 0.013
0.861IleAsn: 0.861 ± 0.017
1.858IlePro: 1.858 ± 0.029
1.023IleGln: 1.023 ± 0.017
2.23IleArg: 2.23 ± 0.028
1.604IleSer: 1.604 ± 0.024
1.695IleThr: 1.695 ± 0.027
2.749IleVal: 2.749 ± 0.035
0.389IleTrp: 0.389 ± 0.01
0.812IleTyr: 0.812 ± 0.016
0.0IleXaa: 0.0 ± 0.0
Lys
3.092LysAla: 3.092 ± 0.054
0.145LysCys: 0.145 ± 0.007
1.131LysAsp: 1.131 ± 0.024
1.0LysGlu: 1.0 ± 0.024
0.548LysPhe: 0.548 ± 0.014
1.766LysGly: 1.766 ± 0.03
0.474LysHis: 0.474 ± 0.012
0.986LysIle: 0.986 ± 0.02
1.225LysLys: 1.225 ± 0.085
2.771LysLeu: 2.771 ± 0.037
0.389LysMet: 0.389 ± 0.011
0.425LysAsn: 0.425 ± 0.013
1.509LysPro: 1.509 ± 0.029
0.793LysGln: 0.793 ± 0.018
1.904LysArg: 1.904 ± 0.038
1.12LysSer: 1.12 ± 0.025
1.242LysThr: 1.242 ± 0.031
1.889LysVal: 1.889 ± 0.029
0.251LysTrp: 0.251 ± 0.009
0.37LysTyr: 0.37 ± 0.011
0.0LysXaa: 0.0 ± 0.0
Leu
14.922LeuAla: 14.922 ± 0.11
1.15LeuCys: 1.15 ± 0.021
8.099LeuAsp: 8.099 ± 0.056
8.76LeuGlu: 8.76 ± 0.073
2.881LeuPhe: 2.881 ± 0.032
10.015LeuGly: 10.015 ± 0.074
2.051LeuHis: 2.051 ± 0.029
3.511LeuIle: 3.511 ± 0.034
1.471LeuLys: 1.471 ± 0.023
9.831LeuLeu: 9.831 ± 0.079
1.624LeuMet: 1.624 ± 0.023
1.649LeuAsn: 1.649 ± 0.024
5.662LeuPro: 5.662 ± 0.047
2.368LeuGln: 2.368 ± 0.03
9.097LeuArg: 9.097 ± 0.069
6.184LeuSer: 6.184 ± 0.047
4.759LeuThr: 4.759 ± 0.04
7.734LeuVal: 7.734 ± 0.053
1.442LeuTrp: 1.442 ± 0.025
1.846LeuTyr: 1.846 ± 0.028
0.0LeuXaa: 0.0 ± 0.0
Met
2.424MetAla: 2.424 ± 0.025
0.189MetCys: 0.189 ± 0.007
0.981MetAsp: 0.981 ± 0.017
0.843MetGlu: 0.843 ± 0.017
0.585MetPhe: 0.585 ± 0.016
1.592MetGly: 1.592 ± 0.022
0.383MetHis: 0.383 ± 0.014
0.783MetIle: 0.783 ± 0.016
0.456MetLys: 0.456 ± 0.012
2.017MetLeu: 2.017 ± 0.029
0.348MetMet: 0.348 ± 0.013
0.411MetAsn: 0.411 ± 0.011
1.104MetPro: 1.104 ± 0.018
0.533MetGln: 0.533 ± 0.013
1.516MetArg: 1.516 ± 0.021
1.281MetSer: 1.281 ± 0.022
1.176MetThr: 1.176 ± 0.02
1.357MetVal: 1.357 ± 0.02
0.224MetTrp: 0.224 ± 0.007
0.25MetTyr: 0.25 ± 0.009
0.0MetXaa: 0.0 ± 0.0
Asn
2.202AsnAla: 2.202 ± 0.026
0.304AsnCys: 0.304 ± 0.01
1.207AsnAsp: 1.207 ± 0.025
1.119AsnGlu: 1.119 ± 0.021
0.738AsnPhe: 0.738 ± 0.015
1.618AsnGly: 1.618 ± 0.028
0.448AsnHis: 0.448 ± 0.01
0.747AsnIle: 0.747 ± 0.016
0.479AsnLys: 0.479 ± 0.016
2.103AsnLeu: 2.103 ± 0.029
0.386AsnMet: 0.386 ± 0.012
0.572AsnAsn: 0.572 ± 0.015
1.554AsnPro: 1.554 ± 0.026
0.593AsnGln: 0.593 ± 0.014
1.162AsnArg: 1.162 ± 0.02
0.921AsnSer: 0.921 ± 0.019
1.004AsnThr: 1.004 ± 0.021
1.402AsnVal: 1.402 ± 0.021
0.306AsnTrp: 0.306 ± 0.011
0.542AsnTyr: 0.542 ± 0.015
0.0AsnXaa: 0.0 ± 0.0
Pro
7.152ProAla: 7.152 ± 0.059
0.579ProCys: 0.579 ± 0.015
3.83ProAsp: 3.83 ± 0.045
5.769ProGlu: 5.769 ± 0.057
1.633ProPhe: 1.633 ± 0.022
5.549ProGly: 5.549 ± 0.045
1.015ProHis: 1.015 ± 0.023
1.822ProIle: 1.822 ± 0.025
1.763ProLys: 1.763 ± 0.031
4.855ProLeu: 4.855 ± 0.048
1.154ProMet: 1.154 ± 0.02
1.361ProAsn: 1.361 ± 0.021
3.743ProPro: 3.743 ± 0.051
1.548ProGln: 1.548 ± 0.024
4.086ProArg: 4.086 ± 0.041
3.884ProSer: 3.884 ± 0.04
3.024ProThr: 3.024 ± 0.037
3.91ProVal: 3.91 ± 0.039
0.98ProTrp: 0.98 ± 0.018
1.02ProTyr: 1.02 ± 0.019
0.0ProXaa: 0.0 ± 0.0
Gln
4.157GlnAla: 4.157 ± 0.043
0.28GlnCys: 0.28 ± 0.01
1.324GlnAsp: 1.324 ± 0.021
1.226GlnGlu: 1.226 ± 0.029
0.798GlnPhe: 0.798 ± 0.017
2.559GlnGly: 2.559 ± 0.03
0.562GlnHis: 0.562 ± 0.013
1.218GlnIle: 1.218 ± 0.019
0.554GlnLys: 0.554 ± 0.017
3.775GlnLeu: 3.775 ± 0.037
0.527GlnMet: 0.527 ± 0.014
0.535GlnAsn: 0.535 ± 0.014
1.827GlnPro: 1.827 ± 0.029
0.889GlnGln: 0.889 ± 0.026
2.804GlnArg: 2.804 ± 0.039
1.41GlnSer: 1.41 ± 0.023
1.53GlnThr: 1.53 ± 0.022
2.266GlnVal: 2.266 ± 0.022
0.456GlnTrp: 0.456 ± 0.011
0.48GlnTyr: 0.48 ± 0.012
0.0GlnXaa: 0.0 ± 0.0
Arg
9.975ArgAla: 9.975 ± 0.084
0.864ArgCys: 0.864 ± 0.017
4.131ArgAsp: 4.131 ± 0.043
5.843ArgGlu: 5.843 ± 0.06
2.76ArgPhe: 2.76 ± 0.034
6.19ArgGly: 6.19 ± 0.062
1.639ArgHis: 1.639 ± 0.025
2.551ArgIle: 2.551 ± 0.032
1.891ArgLys: 1.891 ± 0.033
7.949ArgLeu: 7.949 ± 0.065
1.573ArgMet: 1.573 ± 0.025
1.267ArgAsn: 1.267 ± 0.018
3.973ArgPro: 3.973 ± 0.04
2.088ArgGln: 2.088 ± 0.028
7.04ArgArg: 7.04 ± 0.068
4.305ArgSer: 4.305 ± 0.04
3.149ArgThr: 3.149 ± 0.032
6.29ArgVal: 6.29 ± 0.049
1.622ArgTrp: 1.622 ± 0.026
1.878ArgTyr: 1.878 ± 0.028
0.0ArgXaa: 0.0 ± 0.0
Ser
6.51SerAla: 6.51 ± 0.053
0.81SerCys: 0.81 ± 0.02
3.074SerAsp: 3.074 ± 0.039
4.072SerGlu: 4.072 ± 0.046
1.971SerPhe: 1.971 ± 0.025
5.214SerGly: 5.214 ± 0.044
1.012SerHis: 1.012 ± 0.02
1.849SerIle: 1.849 ± 0.026
1.45SerLys: 1.45 ± 0.029
5.793SerLeu: 5.793 ± 0.044
1.225SerMet: 1.225 ± 0.022
1.104SerAsn: 1.104 ± 0.021
3.563SerPro: 3.563 ± 0.034
1.514SerGln: 1.514 ± 0.024
3.487SerArg: 3.487 ± 0.035
3.955SerSer: 3.955 ± 0.056
3.354SerThr: 3.354 ± 0.041
3.909SerVal: 3.909 ± 0.035
0.988SerTrp: 0.988 ± 0.02
1.09SerTyr: 1.09 ± 0.018
0.0SerXaa: 0.0 ± 0.0
Thr
4.992ThrAla: 4.992 ± 0.042
0.668ThrCys: 0.668 ± 0.018
3.058ThrAsp: 3.058 ± 0.052
3.388ThrGlu: 3.388 ± 0.051
1.587ThrPhe: 1.587 ± 0.024
4.572ThrGly: 4.572 ± 0.048
1.06ThrHis: 1.06 ± 0.021
1.981ThrIle: 1.981 ± 0.025
1.307ThrLys: 1.307 ± 0.028
5.581ThrLeu: 5.581 ± 0.044
0.954ThrMet: 0.954 ± 0.018
1.126ThrAsn: 1.126 ± 0.023
3.219ThrPro: 3.219 ± 0.042
1.498ThrGln: 1.498 ± 0.021
3.37ThrArg: 3.37 ± 0.032
2.675ThrSer: 2.675 ± 0.037
3.162ThrThr: 3.162 ± 0.048
3.516ThrVal: 3.516 ± 0.035
0.819ThrTrp: 0.819 ± 0.02
0.987ThrTyr: 0.987 ± 0.019
0.0ThrXaa: 0.0 ± 0.0
Val
8.935ValAla: 8.935 ± 0.06
0.843ValCys: 0.843 ± 0.018
5.557ValAsp: 5.557 ± 0.041
6.399ValGlu: 6.399 ± 0.05
2.432ValPhe: 2.432 ± 0.028
6.304ValGly: 6.304 ± 0.054
1.826ValHis: 1.826 ± 0.025
2.63ValIle: 2.63 ± 0.032
1.286ValLys: 1.286 ± 0.024
7.551ValLeu: 7.551 ± 0.049
1.182ValMet: 1.182 ± 0.021
1.437ValAsn: 1.437 ± 0.026
3.781ValPro: 3.781 ± 0.036
1.963ValGln: 1.963 ± 0.027
5.356ValArg: 5.356 ± 0.052
3.786ValSer: 3.786 ± 0.041
3.269ValThr: 3.269 ± 0.035
6.126ValVal: 6.126 ± 0.056
1.004ValTrp: 1.004 ± 0.017
1.533ValTyr: 1.533 ± 0.023
0.0ValXaa: 0.0 ± 0.0
Trp
1.666TrpAla: 1.666 ± 0.026
0.173TrpCys: 0.173 ± 0.007
0.818TrpAsp: 0.818 ± 0.017
0.807TrpGlu: 0.807 ± 0.017
0.442TrpPhe: 0.442 ± 0.013
1.141TrpGly: 1.141 ± 0.024
0.299TrpHis: 0.299 ± 0.01
0.707TrpIle: 0.707 ± 0.015
0.342TrpLys: 0.342 ± 0.012
1.871TrpLeu: 1.871 ± 0.027
0.368TrpMet: 0.368 ± 0.01
0.332TrpAsn: 0.332 ± 0.01
0.787TrpPro: 0.787 ± 0.019
0.479TrpGln: 0.479 ± 0.014
1.356TrpArg: 1.356 ± 0.021
1.084TrpSer: 1.084 ± 0.022
1.011TrpThr: 1.011 ± 0.022
1.133TrpVal: 1.133 ± 0.018
0.262TrpTrp: 0.262 ± 0.01
0.293TrpTyr: 0.293 ± 0.01
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.533TyrAla: 2.533 ± 0.032
0.297TyrCys: 0.297 ± 0.009
1.411TyrAsp: 1.411 ± 0.022
1.383TyrGlu: 1.383 ± 0.021
0.766TyrPhe: 0.766 ± 0.015
1.751TyrGly: 1.751 ± 0.025
0.39TyrHis: 0.39 ± 0.01
0.586TyrIle: 0.586 ± 0.013
0.373TyrLys: 0.373 ± 0.012
1.985TyrLeu: 1.985 ± 0.029
0.385TyrMet: 0.385 ± 0.012
0.406TyrAsn: 0.406 ± 0.012
0.979TyrPro: 0.979 ± 0.02
0.586TyrGln: 0.586 ± 0.017
1.606TyrArg: 1.606 ± 0.024
1.006TyrSer: 1.006 ± 0.02
1.015TyrThr: 1.015 ± 0.02
1.482TyrVal: 1.482 ± 0.022
0.362TyrTrp: 0.362 ± 0.011
0.524TyrTyr: 0.524 ± 0.014
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 8437 proteins (3147198 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski