Amino acid dipepetide frequency for Apis mellifera associated microvirus 46

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.148AlaAla: 13.148 ± 3.96
0.0AlaCys: 0.0 ± 0.0
4.383AlaAsp: 4.383 ± 1.828
5.113AlaGlu: 5.113 ± 1.645
2.922AlaPhe: 2.922 ± 2.101
5.113AlaGly: 5.113 ± 2.448
0.0AlaHis: 0.0 ± 0.0
5.844AlaIle: 5.844 ± 1.199
5.844AlaLys: 5.844 ± 2.039
5.113AlaLeu: 5.113 ± 1.851
2.922AlaMet: 2.922 ± 0.978
2.191AlaAsn: 2.191 ± 1.627
6.574AlaPro: 6.574 ± 1.625
2.191AlaGln: 2.191 ± 1.401
8.035AlaArg: 8.035 ± 2.836
10.957AlaSer: 10.957 ± 1.478
5.113AlaThr: 5.113 ± 1.54
6.574AlaVal: 6.574 ± 2.529
1.461AlaTrp: 1.461 ± 0.694
2.922AlaTyr: 2.922 ± 1.269
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.73CysAsp: 0.73 ± 0.649
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
1.461CysGly: 1.461 ± 0.634
0.73CysHis: 0.73 ± 0.649
0.0CysIle: 0.0 ± 0.0
0.73CysLys: 0.73 ± 0.649
0.73CysLeu: 0.73 ± 0.649
0.73CysMet: 0.73 ± 0.685
0.73CysAsn: 0.73 ± 0.542
0.0CysPro: 0.0 ± 0.0
0.73CysGln: 0.73 ± 0.649
0.73CysArg: 0.73 ± 0.649
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.73CysVal: 0.73 ± 0.819
0.73CysTrp: 0.73 ± 0.649
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
4.383AspAla: 4.383 ± 1.983
0.0AspCys: 0.0 ± 0.0
4.383AspAsp: 4.383 ± 2.202
2.191AspGlu: 2.191 ± 1.171
2.191AspPhe: 2.191 ± 1.171
1.461AspGly: 1.461 ± 0.694
0.0AspHis: 0.0 ± 0.0
0.73AspIle: 0.73 ± 0.649
1.461AspLys: 1.461 ± 0.79
5.844AspLeu: 5.844 ± 1.185
0.73AspMet: 0.73 ± 0.769
1.461AspAsn: 1.461 ± 1.05
2.191AspPro: 2.191 ± 2.307
2.191AspGln: 2.191 ± 0.992
4.383AspArg: 4.383 ± 1.867
2.922AspSer: 2.922 ± 0.671
3.652AspThr: 3.652 ± 2.123
1.461AspVal: 1.461 ± 0.967
0.0AspTrp: 0.0 ± 0.0
2.922AspTyr: 2.922 ± 1.043
0.0AspXaa: 0.0 ± 0.0
Glu
6.574GluAla: 6.574 ± 2.477
0.73GluCys: 0.73 ± 0.649
2.191GluAsp: 2.191 ± 1.504
2.191GluGlu: 2.191 ± 0.847
3.652GluPhe: 3.652 ± 1.091
2.922GluGly: 2.922 ± 1.658
0.73GluHis: 0.73 ± 0.542
2.922GluIle: 2.922 ± 0.691
3.652GluLys: 3.652 ± 1.148
7.305GluLeu: 7.305 ± 2.643
0.73GluMet: 0.73 ± 0.753
2.922GluAsn: 2.922 ± 0.691
0.73GluPro: 0.73 ± 0.769
0.73GluGln: 0.73 ± 0.542
2.191GluArg: 2.191 ± 1.622
4.383GluSer: 4.383 ± 1.967
0.73GluThr: 0.73 ± 0.753
2.922GluVal: 2.922 ± 1.626
0.0GluTrp: 0.0 ± 0.0
4.383GluTyr: 4.383 ± 1.178
0.0GluXaa: 0.0 ± 0.0
Phe
2.922PheAla: 2.922 ± 0.643
0.73PheCys: 0.73 ± 0.649
0.73PheAsp: 0.73 ± 0.769
2.922PheGlu: 2.922 ± 1.626
1.461PhePhe: 1.461 ± 0.634
3.652PheGly: 3.652 ± 1.091
0.0PheHis: 0.0 ± 0.0
2.191PheIle: 2.191 ± 0.985
0.73PheLys: 0.73 ± 0.649
4.383PheLeu: 4.383 ± 2.611
2.191PheMet: 2.191 ± 0.962
2.191PheAsn: 2.191 ± 0.792
2.191PhePro: 2.191 ± 1.821
1.461PheGln: 1.461 ± 0.758
2.191PheArg: 2.191 ± 1.033
6.574PheSer: 6.574 ± 2.934
2.922PheThr: 2.922 ± 1.465
1.461PheVal: 1.461 ± 1.085
1.461PheTrp: 1.461 ± 0.634
0.73PheTyr: 0.73 ± 0.542
0.0PheXaa: 0.0 ± 0.0
Gly
5.113GlyAla: 5.113 ± 0.872
0.73GlyCys: 0.73 ± 0.649
5.113GlyAsp: 5.113 ± 1.822
3.652GlyGlu: 3.652 ± 1.284
2.922GlyPhe: 2.922 ± 1.572
9.496GlyGly: 9.496 ± 4.562
1.461GlyHis: 1.461 ± 0.829
5.113GlyIle: 5.113 ± 0.857
2.922GlyLys: 2.922 ± 2.067
3.652GlyLeu: 3.652 ± 1.623
0.0GlyMet: 0.0 ± 0.0
0.0GlyAsn: 0.0 ± 0.0
7.305GlyPro: 7.305 ± 1.94
2.191GlyGln: 2.191 ± 0.475
7.305GlyArg: 7.305 ± 3.854
9.496GlySer: 9.496 ± 1.191
2.922GlyThr: 2.922 ± 2.169
6.574GlyVal: 6.574 ± 1.798
0.0GlyTrp: 0.0 ± 0.0
5.844GlyTyr: 5.844 ± 1.397
0.0GlyXaa: 0.0 ± 0.0
His
0.73HisAla: 0.73 ± 0.649
0.0HisCys: 0.0 ± 0.0
0.73HisAsp: 0.73 ± 0.542
2.922HisGlu: 2.922 ± 2.241
0.0HisPhe: 0.0 ± 0.0
2.191HisGly: 2.191 ± 0.985
0.73HisHis: 0.73 ± 0.542
0.0HisIle: 0.0 ± 0.0
0.73HisLys: 0.73 ± 0.649
1.461HisLeu: 1.461 ± 0.967
0.0HisMet: 0.0 ± 0.0
0.0HisAsn: 0.0 ± 0.0
3.652HisPro: 3.652 ± 1.186
0.0HisGln: 0.0 ± 0.0
1.461HisArg: 1.461 ± 0.634
0.73HisSer: 0.73 ± 0.542
0.73HisThr: 0.73 ± 0.542
1.461HisVal: 1.461 ± 0.634
1.461HisTrp: 1.461 ± 0.694
1.461HisTyr: 1.461 ± 0.634
0.0HisXaa: 0.0 ± 0.0
Ile
2.191IleAla: 2.191 ± 1.024
0.0IleCys: 0.0 ± 0.0
1.461IleAsp: 1.461 ± 1.506
1.461IleGlu: 1.461 ± 1.034
3.652IlePhe: 3.652 ± 1.317
5.113IleGly: 5.113 ± 2.448
0.73IleHis: 0.73 ± 0.542
1.461IleIle: 1.461 ± 0.634
2.191IleLys: 2.191 ± 0.847
0.73IleLeu: 0.73 ± 0.649
0.73IleMet: 0.73 ± 0.542
0.73IleAsn: 0.73 ± 0.819
2.191IlePro: 2.191 ± 1.033
4.383IleGln: 4.383 ± 2.491
4.383IleArg: 4.383 ± 1.572
5.844IleSer: 5.844 ± 1.727
2.191IleThr: 2.191 ± 0.992
1.461IleVal: 1.461 ± 0.967
0.73IleTrp: 0.73 ± 0.542
0.0IleTyr: 0.0 ± 0.0
0.0IleXaa: 0.0 ± 0.0
Lys
5.844LysAla: 5.844 ± 2.503
0.73LysCys: 0.73 ± 0.649
0.73LysAsp: 0.73 ± 0.542
5.113LysGlu: 5.113 ± 1.645
1.461LysPhe: 1.461 ± 1.085
5.113LysGly: 5.113 ± 1.295
0.73LysHis: 0.73 ± 0.753
0.0LysIle: 0.0 ± 0.0
4.383LysLys: 4.383 ± 2.719
3.652LysLeu: 3.652 ± 1.43
1.461LysMet: 1.461 ± 0.79
2.191LysAsn: 2.191 ± 1.235
2.922LysPro: 2.922 ± 1.572
0.0LysGln: 0.0 ± 0.0
5.844LysArg: 5.844 ± 1.988
2.191LysSer: 2.191 ± 1.627
0.73LysThr: 0.73 ± 0.542
2.922LysVal: 2.922 ± 1.508
0.73LysTrp: 0.73 ± 0.753
0.73LysTyr: 0.73 ± 0.753
0.0LysXaa: 0.0 ± 0.0
Leu
6.574LeuAla: 6.574 ± 1.874
0.73LeuCys: 0.73 ± 0.819
3.652LeuAsp: 3.652 ± 0.814
5.844LeuGlu: 5.844 ± 2.915
4.383LeuPhe: 4.383 ± 1.694
8.035LeuGly: 8.035 ± 2.065
1.461LeuHis: 1.461 ± 0.694
2.922LeuIle: 2.922 ± 1.626
5.113LeuLys: 5.113 ± 2.256
5.844LeuLeu: 5.844 ± 1.194
0.73LeuMet: 0.73 ± 0.797
2.922LeuAsn: 2.922 ± 1.459
5.844LeuPro: 5.844 ± 1.986
3.652LeuGln: 3.652 ± 1.968
4.383LeuArg: 4.383 ± 2.014
7.305LeuSer: 7.305 ± 2.435
2.922LeuThr: 2.922 ± 1.489
3.652LeuVal: 3.652 ± 1.566
0.73LeuTrp: 0.73 ± 0.649
0.73LeuTyr: 0.73 ± 0.542
0.0LeuXaa: 0.0 ± 0.0
Met
2.191MetAla: 2.191 ± 0.992
0.0MetCys: 0.0 ± 0.0
0.73MetAsp: 0.73 ± 0.542
1.461MetGlu: 1.461 ± 1.085
0.0MetPhe: 0.0 ± 0.0
3.652MetGly: 3.652 ± 2.802
0.73MetHis: 0.73 ± 0.542
0.0MetIle: 0.0 ± 0.0
2.922MetLys: 2.922 ± 1.032
0.73MetLeu: 0.73 ± 0.649
0.0MetMet: 0.0 ± 0.0
0.0MetAsn: 0.0 ± 0.0
1.461MetPro: 1.461 ± 1.506
0.73MetGln: 0.73 ± 0.542
2.922MetArg: 2.922 ± 1.42
1.461MetSer: 1.461 ± 1.299
0.0MetThr: 0.0 ± 0.0
0.73MetVal: 0.73 ± 0.753
0.0MetTrp: 0.0 ± 0.0
0.73MetTyr: 0.73 ± 0.542
0.0MetXaa: 0.0 ± 0.0
Asn
5.844AsnAla: 5.844 ± 1.284
0.0AsnCys: 0.0 ± 0.0
0.73AsnAsp: 0.73 ± 0.753
0.73AsnGlu: 0.73 ± 0.542
1.461AsnPhe: 1.461 ± 0.758
0.0AsnGly: 0.0 ± 0.0
0.0AsnHis: 0.0 ± 0.0
0.0AsnIle: 0.0 ± 0.0
0.73AsnLys: 0.73 ± 0.753
2.922AsnLeu: 2.922 ± 1.087
1.461AsnMet: 1.461 ± 0.694
0.73AsnAsn: 0.73 ± 0.649
4.383AsnPro: 4.383 ± 1.777
1.461AsnGln: 1.461 ± 0.694
3.652AsnArg: 3.652 ± 1.937
0.73AsnSer: 0.73 ± 0.649
2.191AsnThr: 2.191 ± 0.992
2.191AsnVal: 2.191 ± 1.033
0.73AsnTrp: 0.73 ± 0.753
0.73AsnTyr: 0.73 ± 0.542
0.0AsnXaa: 0.0 ± 0.0
Pro
4.383ProAla: 4.383 ± 1.935
2.191ProCys: 2.191 ± 1.164
2.191ProAsp: 2.191 ± 0.985
5.844ProGlu: 5.844 ± 1.815
3.652ProPhe: 3.652 ± 2.668
7.305ProGly: 7.305 ± 0.891
2.922ProHis: 2.922 ± 1.489
2.922ProIle: 2.922 ± 1.722
2.922ProLys: 2.922 ± 1.347
6.574ProLeu: 6.574 ± 0.223
0.0ProMet: 0.0 ± 0.0
0.73ProAsn: 0.73 ± 0.649
4.383ProPro: 4.383 ± 2.96
2.191ProGln: 2.191 ± 1.343
2.922ProArg: 2.922 ± 0.943
8.766ProSer: 8.766 ± 4.574
4.383ProThr: 4.383 ± 2.081
4.383ProVal: 4.383 ± 1.143
0.73ProTrp: 0.73 ± 0.542
0.73ProTyr: 0.73 ± 0.542
0.0ProXaa: 0.0 ± 0.0
Gln
5.113GlnAla: 5.113 ± 2.413
0.73GlnCys: 0.73 ± 0.649
2.191GlnAsp: 2.191 ± 1.033
0.73GlnGlu: 0.73 ± 0.542
2.922GlnPhe: 2.922 ± 1.459
1.461GlnGly: 1.461 ± 0.694
1.461GlnHis: 1.461 ± 1.085
2.191GlnIle: 2.191 ± 1.343
2.191GlnLys: 2.191 ± 0.475
2.191GlnLeu: 2.191 ± 1.343
0.0GlnMet: 0.0 ± 0.0
1.461GlnAsn: 1.461 ± 0.694
0.0GlnPro: 0.0 ± 0.0
1.461GlnGln: 1.461 ± 1.085
4.383GlnArg: 4.383 ± 1.309
2.191GlnSer: 2.191 ± 1.948
1.461GlnThr: 1.461 ± 1.085
1.461GlnVal: 1.461 ± 1.095
0.73GlnTrp: 0.73 ± 0.753
0.0GlnTyr: 0.0 ± 0.0
0.0GlnXaa: 0.0 ± 0.0
Arg
5.113ArgAla: 5.113 ± 2.654
0.73ArgCys: 0.73 ± 0.819
2.922ArgAsp: 2.922 ± 1.387
3.652ArgGlu: 3.652 ± 0.665
2.191ArgPhe: 2.191 ± 0.888
2.922ArgGly: 2.922 ± 1.285
1.461ArgHis: 1.461 ± 1.299
3.652ArgIle: 3.652 ± 1.431
0.73ArgLys: 0.73 ± 0.542
6.574ArgLeu: 6.574 ± 1.651
2.922ArgMet: 2.922 ± 0.961
2.922ArgAsn: 2.922 ± 0.691
5.844ArgPro: 5.844 ± 2.421
4.383ArgGln: 4.383 ± 1.181
6.574ArgArg: 6.574 ± 3.942
10.226ArgSer: 10.226 ± 4.937
1.461ArgThr: 1.461 ± 0.634
8.035ArgVal: 8.035 ± 2.024
1.461ArgTrp: 1.461 ± 1.034
5.113ArgTyr: 5.113 ± 1.791
0.0ArgXaa: 0.0 ± 0.0
Ser
8.035SerAla: 8.035 ± 0.704
1.461SerCys: 1.461 ± 0.634
3.652SerAsp: 3.652 ± 1.937
3.652SerGlu: 3.652 ± 1.082
5.113SerPhe: 5.113 ± 1.795
9.496SerGly: 9.496 ± 4.054
3.652SerHis: 3.652 ± 1.284
3.652SerIle: 3.652 ± 1.148
4.383SerLys: 4.383 ± 1.747
5.844SerLeu: 5.844 ± 1.96
2.191SerMet: 2.191 ± 1.401
5.113SerAsn: 5.113 ± 1.666
8.766SerPro: 8.766 ± 4.118
3.652SerGln: 3.652 ± 1.082
5.844SerArg: 5.844 ± 3.983
8.035SerSer: 8.035 ± 0.536
3.652SerThr: 3.652 ± 0.996
9.496SerVal: 9.496 ± 2.543
0.0SerTrp: 0.0 ± 0.0
1.461SerTyr: 1.461 ± 0.79
0.0SerXaa: 0.0 ± 0.0
Thr
3.652ThrAla: 3.652 ± 1.091
0.0ThrCys: 0.0 ± 0.0
2.191ThrAsp: 2.191 ± 1.033
1.461ThrGlu: 1.461 ± 1.085
2.191ThrPhe: 2.191 ± 1.627
3.652ThrGly: 3.652 ± 1.937
0.73ThrHis: 0.73 ± 0.649
3.652ThrIle: 3.652 ± 1.623
0.73ThrLys: 0.73 ± 0.542
2.922ThrLeu: 2.922 ± 0.643
0.73ThrMet: 0.73 ± 0.542
2.922ThrAsn: 2.922 ± 2.169
2.191ThrPro: 2.191 ± 0.886
0.73ThrGln: 0.73 ± 0.542
2.191ThrArg: 2.191 ± 1.024
5.113ThrSer: 5.113 ± 1.885
2.922ThrThr: 2.922 ± 1.269
2.191ThrVal: 2.191 ± 1.343
0.0ThrTrp: 0.0 ± 0.0
2.922ThrTyr: 2.922 ± 1.269
0.0ThrXaa: 0.0 ± 0.0
Val
9.496ValAla: 9.496 ± 1.762
0.0ValCys: 0.0 ± 0.0
2.922ValAsp: 2.922 ± 1.42
2.191ValGlu: 2.191 ± 0.847
0.73ValPhe: 0.73 ± 0.542
5.844ValGly: 5.844 ± 1.199
0.73ValHis: 0.73 ± 0.649
2.922ValIle: 2.922 ± 1.516
3.652ValLys: 3.652 ± 1.498
7.305ValLeu: 7.305 ± 2.472
0.73ValMet: 0.73 ± 0.542
0.0ValAsn: 0.0 ± 0.0
7.305ValPro: 7.305 ± 2.345
0.0ValGln: 0.0 ± 0.0
5.844ValArg: 5.844 ± 2.812
5.113ValSer: 5.113 ± 2.373
2.922ValThr: 2.922 ± 1.44
5.844ValVal: 5.844 ± 1.815
0.73ValTrp: 0.73 ± 0.753
1.461ValTyr: 1.461 ± 0.694
0.0ValXaa: 0.0 ± 0.0
Trp
2.191TrpAla: 2.191 ± 1.637
0.0TrpCys: 0.0 ± 0.0
0.73TrpAsp: 0.73 ± 0.753
0.73TrpGlu: 0.73 ± 0.542
0.73TrpPhe: 0.73 ± 0.542
0.0TrpGly: 0.0 ± 0.0
0.73TrpHis: 0.73 ± 0.542
0.0TrpIle: 0.0 ± 0.0
0.73TrpLys: 0.73 ± 0.753
0.0TrpLeu: 0.0 ± 0.0
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
1.461TrpPro: 1.461 ± 1.085
0.73TrpGln: 0.73 ± 0.542
0.73TrpArg: 0.73 ± 0.753
2.191TrpSer: 2.191 ± 1.401
1.461TrpThr: 1.461 ± 1.299
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.922TyrAla: 2.922 ± 2.169
0.0TyrCys: 0.0 ± 0.0
2.191TyrAsp: 2.191 ± 0.886
0.73TyrGlu: 0.73 ± 0.753
1.461TyrPhe: 1.461 ± 1.085
2.922TyrGly: 2.922 ± 1.359
1.461TyrHis: 1.461 ± 0.79
1.461TyrIle: 1.461 ± 0.634
0.73TyrLys: 0.73 ± 0.753
4.383TyrLeu: 4.383 ± 1.599
1.461TyrMet: 1.461 ± 1.085
1.461TyrAsn: 1.461 ± 1.506
0.73TyrPro: 0.73 ± 0.649
1.461TyrGln: 1.461 ± 0.634
2.922TyrArg: 2.922 ± 1.44
2.922TyrSer: 2.922 ± 0.902
0.73TyrThr: 0.73 ± 0.542
2.191TyrVal: 2.191 ± 1.164
0.73TyrTrp: 0.73 ± 0.542
0.0TyrTyr: 0.0 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (1370 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski