Amino acid dipepetide frequency for Aeromonas phage 32

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.452AlaAla: 11.452 ± 1.5
1.11AlaCys: 1.11 ± 0.354
5.83AlaAsp: 5.83 ± 0.661
6.316AlaGlu: 6.316 ± 0.623
2.846AlaPhe: 2.846 ± 0.431
9.092AlaGly: 9.092 ± 1.14
2.152AlaHis: 2.152 ± 0.333
6.455AlaIle: 6.455 ± 0.69
6.871AlaLys: 6.871 ± 0.927
9.162AlaLeu: 9.162 ± 0.743
3.54AlaMet: 3.54 ± 0.561
3.262AlaAsn: 3.262 ± 0.503
3.817AlaPro: 3.817 ± 0.47
3.887AlaGln: 3.887 ± 0.594
6.316AlaArg: 6.316 ± 0.627
6.941AlaSer: 6.941 ± 0.792
6.732AlaThr: 6.732 ± 0.926
6.524AlaVal: 6.524 ± 0.955
1.18AlaTrp: 1.18 ± 0.265
3.054AlaTyr: 3.054 ± 0.461
0.0AlaXaa: 0.0 ± 0.0
Cys
1.18CysAla: 1.18 ± 0.263
0.347CysCys: 0.347 ± 0.161
0.694CysAsp: 0.694 ± 0.233
1.18CysGlu: 1.18 ± 0.337
0.416CysPhe: 0.416 ± 0.201
1.735CysGly: 1.735 ± 0.334
0.278CysHis: 0.278 ± 0.139
0.972CysIle: 0.972 ± 0.257
0.833CysLys: 0.833 ± 0.253
1.458CysLeu: 1.458 ± 0.321
0.208CysMet: 0.208 ± 0.142
0.416CysAsn: 0.416 ± 0.175
1.041CysPro: 1.041 ± 0.291
0.625CysGln: 0.625 ± 0.225
0.763CysArg: 0.763 ± 0.271
0.902CysSer: 0.902 ± 0.246
0.763CysThr: 0.763 ± 0.283
0.902CysVal: 0.902 ± 0.287
0.278CysTrp: 0.278 ± 0.161
0.347CysTyr: 0.347 ± 0.172
0.0CysXaa: 0.0 ± 0.0
Asp
6.177AspAla: 6.177 ± 0.547
0.972AspCys: 0.972 ± 0.3
2.429AspAsp: 2.429 ± 0.382
2.776AspGlu: 2.776 ± 0.406
1.527AspPhe: 1.527 ± 0.327
4.65AspGly: 4.65 ± 0.588
1.319AspHis: 1.319 ± 0.343
2.707AspIle: 2.707 ± 0.407
3.47AspLys: 3.47 ± 0.471
4.858AspLeu: 4.858 ± 0.738
1.527AspMet: 1.527 ± 0.324
1.319AspAsn: 1.319 ± 0.367
2.707AspPro: 2.707 ± 0.445
2.013AspGln: 2.013 ± 0.388
3.817AspArg: 3.817 ± 0.602
2.36AspSer: 2.36 ± 0.369
2.499AspThr: 2.499 ± 0.462
3.887AspVal: 3.887 ± 0.514
0.972AspTrp: 0.972 ± 0.305
1.18AspTyr: 1.18 ± 0.257
0.0AspXaa: 0.0 ± 0.0
Glu
7.079GluAla: 7.079 ± 0.627
0.833GluCys: 0.833 ± 0.264
2.221GluAsp: 2.221 ± 0.425
4.511GluGlu: 4.511 ± 0.996
2.013GluPhe: 2.013 ± 0.412
4.234GluGly: 4.234 ± 0.7
1.596GluHis: 1.596 ± 0.326
2.776GluIle: 2.776 ± 0.507
3.401GluLys: 3.401 ± 0.469
6.871GluLeu: 6.871 ± 0.803
1.874GluMet: 1.874 ± 0.363
1.943GluAsn: 1.943 ± 0.325
2.499GluPro: 2.499 ± 0.512
3.054GluGln: 3.054 ± 0.443
4.234GluArg: 4.234 ± 0.52
3.262GluSer: 3.262 ± 0.362
3.054GluThr: 3.054 ± 0.559
4.789GluVal: 4.789 ± 0.563
1.666GluTrp: 1.666 ± 0.383
1.596GluTyr: 1.596 ± 0.411
0.0GluXaa: 0.0 ± 0.0
Phe
2.637PheAla: 2.637 ± 0.456
0.555PheCys: 0.555 ± 0.161
2.221PheAsp: 2.221 ± 0.463
1.388PheGlu: 1.388 ± 0.284
0.416PhePhe: 0.416 ± 0.185
2.637PheGly: 2.637 ± 0.508
0.486PheHis: 0.486 ± 0.175
1.874PheIle: 1.874 ± 0.371
2.082PheLys: 2.082 ± 0.485
2.429PheLeu: 2.429 ± 0.478
0.972PheMet: 0.972 ± 0.254
1.249PheAsn: 1.249 ± 0.324
1.596PhePro: 1.596 ± 0.324
1.249PheGln: 1.249 ± 0.337
2.152PheArg: 2.152 ± 0.346
1.388PheSer: 1.388 ± 0.32
2.082PheThr: 2.082 ± 0.374
1.943PheVal: 1.943 ± 0.389
0.555PheTrp: 0.555 ± 0.192
0.486PheTyr: 0.486 ± 0.199
0.0PheXaa: 0.0 ± 0.0
Gly
6.316GlyAla: 6.316 ± 0.831
1.041GlyCys: 1.041 ± 0.271
3.47GlyAsp: 3.47 ± 0.528
5.761GlyGlu: 5.761 ± 0.508
3.193GlyPhe: 3.193 ± 0.526
6.455GlyGly: 6.455 ± 0.862
2.29GlyHis: 2.29 ± 0.358
3.47GlyIle: 3.47 ± 0.504
4.72GlyLys: 4.72 ± 0.556
6.455GlyLeu: 6.455 ± 0.515
4.026GlyMet: 4.026 ± 0.622
2.29GlyAsn: 2.29 ± 0.57
3.123GlyPro: 3.123 ± 0.561
2.29GlyGln: 2.29 ± 0.441
3.748GlyArg: 3.748 ± 0.54
3.887GlySer: 3.887 ± 0.475
4.442GlyThr: 4.442 ± 0.654
6.177GlyVal: 6.177 ± 0.632
1.319GlyTrp: 1.319 ± 0.299
1.666GlyTyr: 1.666 ± 0.4
0.0GlyXaa: 0.0 ± 0.0
His
2.29HisAla: 2.29 ± 0.36
0.625HisCys: 0.625 ± 0.183
1.041HisAsp: 1.041 ± 0.293
1.874HisGlu: 1.874 ± 0.379
1.11HisPhe: 1.11 ± 0.3
1.735HisGly: 1.735 ± 0.423
1.527HisHis: 1.527 ± 0.396
0.902HisIle: 0.902 ± 0.21
1.11HisLys: 1.11 ± 0.269
1.943HisLeu: 1.943 ± 0.428
0.555HisMet: 0.555 ± 0.179
0.416HisAsn: 0.416 ± 0.17
0.972HisPro: 0.972 ± 0.288
1.18HisGln: 1.18 ± 0.274
1.458HisArg: 1.458 ± 0.367
1.041HisSer: 1.041 ± 0.247
1.666HisThr: 1.666 ± 0.392
1.319HisVal: 1.319 ± 0.343
0.416HisTrp: 0.416 ± 0.153
0.833HisTyr: 0.833 ± 0.252
0.0HisXaa: 0.0 ± 0.0
Ile
5.483IleAla: 5.483 ± 0.718
0.763IleCys: 0.763 ± 0.202
2.846IleAsp: 2.846 ± 0.399
3.817IleGlu: 3.817 ± 0.553
1.041IlePhe: 1.041 ± 0.313
2.29IleGly: 2.29 ± 0.365
1.319IleHis: 1.319 ± 0.243
2.429IleIle: 2.429 ± 0.441
3.679IleLys: 3.679 ± 0.545
3.47IleLeu: 3.47 ± 0.456
1.666IleMet: 1.666 ± 0.323
1.527IleAsn: 1.527 ± 0.39
2.429IlePro: 2.429 ± 0.338
0.972IleGln: 0.972 ± 0.277
3.054IleArg: 3.054 ± 0.406
3.401IleSer: 3.401 ± 0.458
4.303IleThr: 4.303 ± 0.498
2.984IleVal: 2.984 ± 0.437
0.763IleTrp: 0.763 ± 0.183
1.11IleTyr: 1.11 ± 0.287
0.0IleXaa: 0.0 ± 0.0
Lys
9.856LysAla: 9.856 ± 0.983
0.902LysCys: 0.902 ± 0.291
3.748LysAsp: 3.748 ± 0.531
3.47LysGlu: 3.47 ± 0.493
1.805LysPhe: 1.805 ± 0.352
5.344LysGly: 5.344 ± 0.777
1.319LysHis: 1.319 ± 0.281
2.082LysIle: 2.082 ± 0.409
3.331LysLys: 3.331 ± 0.424
5.136LysLeu: 5.136 ± 0.773
1.735LysMet: 1.735 ± 0.409
1.666LysAsn: 1.666 ± 0.358
3.123LysPro: 3.123 ± 0.416
2.29LysGln: 2.29 ± 0.43
3.956LysArg: 3.956 ± 0.61
2.221LysSer: 2.221 ± 0.369
2.984LysThr: 2.984 ± 0.411
4.581LysVal: 4.581 ± 0.578
0.902LysTrp: 0.902 ± 0.206
1.11LysTyr: 1.11 ± 0.243
0.0LysXaa: 0.0 ± 0.0
Leu
8.606LeuAla: 8.606 ± 1.114
1.11LeuCys: 1.11 ± 0.252
5.691LeuAsp: 5.691 ± 0.685
6.455LeuGlu: 6.455 ± 0.584
1.388LeuPhe: 1.388 ± 0.355
5.205LeuGly: 5.205 ± 0.493
2.013LeuHis: 2.013 ± 0.317
4.095LeuIle: 4.095 ± 0.481
4.789LeuLys: 4.789 ± 0.523
6.038LeuLeu: 6.038 ± 0.765
2.637LeuMet: 2.637 ± 0.409
3.887LeuAsn: 3.887 ± 0.565
3.401LeuPro: 3.401 ± 0.41
2.707LeuGln: 2.707 ± 0.364
5.691LeuArg: 5.691 ± 0.671
5.969LeuSer: 5.969 ± 0.517
6.941LeuThr: 6.941 ± 0.802
5.136LeuVal: 5.136 ± 0.609
1.596LeuTrp: 1.596 ± 0.352
1.735LeuTyr: 1.735 ± 0.355
0.0LeuXaa: 0.0 ± 0.0
Met
5.136MetAla: 5.136 ± 0.704
0.208MetCys: 0.208 ± 0.107
1.735MetAsp: 1.735 ± 0.294
1.666MetGlu: 1.666 ± 0.418
0.694MetPhe: 0.694 ± 0.22
2.429MetGly: 2.429 ± 0.492
0.278MetHis: 0.278 ± 0.125
1.18MetIle: 1.18 ± 0.259
2.915MetLys: 2.915 ± 0.362
2.082MetLeu: 2.082 ± 0.389
0.972MetMet: 0.972 ± 0.236
1.11MetAsn: 1.11 ± 0.333
1.249MetPro: 1.249 ± 0.379
1.11MetGln: 1.11 ± 0.247
1.319MetArg: 1.319 ± 0.317
2.568MetSer: 2.568 ± 0.358
3.123MetThr: 3.123 ± 0.471
2.568MetVal: 2.568 ± 0.401
0.486MetTrp: 0.486 ± 0.2
0.347MetTyr: 0.347 ± 0.119
0.0MetXaa: 0.0 ± 0.0
Asn
2.846AsnAla: 2.846 ± 0.483
0.486AsnCys: 0.486 ± 0.144
1.596AsnAsp: 1.596 ± 0.342
2.152AsnGlu: 2.152 ± 0.41
0.763AsnPhe: 0.763 ± 0.218
2.984AsnGly: 2.984 ± 0.54
0.972AsnHis: 0.972 ± 0.299
1.18AsnIle: 1.18 ± 0.246
2.36AsnLys: 2.36 ± 0.465
2.846AsnLeu: 2.846 ± 0.455
1.735AsnMet: 1.735 ± 0.39
1.319AsnAsn: 1.319 ± 0.35
2.29AsnPro: 2.29 ± 0.326
1.319AsnGln: 1.319 ± 0.252
2.152AsnArg: 2.152 ± 0.437
2.013AsnSer: 2.013 ± 0.401
1.735AsnThr: 1.735 ± 0.411
1.596AsnVal: 1.596 ± 0.445
0.902AsnTrp: 0.902 ± 0.27
0.972AsnTyr: 0.972 ± 0.219
0.0AsnXaa: 0.0 ± 0.0
Pro
3.956ProAla: 3.956 ± 0.451
0.555ProCys: 0.555 ± 0.253
2.984ProAsp: 2.984 ± 0.415
3.47ProGlu: 3.47 ± 0.536
1.596ProPhe: 1.596 ± 0.347
3.331ProGly: 3.331 ± 0.58
1.11ProHis: 1.11 ± 0.256
1.666ProIle: 1.666 ± 0.321
3.054ProLys: 3.054 ± 0.426
3.331ProLeu: 3.331 ± 0.419
0.833ProMet: 0.833 ± 0.214
1.458ProAsn: 1.458 ± 0.376
1.249ProPro: 1.249 ± 0.351
1.666ProGln: 1.666 ± 0.348
1.458ProArg: 1.458 ± 0.246
3.123ProSer: 3.123 ± 0.669
2.846ProThr: 2.846 ± 0.436
4.234ProVal: 4.234 ± 0.568
0.347ProTrp: 0.347 ± 0.177
1.249ProTyr: 1.249 ± 0.283
0.0ProXaa: 0.0 ± 0.0
Gln
4.72GlnAla: 4.72 ± 0.589
0.625GlnCys: 0.625 ± 0.26
1.249GlnAsp: 1.249 ± 0.286
2.013GlnGlu: 2.013 ± 0.388
0.902GlnPhe: 0.902 ± 0.249
2.776GlnGly: 2.776 ± 0.412
0.833GlnHis: 0.833 ± 0.278
1.666GlnIle: 1.666 ± 0.347
1.943GlnLys: 1.943 ± 0.415
4.026GlnLeu: 4.026 ± 0.57
1.527GlnMet: 1.527 ± 0.265
1.388GlnAsn: 1.388 ± 0.297
1.11GlnPro: 1.11 ± 0.281
1.666GlnGln: 1.666 ± 0.591
2.568GlnArg: 2.568 ± 0.411
2.082GlnSer: 2.082 ± 0.358
1.805GlnThr: 1.805 ± 0.4
2.637GlnVal: 2.637 ± 0.445
0.902GlnTrp: 0.902 ± 0.251
0.833GlnTyr: 0.833 ± 0.234
0.0GlnXaa: 0.0 ± 0.0
Arg
5.761ArgAla: 5.761 ± 0.567
1.249ArgCys: 1.249 ± 0.318
2.152ArgAsp: 2.152 ± 0.411
3.123ArgGlu: 3.123 ± 0.531
2.707ArgPhe: 2.707 ± 0.335
4.373ArgGly: 4.373 ± 0.499
1.735ArgHis: 1.735 ± 0.37
2.984ArgIle: 2.984 ± 0.371
3.401ArgLys: 3.401 ± 0.455
5.622ArgLeu: 5.622 ± 0.582
1.943ArgMet: 1.943 ± 0.389
3.123ArgAsn: 3.123 ± 0.444
2.776ArgPro: 2.776 ± 0.442
2.637ArgGln: 2.637 ± 0.567
3.47ArgArg: 3.47 ± 0.759
3.123ArgSer: 3.123 ± 0.583
3.401ArgThr: 3.401 ± 0.563
3.817ArgVal: 3.817 ± 0.598
0.972ArgTrp: 0.972 ± 0.35
1.249ArgTyr: 1.249 ± 0.3
0.0ArgXaa: 0.0 ± 0.0
Ser
5.691SerAla: 5.691 ± 0.607
0.902SerCys: 0.902 ± 0.265
3.54SerAsp: 3.54 ± 0.478
2.637SerGlu: 2.637 ± 0.392
2.221SerPhe: 2.221 ± 0.39
4.234SerGly: 4.234 ± 0.656
0.902SerHis: 0.902 ± 0.25
3.47SerIle: 3.47 ± 0.488
2.637SerLys: 2.637 ± 0.405
5.691SerLeu: 5.691 ± 0.686
2.221SerMet: 2.221 ± 0.37
1.805SerAsn: 1.805 ± 0.293
2.707SerPro: 2.707 ± 0.348
2.429SerGln: 2.429 ± 0.371
3.609SerArg: 3.609 ± 0.557
3.123SerSer: 3.123 ± 0.452
3.679SerThr: 3.679 ± 0.511
2.082SerVal: 2.082 ± 0.496
0.972SerTrp: 0.972 ± 0.234
1.11SerTyr: 1.11 ± 0.268
0.0SerXaa: 0.0 ± 0.0
Thr
6.871ThrAla: 6.871 ± 0.853
1.249ThrCys: 1.249 ± 0.326
3.401ThrAsp: 3.401 ± 0.423
3.748ThrGlu: 3.748 ± 0.717
2.36ThrPhe: 2.36 ± 0.488
5.275ThrGly: 5.275 ± 0.671
1.18ThrHis: 1.18 ± 0.298
3.401ThrIle: 3.401 ± 0.553
3.748ThrLys: 3.748 ± 0.6
5.761ThrLeu: 5.761 ± 0.554
2.152ThrMet: 2.152 ± 0.433
1.596ThrAsn: 1.596 ± 0.367
3.609ThrPro: 3.609 ± 0.597
1.527ThrGln: 1.527 ± 0.298
3.054ThrArg: 3.054 ± 0.566
2.637ThrSer: 2.637 ± 0.37
3.956ThrThr: 3.956 ± 0.472
5.275ThrVal: 5.275 ± 0.594
0.694ThrTrp: 0.694 ± 0.275
1.805ThrTyr: 1.805 ± 0.331
0.0ThrXaa: 0.0 ± 0.0
Val
6.594ValAla: 6.594 ± 0.82
1.041ValCys: 1.041 ± 0.282
4.442ValAsp: 4.442 ± 0.716
4.511ValGlu: 4.511 ± 0.643
1.735ValPhe: 1.735 ± 0.335
4.65ValGly: 4.65 ± 0.902
1.874ValHis: 1.874 ± 0.479
4.65ValIle: 4.65 ± 0.474
5.622ValLys: 5.622 ± 0.696
4.858ValLeu: 4.858 ± 0.551
2.082ValMet: 2.082 ± 0.401
2.499ValAsn: 2.499 ± 0.507
2.637ValPro: 2.637 ± 0.37
2.846ValGln: 2.846 ± 0.399
3.401ValArg: 3.401 ± 0.546
3.401ValSer: 3.401 ± 0.435
4.72ValThr: 4.72 ± 0.73
4.928ValVal: 4.928 ± 0.699
1.041ValTrp: 1.041 ± 0.226
1.249ValTyr: 1.249 ± 0.322
0.0ValXaa: 0.0 ± 0.0
Trp
1.805TrpAla: 1.805 ± 0.3
0.139TrpCys: 0.139 ± 0.089
1.11TrpAsp: 1.11 ± 0.333
1.319TrpGlu: 1.319 ± 0.314
0.972TrpPhe: 0.972 ± 0.266
0.625TrpGly: 0.625 ± 0.182
0.208TrpHis: 0.208 ± 0.149
0.763TrpIle: 0.763 ± 0.201
0.625TrpLys: 0.625 ± 0.19
1.041TrpLeu: 1.041 ± 0.299
0.555TrpMet: 0.555 ± 0.186
0.833TrpAsn: 0.833 ± 0.214
0.555TrpPro: 0.555 ± 0.187
0.694TrpGln: 0.694 ± 0.264
0.972TrpArg: 0.972 ± 0.29
1.18TrpSer: 1.18 ± 0.328
0.763TrpThr: 0.763 ± 0.25
1.666TrpVal: 1.666 ± 0.322
0.0TrpTrp: 0.0 ± 0.0
0.486TrpTyr: 0.486 ± 0.187
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.082TyrAla: 2.082 ± 0.318
0.625TyrCys: 0.625 ± 0.197
0.763TyrAsp: 0.763 ± 0.217
1.319TyrGlu: 1.319 ± 0.325
0.694TyrPhe: 0.694 ± 0.203
2.082TyrGly: 2.082 ± 0.412
0.625TyrHis: 0.625 ± 0.196
0.694TyrIle: 0.694 ± 0.218
0.972TyrLys: 0.972 ± 0.237
2.013TyrLeu: 2.013 ± 0.366
0.347TyrMet: 0.347 ± 0.159
1.11TyrAsn: 1.11 ± 0.262
0.625TyrPro: 0.625 ± 0.19
1.11TyrGln: 1.11 ± 0.23
2.429TyrArg: 2.429 ± 0.421
1.041TyrSer: 1.041 ± 0.265
1.805TyrThr: 1.805 ± 0.365
1.735TyrVal: 1.735 ± 0.403
0.347TyrTrp: 0.347 ± 0.16
0.625TyrTyr: 0.625 ± 0.195
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 83 proteins (14409 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski