Amino acid dipepetide frequency for Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.846AlaAla: 2.846 ± 0.157
0.565AlaCys: 0.565 ± 0.055
2.157AlaAsp: 2.157 ± 0.1
2.208AlaGlu: 2.208 ± 0.123
3.496AlaPhe: 3.496 ± 0.143
2.508AlaGly: 2.508 ± 0.15
0.751AlaHis: 0.751 ± 0.062
5.648AlaIle: 5.648 ± 0.205
5.721AlaLys: 5.721 ± 0.18
6.314AlaLeu: 6.314 ± 0.202
0.858AlaMet: 0.858 ± 0.063
4.75AlaAsn: 4.75 ± 0.166
1.186AlaPro: 1.186 ± 0.09
2.107AlaGln: 2.107 ± 0.106
1.683AlaArg: 1.683 ± 0.108
3.88AlaSer: 3.88 ± 0.141
2.92AlaThr: 2.92 ± 0.133
3.801AlaVal: 3.801 ± 0.166
0.452AlaTrp: 0.452 ± 0.057
1.813AlaTyr: 1.813 ± 0.109
0.0AlaXaa: 0.0 ± 0.0
Cys
0.356CysAla: 0.356 ± 0.046
0.124CysCys: 0.124 ± 0.03
0.486CysAsp: 0.486 ± 0.055
0.604CysGlu: 0.604 ± 0.062
0.695CysPhe: 0.695 ± 0.071
0.633CysGly: 0.633 ± 0.06
0.209CysHis: 0.209 ± 0.032
0.446CysIle: 0.446 ± 0.048
0.616CysLys: 0.616 ± 0.069
1.028CysLeu: 1.028 ± 0.088
0.13CysMet: 0.13 ± 0.026
0.486CysAsn: 0.486 ± 0.06
0.237CysPro: 0.237 ± 0.041
0.294CysGln: 0.294 ± 0.04
0.198CysArg: 0.198 ± 0.033
0.565CysSer: 0.565 ± 0.052
0.305CysThr: 0.305 ± 0.043
0.435CysVal: 0.435 ± 0.052
0.096CysTrp: 0.096 ± 0.026
0.305CysTyr: 0.305 ± 0.048
0.0CysXaa: 0.0 ± 0.0
Asp
2.598AspAla: 2.598 ± 0.109
0.412AspCys: 0.412 ± 0.049
2.135AspAsp: 2.135 ± 0.154
3.462AspGlu: 3.462 ± 0.199
3.49AspPhe: 3.49 ± 0.137
2.383AspGly: 2.383 ± 0.14
0.988AspHis: 0.988 ± 0.075
3.355AspIle: 3.355 ± 0.145
4.507AspLys: 4.507 ± 0.173
5.456AspLeu: 5.456 ± 0.181
0.627AspMet: 0.627 ± 0.065
3.304AspAsn: 3.304 ± 0.149
1.779AspPro: 1.779 ± 0.121
2.965AspGln: 2.965 ± 0.181
1.158AspArg: 1.158 ± 0.096
3.304AspSer: 3.304 ± 0.198
1.988AspThr: 1.988 ± 0.106
2.824AspVal: 2.824 ± 0.12
0.559AspTrp: 0.559 ± 0.059
1.858AspTyr: 1.858 ± 0.109
0.0AspXaa: 0.0 ± 0.0
Glu
2.993GluAla: 2.993 ± 0.173
0.277GluCys: 0.277 ± 0.045
1.66GluAsp: 1.66 ± 0.119
2.649GluGlu: 2.649 ± 0.202
2.671GluPhe: 2.671 ± 0.137
1.881GluGly: 1.881 ± 0.12
0.853GluHis: 0.853 ± 0.073
5.732GluIle: 5.732 ± 0.251
6.574GluLys: 6.574 ± 0.259
6.862GluLeu: 6.862 ± 0.318
1.18GluMet: 1.18 ± 0.087
4.473GluAsn: 4.473 ± 0.209
1.525GluPro: 1.525 ± 0.209
3.27GluGln: 3.27 ± 0.186
2.135GluArg: 2.135 ± 0.168
3.027GluSer: 3.027 ± 0.172
3.174GluThr: 3.174 ± 0.212
3.343GluVal: 3.343 ± 0.199
0.508GluTrp: 0.508 ± 0.063
1.615GluTyr: 1.615 ± 0.104
0.0GluXaa: 0.0 ± 0.0
Phe
3.372PheAla: 3.372 ± 0.148
0.689PheCys: 0.689 ± 0.063
3.948PheAsp: 3.948 ± 0.248
3.812PheGlu: 3.812 ± 0.164
3.999PhePhe: 3.999 ± 0.202
3.101PheGly: 3.101 ± 0.139
0.988PheHis: 0.988 ± 0.072
4.688PheIle: 4.688 ± 0.197
5.134PheLys: 5.134 ± 0.176
6.828PheLeu: 6.828 ± 0.256
0.762PheMet: 0.762 ± 0.067
4.953PheAsn: 4.953 ± 0.205
1.333PhePro: 1.333 ± 0.098
2.604PheGln: 2.604 ± 0.155
1.389PheArg: 1.389 ± 0.079
5.015PheSer: 5.015 ± 0.177
2.609PheThr: 2.609 ± 0.114
3.552PheVal: 3.552 ± 0.178
0.768PheTrp: 0.768 ± 0.072
2.039PheTyr: 2.039 ± 0.118
0.0PheXaa: 0.0 ± 0.0
Gly
2.321GlyAla: 2.321 ± 0.138
0.373GlyCys: 0.373 ± 0.044
2.061GlyAsp: 2.061 ± 0.115
2.107GlyGlu: 2.107 ± 0.116
3.575GlyPhe: 3.575 ± 0.17
2.892GlyGly: 2.892 ± 0.169
0.751GlyHis: 0.751 ± 0.084
4.993GlyIle: 4.993 ± 0.208
3.643GlyLys: 3.643 ± 0.191
4.812GlyLeu: 4.812 ± 0.203
0.988GlyMet: 0.988 ± 0.076
2.321GlyAsn: 2.321 ± 0.13
0.932GlyPro: 0.932 ± 0.078
1.576GlyGln: 1.576 ± 0.109
1.508GlyArg: 1.508 ± 0.11
3.456GlySer: 3.456 ± 0.159
2.242GlyThr: 2.242 ± 0.133
3.264GlyVal: 3.264 ± 0.163
0.429GlyTrp: 0.429 ± 0.044
2.016GlyTyr: 2.016 ± 0.12
0.0GlyXaa: 0.0 ± 0.0
His
0.875HisAla: 0.875 ± 0.072
0.13HisCys: 0.13 ± 0.032
0.853HisAsp: 0.853 ± 0.076
0.836HisGlu: 0.836 ± 0.072
1.158HisPhe: 1.158 ± 0.087
0.864HisGly: 0.864 ± 0.079
0.401HisHis: 0.401 ± 0.053
0.938HisIle: 0.938 ± 0.069
1.237HisLys: 1.237 ± 0.087
1.779HisLeu: 1.779 ± 0.097
0.192HisMet: 0.192 ± 0.034
1.158HisAsn: 1.158 ± 0.091
0.604HisPro: 0.604 ± 0.064
0.892HisGln: 0.892 ± 0.081
0.441HisArg: 0.441 ± 0.046
0.971HisSer: 0.971 ± 0.074
0.672HisThr: 0.672 ± 0.068
0.836HisVal: 0.836 ± 0.062
0.181HisTrp: 0.181 ± 0.037
0.745HisTyr: 0.745 ± 0.06
0.0HisXaa: 0.0 ± 0.0
Ile
5.811IleAla: 5.811 ± 0.223
0.768IleCys: 0.768 ± 0.066
5.202IleAsp: 5.202 ± 0.18
4.987IleGlu: 4.987 ± 0.214
4.529IlePhe: 4.529 ± 0.17
4.179IleGly: 4.179 ± 0.162
1.192IleHis: 1.192 ± 0.074
6.489IleIle: 6.489 ± 0.243
8.025IleLys: 8.025 ± 0.266
6.195IleLeu: 6.195 ± 0.198
1.096IleMet: 1.096 ± 0.075
7.173IleAsn: 7.173 ± 0.225
2.7IlePro: 2.7 ± 0.137
2.677IleGln: 2.677 ± 0.118
2.649IleArg: 2.649 ± 0.109
5.738IleSer: 5.738 ± 0.19
4.597IleThr: 4.597 ± 0.156
5.608IleVal: 5.608 ± 0.236
0.565IleTrp: 0.565 ± 0.062
2.434IleTyr: 2.434 ± 0.118
0.0IleXaa: 0.0 ± 0.0
Lys
5.337LysAla: 5.337 ± 0.194
0.412LysCys: 0.412 ± 0.052
4.253LysAsp: 4.253 ± 0.153
5.636LysGlu: 5.636 ± 0.26
3.394LysPhe: 3.394 ± 0.137
3.338LysGly: 3.338 ± 0.169
1.762LysHis: 1.762 ± 0.089
7.523LysIle: 7.523 ± 0.223
10.013LysLys: 10.013 ± 0.271
10.409LysLeu: 10.409 ± 0.272
1.468LysMet: 1.468 ± 0.108
7.461LysAsn: 7.461 ± 0.212
3.417LysPro: 3.417 ± 0.172
6.303LysGln: 6.303 ± 0.29
3.801LysArg: 3.801 ± 0.176
5.377LysSer: 5.377 ± 0.185
6.647LysThr: 6.647 ± 0.238
4.795LysVal: 4.795 ± 0.182
0.87LysTrp: 0.87 ± 0.08
2.796LysTyr: 2.796 ± 0.109
0.0LysXaa: 0.0 ± 0.0
Leu
6.653LeuAla: 6.653 ± 0.227
0.808LeuCys: 0.808 ± 0.062
5.173LeuAsp: 5.173 ± 0.161
5.998LeuGlu: 5.998 ± 0.27
6.687LeuPhe: 6.687 ± 0.268
4.699LeuGly: 4.699 ± 0.2
1.361LeuHis: 1.361 ± 0.086
9.714LeuIle: 9.714 ± 0.298
11.041LeuLys: 11.041 ± 0.283
10.86LeuLeu: 10.86 ± 0.308
1.768LeuMet: 1.768 ± 0.103
7.884LeuAsn: 7.884 ± 0.252
3.157LeuPro: 3.157 ± 0.146
4.219LeuGln: 4.219 ± 0.212
2.931LeuArg: 2.931 ± 0.131
6.964LeuSer: 6.964 ± 0.198
6.354LeuThr: 6.354 ± 0.216
7.139LeuVal: 7.139 ± 0.233
0.842LeuTrp: 0.842 ± 0.074
2.592LeuTyr: 2.592 ± 0.125
0.0LeuXaa: 0.0 ± 0.0
Met
1.034MetAla: 1.034 ± 0.084
0.102MetCys: 0.102 ± 0.024
0.847MetAsp: 0.847 ± 0.07
0.87MetGlu: 0.87 ± 0.07
0.649MetPhe: 0.649 ± 0.06
0.847MetGly: 0.847 ± 0.08
0.254MetHis: 0.254 ± 0.041
1.395MetIle: 1.395 ± 0.1
1.265MetLys: 1.265 ± 0.084
1.643MetLeu: 1.643 ± 0.11
0.294MetMet: 0.294 ± 0.039
0.881MetAsn: 0.881 ± 0.076
0.401MetPro: 0.401 ± 0.055
0.938MetGln: 0.938 ± 0.074
0.587MetArg: 0.587 ± 0.056
0.954MetSer: 0.954 ± 0.071
0.672MetThr: 0.672 ± 0.069
1.169MetVal: 1.169 ± 0.081
0.119MetTrp: 0.119 ± 0.031
0.356MetTyr: 0.356 ± 0.05
0.0MetXaa: 0.0 ± 0.0
Asn
3.53AsnAla: 3.53 ± 0.125
0.678AsnCys: 0.678 ± 0.073
3.62AsnAsp: 3.62 ± 0.171
4.467AsnGlu: 4.467 ± 0.208
4.738AsnPhe: 4.738 ± 0.173
3.326AsnGly: 3.326 ± 0.172
1.412AsnHis: 1.412 ± 0.104
5.004AsnIle: 5.004 ± 0.17
7.5AsnLys: 7.5 ± 0.189
7.85AsnLeu: 7.85 ± 0.231
0.83AsnMet: 0.83 ± 0.071
6.596AsnAsn: 6.596 ± 0.267
2.756AsnPro: 2.756 ± 0.144
5.156AsnGln: 5.156 ± 0.25
2.157AsnArg: 2.157 ± 0.107
5.122AsnSer: 5.122 ± 0.193
3.49AsnThr: 3.49 ± 0.163
3.276AsnVal: 3.276 ± 0.128
1.017AsnTrp: 1.017 ± 0.084
2.7AsnTyr: 2.7 ± 0.134
0.0AsnXaa: 0.0 ± 0.0
Pro
1.259ProAla: 1.259 ± 0.08
0.232ProCys: 0.232 ± 0.041
1.305ProAsp: 1.305 ± 0.085
1.852ProGlu: 1.852 ± 0.213
1.994ProPhe: 1.994 ± 0.114
1.316ProGly: 1.316 ± 0.084
0.503ProHis: 0.503 ± 0.062
2.27ProIle: 2.27 ± 0.132
2.558ProLys: 2.558 ± 0.129
3.541ProLeu: 3.541 ± 0.128
0.407ProMet: 0.407 ± 0.045
2.406ProAsn: 2.406 ± 0.143
0.762ProPro: 0.762 ± 0.074
1.186ProGln: 1.186 ± 0.118
0.762ProArg: 0.762 ± 0.076
2.095ProSer: 2.095 ± 0.125
1.926ProThr: 1.926 ± 0.122
2.186ProVal: 2.186 ± 0.141
0.294ProTrp: 0.294 ± 0.04
1.034ProTyr: 1.034 ± 0.078
0.0ProXaa: 0.0 ± 0.0
Gln
3.095GlnAla: 3.095 ± 0.176
0.203GlnCys: 0.203 ± 0.031
1.756GlnAsp: 1.756 ± 0.103
2.253GlnGlu: 2.253 ± 0.157
2.762GlnPhe: 2.762 ± 0.141
1.412GlnGly: 1.412 ± 0.102
0.638GlnHis: 0.638 ± 0.064
3.897GlnIle: 3.897 ± 0.173
5.06GlnLys: 5.06 ± 0.244
5.958GlnLeu: 5.958 ± 0.217
0.7GlnMet: 0.7 ± 0.059
3.507GlnAsn: 3.507 ± 0.164
1.768GlnPro: 1.768 ± 0.27
2.818GlnGln: 2.818 ± 0.248
1.835GlnArg: 1.835 ± 0.138
2.344GlnSer: 2.344 ± 0.128
3.287GlnThr: 3.287 ± 0.154
2.259GlnVal: 2.259 ± 0.122
0.418GlnTrp: 0.418 ± 0.054
1.389GlnTyr: 1.389 ± 0.104
0.0GlnXaa: 0.0 ± 0.0
Arg
1.7ArgAla: 1.7 ± 0.117
0.288ArgCys: 0.288 ± 0.046
1.542ArgAsp: 1.542 ± 0.096
1.768ArgGlu: 1.768 ± 0.139
2.191ArgPhe: 2.191 ± 0.107
1.418ArgGly: 1.418 ± 0.092
0.441ArgHis: 0.441 ± 0.055
2.722ArgIle: 2.722 ± 0.127
2.688ArgLys: 2.688 ± 0.138
3.315ArgLeu: 3.315 ± 0.181
0.576ArgMet: 0.576 ± 0.061
2.129ArgAsn: 2.129 ± 0.119
0.796ArgPro: 0.796 ± 0.081
1.288ArgGln: 1.288 ± 0.098
1.118ArgArg: 1.118 ± 0.091
2.011ArgSer: 2.011 ± 0.115
1.485ArgThr: 1.485 ± 0.111
1.909ArgVal: 1.909 ± 0.111
0.35ArgTrp: 0.35 ± 0.04
1.186ArgTyr: 1.186 ± 0.091
0.0ArgXaa: 0.0 ± 0.0
Ser
3.338SerAla: 3.338 ± 0.156
0.672SerCys: 0.672 ± 0.059
3.75SerAsp: 3.75 ± 0.149
4.106SerGlu: 4.106 ± 0.224
5.388SerPhe: 5.388 ± 0.178
3.637SerGly: 3.637 ± 0.168
0.915SerHis: 0.915 ± 0.067
4.614SerIle: 4.614 ± 0.193
5.105SerLys: 5.105 ± 0.169
7.715SerLeu: 7.715 ± 0.217
0.983SerMet: 0.983 ± 0.069
4.433SerAsn: 4.433 ± 0.192
1.683SerPro: 1.683 ± 0.111
2.541SerGln: 2.541 ± 0.147
1.638SerArg: 1.638 ± 0.095
5.269SerSer: 5.269 ± 0.373
3.185SerThr: 3.185 ± 0.191
4.083SerVal: 4.083 ± 0.19
0.813SerTrp: 0.813 ± 0.069
2.711SerTyr: 2.711 ± 0.113
0.0SerXaa: 0.0 ± 0.0
Thr
2.88ThrAla: 2.88 ± 0.146
0.26ThrCys: 0.26 ± 0.04
2.666ThrAsp: 2.666 ± 0.143
2.496ThrGlu: 2.496 ± 0.166
2.677ThrPhe: 2.677 ± 0.137
2.671ThrGly: 2.671 ± 0.124
0.7ThrHis: 0.7 ± 0.068
4.84ThrIle: 4.84 ± 0.168
5.512ThrLys: 5.512 ± 0.191
5.094ThrLeu: 5.094 ± 0.186
0.808ThrMet: 0.808 ± 0.069
4.49ThrAsn: 4.49 ± 0.169
2.146ThrPro: 2.146 ± 0.119
1.915ThrGln: 1.915 ± 0.124
1.604ThrArg: 1.604 ± 0.099
3.665ThrSer: 3.665 ± 0.166
3.852ThrThr: 3.852 ± 0.19
3.942ThrVal: 3.942 ± 0.155
0.373ThrTrp: 0.373 ± 0.046
1.384ThrTyr: 1.384 ± 0.091
0.0ThrXaa: 0.0 ± 0.0
Val
3.519ValAla: 3.519 ± 0.154
0.689ValCys: 0.689 ± 0.061
3.564ValAsp: 3.564 ± 0.165
3.891ValGlu: 3.891 ± 0.217
4.078ValPhe: 4.078 ± 0.184
3.038ValGly: 3.038 ± 0.134
0.966ValHis: 0.966 ± 0.073
5.54ValIle: 5.54 ± 0.185
5.173ValLys: 5.173 ± 0.186
6.195ValLeu: 6.195 ± 0.188
1.011ValMet: 1.011 ± 0.067
4.236ValAsn: 4.236 ± 0.154
1.474ValPro: 1.474 ± 0.105
2.157ValGln: 2.157 ± 0.132
1.796ValArg: 1.796 ± 0.112
4.304ValSer: 4.304 ± 0.142
2.553ValThr: 2.553 ± 0.128
4.354ValVal: 4.354 ± 0.169
0.52ValTrp: 0.52 ± 0.06
2.044ValTyr: 2.044 ± 0.102
0.0ValXaa: 0.0 ± 0.0
Trp
0.378TrpAla: 0.378 ± 0.054
0.062TrpCys: 0.062 ± 0.018
0.339TrpAsp: 0.339 ± 0.039
0.356TrpGlu: 0.356 ± 0.048
0.83TrpPhe: 0.83 ± 0.07
0.333TrpGly: 0.333 ± 0.051
0.102TrpHis: 0.102 ± 0.025
0.971TrpIle: 0.971 ± 0.08
1.214TrpLys: 1.214 ± 0.085
1.242TrpLeu: 1.242 ± 0.095
0.169TrpMet: 0.169 ± 0.032
0.813TrpAsn: 0.813 ± 0.07
0.237TrpPro: 0.237 ± 0.037
0.282TrpGln: 0.282 ± 0.041
0.265TrpArg: 0.265 ± 0.035
0.599TrpSer: 0.599 ± 0.061
0.638TrpThr: 0.638 ± 0.068
0.435TrpVal: 0.435 ± 0.053
0.147TrpTrp: 0.147 ± 0.029
0.305TrpTyr: 0.305 ± 0.049
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.768TyrAla: 1.768 ± 0.109
0.503TyrCys: 0.503 ± 0.059
1.835TyrAsp: 1.835 ± 0.115
2.044TyrGlu: 2.044 ± 0.111
2.581TyrPhe: 2.581 ± 0.135
1.785TyrGly: 1.785 ± 0.094
0.576TyrHis: 0.576 ± 0.05
1.835TyrIle: 1.835 ± 0.103
2.429TyrLys: 2.429 ± 0.122
3.744TyrLeu: 3.744 ± 0.146
0.424TyrMet: 0.424 ± 0.039
1.773TyrAsn: 1.773 ± 0.098
0.994TyrPro: 0.994 ± 0.078
2.174TyrGln: 2.174 ± 0.123
1.265TyrArg: 1.265 ± 0.082
1.92TyrSer: 1.92 ± 0.117
1.378TyrThr: 1.378 ± 0.086
1.892TyrVal: 1.892 ± 0.104
0.401TyrTrp: 0.401 ± 0.051
1.09TyrTyr: 1.09 ± 0.099
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 483 proteins (177065 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski