Amino acid dipepetide frequency for Alteromonas phage PB15

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.205AlaAla: 8.205 ± 1.478
0.529AlaCys: 0.529 ± 0.228
4.059AlaAsp: 4.059 ± 0.714
7.058AlaGlu: 7.058 ± 0.778
2.647AlaPhe: 2.647 ± 0.536
8.735AlaGly: 8.735 ± 0.99
1.588AlaHis: 1.588 ± 0.444
5.558AlaIle: 5.558 ± 0.71
6.353AlaLys: 6.353 ± 0.79
7.147AlaLeu: 7.147 ± 1.253
2.382AlaMet: 2.382 ± 0.583
4.059AlaAsn: 4.059 ± 0.715
3.176AlaPro: 3.176 ± 0.565
3.706AlaGln: 3.706 ± 0.554
2.912AlaArg: 2.912 ± 0.611
5.47AlaSer: 5.47 ± 0.84
3.794AlaThr: 3.794 ± 0.53
5.823AlaVal: 5.823 ± 0.829
1.147AlaTrp: 1.147 ± 0.344
2.47AlaTyr: 2.47 ± 0.534
0.0AlaXaa: 0.0 ± 0.0
Cys
1.059CysAla: 1.059 ± 0.377
0.441CysCys: 0.441 ± 0.275
0.971CysAsp: 0.971 ± 0.281
0.706CysGlu: 0.706 ± 0.25
0.441CysPhe: 0.441 ± 0.202
0.971CysGly: 0.971 ± 0.258
0.529CysHis: 0.529 ± 0.218
0.794CysIle: 0.794 ± 0.236
0.882CysLys: 0.882 ± 0.25
0.706CysLeu: 0.706 ± 0.241
0.618CysMet: 0.618 ± 0.226
0.529CysAsn: 0.529 ± 0.211
0.441CysPro: 0.441 ± 0.179
0.441CysGln: 0.441 ± 0.236
0.441CysArg: 0.441 ± 0.179
0.706CysSer: 0.706 ± 0.253
0.706CysThr: 0.706 ± 0.224
0.618CysVal: 0.618 ± 0.288
0.265CysTrp: 0.265 ± 0.199
0.794CysTyr: 0.794 ± 0.502
0.0CysXaa: 0.0 ± 0.0
Asp
6.264AspAla: 6.264 ± 0.726
1.059AspCys: 1.059 ± 0.387
3.529AspAsp: 3.529 ± 0.636
4.059AspGlu: 4.059 ± 0.641
2.118AspPhe: 2.118 ± 0.463
4.676AspGly: 4.676 ± 0.716
1.323AspHis: 1.323 ± 0.367
2.647AspIle: 2.647 ± 0.405
2.382AspLys: 2.382 ± 0.522
5.735AspLeu: 5.735 ± 0.76
2.118AspMet: 2.118 ± 0.356
2.647AspAsn: 2.647 ± 0.552
1.765AspPro: 1.765 ± 0.39
1.235AspGln: 1.235 ± 0.287
2.118AspArg: 2.118 ± 0.357
3.706AspSer: 3.706 ± 0.464
2.735AspThr: 2.735 ± 0.46
3.617AspVal: 3.617 ± 0.557
1.059AspTrp: 1.059 ± 0.324
2.647AspTyr: 2.647 ± 0.441
0.0AspXaa: 0.0 ± 0.0
Glu
6.97GluAla: 6.97 ± 1.059
0.971GluCys: 0.971 ± 0.294
2.647GluAsp: 2.647 ± 0.461
4.5GluGlu: 4.5 ± 0.695
3.265GluPhe: 3.265 ± 0.484
4.412GluGly: 4.412 ± 0.623
1.765GluHis: 1.765 ± 0.427
5.294GluIle: 5.294 ± 0.662
3.529GluLys: 3.529 ± 0.603
6.0GluLeu: 6.0 ± 1.004
2.029GluMet: 2.029 ± 0.365
3.0GluAsn: 3.0 ± 0.486
2.647GluPro: 2.647 ± 0.434
4.235GluGln: 4.235 ± 0.662
3.265GluArg: 3.265 ± 0.743
4.5GluSer: 4.5 ± 0.636
2.382GluThr: 2.382 ± 0.394
3.617GluVal: 3.617 ± 0.556
0.882GluTrp: 0.882 ± 0.212
2.647GluTyr: 2.647 ± 0.499
0.0GluXaa: 0.0 ± 0.0
Phe
3.088PheAla: 3.088 ± 0.443
0.794PheCys: 0.794 ± 0.249
3.088PheAsp: 3.088 ± 0.469
2.206PheGlu: 2.206 ± 0.434
1.235PhePhe: 1.235 ± 0.404
4.323PheGly: 4.323 ± 0.665
0.441PheHis: 0.441 ± 0.176
3.088PheIle: 3.088 ± 0.571
2.118PheLys: 2.118 ± 0.487
1.412PheLeu: 1.412 ± 0.42
0.706PheMet: 0.706 ± 0.287
1.676PheAsn: 1.676 ± 0.414
0.971PhePro: 0.971 ± 0.233
0.706PheGln: 0.706 ± 0.231
0.971PheArg: 0.971 ± 0.327
2.294PheSer: 2.294 ± 0.351
4.147PheThr: 4.147 ± 0.694
2.029PheVal: 2.029 ± 0.401
0.441PheTrp: 0.441 ± 0.204
1.412PheTyr: 1.412 ± 0.348
0.0PheXaa: 0.0 ± 0.0
Gly
6.0GlyAla: 6.0 ± 0.803
1.588GlyCys: 1.588 ± 0.484
5.647GlyAsp: 5.647 ± 0.611
6.0GlyGlu: 6.0 ± 0.752
3.176GlyPhe: 3.176 ± 0.457
8.47GlyGly: 8.47 ± 1.697
1.588GlyHis: 1.588 ± 0.365
4.5GlyIle: 4.5 ± 0.764
4.588GlyLys: 4.588 ± 0.7
6.0GlyLeu: 6.0 ± 0.741
1.853GlyMet: 1.853 ± 0.504
3.882GlyAsn: 3.882 ± 0.725
1.147GlyPro: 1.147 ± 0.26
3.0GlyGln: 3.0 ± 0.386
3.706GlyArg: 3.706 ± 0.605
5.206GlySer: 5.206 ± 0.657
4.323GlyThr: 4.323 ± 0.93
6.088GlyVal: 6.088 ± 1.266
0.971GlyTrp: 0.971 ± 0.285
3.794GlyTyr: 3.794 ± 0.639
0.0GlyXaa: 0.0 ± 0.0
His
1.147HisAla: 1.147 ± 0.343
0.529HisCys: 0.529 ± 0.235
0.529HisAsp: 0.529 ± 0.275
1.588HisGlu: 1.588 ± 0.443
0.441HisPhe: 0.441 ± 0.179
2.118HisGly: 2.118 ± 0.509
0.441HisHis: 0.441 ± 0.249
1.323HisIle: 1.323 ± 0.353
0.794HisLys: 0.794 ± 0.227
1.5HisLeu: 1.5 ± 0.439
0.353HisMet: 0.353 ± 0.194
1.147HisAsn: 1.147 ± 0.36
1.059HisPro: 1.059 ± 0.341
0.353HisGln: 0.353 ± 0.175
0.529HisArg: 0.529 ± 0.319
1.412HisSer: 1.412 ± 0.336
1.235HisThr: 1.235 ± 0.334
0.882HisVal: 0.882 ± 0.279
0.441HisTrp: 0.441 ± 0.184
0.794HisTyr: 0.794 ± 0.27
0.0HisXaa: 0.0 ± 0.0
Ile
4.676IleAla: 4.676 ± 0.861
0.618IleCys: 0.618 ± 0.189
4.764IleAsp: 4.764 ± 0.615
4.853IleGlu: 4.853 ± 0.648
1.676IlePhe: 1.676 ± 0.395
4.676IleGly: 4.676 ± 0.704
0.882IleHis: 0.882 ± 0.318
3.088IleIle: 3.088 ± 0.531
4.676IleLys: 4.676 ± 0.725
3.0IleLeu: 3.0 ± 0.524
1.147IleMet: 1.147 ± 0.352
4.412IleAsn: 4.412 ± 0.505
2.47IlePro: 2.47 ± 0.57
2.029IleGln: 2.029 ± 0.397
4.323IleArg: 4.323 ± 0.574
5.558IleSer: 5.558 ± 0.834
3.97IleThr: 3.97 ± 0.767
3.794IleVal: 3.794 ± 0.555
0.706IleTrp: 0.706 ± 0.228
2.029IleTyr: 2.029 ± 0.433
0.0IleXaa: 0.0 ± 0.0
Lys
6.0LysAla: 6.0 ± 0.736
0.794LysCys: 0.794 ± 0.251
3.617LysAsp: 3.617 ± 0.535
2.912LysGlu: 2.912 ± 0.573
1.588LysPhe: 1.588 ± 0.374
4.147LysGly: 4.147 ± 0.565
1.059LysHis: 1.059 ± 0.367
2.823LysIle: 2.823 ± 0.574
3.794LysLys: 3.794 ± 0.52
4.588LysLeu: 4.588 ± 0.726
2.029LysMet: 2.029 ± 0.468
1.941LysAsn: 1.941 ± 0.346
2.647LysPro: 2.647 ± 0.624
2.47LysGln: 2.47 ± 0.504
2.735LysArg: 2.735 ± 0.483
4.588LysSer: 4.588 ± 0.9
2.912LysThr: 2.912 ± 0.494
4.235LysVal: 4.235 ± 0.649
0.794LysTrp: 0.794 ± 0.243
1.235LysTyr: 1.235 ± 0.279
0.0LysXaa: 0.0 ± 0.0
Leu
6.441LeuAla: 6.441 ± 0.959
0.706LeuCys: 0.706 ± 0.259
3.617LeuAsp: 3.617 ± 0.497
5.558LeuGlu: 5.558 ± 0.743
2.912LeuPhe: 2.912 ± 0.405
4.235LeuGly: 4.235 ± 0.656
1.323LeuHis: 1.323 ± 0.411
4.853LeuIle: 4.853 ± 0.509
4.323LeuLys: 4.323 ± 0.614
4.764LeuLeu: 4.764 ± 0.626
2.382LeuMet: 2.382 ± 0.39
2.823LeuAsn: 2.823 ± 0.409
3.441LeuPro: 3.441 ± 0.76
3.617LeuGln: 3.617 ± 0.519
4.059LeuArg: 4.059 ± 0.66
6.441LeuSer: 6.441 ± 1.045
5.117LeuThr: 5.117 ± 0.727
5.647LeuVal: 5.647 ± 0.76
1.412LeuTrp: 1.412 ± 0.414
2.029LeuTyr: 2.029 ± 0.399
0.0LeuXaa: 0.0 ± 0.0
Met
3.353MetAla: 3.353 ± 0.545
0.353MetCys: 0.353 ± 0.188
0.882MetAsp: 0.882 ± 0.249
2.206MetGlu: 2.206 ± 0.452
0.706MetPhe: 0.706 ± 0.227
1.853MetGly: 1.853 ± 0.457
0.794MetHis: 0.794 ± 0.274
1.765MetIle: 1.765 ± 0.391
1.765MetLys: 1.765 ± 0.422
2.823MetLeu: 2.823 ± 0.527
0.529MetMet: 0.529 ± 0.199
1.059MetAsn: 1.059 ± 0.308
1.235MetPro: 1.235 ± 0.351
1.323MetGln: 1.323 ± 0.393
1.676MetArg: 1.676 ± 0.401
2.559MetSer: 2.559 ± 0.481
1.765MetThr: 1.765 ± 0.405
1.147MetVal: 1.147 ± 0.249
0.441MetTrp: 0.441 ± 0.178
0.441MetTyr: 0.441 ± 0.184
0.0MetXaa: 0.0 ± 0.0
Asn
4.5AsnAla: 4.5 ± 0.649
0.618AsnCys: 0.618 ± 0.223
3.0AsnAsp: 3.0 ± 0.553
2.647AsnGlu: 2.647 ± 0.632
2.206AsnPhe: 2.206 ± 0.458
5.294AsnGly: 5.294 ± 0.882
1.412AsnHis: 1.412 ± 0.408
3.0AsnIle: 3.0 ± 0.629
2.294AsnLys: 2.294 ± 0.517
3.882AsnLeu: 3.882 ± 0.667
1.323AsnMet: 1.323 ± 0.371
2.559AsnAsn: 2.559 ± 0.501
2.47AsnPro: 2.47 ± 0.49
2.118AsnGln: 2.118 ± 0.385
1.853AsnArg: 1.853 ± 0.352
2.206AsnSer: 2.206 ± 0.737
2.735AsnThr: 2.735 ± 0.695
2.118AsnVal: 2.118 ± 0.415
0.353AsnTrp: 0.353 ± 0.179
1.5AsnTyr: 1.5 ± 0.431
0.0AsnXaa: 0.0 ± 0.0
Pro
1.853ProAla: 1.853 ± 0.443
0.265ProCys: 0.265 ± 0.134
2.912ProAsp: 2.912 ± 0.504
2.47ProGlu: 2.47 ± 0.55
1.323ProPhe: 1.323 ± 0.347
1.765ProGly: 1.765 ± 0.407
0.971ProHis: 0.971 ± 0.238
3.706ProIle: 3.706 ± 0.644
0.971ProLys: 0.971 ± 0.381
2.47ProLeu: 2.47 ± 0.501
1.412ProMet: 1.412 ± 0.397
2.206ProAsn: 2.206 ± 0.45
1.941ProPro: 1.941 ± 0.317
1.412ProGln: 1.412 ± 0.376
1.323ProArg: 1.323 ± 0.361
3.97ProSer: 3.97 ± 0.635
3.265ProThr: 3.265 ± 0.583
1.765ProVal: 1.765 ± 0.376
0.882ProTrp: 0.882 ± 0.291
1.323ProTyr: 1.323 ± 0.474
0.0ProXaa: 0.0 ± 0.0
Gln
2.912GlnAla: 2.912 ± 0.501
0.176GlnCys: 0.176 ± 0.126
1.765GlnAsp: 1.765 ± 0.382
2.47GlnGlu: 2.47 ± 0.452
1.235GlnPhe: 1.235 ± 0.315
2.382GlnGly: 2.382 ± 0.512
0.529GlnHis: 0.529 ± 0.22
1.853GlnIle: 1.853 ± 0.366
2.206GlnLys: 2.206 ± 0.566
4.059GlnLeu: 4.059 ± 0.561
1.676GlnMet: 1.676 ± 0.346
1.853GlnAsn: 1.853 ± 0.411
2.206GlnPro: 2.206 ± 0.403
2.294GlnGln: 2.294 ± 0.557
2.47GlnArg: 2.47 ± 0.441
3.088GlnSer: 3.088 ± 0.484
1.941GlnThr: 1.941 ± 0.464
2.294GlnVal: 2.294 ± 0.483
0.618GlnTrp: 0.618 ± 0.236
1.235GlnTyr: 1.235 ± 0.311
0.0GlnXaa: 0.0 ± 0.0
Arg
3.353ArgAla: 3.353 ± 0.467
0.882ArgCys: 0.882 ± 0.265
2.912ArgAsp: 2.912 ± 0.537
3.529ArgGlu: 3.529 ± 0.599
1.5ArgPhe: 1.5 ± 0.521
3.0ArgGly: 3.0 ± 0.507
0.706ArgHis: 0.706 ± 0.296
3.176ArgIle: 3.176 ± 0.565
2.912ArgLys: 2.912 ± 0.493
4.235ArgLeu: 4.235 ± 0.739
1.676ArgMet: 1.676 ± 0.41
2.382ArgAsn: 2.382 ± 0.544
1.765ArgPro: 1.765 ± 0.399
2.118ArgGln: 2.118 ± 0.393
2.118ArgArg: 2.118 ± 0.485
3.0ArgSer: 3.0 ± 0.536
2.206ArgThr: 2.206 ± 0.379
3.265ArgVal: 3.265 ± 0.507
1.059ArgTrp: 1.059 ± 0.361
1.147ArgTyr: 1.147 ± 0.33
0.0ArgXaa: 0.0 ± 0.0
Ser
6.617SerAla: 6.617 ± 1.017
0.706SerCys: 0.706 ± 0.284
4.853SerAsp: 4.853 ± 0.582
5.47SerGlu: 5.47 ± 0.584
2.823SerPhe: 2.823 ± 0.447
6.705SerGly: 6.705 ± 0.852
1.059SerHis: 1.059 ± 0.264
5.823SerIle: 5.823 ± 0.994
3.265SerLys: 3.265 ± 0.542
4.853SerLeu: 4.853 ± 0.585
2.206SerMet: 2.206 ± 0.444
3.265SerAsn: 3.265 ± 0.609
2.647SerPro: 2.647 ± 0.462
2.647SerGln: 2.647 ± 0.505
2.823SerArg: 2.823 ± 0.557
4.059SerSer: 4.059 ± 0.711
4.676SerThr: 4.676 ± 0.702
5.294SerVal: 5.294 ± 0.706
0.706SerTrp: 0.706 ± 0.237
1.5SerTyr: 1.5 ± 0.391
0.0SerXaa: 0.0 ± 0.0
Thr
5.735ThrAla: 5.735 ± 0.867
0.794ThrCys: 0.794 ± 0.222
2.735ThrAsp: 2.735 ± 0.484
3.0ThrGlu: 3.0 ± 0.607
2.912ThrPhe: 2.912 ± 0.701
5.206ThrGly: 5.206 ± 0.875
1.147ThrHis: 1.147 ± 0.304
3.706ThrIle: 3.706 ± 0.489
2.559ThrLys: 2.559 ± 0.385
3.794ThrLeu: 3.794 ± 0.715
1.676ThrMet: 1.676 ± 0.409
2.559ThrAsn: 2.559 ± 0.415
2.47ThrPro: 2.47 ± 0.522
1.941ThrGln: 1.941 ± 0.516
2.47ThrArg: 2.47 ± 0.512
4.5ThrSer: 4.5 ± 0.768
3.617ThrThr: 3.617 ± 0.662
2.735ThrVal: 2.735 ± 0.542
0.882ThrTrp: 0.882 ± 0.29
2.823ThrTyr: 2.823 ± 0.592
0.0ThrXaa: 0.0 ± 0.0
Val
4.764ValAla: 4.764 ± 0.714
0.706ValCys: 0.706 ± 0.23
2.823ValAsp: 2.823 ± 0.362
4.676ValGlu: 4.676 ± 0.594
3.088ValPhe: 3.088 ± 0.491
4.941ValGly: 4.941 ± 0.934
0.618ValHis: 0.618 ± 0.253
3.529ValIle: 3.529 ± 0.528
4.412ValLys: 4.412 ± 0.55
3.706ValLeu: 3.706 ± 0.697
1.147ValMet: 1.147 ± 0.444
3.529ValAsn: 3.529 ± 0.499
1.941ValPro: 1.941 ± 0.45
1.853ValGln: 1.853 ± 0.364
3.706ValArg: 3.706 ± 0.57
5.382ValSer: 5.382 ± 0.632
3.088ValThr: 3.088 ± 0.536
3.794ValVal: 3.794 ± 0.796
0.882ValTrp: 0.882 ± 0.266
2.912ValTyr: 2.912 ± 0.558
0.0ValXaa: 0.0 ± 0.0
Trp
0.971TrpAla: 0.971 ± 0.249
0.176TrpCys: 0.176 ± 0.131
0.882TrpAsp: 0.882 ± 0.271
0.882TrpGlu: 0.882 ± 0.245
0.441TrpPhe: 0.441 ± 0.17
0.529TrpGly: 0.529 ± 0.176
0.176TrpHis: 0.176 ± 0.124
0.618TrpIle: 0.618 ± 0.238
0.971TrpLys: 0.971 ± 0.334
2.206TrpLeu: 2.206 ± 0.421
0.265TrpMet: 0.265 ± 0.134
0.794TrpAsn: 0.794 ± 0.243
0.618TrpPro: 0.618 ± 0.21
0.618TrpGln: 0.618 ± 0.202
1.147TrpArg: 1.147 ± 0.322
1.059TrpSer: 1.059 ± 0.258
0.618TrpThr: 0.618 ± 0.187
0.794TrpVal: 0.794 ± 0.251
0.0TrpTrp: 0.0 ± 0.0
0.794TrpTyr: 0.794 ± 0.279
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.0TyrAla: 3.0 ± 0.434
0.353TyrCys: 0.353 ± 0.177
2.206TyrAsp: 2.206 ± 0.345
1.765TyrGlu: 1.765 ± 0.437
1.412TyrPhe: 1.412 ± 0.312
3.088TyrGly: 3.088 ± 0.559
0.265TyrHis: 0.265 ± 0.154
2.206TyrIle: 2.206 ± 0.577
2.118TyrLys: 2.118 ± 0.442
2.823TyrLeu: 2.823 ± 0.505
1.059TyrMet: 1.059 ± 0.338
1.765TyrAsn: 1.765 ± 0.473
1.147TyrPro: 1.147 ± 0.341
1.147TyrGln: 1.147 ± 0.358
2.294TyrArg: 2.294 ± 0.491
2.294TyrSer: 2.294 ± 0.451
2.029TyrThr: 2.029 ± 0.433
1.941TyrVal: 1.941 ± 0.403
0.618TyrTrp: 0.618 ± 0.245
0.882TyrTyr: 0.882 ± 0.208
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 61 proteins (11335 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski