Amino acid dipepetide frequency for Prevotellaceae bacterium HUN156

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.17AlaAla: 6.17 ± 0.116	1.042AlaCys: 1.042 ± 0.036	4.621AlaAsp: 4.621 ± 0.093	4.888AlaGlu: 4.888 ± 0.078	3.13AlaPhe: 3.13 ± 0.086	5.001AlaGly: 5.001 ± 0.09	1.439AlaHis: 1.439 ± 0.045	5.096AlaIle: 5.096 ± 0.091	4.629AlaLys: 4.629 ± 0.083	6.65AlaLeu: 6.65 ± 0.1	2.168AlaMet: 2.168 ± 0.054	3.374AlaAsn: 3.374 ± 0.07	2.439AlaPro: 2.439 ± 0.053	3.279AlaGln: 3.279 ± 0.067	2.902AlaArg: 2.902 ± 0.057	4.121AlaSer: 4.121 ± 0.071	4.466AlaThr: 4.466 ± 0.087	4.867AlaVal: 4.867 ± 0.077	0.874AlaTrp: 0.874 ± 0.034	2.912AlaTyr: 2.912 ± 0.064	0.0AlaXaa: 0.0 ± 0.0
Cys	0.909CysAla: 0.909 ± 0.036	0.227CysCys: 0.227 ± 0.016	0.744CysAsp: 0.744 ± 0.031	0.808CysGlu: 0.808 ± 0.035	0.535CysPhe: 0.535 ± 0.025	1.15CysGly: 1.15 ± 0.038	0.383CysHis: 0.383 ± 0.023	0.862CysIle: 0.862 ± 0.033	0.667CysLys: 0.667 ± 0.028	1.123CysLeu: 1.123 ± 0.03	0.342CysMet: 0.342 ± 0.02	0.608CysAsn: 0.608 ± 0.028	0.565CysPro: 0.565 ± 0.03	0.481CysGln: 0.481 ± 0.027	0.603CysArg: 0.603 ± 0.027	0.897CysSer: 0.897 ± 0.041	0.74CysThr: 0.74 ± 0.031	0.877CysVal: 0.877 ± 0.035	0.189CysTrp: 0.189 ± 0.015	0.616CysTyr: 0.616 ± 0.027	0.0CysXaa: 0.0 ± 0.0
Asp	4.513AspAla: 4.513 ± 0.078	0.761AspCys: 0.761 ± 0.033	3.577AspAsp: 3.577 ± 0.078	4.329AspGlu: 4.329 ± 0.081	2.932AspPhe: 2.932 ± 0.062	4.606AspGly: 4.606 ± 0.091	1.064AspHis: 1.064 ± 0.039	4.22AspIle: 4.22 ± 0.072	3.531AspLys: 3.531 ± 0.072	4.505AspLeu: 4.505 ± 0.081	1.732AspMet: 1.732 ± 0.052	2.906AspAsn: 2.906 ± 0.07	1.847AspPro: 1.847 ± 0.045	1.583AspGln: 1.583 ± 0.046	2.278AspArg: 2.278 ± 0.051	3.159AspSer: 3.159 ± 0.067	2.795AspThr: 2.795 ± 0.058	3.866AspVal: 3.866 ± 0.077	0.874AspTrp: 0.874 ± 0.033	3.11AspTyr: 3.11 ± 0.063	0.0AspXaa: 0.0 ± 0.0
Glu	5.066GluAla: 5.066 ± 0.083	0.734GluCys: 0.734 ± 0.029	3.547GluAsp: 3.547 ± 0.068	5.053GluGlu: 5.053 ± 0.102	2.324GluPhe: 2.324 ± 0.055	4.335GluGly: 4.335 ± 0.077	1.477GluHis: 1.477 ± 0.038	4.012GluIle: 4.012 ± 0.076	4.603GluLys: 4.603 ± 0.094	5.884GluLeu: 5.884 ± 0.097	2.111GluMet: 2.111 ± 0.053	3.266GluAsn: 3.266 ± 0.067	1.998GluPro: 1.998 ± 0.048	3.23GluGln: 3.23 ± 0.071	3.407GluArg: 3.407 ± 0.072	2.849GluSer: 2.849 ± 0.072	3.254GluThr: 3.254 ± 0.067	4.303GluVal: 4.303 ± 0.076	0.913GluTrp: 0.913 ± 0.034	2.75GluTyr: 2.75 ± 0.061	0.0GluXaa: 0.0 ± 0.0
Phe	2.959PheAla: 2.959 ± 0.059	0.734PheCys: 0.734 ± 0.028	2.798PheAsp: 2.798 ± 0.06	2.425PheGlu: 2.425 ± 0.058	1.827PhePhe: 1.827 ± 0.053	3.121PheGly: 3.121 ± 0.066	0.935PheHis: 0.935 ± 0.033	2.573PheIle: 2.573 ± 0.061	2.333PheLys: 2.333 ± 0.054	3.44PheLeu: 3.44 ± 0.071	1.189PheMet: 1.189 ± 0.046	2.177PheAsn: 2.177 ± 0.056	1.527PhePro: 1.527 ± 0.047	1.324PheGln: 1.324 ± 0.04	1.886PheArg: 1.886 ± 0.044	3.021PheSer: 3.021 ± 0.061	2.64PheThr: 2.64 ± 0.063	2.912PheVal: 2.912 ± 0.061	0.558PheTrp: 0.558 ± 0.027	1.789PheTyr: 1.789 ± 0.043	0.0PheXaa: 0.0 ± 0.0
Gly	4.653GlyAla: 4.653 ± 0.083	1.072GlyCys: 1.072 ± 0.045	3.842GlyAsp: 3.842 ± 0.073	4.171GlyGlu: 4.171 ± 0.075	3.019GlyPhe: 3.019 ± 0.063	5.045GlyGly: 5.045 ± 0.136	1.478GlyHis: 1.478 ± 0.045	5.104GlyIle: 5.104 ± 0.079	4.817GlyLys: 4.817 ± 0.091	5.681GlyLeu: 5.681 ± 0.082	2.132GlyMet: 2.132 ± 0.059	3.343GlyAsn: 3.343 ± 0.08	1.418GlyPro: 1.418 ± 0.043	2.322GlyGln: 2.322 ± 0.053	3.11GlyArg: 3.11 ± 0.07	3.981GlySer: 3.981 ± 0.087	4.27GlyThr: 4.27 ± 0.101	4.766GlyVal: 4.766 ± 0.088	1.002GlyTrp: 1.002 ± 0.042	3.236GlyTyr: 3.236 ± 0.07	0.0GlyXaa: 0.0 ± 0.0
His	1.319HisAla: 1.319 ± 0.038	0.35HisCys: 0.35 ± 0.021	1.111HisAsp: 1.111 ± 0.036	1.237HisGlu: 1.237 ± 0.041	1.132HisPhe: 1.132 ± 0.037	1.426HisGly: 1.426 ± 0.041	0.623HisHis: 0.623 ± 0.03	1.511HisIle: 1.511 ± 0.043	1.067HisLys: 1.067 ± 0.038	1.928HisLeu: 1.928 ± 0.05	0.456HisMet: 0.456 ± 0.024	1.016HisAsn: 1.016 ± 0.035	1.014HisPro: 1.014 ± 0.038	0.848HisGln: 0.848 ± 0.036	1.053HisArg: 1.053 ± 0.039	1.192HisSer: 1.192 ± 0.039	1.097HisThr: 1.097 ± 0.03	1.288HisVal: 1.288 ± 0.038	0.23HisTrp: 0.23 ± 0.017	1.01HisTyr: 1.01 ± 0.04	0.0HisXaa: 0.0 ± 0.0
Ile	5.226IleAla: 5.226 ± 0.09	1.003IleCys: 1.003 ± 0.038	4.481IleAsp: 4.481 ± 0.066	4.382IleGlu: 4.382 ± 0.088	2.49IlePhe: 2.49 ± 0.061	4.604IleGly: 4.604 ± 0.072	1.338IleHis: 1.338 ± 0.041	4.538IleIle: 4.538 ± 0.089	3.96IleLys: 3.96 ± 0.078	5.244IleLeu: 5.244 ± 0.111	1.553IleMet: 1.553 ± 0.047	3.397IleAsn: 3.397 ± 0.078	2.946IlePro: 2.946 ± 0.066	2.181IleGln: 2.181 ± 0.046	3.136IleArg: 3.136 ± 0.067	4.128IleSer: 4.128 ± 0.083	4.229IleThr: 4.229 ± 0.093	4.437IleVal: 4.437 ± 0.075	0.629IleTrp: 0.629 ± 0.028	2.578IleTyr: 2.578 ± 0.066	0.0IleXaa: 0.0 ± 0.0
Lys	5.031LysAla: 5.031 ± 0.09	0.544LysCys: 0.544 ± 0.027	3.813LysAsp: 3.813 ± 0.075	4.918LysGlu: 4.918 ± 0.097	1.956LysPhe: 1.956 ± 0.053	4.244LysGly: 4.244 ± 0.077	1.251LysHis: 1.251 ± 0.039	3.733LysIle: 3.733 ± 0.065	4.875LysLys: 4.875 ± 0.1	5.091LysLeu: 5.091 ± 0.085	2.327LysMet: 2.327 ± 0.052	3.233LysAsn: 3.233 ± 0.063	2.211LysPro: 2.211 ± 0.056	2.696LysGln: 2.696 ± 0.059	2.956LysArg: 2.956 ± 0.077	3.193LysSer: 3.193 ± 0.062	3.567LysThr: 3.567 ± 0.068	4.201LysVal: 4.201 ± 0.075	0.779LysTrp: 0.779 ± 0.028	2.746LysTyr: 2.746 ± 0.052	0.0LysXaa: 0.0 ± 0.0
Leu	6.245LeuAla: 6.245 ± 0.097	1.362LeuCys: 1.362 ± 0.038	4.627LeuAsp: 4.627 ± 0.073	4.858LeuGlu: 4.858 ± 0.078	3.904LeuPhe: 3.904 ± 0.074	5.342LeuGly: 5.342 ± 0.086	1.849LeuHis: 1.849 ± 0.052	4.917LeuIle: 4.917 ± 0.093	5.691LeuLys: 5.691 ± 0.092	8.256LeuLeu: 8.256 ± 0.143	2.7LeuMet: 2.7 ± 0.061	4.258LeuAsn: 4.258 ± 0.074	3.876LeuPro: 3.876 ± 0.073	3.485LeuGln: 3.485 ± 0.078	4.28LeuArg: 4.28 ± 0.083	6.234LeuSer: 6.234 ± 0.086	5.782LeuThr: 5.782 ± 0.092	5.244LeuVal: 5.244 ± 0.097	1.042LeuTrp: 1.042 ± 0.039	3.379LeuTyr: 3.379 ± 0.063	0.0LeuXaa: 0.0 ± 0.0
Met	2.538MetAla: 2.538 ± 0.055	0.297MetCys: 0.297 ± 0.02	1.459MetAsp: 1.459 ± 0.044	1.861MetGlu: 1.861 ± 0.054	0.982MetPhe: 0.982 ± 0.032	1.94MetGly: 1.94 ± 0.05	0.551MetHis: 0.551 ± 0.027	1.65MetIle: 1.65 ± 0.041	2.585MetLys: 2.585 ± 0.052	2.74MetLeu: 2.74 ± 0.062	1.115MetMet: 1.115 ± 0.043	1.581MetAsn: 1.581 ± 0.045	1.36MetPro: 1.36 ± 0.037	1.315MetGln: 1.315 ± 0.04	1.512MetArg: 1.512 ± 0.042	1.631MetSer: 1.631 ± 0.041	1.9MetThr: 1.9 ± 0.052	1.803MetVal: 1.803 ± 0.043	0.292MetTrp: 0.292 ± 0.018	0.846MetTyr: 0.846 ± 0.032	0.0MetXaa: 0.0 ± 0.0
Asn	3.581AsnAla: 3.581 ± 0.07	0.61AsnCys: 0.61 ± 0.037	2.795AsnAsp: 2.795 ± 0.062	2.962AsnGlu: 2.962 ± 0.058	1.981AsnPhe: 1.981 ± 0.053	4.087AsnGly: 4.087 ± 0.102	1.041AsnHis: 1.041 ± 0.032	3.637AsnIle: 3.637 ± 0.066	2.869AsnLys: 2.869 ± 0.069	3.838AsnLeu: 3.838 ± 0.066	1.369AsnMet: 1.369 ± 0.038	2.594AsnAsn: 2.594 ± 0.072	2.442AsnPro: 2.442 ± 0.047	1.737AsnGln: 1.737 ± 0.048	2.184AsnArg: 2.184 ± 0.053	2.769AsnSer: 2.769 ± 0.075	2.78AsnThr: 2.78 ± 0.071	3.199AsnVal: 3.199 ± 0.067	0.636AsnTrp: 0.636 ± 0.027	2.355AsnTyr: 2.355 ± 0.06	0.0AsnXaa: 0.0 ± 0.0
Pro	2.778ProAla: 2.778 ± 0.063	0.374ProCys: 0.374 ± 0.019	2.385ProAsp: 2.385 ± 0.062	3.143ProGlu: 3.143 ± 0.06	1.656ProPhe: 1.656 ± 0.049	2.107ProGly: 2.107 ± 0.053	0.775ProHis: 0.775 ± 0.034	2.342ProIle: 2.342 ± 0.054	2.125ProLys: 2.125 ± 0.051	3.136ProLeu: 3.136 ± 0.066	1.078ProMet: 1.078 ± 0.037	1.851ProAsn: 1.851 ± 0.047	0.688ProPro: 0.688 ± 0.032	1.629ProGln: 1.629 ± 0.046	1.345ProArg: 1.345 ± 0.038	2.121ProSer: 2.121 ± 0.049	2.325ProThr: 2.325 ± 0.054	2.654ProVal: 2.654 ± 0.055	0.485ProTrp: 0.485 ± 0.028	1.791ProTyr: 1.791 ± 0.047	0.0ProXaa: 0.0 ± 0.0
Gln	2.64GlnAla: 2.64 ± 0.057	0.464GlnCys: 0.464 ± 0.026	1.752GlnAsp: 1.752 ± 0.045	2.6GlnGlu: 2.6 ± 0.061	1.566GlnPhe: 1.566 ± 0.048	2.292GlnGly: 2.292 ± 0.06	0.88GlnHis: 0.88 ± 0.034	2.357GlnIle: 2.357 ± 0.052	2.601GlnLys: 2.601 ± 0.057	4.149GlnLeu: 4.149 ± 0.077	1.396GlnMet: 1.396 ± 0.038	1.752GlnAsn: 1.752 ± 0.046	1.547GlnPro: 1.547 ± 0.043	2.511GlnGln: 2.511 ± 0.071	2.146GlnArg: 2.146 ± 0.055	1.948GlnSer: 1.948 ± 0.05	2.147GlnThr: 2.147 ± 0.055	2.362GlnVal: 2.362 ± 0.059	0.637GlnTrp: 0.637 ± 0.032	1.713GlnTyr: 1.713 ± 0.047	0.0GlnXaa: 0.0 ± 0.0
Arg	2.792ArgAla: 2.792 ± 0.06	0.501ArgCys: 0.501 ± 0.024	2.384ArgAsp: 2.384 ± 0.06	3.15ArgGlu: 3.15 ± 0.067	2.016ArgPhe: 2.016 ± 0.055	2.522ArgGly: 2.522 ± 0.06	1.098ArgHis: 1.098 ± 0.038	3.401ArgIle: 3.401 ± 0.071	2.963ArgLys: 2.963 ± 0.061	4.38ArgLeu: 4.38 ± 0.067	1.676ArgMet: 1.676 ± 0.049	2.219ArgAsn: 2.219 ± 0.049	1.559ArgPro: 1.559 ± 0.048	2.341ArgGln: 2.341 ± 0.055	2.461ArgArg: 2.461 ± 0.065	2.226ArgSer: 2.226 ± 0.055	2.318ArgThr: 2.318 ± 0.051	2.611ArgVal: 2.611 ± 0.061	0.736ArgTrp: 0.736 ± 0.031	2.266ArgTyr: 2.266 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	4.142SerAla: 4.142 ± 0.079	0.826SerCys: 0.826 ± 0.034	3.369SerAsp: 3.369 ± 0.065	3.539SerGlu: 3.539 ± 0.058	2.786SerPhe: 2.786 ± 0.063	4.215SerGly: 4.215 ± 0.101	1.225SerHis: 1.225 ± 0.036	4.094SerIle: 4.094 ± 0.09	3.26SerLys: 3.26 ± 0.066	5.219SerLeu: 5.219 ± 0.081	1.627SerMet: 1.627 ± 0.049	2.733SerAsn: 2.733 ± 0.067	2.087SerPro: 2.087 ± 0.055	2.132SerGln: 2.132 ± 0.049	2.446SerArg: 2.446 ± 0.053	3.791SerSer: 3.791 ± 0.09	3.273SerThr: 3.273 ± 0.075	4.115SerVal: 4.115 ± 0.085	0.832SerTrp: 0.832 ± 0.033	2.556SerTyr: 2.556 ± 0.06	0.0SerXaa: 0.0 ± 0.0
Thr	4.519ThrAla: 4.519 ± 0.093	0.648ThrCys: 0.648 ± 0.028	3.482ThrAsp: 3.482 ± 0.067	3.301ThrGlu: 3.301 ± 0.057	2.755ThrPhe: 2.755 ± 0.061	4.234ThrGly: 4.234 ± 0.081	1.096ThrHis: 1.096 ± 0.04	4.515ThrIle: 4.515 ± 0.092	3.091ThrLys: 3.091 ± 0.064	5.657ThrLeu: 5.657 ± 0.109	1.504ThrMet: 1.504 ± 0.045	2.613ThrAsn: 2.613 ± 0.065	2.765ThrPro: 2.765 ± 0.059	1.876ThrGln: 1.876 ± 0.042	2.197ThrArg: 2.197 ± 0.051	3.528ThrSer: 3.528 ± 0.091	3.652ThrThr: 3.652 ± 0.097	4.043ThrVal: 4.043 ± 0.09	0.751ThrTrp: 0.751 ± 0.031	2.488ThrTyr: 2.488 ± 0.06	0.0ThrXaa: 0.0 ± 0.0
Val	5.046ValAla: 5.046 ± 0.085	0.98ValCys: 0.98 ± 0.036	3.861ValAsp: 3.861 ± 0.078	4.304ValGlu: 4.304 ± 0.089	2.648ValPhe: 2.648 ± 0.057	4.324ValGly: 4.324 ± 0.076	1.102ValHis: 1.102 ± 0.039	4.356ValIle: 4.356 ± 0.078	4.417ValLys: 4.417 ± 0.074	5.564ValLeu: 5.564 ± 0.082	1.913ValMet: 1.913 ± 0.045	3.34ValAsn: 3.34 ± 0.069	2.495ValPro: 2.495 ± 0.052	2.0ValGln: 2.0 ± 0.054	2.85ValArg: 2.85 ± 0.06	4.171ValSer: 4.171 ± 0.066	4.123ValThr: 4.123 ± 0.102	4.798ValVal: 4.798 ± 0.085	0.792ValTrp: 0.792 ± 0.029	2.601ValTyr: 2.601 ± 0.064	0.0ValXaa: 0.0 ± 0.0
Trp	0.853TrpAla: 0.853 ± 0.03	0.189TrpCys: 0.189 ± 0.016	0.747TrpAsp: 0.747 ± 0.03	0.691TrpGlu: 0.691 ± 0.032	0.55TrpPhe: 0.55 ± 0.027	0.905TrpGly: 0.905 ± 0.038	0.324TrpHis: 0.324 ± 0.022	0.773TrpIle: 0.773 ± 0.034	0.874TrpLys: 0.874 ± 0.033	1.308TrpLeu: 1.308 ± 0.037	0.474TrpMet: 0.474 ± 0.024	0.782TrpAsn: 0.782 ± 0.035	0.313TrpPro: 0.313 ± 0.02	0.68TrpGln: 0.68 ± 0.034	0.678TrpArg: 0.678 ± 0.029	0.776TrpSer: 0.776 ± 0.029	0.699TrpThr: 0.699 ± 0.029	0.669TrpVal: 0.669 ± 0.032	0.231TrpTrp: 0.231 ± 0.02	0.54TrpTyr: 0.54 ± 0.027	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.086TyrAla: 3.086 ± 0.062	0.61TyrCys: 0.61 ± 0.029	2.793TyrAsp: 2.793 ± 0.055	2.493TyrGlu: 2.493 ± 0.059	1.978TyrPhe: 1.978 ± 0.053	2.963TyrGly: 2.963 ± 0.061	0.979TyrHis: 0.979 ± 0.041	2.791TyrIle: 2.791 ± 0.058	2.406TyrLys: 2.406 ± 0.053	3.54TyrLeu: 3.54 ± 0.069	1.097TyrMet: 1.097 ± 0.037	2.426TyrAsn: 2.426 ± 0.064	1.692TyrPro: 1.692 ± 0.046	1.813TyrGln: 1.813 ± 0.052	2.188TyrArg: 2.188 ± 0.047	2.528TyrSer: 2.528 ± 0.06	2.658TyrThr: 2.658 ± 0.066	2.67TyrVal: 2.67 ± 0.061	0.573TyrTrp: 0.573 ± 0.027	2.296TyrTyr: 2.296 ± 0.072	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2311 proteins (842443 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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