Amino acid dipepetide frequency for Paeniclostridium sordellii (Clostridium sordellii)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	2.829AlaAla: 2.829 ± 0.075	0.737AlaCys: 0.737 ± 0.029	2.173AlaAsp: 2.173 ± 0.047	2.398AlaGlu: 2.398 ± 0.057	2.259AlaPhe: 2.259 ± 0.052	3.295AlaGly: 3.295 ± 0.065	0.771AlaHis: 0.771 ± 0.026	5.859AlaIle: 5.859 ± 0.085	4.717AlaLys: 4.717 ± 0.076	5.22AlaLeu: 5.22 ± 0.09	1.635AlaMet: 1.635 ± 0.047	2.845AlaAsn: 2.845 ± 0.055	1.276AlaPro: 1.276 ± 0.041	1.391AlaGln: 1.391 ± 0.043	1.68AlaArg: 1.68 ± 0.042	3.238AlaSer: 3.238 ± 0.064	2.724AlaThr: 2.724 ± 0.058	3.33AlaVal: 3.33 ± 0.064	0.305AlaTrp: 0.305 ± 0.018	1.985AlaTyr: 1.985 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.598CysAla: 0.598 ± 0.027	0.198CysCys: 0.198 ± 0.017	0.728CysAsp: 0.728 ± 0.027	0.876CysGlu: 0.876 ± 0.034	0.491CysPhe: 0.491 ± 0.025	1.025CysGly: 1.025 ± 0.033	0.187CysHis: 0.187 ± 0.016	1.375CysIle: 1.375 ± 0.037	1.028CysLys: 1.028 ± 0.036	0.88CysLeu: 0.88 ± 0.031	0.322CysMet: 0.322 ± 0.016	0.721CysAsn: 0.721 ± 0.031	0.468CysPro: 0.468 ± 0.029	0.193CysGln: 0.193 ± 0.015	0.337CysArg: 0.337 ± 0.02	0.784CysSer: 0.784 ± 0.027	0.542CysThr: 0.542 ± 0.024	0.649CysVal: 0.649 ± 0.027	0.062CysTrp: 0.062 ± 0.009	0.391CysTyr: 0.391 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	2.499AspAla: 2.499 ± 0.052	0.629AspCys: 0.629 ± 0.028	2.837AspAsp: 2.837 ± 0.061	4.83AspGlu: 4.83 ± 0.088	2.728AspPhe: 2.728 ± 0.052	3.212AspGly: 3.212 ± 0.073	0.553AspHis: 0.553 ± 0.025	7.212AspIle: 7.212 ± 0.111	6.297AspLys: 6.297 ± 0.088	5.374AspLeu: 5.374 ± 0.07	1.674AspMet: 1.674 ± 0.039	3.508AspAsn: 3.508 ± 0.074	1.211AspPro: 1.211 ± 0.039	0.84AspGln: 0.84 ± 0.029	1.741AspArg: 1.741 ± 0.044	3.416AspSer: 3.416 ± 0.068	2.589AspThr: 2.589 ± 0.062	3.538AspVal: 3.538 ± 0.07	0.314AspTrp: 0.314 ± 0.018	2.784AspTyr: 2.784 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	3.522GluAla: 3.522 ± 0.073	0.716GluCys: 0.716 ± 0.027	4.493GluAsp: 4.493 ± 0.093	6.304GluGlu: 6.304 ± 0.093	3.113GluPhe: 3.113 ± 0.059	3.782GluGly: 3.782 ± 0.061	0.888GluHis: 0.888 ± 0.029	7.084GluIle: 7.084 ± 0.097	7.563GluLys: 7.563 ± 0.106	6.56GluLeu: 6.56 ± 0.083	1.675GluMet: 1.675 ± 0.04	5.921GluAsn: 5.921 ± 0.087	1.234GluPro: 1.234 ± 0.041	1.52GluGln: 1.52 ± 0.046	2.116GluArg: 2.116 ± 0.046	3.81GluSer: 3.81 ± 0.063	2.845GluThr: 2.845 ± 0.058	4.888GluVal: 4.888 ± 0.094	0.311GluTrp: 0.311 ± 0.019	3.106GluTyr: 3.106 ± 0.068	0.0GluXaa: 0.0 ± 0.0
Phe	2.212PheAla: 2.212 ± 0.049	0.465PheCys: 0.465 ± 0.02	2.584PheAsp: 2.584 ± 0.051	2.924PheGlu: 2.924 ± 0.057	1.871PhePhe: 1.871 ± 0.055	2.796PheGly: 2.796 ± 0.059	0.46PheHis: 0.46 ± 0.018	5.236PheIle: 5.236 ± 0.098	4.107PheLys: 4.107 ± 0.069	3.994PheLeu: 3.994 ± 0.084	1.242PheMet: 1.242 ± 0.036	3.146PheAsn: 3.146 ± 0.064	0.974PhePro: 0.974 ± 0.034	0.68PheGln: 0.68 ± 0.026	1.122PheArg: 1.122 ± 0.033	2.917PheSer: 2.917 ± 0.063	2.295PheThr: 2.295 ± 0.05	2.679PheVal: 2.679 ± 0.06	0.262PheTrp: 0.262 ± 0.015	1.713PheTyr: 1.713 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	3.823GlyAla: 3.823 ± 0.078	1.021GlyCys: 1.021 ± 0.034	3.066GlyAsp: 3.066 ± 0.055	3.799GlyGlu: 3.799 ± 0.073	3.11GlyPhe: 3.11 ± 0.058	4.012GlyGly: 4.012 ± 0.088	1.013GlyHis: 1.013 ± 0.033	6.685GlyIle: 6.685 ± 0.101	5.209GlyLys: 5.209 ± 0.078	5.354GlyLeu: 5.354 ± 0.085	1.77GlyMet: 1.77 ± 0.044	3.218GlyAsn: 3.218 ± 0.067	1.311GlyPro: 1.311 ± 0.045	1.423GlyGln: 1.423 ± 0.035	1.901GlyArg: 1.901 ± 0.049	3.617GlySer: 3.617 ± 0.071	3.075GlyThr: 3.075 ± 0.066	4.739GlyVal: 4.739 ± 0.072	0.431GlyTrp: 0.431 ± 0.029	3.204GlyTyr: 3.204 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	0.632HisAla: 0.632 ± 0.024	0.191HisCys: 0.191 ± 0.016	0.682HisAsp: 0.682 ± 0.026	0.874HisGlu: 0.874 ± 0.029	0.568HisPhe: 0.568 ± 0.026	0.927HisGly: 0.927 ± 0.037	0.246HisHis: 0.246 ± 0.018	1.364HisIle: 1.364 ± 0.034	1.169HisLys: 1.169 ± 0.036	1.145HisLeu: 1.145 ± 0.034	0.369HisMet: 0.369 ± 0.022	0.819HisAsn: 0.819 ± 0.029	0.547HisPro: 0.547 ± 0.025	0.305HisGln: 0.305 ± 0.017	0.445HisArg: 0.445 ± 0.023	0.824HisSer: 0.824 ± 0.03	0.705HisThr: 0.705 ± 0.027	0.717HisVal: 0.717 ± 0.028	0.1HisTrp: 0.1 ± 0.01	0.526HisTyr: 0.526 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.638IleAla: 5.638 ± 0.083	1.43IleCys: 1.43 ± 0.039	6.934IleAsp: 6.934 ± 0.083	7.437IleGlu: 7.437 ± 0.108	4.438IlePhe: 4.438 ± 0.09	6.774IleGly: 6.774 ± 0.107	1.271IleHis: 1.271 ± 0.04	10.096IleIle: 10.096 ± 0.158	9.951IleLys: 9.951 ± 0.113	9.695IleLeu: 9.695 ± 0.128	2.395IleMet: 2.395 ± 0.053	7.331IleAsn: 7.331 ± 0.113	3.333IlePro: 3.333 ± 0.063	2.242IleGln: 2.242 ± 0.047	2.751IleArg: 2.751 ± 0.054	7.706IleSer: 7.706 ± 0.105	4.907IleThr: 4.907 ± 0.078	6.791IleVal: 6.791 ± 0.09	0.526IleTrp: 0.526 ± 0.025	4.065IleTyr: 4.065 ± 0.069	0.0IleXaa: 0.0 ± 0.0
Lys	4.464LysAla: 4.464 ± 0.072	0.89LysCys: 0.89 ± 0.037	6.818LysAsp: 6.818 ± 0.098	9.035LysGlu: 9.035 ± 0.122	3.871LysPhe: 3.871 ± 0.062	4.872LysGly: 4.872 ± 0.07	1.282LysHis: 1.282 ± 0.035	8.722LysIle: 8.722 ± 0.109	9.01LysLys: 9.01 ± 0.104	8.18LysLeu: 8.18 ± 0.088	2.523LysMet: 2.523 ± 0.05	7.661LysAsn: 7.661 ± 0.105	2.192LysPro: 2.192 ± 0.056	2.236LysGln: 2.236 ± 0.046	2.681LysArg: 2.681 ± 0.048	6.076LysSer: 6.076 ± 0.086	4.212LysThr: 4.212 ± 0.073	6.09LysVal: 6.09 ± 0.08	0.558LysTrp: 0.558 ± 0.026	4.539LysTyr: 4.539 ± 0.07	0.0LysXaa: 0.0 ± 0.0
Leu	5.004LeuAla: 5.004 ± 0.082	0.967LeuCys: 0.967 ± 0.031	5.772LeuAsp: 5.772 ± 0.074	6.477LeuGlu: 6.477 ± 0.087	3.712LeuPhe: 3.712 ± 0.074	6.279LeuGly: 6.279 ± 0.097	0.972LeuHis: 0.972 ± 0.032	8.751LeuIle: 8.751 ± 0.141	8.676LeuLys: 8.676 ± 0.103	7.381LeuLeu: 7.381 ± 0.103	2.276LeuMet: 2.276 ± 0.047	6.691LeuAsn: 6.691 ± 0.087	2.486LeuPro: 2.486 ± 0.042	1.785LeuGln: 1.785 ± 0.042	2.743LeuArg: 2.743 ± 0.05	6.617LeuSer: 6.617 ± 0.087	4.313LeuThr: 4.313 ± 0.081	5.893LeuVal: 5.893 ± 0.093	0.509LeuTrp: 0.509 ± 0.025	3.308LeuTyr: 3.308 ± 0.066	0.0LeuXaa: 0.0 ± 0.0
Met	1.615MetAla: 1.615 ± 0.042	0.28MetCys: 0.28 ± 0.016	1.52MetAsp: 1.52 ± 0.042	1.697MetGlu: 1.697 ± 0.041	1.048MetPhe: 1.048 ± 0.033	1.828MetGly: 1.828 ± 0.044	0.329MetHis: 0.329 ± 0.017	2.543MetIle: 2.543 ± 0.048	2.621MetLys: 2.621 ± 0.055	2.259MetLeu: 2.259 ± 0.05	0.736MetMet: 0.736 ± 0.03	1.819MetAsn: 1.819 ± 0.045	0.858MetPro: 0.858 ± 0.029	0.663MetGln: 0.663 ± 0.026	0.768MetArg: 0.768 ± 0.027	1.764MetSer: 1.764 ± 0.038	1.266MetThr: 1.266 ± 0.033	1.624MetVal: 1.624 ± 0.043	0.131MetTrp: 0.131 ± 0.013	0.992MetTyr: 0.992 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	2.617AsnAla: 2.617 ± 0.055	0.756AsnCys: 0.756 ± 0.029	3.34AsnAsp: 3.34 ± 0.056	4.878AsnGlu: 4.878 ± 0.076	2.782AsnPhe: 2.782 ± 0.051	3.471AsnGly: 3.471 ± 0.065	0.94AsnHis: 0.94 ± 0.031	8.29AsnIle: 8.29 ± 0.118	7.514AsnLys: 7.514 ± 0.119	6.77AsnLeu: 6.77 ± 0.09	1.854AsnMet: 1.854 ± 0.039	4.984AsnAsn: 4.984 ± 0.116	2.23AsnPro: 2.23 ± 0.056	1.737AsnGln: 1.737 ± 0.042	1.896AsnArg: 1.896 ± 0.049	4.113AsnSer: 4.113 ± 0.072	3.166AsnThr: 3.166 ± 0.063	3.598AsnVal: 3.598 ± 0.059	0.418AsnTrp: 0.418 ± 0.022	2.877AsnTyr: 2.877 ± 0.057	0.0AsnXaa: 0.0 ± 0.0
Pro	1.275ProAla: 1.275 ± 0.041	0.295ProCys: 0.295 ± 0.019	1.331ProAsp: 1.331 ± 0.037	1.806ProGlu: 1.806 ± 0.048	1.252ProPhe: 1.252 ± 0.034	1.647ProGly: 1.647 ± 0.049	0.441ProHis: 0.441 ± 0.02	2.881ProIle: 2.881 ± 0.059	2.37ProLys: 2.37 ± 0.048	2.182ProLeu: 2.182 ± 0.042	0.763ProMet: 0.763 ± 0.033	1.625ProAsn: 1.625 ± 0.038	0.523ProPro: 0.523 ± 0.026	0.754ProGln: 0.754 ± 0.031	0.722ProArg: 0.722 ± 0.024	1.726ProSer: 1.726 ± 0.04	1.513ProThr: 1.513 ± 0.043	1.864ProVal: 1.864 ± 0.047	0.201ProTrp: 0.201 ± 0.012	1.169ProTyr: 1.169 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	1.277GlnAla: 1.277 ± 0.04	0.223GlnCys: 0.223 ± 0.016	1.19GlnAsp: 1.19 ± 0.033	1.602GlnGlu: 1.602 ± 0.046	0.871GlnPhe: 0.871 ± 0.025	1.482GlnGly: 1.482 ± 0.042	0.295GlnHis: 0.295 ± 0.017	2.284GlnIle: 2.284 ± 0.052	1.964GlnLys: 1.964 ± 0.046	1.934GlnLeu: 1.934 ± 0.039	0.669GlnMet: 0.669 ± 0.027	1.515GlnAsn: 1.515 ± 0.035	0.584GlnPro: 0.584 ± 0.023	0.606GlnGln: 0.606 ± 0.027	0.884GlnArg: 0.884 ± 0.03	1.377GlnSer: 1.377 ± 0.039	1.056GlnThr: 1.056 ± 0.033	1.533GlnVal: 1.533 ± 0.043	0.145GlnTrp: 0.145 ± 0.011	0.895GlnTyr: 0.895 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	1.583ArgAla: 1.583 ± 0.035	0.387ArgCys: 0.387 ± 0.019	1.741ArgAsp: 1.741 ± 0.044	2.377ArgGlu: 2.377 ± 0.049	1.271ArgPhe: 1.271 ± 0.038	1.8ArgGly: 1.8 ± 0.046	0.417ArgHis: 0.417 ± 0.024	2.599ArgIle: 2.599 ± 0.046	2.809ArgLys: 2.809 ± 0.059	2.635ArgLeu: 2.635 ± 0.056	0.782ArgMet: 0.782 ± 0.026	1.91ArgAsn: 1.91 ± 0.051	0.798ArgPro: 0.798 ± 0.027	0.809ArgGln: 0.809 ± 0.031	1.123ArgArg: 1.123 ± 0.039	1.432ArgSer: 1.432 ± 0.039	1.3ArgThr: 1.3 ± 0.036	2.091ArgVal: 2.091 ± 0.052	0.181ArgTrp: 0.181 ± 0.013	1.456ArgTyr: 1.456 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	2.858SerAla: 2.858 ± 0.054	0.715SerCys: 0.715 ± 0.027	3.292SerAsp: 3.292 ± 0.057	3.859SerGlu: 3.859 ± 0.066	2.964SerPhe: 2.964 ± 0.058	4.015SerGly: 4.015 ± 0.073	0.854SerHis: 0.854 ± 0.033	7.582SerIle: 7.582 ± 0.088	6.635SerLys: 6.635 ± 0.075	6.033SerLeu: 6.033 ± 0.079	1.711SerMet: 1.711 ± 0.039	4.337SerAsn: 4.337 ± 0.077	1.563SerPro: 1.563 ± 0.039	1.798SerGln: 1.798 ± 0.045	1.922SerArg: 1.922 ± 0.041	4.384SerSer: 4.384 ± 0.083	3.175SerThr: 3.175 ± 0.056	3.724SerVal: 3.724 ± 0.062	0.377SerTrp: 0.377 ± 0.021	2.763SerTyr: 2.763 ± 0.053	0.0SerXaa: 0.0 ± 0.0
Thr	2.505ThrAla: 2.505 ± 0.064	0.508ThrCys: 0.508 ± 0.021	2.417ThrAsp: 2.417 ± 0.057	2.432ThrGlu: 2.432 ± 0.049	2.106ThrPhe: 2.106 ± 0.044	3.34ThrGly: 3.34 ± 0.065	0.786ThrHis: 0.786 ± 0.028	5.338ThrIle: 5.338 ± 0.083	4.025ThrLys: 4.025 ± 0.066	4.698ThrLeu: 4.698 ± 0.074	1.178ThrMet: 1.178 ± 0.033	2.862ThrAsn: 2.862 ± 0.053	1.697ThrPro: 1.697 ± 0.047	1.16ThrGln: 1.16 ± 0.035	1.353ThrArg: 1.353 ± 0.038	3.253ThrSer: 3.253 ± 0.056	2.663ThrThr: 2.663 ± 0.07	3.202ThrVal: 3.202 ± 0.061	0.317ThrTrp: 0.317 ± 0.018	1.996ThrTyr: 1.996 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	3.655ValAla: 3.655 ± 0.068	0.903ValCys: 0.903 ± 0.035	4.06ValAsp: 4.06 ± 0.065	4.335ValGlu: 4.335 ± 0.071	2.974ValPhe: 2.974 ± 0.058	4.365ValGly: 4.365 ± 0.065	0.824ValHis: 0.824 ± 0.023	6.235ValIle: 6.235 ± 0.079	5.44ValLys: 5.44 ± 0.085	6.021ValLeu: 6.021 ± 0.088	1.526ValMet: 1.526 ± 0.038	3.983ValAsn: 3.983 ± 0.069	1.73ValPro: 1.73 ± 0.044	1.241ValGln: 1.241 ± 0.037	1.851ValArg: 1.851 ± 0.044	4.399ValSer: 4.399 ± 0.07	3.148ValThr: 3.148 ± 0.068	4.556ValVal: 4.556 ± 0.077	0.354ValTrp: 0.354 ± 0.02	2.502ValTyr: 2.502 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	0.34TrpAla: 0.34 ± 0.021	0.072TrpCys: 0.072 ± 0.008	0.374TrpAsp: 0.374 ± 0.02	0.38TrpGlu: 0.38 ± 0.02	0.264TrpPhe: 0.264 ± 0.016	0.389TrpGly: 0.389 ± 0.02	0.105TrpHis: 0.105 ± 0.012	0.619TrpIle: 0.619 ± 0.025	0.394TrpLys: 0.394 ± 0.022	0.481TrpLeu: 0.481 ± 0.022	0.162TrpMet: 0.162 ± 0.012	0.397TrpAsn: 0.397 ± 0.023	0.125TrpPro: 0.125 ± 0.011	0.16TrpGln: 0.16 ± 0.015	0.186TrpArg: 0.186 ± 0.014	0.342TrpSer: 0.342 ± 0.019	0.278TrpThr: 0.278 ± 0.017	0.417TrpVal: 0.417 ± 0.024	0.078TrpTrp: 0.078 ± 0.01	0.27TrpTyr: 0.27 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.72TyrAla: 1.72 ± 0.045	0.47TyrCys: 0.47 ± 0.023	2.434TyrAsp: 2.434 ± 0.052	3.129TyrGlu: 3.129 ± 0.065	1.988TyrPhe: 1.988 ± 0.065	2.468TyrGly: 2.468 ± 0.054	0.52TyrHis: 0.52 ± 0.021	4.956TyrIle: 4.956 ± 0.081	4.413TyrLys: 4.413 ± 0.078	3.818TyrLeu: 3.818 ± 0.067	1.098TyrMet: 1.098 ± 0.036	2.937TyrAsn: 2.937 ± 0.06	1.201TyrPro: 1.201 ± 0.036	0.843TyrGln: 0.843 ± 0.027	1.279TyrArg: 1.279 ± 0.038	2.765TyrSer: 2.765 ± 0.054	2.063TyrThr: 2.063 ± 0.048	2.178TyrVal: 2.178 ± 0.052	0.257TyrTrp: 0.257 ± 0.016	1.701TyrTyr: 1.701 ± 0.049	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3465 proteins (1022320 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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