Amino acid dipepetide frequency for Anaerocolumna aminovalerica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.336AlaAla: 5.336 ± 0.081	0.786AlaCys: 0.786 ± 0.026	3.405AlaAsp: 3.405 ± 0.059	4.172AlaGlu: 4.172 ± 0.064	2.767AlaPhe: 2.767 ± 0.051	4.855AlaGly: 4.855 ± 0.073	0.892AlaHis: 0.892 ± 0.031	5.493AlaIle: 5.493 ± 0.071	4.854AlaLys: 4.854 ± 0.071	5.916AlaLeu: 5.916 ± 0.074	1.897AlaMet: 1.897 ± 0.042	2.774AlaAsn: 2.774 ± 0.056	1.679AlaPro: 1.679 ± 0.032	1.661AlaGln: 1.661 ± 0.042	2.198AlaArg: 2.198 ± 0.047	3.62AlaSer: 3.62 ± 0.063	3.018AlaThr: 3.018 ± 0.063	4.831AlaVal: 4.831 ± 0.057	0.465AlaTrp: 0.465 ± 0.019	2.437AlaTyr: 2.437 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.609CysAla: 0.609 ± 0.025	0.173CysCys: 0.173 ± 0.012	0.654CysAsp: 0.654 ± 0.024	0.7CysGlu: 0.7 ± 0.023	0.554CysPhe: 0.554 ± 0.02	1.055CysGly: 1.055 ± 0.033	0.265CysHis: 0.265 ± 0.013	1.097CysIle: 1.097 ± 0.032	0.866CysLys: 0.866 ± 0.028	0.938CysLeu: 0.938 ± 0.028	0.335CysMet: 0.335 ± 0.018	0.644CysAsn: 0.644 ± 0.023	0.503CysPro: 0.503 ± 0.033	0.3CysGln: 0.3 ± 0.013	0.421CysArg: 0.421 ± 0.017	0.783CysSer: 0.783 ± 0.027	0.636CysThr: 0.636 ± 0.025	0.703CysVal: 0.703 ± 0.025	0.085CysTrp: 0.085 ± 0.009	0.466CysTyr: 0.466 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	3.092AspAla: 3.092 ± 0.06	0.632AspCys: 0.632 ± 0.023	2.451AspAsp: 2.451 ± 0.039	4.175AspGlu: 4.175 ± 0.063	2.676AspPhe: 2.676 ± 0.043	3.612AspGly: 3.612 ± 0.054	0.735AspHis: 0.735 ± 0.023	5.409AspIle: 5.409 ± 0.057	4.456AspLys: 4.456 ± 0.055	4.555AspLeu: 4.555 ± 0.063	1.68AspMet: 1.68 ± 0.039	3.055AspAsn: 3.055 ± 0.056	1.595AspPro: 1.595 ± 0.034	1.208AspGln: 1.208 ± 0.029	1.944AspArg: 1.944 ± 0.039	3.272AspSer: 3.272 ± 0.055	3.051AspThr: 3.051 ± 0.05	3.46AspVal: 3.46 ± 0.058	0.515AspTrp: 0.515 ± 0.023	2.855AspTyr: 2.855 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	4.81GluAla: 4.81 ± 0.07	0.699GluCys: 0.699 ± 0.026	4.282GluAsp: 4.282 ± 0.065	7.097GluGlu: 7.097 ± 0.1	2.818GluPhe: 2.818 ± 0.043	4.317GluGly: 4.317 ± 0.061	1.221GluHis: 1.221 ± 0.029	6.239GluIle: 6.239 ± 0.072	6.561GluLys: 6.561 ± 0.088	6.849GluLeu: 6.849 ± 0.086	2.052GluMet: 2.052 ± 0.037	4.395GluAsn: 4.395 ± 0.067	1.783GluPro: 1.783 ± 0.039	2.596GluGln: 2.596 ± 0.046	2.743GluArg: 2.743 ± 0.049	3.496GluSer: 3.496 ± 0.054	3.643GluThr: 3.643 ± 0.061	4.553GluVal: 4.553 ± 0.057	0.553GluTrp: 0.553 ± 0.023	3.363GluTyr: 3.363 ± 0.053	0.0GluXaa: 0.0 ± 0.0
Phe	2.557PheAla: 2.557 ± 0.049	0.58PheCys: 0.58 ± 0.022	2.495PheAsp: 2.495 ± 0.042	2.711PheGlu: 2.711 ± 0.042	1.933PhePhe: 1.933 ± 0.05	2.875PheGly: 2.875 ± 0.049	0.836PheHis: 0.836 ± 0.025	4.064PheIle: 4.064 ± 0.073	2.683PheLys: 2.683 ± 0.045	3.928PheLeu: 3.928 ± 0.066	1.217PheMet: 1.217 ± 0.03	2.178PheAsn: 2.178 ± 0.046	1.3PhePro: 1.3 ± 0.032	1.341PheGln: 1.341 ± 0.036	1.494PheArg: 1.494 ± 0.033	3.049PheSer: 3.049 ± 0.046	2.578PheThr: 2.578 ± 0.044	2.654PheVal: 2.654 ± 0.046	0.382PheTrp: 0.382 ± 0.016	1.94PheTyr: 1.94 ± 0.046	0.0PheXaa: 0.0 ± 0.0
Gly	4.23GlyAla: 4.23 ± 0.071	0.946GlyCys: 0.946 ± 0.032	3.169GlyAsp: 3.169 ± 0.053	4.343GlyGlu: 4.343 ± 0.061	3.201GlyPhe: 3.201 ± 0.048	4.372GlyGly: 4.372 ± 0.075	1.071GlyHis: 1.071 ± 0.027	6.837GlyIle: 6.837 ± 0.087	5.546GlyLys: 5.546 ± 0.074	5.713GlyLeu: 5.713 ± 0.079	2.021GlyMet: 2.021 ± 0.04	3.455GlyAsn: 3.455 ± 0.063	1.355GlyPro: 1.355 ± 0.059	1.808GlyGln: 1.808 ± 0.039	2.477GlyArg: 2.477 ± 0.047	3.907GlySer: 3.907 ± 0.06	3.945GlyThr: 3.945 ± 0.065	4.553GlyVal: 4.553 ± 0.066	0.585GlyTrp: 0.585 ± 0.025	3.288GlyTyr: 3.288 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	0.856HisAla: 0.856 ± 0.024	0.249HisCys: 0.249 ± 0.015	0.808HisAsp: 0.808 ± 0.024	1.022HisGlu: 1.022 ± 0.031	0.781HisPhe: 0.781 ± 0.027	1.198HisGly: 1.198 ± 0.028	0.355HisHis: 0.355 ± 0.02	1.641HisIle: 1.641 ± 0.034	1.122HisLys: 1.122 ± 0.026	1.4HisLeu: 1.4 ± 0.037	0.478HisMet: 0.478 ± 0.021	0.915HisAsn: 0.915 ± 0.026	0.689HisPro: 0.689 ± 0.025	0.513HisGln: 0.513 ± 0.022	0.583HisArg: 0.583 ± 0.022	1.005HisSer: 1.005 ± 0.031	0.882HisThr: 0.882 ± 0.029	0.966HisVal: 0.966 ± 0.027	0.138HisTrp: 0.138 ± 0.01	0.737HisTyr: 0.737 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	5.997IleAla: 5.997 ± 0.085	1.18IleCys: 1.18 ± 0.03	4.841IleAsp: 4.841 ± 0.069	5.934IleGlu: 5.934 ± 0.082	3.574IlePhe: 3.574 ± 0.075	5.823IleGly: 5.823 ± 0.075	1.641IleHis: 1.641 ± 0.033	7.969IleIle: 7.969 ± 0.104	6.437IleLys: 6.437 ± 0.078	8.624IleLeu: 8.624 ± 0.106	2.333IleMet: 2.333 ± 0.044	4.737IleAsn: 4.737 ± 0.061	3.509IlePro: 3.509 ± 0.058	2.741IleGln: 2.741 ± 0.044	3.358IleArg: 3.358 ± 0.054	6.205IleSer: 6.205 ± 0.087	5.369IleThr: 5.369 ± 0.074	5.416IleVal: 5.416 ± 0.075	0.644IleTrp: 0.644 ± 0.022	3.448IleTyr: 3.448 ± 0.049	0.0IleXaa: 0.0 ± 0.0
Lys	4.935LysAla: 4.935 ± 0.077	0.671LysCys: 0.671 ± 0.026	4.848LysAsp: 4.848 ± 0.062	8.141LysGlu: 8.141 ± 0.111	2.258LysPhe: 2.258 ± 0.044	4.635LysGly: 4.635 ± 0.064	1.145LysHis: 1.145 ± 0.028	6.103LysIle: 6.103 ± 0.063	6.871LysLys: 6.871 ± 0.085	6.361LysLeu: 6.361 ± 0.067	2.205LysMet: 2.205 ± 0.039	4.709LysAsn: 4.709 ± 0.069	2.113LysPro: 2.113 ± 0.042	2.471LysGln: 2.471 ± 0.043	2.955LysArg: 2.955 ± 0.047	4.115LysSer: 4.115 ± 0.064	3.965LysThr: 3.965 ± 0.057	5.02LysVal: 5.02 ± 0.064	0.586LysTrp: 0.586 ± 0.024	3.355LysTyr: 3.355 ± 0.055	0.0LysXaa: 0.0 ± 0.0
Leu	5.756LeuAla: 5.756 ± 0.07	1.197LeuCys: 1.197 ± 0.036	4.867LeuAsp: 4.867 ± 0.067	6.397LeuGlu: 6.397 ± 0.069	4.04LeuPhe: 4.04 ± 0.068	5.787LeuGly: 5.787 ± 0.069	1.49LeuHis: 1.49 ± 0.038	7.586LeuIle: 7.586 ± 0.086	6.939LeuLys: 6.939 ± 0.073	8.846LeuLeu: 8.846 ± 0.105	2.505LeuMet: 2.505 ± 0.042	4.932LeuAsn: 4.932 ± 0.067	3.283LeuPro: 3.283 ± 0.051	2.626LeuGln: 2.626 ± 0.049	3.326LeuArg: 3.326 ± 0.061	6.776LeuSer: 6.776 ± 0.09	5.089LeuThr: 5.089 ± 0.062	5.263LeuVal: 5.263 ± 0.076	0.701LeuTrp: 0.701 ± 0.024	3.565LeuTyr: 3.565 ± 0.057	0.0LeuXaa: 0.0 ± 0.0
Met	1.989MetAla: 1.989 ± 0.042	0.258MetCys: 0.258 ± 0.014	1.729MetAsp: 1.729 ± 0.035	2.343MetGlu: 2.343 ± 0.043	1.041MetPhe: 1.041 ± 0.029	1.909MetGly: 1.909 ± 0.037	0.371MetHis: 0.371 ± 0.017	2.212MetIle: 2.212 ± 0.04	2.62MetLys: 2.62 ± 0.037	2.543MetLeu: 2.543 ± 0.047	0.727MetMet: 0.727 ± 0.025	1.772MetAsn: 1.772 ± 0.034	1.034MetPro: 1.034 ± 0.029	0.823MetGln: 0.823 ± 0.026	0.947MetArg: 0.947 ± 0.032	1.659MetSer: 1.659 ± 0.035	1.428MetThr: 1.428 ± 0.026	1.816MetVal: 1.816 ± 0.039	0.185MetTrp: 0.185 ± 0.013	0.88MetTyr: 0.88 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.034AsnAla: 3.034 ± 0.054	0.588AsnCys: 0.588 ± 0.021	2.559AsnAsp: 2.559 ± 0.05	3.647AsnGlu: 3.647 ± 0.061	2.139AsnPhe: 2.139 ± 0.041	3.784AsnGly: 3.784 ± 0.063	1.027AsnHis: 1.027 ± 0.028	5.292AsnIle: 5.292 ± 0.077	4.221AsnLys: 4.221 ± 0.06	4.735AsnLeu: 4.735 ± 0.075	1.598AsnMet: 1.598 ± 0.035	3.326AsnAsn: 3.326 ± 0.063	2.279AsnPro: 2.279 ± 0.039	1.958AsnGln: 1.958 ± 0.041	2.111AsnArg: 2.111 ± 0.049	3.345AsnSer: 3.345 ± 0.06	3.02AsnThr: 3.02 ± 0.051	3.073AsnVal: 3.073 ± 0.046	0.48AsnTrp: 0.48 ± 0.022	2.558AsnTyr: 2.558 ± 0.044	0.0AsnXaa: 0.0 ± 0.0
Pro	1.959ProAla: 1.959 ± 0.043	0.356ProCys: 0.356 ± 0.024	2.035ProAsp: 2.035 ± 0.038	2.755ProGlu: 2.755 ± 0.051	1.553ProPhe: 1.553 ± 0.035	2.073ProGly: 2.073 ± 0.052	0.521ProHis: 0.521 ± 0.021	2.615ProIle: 2.615 ± 0.044	2.055ProLys: 2.055 ± 0.038	2.651ProLeu: 2.651 ± 0.046	0.832ProMet: 0.832 ± 0.024	1.554ProAsn: 1.554 ± 0.037	0.76ProPro: 0.76 ± 0.04	0.917ProGln: 0.917 ± 0.028	0.922ProArg: 0.922 ± 0.026	1.924ProSer: 1.924 ± 0.039	1.704ProThr: 1.704 ± 0.045	2.489ProVal: 2.489 ± 0.044	0.312ProTrp: 0.312 ± 0.016	1.468ProTyr: 1.468 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	1.82GlnAla: 1.82 ± 0.041	0.33GlnCys: 0.33 ± 0.017	1.529GlnAsp: 1.529 ± 0.039	2.2GlnGlu: 2.2 ± 0.049	1.2GlnPhe: 1.2 ± 0.032	1.855GlnGly: 1.855 ± 0.046	0.385GlnHis: 0.385 ± 0.019	2.7GlnIle: 2.7 ± 0.041	2.397GlnLys: 2.397 ± 0.045	2.951GlnLeu: 2.951 ± 0.049	0.944GlnMet: 0.944 ± 0.026	1.745GlnAsn: 1.745 ± 0.042	0.812GlnPro: 0.812 ± 0.028	0.927GlnGln: 0.927 ± 0.028	1.121GlnArg: 1.121 ± 0.029	1.666GlnSer: 1.666 ± 0.037	1.487GlnThr: 1.487 ± 0.035	1.904GlnVal: 1.904 ± 0.036	0.289GlnTrp: 0.289 ± 0.014	1.375GlnTyr: 1.375 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	1.92ArgAla: 1.92 ± 0.038	0.431ArgCys: 0.431 ± 0.023	1.843ArgAsp: 1.843 ± 0.038	2.958ArgGlu: 2.958 ± 0.056	1.589ArgPhe: 1.589 ± 0.039	2.033ArgGly: 2.033 ± 0.045	0.55ArgHis: 0.55 ± 0.019	3.441ArgIle: 3.441 ± 0.053	3.124ArgLys: 3.124 ± 0.05	3.278ArgLeu: 3.278 ± 0.06	1.166ArgMet: 1.166 ± 0.027	2.202ArgAsn: 2.202 ± 0.042	1.045ArgPro: 1.045 ± 0.034	1.142ArgGln: 1.142 ± 0.035	1.591ArgArg: 1.591 ± 0.043	1.841ArgSer: 1.841 ± 0.037	1.925ArgThr: 1.925 ± 0.043	2.26ArgVal: 2.26 ± 0.044	0.288ArgTrp: 0.288 ± 0.014	1.627ArgTyr: 1.627 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	3.579SerAla: 3.579 ± 0.058	0.689SerCys: 0.689 ± 0.023	3.184SerAsp: 3.184 ± 0.055	4.073SerGlu: 4.073 ± 0.063	3.084SerPhe: 3.084 ± 0.055	4.636SerGly: 4.636 ± 0.068	1.034SerHis: 1.034 ± 0.03	5.678SerIle: 5.678 ± 0.073	4.673SerLys: 4.673 ± 0.064	5.646SerLeu: 5.646 ± 0.073	1.781SerMet: 1.781 ± 0.036	3.265SerAsn: 3.265 ± 0.049	1.79SerPro: 1.79 ± 0.036	1.828SerGln: 1.828 ± 0.037	2.216SerArg: 2.216 ± 0.039	4.004SerSer: 4.004 ± 0.061	3.169SerThr: 3.169 ± 0.058	4.044SerVal: 4.044 ± 0.063	0.504SerTrp: 0.504 ± 0.021	2.745SerTyr: 2.745 ± 0.056	0.0SerXaa: 0.0 ± 0.0
Thr	3.759ThrAla: 3.759 ± 0.066	0.547ThrCys: 0.547 ± 0.022	2.988ThrAsp: 2.988 ± 0.056	3.531ThrGlu: 3.531 ± 0.056	2.291ThrPhe: 2.291 ± 0.045	4.409ThrGly: 4.409 ± 0.071	0.88ThrHis: 0.88 ± 0.03	5.032ThrIle: 5.032 ± 0.066	3.642ThrLys: 3.642 ± 0.062	5.141ThrLeu: 5.141 ± 0.063	1.434ThrMet: 1.434 ± 0.035	2.659ThrAsn: 2.659 ± 0.046	2.116ThrPro: 2.116 ± 0.045	1.343ThrGln: 1.343 ± 0.036	1.675ThrArg: 1.675 ± 0.034	3.214ThrSer: 3.214 ± 0.056	3.039ThrThr: 3.039 ± 0.065	4.147ThrVal: 4.147 ± 0.066	0.44ThrTrp: 0.44 ± 0.019	2.22ThrTyr: 2.22 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	4.036ValAla: 4.036 ± 0.065	0.826ValCys: 0.826 ± 0.023	3.628ValAsp: 3.628 ± 0.048	4.2ValGlu: 4.2 ± 0.062	2.904ValPhe: 2.904 ± 0.052	4.051ValGly: 4.051 ± 0.059	0.949ValHis: 0.949 ± 0.032	5.967ValIle: 5.967 ± 0.077	4.81ValLys: 4.81 ± 0.073	6.241ValLeu: 6.241 ± 0.071	1.735ValMet: 1.735 ± 0.038	3.394ValAsn: 3.394 ± 0.046	2.15ValPro: 2.15 ± 0.048	1.7ValGln: 1.7 ± 0.037	2.197ValArg: 2.197 ± 0.042	4.396ValSer: 4.396 ± 0.054	3.921ValThr: 3.921 ± 0.066	4.321ValVal: 4.321 ± 0.069	0.476ValTrp: 0.476 ± 0.02	2.605ValTyr: 2.605 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	0.468TrpAla: 0.468 ± 0.02	0.113TrpCys: 0.113 ± 0.008	0.514TrpAsp: 0.514 ± 0.024	0.553TrpGlu: 0.553 ± 0.023	0.404TrpPhe: 0.404 ± 0.018	0.587TrpGly: 0.587 ± 0.023	0.16TrpHis: 0.16 ± 0.01	0.661TrpIle: 0.661 ± 0.022	0.619TrpLys: 0.619 ± 0.023	0.769TrpLeu: 0.769 ± 0.025	0.239TrpMet: 0.239 ± 0.013	0.546TrpAsn: 0.546 ± 0.022	0.211TrpPro: 0.211 ± 0.015	0.264TrpGln: 0.264 ± 0.015	0.298TrpArg: 0.298 ± 0.017	0.473TrpSer: 0.473 ± 0.018	0.34TrpThr: 0.34 ± 0.016	0.472TrpVal: 0.472 ± 0.019	0.108TrpTrp: 0.108 ± 0.009	0.3TrpTyr: 0.3 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.316TyrAla: 2.316 ± 0.043	0.539TyrCys: 0.539 ± 0.022	2.597TyrAsp: 2.597 ± 0.05	3.115TyrGlu: 3.115 ± 0.059	1.99TyrPhe: 1.99 ± 0.041	2.955TyrGly: 2.955 ± 0.044	0.807TyrHis: 0.807 ± 0.027	3.743TyrIle: 3.743 ± 0.06	2.964TyrLys: 2.964 ± 0.046	3.889TyrLeu: 3.889 ± 0.059	1.106TyrMet: 1.106 ± 0.027	2.515TyrAsn: 2.515 ± 0.049	1.455TyrPro: 1.455 ± 0.033	1.473TyrGln: 1.473 ± 0.037	1.677TyrArg: 1.677 ± 0.035	2.871TyrSer: 2.871 ± 0.053	2.296TyrThr: 2.296 ± 0.047	2.564TyrVal: 2.564 ± 0.044	0.36TyrTrp: 0.36 ± 0.021	2.12TyrTyr: 2.12 ± 0.049	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4029 proteins (1286805 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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