Amino acid dipepetide frequency for Sphaerotilus hippei

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.778AlaAla: 18.778 ± 0.189
1.491AlaCys: 1.491 ± 0.037
6.989AlaAsp: 6.989 ± 0.081
6.77AlaGlu: 6.77 ± 0.088
3.487AlaPhe: 3.487 ± 0.052
11.578AlaGly: 11.578 ± 0.102
2.838AlaHis: 2.838 ± 0.047
4.459AlaIle: 4.459 ± 0.066
2.416AlaLys: 2.416 ± 0.056
16.069AlaLeu: 16.069 ± 0.148
3.317AlaMet: 3.317 ± 0.057
2.101AlaAsn: 2.101 ± 0.045
6.69AlaPro: 6.69 ± 0.105
5.545AlaGln: 5.545 ± 0.09
10.872AlaArg: 10.872 ± 0.122
6.803AlaSer: 6.803 ± 0.102
6.381AlaThr: 6.381 ± 0.102
9.212AlaVal: 9.212 ± 0.099
2.172AlaTrp: 2.172 ± 0.051
2.163AlaTyr: 2.163 ± 0.041
0.0AlaXaa: 0.0 ± 0.0
Cys
1.212CysAla: 1.212 ± 0.032
0.136CysCys: 0.136 ± 0.011
0.583CysAsp: 0.583 ± 0.024
0.52CysGlu: 0.52 ± 0.02
0.284CysPhe: 0.284 ± 0.014
1.024CysGly: 1.024 ± 0.032
0.322CysHis: 0.322 ± 0.017
0.378CysIle: 0.378 ± 0.019
0.163CysLys: 0.163 ± 0.011
0.953CysLeu: 0.953 ± 0.025
0.19CysMet: 0.19 ± 0.013
0.2CysAsn: 0.2 ± 0.012
0.513CysPro: 0.513 ± 0.022
0.313CysGln: 0.313 ± 0.015
0.713CysArg: 0.713 ± 0.024
0.559CysSer: 0.559 ± 0.02
0.552CysThr: 0.552 ± 0.022
0.687CysVal: 0.687 ± 0.026
0.148CysTrp: 0.148 ± 0.012
0.182CysTyr: 0.182 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
6.971AspAla: 6.971 ± 0.085
0.44AspCys: 0.44 ± 0.018
2.993AspAsp: 2.993 ± 0.062
3.592AspGlu: 3.592 ± 0.059
1.895AspPhe: 1.895 ± 0.035
5.086AspGly: 5.086 ± 0.086
1.351AspHis: 1.351 ± 0.039
2.16AspIle: 2.16 ± 0.046
1.229AspLys: 1.229 ± 0.037
6.21AspLeu: 6.21 ± 0.078
1.1AspMet: 1.1 ± 0.031
0.991AspAsn: 0.991 ± 0.03
3.3AspPro: 3.3 ± 0.055
1.834AspGln: 1.834 ± 0.037
4.133AspArg: 4.133 ± 0.059
2.207AspSer: 2.207 ± 0.054
2.887AspThr: 2.887 ± 0.068
3.935AspVal: 3.935 ± 0.064
0.968AspTrp: 0.968 ± 0.031
1.195AspTyr: 1.195 ± 0.036
0.0AspXaa: 0.0 ± 0.0
Glu
7.593GluAla: 7.593 ± 0.097
0.373GluCys: 0.373 ± 0.018
2.145GluAsp: 2.145 ± 0.045
2.126GluGlu: 2.126 ± 0.047
1.658GluPhe: 1.658 ± 0.036
3.655GluGly: 3.655 ± 0.055
1.504GluHis: 1.504 ± 0.034
2.314GluIle: 2.314 ± 0.043
1.268GluLys: 1.268 ± 0.036
6.217GluLeu: 6.217 ± 0.081
1.138GluMet: 1.138 ± 0.027
0.948GluAsn: 0.948 ± 0.025
2.826GluPro: 2.826 ± 0.053
2.928GluGln: 2.928 ± 0.053
5.211GluArg: 5.211 ± 0.078
2.372GluSer: 2.372 ± 0.048
2.364GluThr: 2.364 ± 0.055
4.36GluVal: 4.36 ± 0.058
0.646GluTrp: 0.646 ± 0.022
0.813GluTyr: 0.813 ± 0.024
0.0GluXaa: 0.0 ± 0.0
Phe
3.409PheAla: 3.409 ± 0.056
0.332PheCys: 0.332 ± 0.013
2.359PheAsp: 2.359 ± 0.041
2.096PheGlu: 2.096 ± 0.041
1.182PhePhe: 1.182 ± 0.037
3.0PheGly: 3.0 ± 0.052
0.767PheHis: 0.767 ± 0.028
1.296PheIle: 1.296 ± 0.036
0.871PheLys: 0.871 ± 0.027
2.753PheLeu: 2.753 ± 0.047
0.768PheMet: 0.768 ± 0.027
0.857PheAsn: 0.857 ± 0.026
1.31PhePro: 1.31 ± 0.031
1.035PheGln: 1.035 ± 0.027
1.868PheArg: 1.868 ± 0.039
1.841PheSer: 1.841 ± 0.034
1.631PheThr: 1.631 ± 0.035
2.543PheVal: 2.543 ± 0.038
0.458PheTrp: 0.458 ± 0.018
0.663PheTyr: 0.663 ± 0.026
0.0PheXaa: 0.0 ± 0.0
Gly
9.352GlyAla: 9.352 ± 0.095
1.013GlyCys: 1.013 ± 0.03
4.094GlyAsp: 4.094 ± 0.064
4.653GlyGlu: 4.653 ± 0.062
2.915GlyPhe: 2.915 ± 0.051
6.959GlyGly: 6.959 ± 0.098
2.235GlyHis: 2.235 ± 0.044
3.342GlyIle: 3.342 ± 0.056
2.354GlyLys: 2.354 ± 0.053
10.278GlyLeu: 10.278 ± 0.096
2.085GlyMet: 2.085 ± 0.042
1.643GlyAsn: 1.643 ± 0.035
3.726GlyPro: 3.726 ± 0.051
3.628GlyGln: 3.628 ± 0.06
6.665GlyArg: 6.665 ± 0.089
4.888GlySer: 4.888 ± 0.138
4.558GlyThr: 4.558 ± 0.145
6.666GlyVal: 6.666 ± 0.072
1.642GlyTrp: 1.642 ± 0.036
1.909GlyTyr: 1.909 ± 0.041
0.0GlyXaa: 0.0 ± 0.0
His
3.074HisAla: 3.074 ± 0.053
0.323HisCys: 0.323 ± 0.017
1.47HisAsp: 1.47 ± 0.039
1.383HisGlu: 1.383 ± 0.029
0.911HisPhe: 0.911 ± 0.029
2.396HisGly: 2.396 ± 0.05
0.822HisHis: 0.822 ± 0.028
0.844HisIle: 0.844 ± 0.029
0.434HisLys: 0.434 ± 0.019
2.823HisLeu: 2.823 ± 0.055
0.455HisMet: 0.455 ± 0.017
0.444HisAsn: 0.444 ± 0.02
1.733HisPro: 1.733 ± 0.042
0.943HisGln: 0.943 ± 0.027
1.986HisArg: 1.986 ± 0.048
0.958HisSer: 0.958 ± 0.026
1.107HisThr: 1.107 ± 0.03
1.626HisVal: 1.626 ± 0.035
0.491HisTrp: 0.491 ± 0.021
0.609HisTyr: 0.609 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
5.124IleAla: 5.124 ± 0.074
0.339IleCys: 0.339 ± 0.016
3.173IleAsp: 3.173 ± 0.046
3.106IleGlu: 3.106 ± 0.053
1.034IlePhe: 1.034 ± 0.028
3.975IleGly: 3.975 ± 0.074
0.854IleHis: 0.854 ± 0.023
1.313IleIle: 1.313 ± 0.038
1.114IleLys: 1.114 ± 0.038
2.781IleLeu: 2.781 ± 0.056
0.646IleMet: 0.646 ± 0.023
1.111IleAsn: 1.111 ± 0.032
1.648IlePro: 1.648 ± 0.037
1.178IleGln: 1.178 ± 0.031
2.515IleArg: 2.515 ± 0.044
2.122IleSer: 2.122 ± 0.053
2.365IleThr: 2.365 ± 0.051
3.012IleVal: 3.012 ± 0.051
0.363IleTrp: 0.363 ± 0.018
0.749IleTyr: 0.749 ± 0.026
0.0IleXaa: 0.0 ± 0.0
Lys
3.103LysAla: 3.103 ± 0.07
0.124LysCys: 0.124 ± 0.01
1.247LysAsp: 1.247 ± 0.037
1.115LysGlu: 1.115 ± 0.039
0.701LysPhe: 0.701 ± 0.022
1.895LysGly: 1.895 ± 0.048
0.448LysHis: 0.448 ± 0.02
1.067LysIle: 1.067 ± 0.033
0.944LysLys: 0.944 ± 0.034
2.541LysLeu: 2.541 ± 0.056
0.559LysMet: 0.559 ± 0.024
0.656LysAsn: 0.656 ± 0.023
1.353LysPro: 1.353 ± 0.032
0.828LysGln: 0.828 ± 0.028
1.595LysArg: 1.595 ± 0.035
1.314LysSer: 1.314 ± 0.035
1.348LysThr: 1.348 ± 0.038
2.082LysVal: 2.082 ± 0.048
0.256LysTrp: 0.256 ± 0.013
0.473LysTyr: 0.473 ± 0.02
0.0LysXaa: 0.0 ± 0.0
Leu
15.867LeuAla: 15.867 ± 0.134
1.082LeuCys: 1.082 ± 0.031
6.649LeuAsp: 6.649 ± 0.081
5.718LeuGlu: 5.718 ± 0.085
3.159LeuPhe: 3.159 ± 0.045
9.568LeuGly: 9.568 ± 0.099
2.793LeuHis: 2.793 ± 0.056
4.351LeuIle: 4.351 ± 0.061
3.077LeuLys: 3.077 ± 0.053
12.729LeuLeu: 12.729 ± 0.14
2.782LeuMet: 2.782 ± 0.055
2.396LeuAsn: 2.396 ± 0.039
6.818LeuPro: 6.818 ± 0.079
5.06LeuGln: 5.06 ± 0.073
8.775LeuArg: 8.775 ± 0.101
6.699LeuSer: 6.699 ± 0.093
5.656LeuThr: 5.656 ± 0.093
8.527LeuVal: 8.527 ± 0.098
1.533LeuTrp: 1.533 ± 0.039
1.912LeuTyr: 1.912 ± 0.039
0.0LeuXaa: 0.0 ± 0.0
Met
3.058MetAla: 3.058 ± 0.051
0.156MetCys: 0.156 ± 0.01
1.197MetAsp: 1.197 ± 0.029
0.898MetGlu: 0.898 ± 0.028
0.601MetPhe: 0.601 ± 0.022
1.708MetGly: 1.708 ± 0.038
0.522MetHis: 0.522 ± 0.024
0.862MetIle: 0.862 ± 0.028
0.851MetLys: 0.851 ± 0.028
2.606MetLeu: 2.606 ± 0.053
0.542MetMet: 0.542 ± 0.022
0.865MetAsn: 0.865 ± 0.024
1.425MetPro: 1.425 ± 0.031
0.99MetGln: 0.99 ± 0.028
1.67MetArg: 1.67 ± 0.042
1.719MetSer: 1.719 ± 0.039
1.424MetThr: 1.424 ± 0.032
1.652MetVal: 1.652 ± 0.043
0.197MetTrp: 0.197 ± 0.013
0.318MetTyr: 0.318 ± 0.015
0.0MetXaa: 0.0 ± 0.0
Asn
2.591AsnAla: 2.591 ± 0.051
0.2AsnCys: 0.2 ± 0.013
1.122AsnAsp: 1.122 ± 0.032
0.999AsnGlu: 0.999 ± 0.032
0.678AsnPhe: 0.678 ± 0.026
1.693AsnGly: 1.693 ± 0.051
0.456AsnHis: 0.456 ± 0.017
0.904AsnIle: 0.904 ± 0.026
0.593AsnLys: 0.593 ± 0.021
2.243AsnLeu: 2.243 ± 0.042
0.404AsnMet: 0.404 ± 0.019
0.513AsnAsn: 0.513 ± 0.023
1.413AsnPro: 1.413 ± 0.032
0.774AsnGln: 0.774 ± 0.027
1.44AsnArg: 1.44 ± 0.031
0.937AsnSer: 0.937 ± 0.026
1.118AsnThr: 1.118 ± 0.03
1.536AsnVal: 1.536 ± 0.037
0.308AsnTrp: 0.308 ± 0.015
0.492AsnTyr: 0.492 ± 0.019
0.0AsnXaa: 0.0 ± 0.0
Pro
8.524ProAla: 8.524 ± 0.112
0.455ProCys: 0.455 ± 0.017
3.459ProAsp: 3.459 ± 0.051
3.3ProGlu: 3.3 ± 0.059
1.625ProPhe: 1.625 ± 0.035
5.255ProGly: 5.255 ± 0.076
1.183ProHis: 1.183 ± 0.03
1.678ProIle: 1.678 ± 0.042
1.063ProLys: 1.063 ± 0.034
5.542ProLeu: 5.542 ± 0.073
1.402ProMet: 1.402 ± 0.031
0.917ProAsn: 0.917 ± 0.027
3.078ProPro: 3.078 ± 0.06
2.068ProGln: 2.068 ± 0.039
3.562ProArg: 3.562 ± 0.056
2.759ProSer: 2.759 ± 0.05
2.597ProThr: 2.597 ± 0.049
4.932ProVal: 4.932 ± 0.07
0.894ProTrp: 0.894 ± 0.026
0.984ProTyr: 0.984 ± 0.026
0.0ProXaa: 0.0 ± 0.0
Gln
6.713GlnAla: 6.713 ± 0.082
0.275GlnCys: 0.275 ± 0.014
1.744GlnAsp: 1.744 ± 0.036
1.504GlnGlu: 1.504 ± 0.035
1.104GlnPhe: 1.104 ± 0.029
3.334GlnGly: 3.334 ± 0.052
1.039GlnHis: 1.039 ± 0.027
1.69GlnIle: 1.69 ± 0.036
0.835GlnLys: 0.835 ± 0.026
4.499GlnLeu: 4.499 ± 0.057
0.886GlnMet: 0.886 ± 0.027
0.642GlnAsn: 0.642 ± 0.023
2.464GlnPro: 2.464 ± 0.046
2.165GlnGln: 2.165 ± 0.05
4.041GlnArg: 4.041 ± 0.066
1.812GlnSer: 1.812 ± 0.042
1.807GlnThr: 1.807 ± 0.036
3.577GlnVal: 3.577 ± 0.052
0.679GlnTrp: 0.679 ± 0.023
0.616GlnTyr: 0.616 ± 0.019
0.0GlnXaa: 0.0 ± 0.0
Arg
8.615ArgAla: 8.615 ± 0.099
0.809ArgCys: 0.809 ± 0.028
3.901ArgAsp: 3.901 ± 0.065
4.298ArgGlu: 4.298 ± 0.078
2.744ArgPhe: 2.744 ± 0.055
5.115ArgGly: 5.115 ± 0.072
2.579ArgHis: 2.579 ± 0.057
3.36ArgIle: 3.36 ± 0.045
1.633ArgLys: 1.633 ± 0.032
10.295ArgLeu: 10.295 ± 0.111
1.875ArgMet: 1.875 ± 0.035
1.462ArgAsn: 1.462 ± 0.036
4.375ArgPro: 4.375 ± 0.076
3.865ArgGln: 3.865 ± 0.067
6.715ArgArg: 6.715 ± 0.1
4.254ArgSer: 4.254 ± 0.059
3.682ArgThr: 3.682 ± 0.049
5.457ArgVal: 5.457 ± 0.066
1.589ArgTrp: 1.589 ± 0.042
1.671ArgTyr: 1.671 ± 0.039
0.0ArgXaa: 0.0 ± 0.0
Ser
6.69SerAla: 6.69 ± 0.121
0.499SerCys: 0.499 ± 0.019
2.707SerAsp: 2.707 ± 0.078
2.357SerGlu: 2.357 ± 0.046
1.878SerPhe: 1.878 ± 0.047
5.235SerGly: 5.235 ± 0.101
1.198SerHis: 1.198 ± 0.028
2.075SerIle: 2.075 ± 0.043
1.126SerLys: 1.126 ± 0.034
5.916SerLeu: 5.916 ± 0.069
1.3SerMet: 1.3 ± 0.032
1.149SerAsn: 1.149 ± 0.037
3.114SerPro: 3.114 ± 0.053
1.79SerGln: 1.79 ± 0.037
4.08SerArg: 4.08 ± 0.059
3.145SerSer: 3.145 ± 0.066
3.258SerThr: 3.258 ± 0.074
4.156SerVal: 4.156 ± 0.099
0.747SerTrp: 0.747 ± 0.022
1.047SerTyr: 1.047 ± 0.032
0.0SerXaa: 0.0 ± 0.0
Thr
6.07ThrAla: 6.07 ± 0.095
0.449ThrCys: 0.449 ± 0.021
2.692ThrAsp: 2.692 ± 0.072
2.348ThrGlu: 2.348 ± 0.039
1.495ThrPhe: 1.495 ± 0.036
4.982ThrGly: 4.982 ± 0.123
1.146ThrHis: 1.146 ± 0.028
1.841ThrIle: 1.841 ± 0.04
0.92ThrLys: 0.92 ± 0.032
7.042ThrLeu: 7.042 ± 0.123
1.118ThrMet: 1.118 ± 0.033
0.922ThrAsn: 0.922 ± 0.031
3.553ThrPro: 3.553 ± 0.061
1.714ThrGln: 1.714 ± 0.035
3.611ThrArg: 3.611 ± 0.057
2.719ThrSer: 2.719 ± 0.058
2.857ThrThr: 2.857 ± 0.07
4.525ThrVal: 4.525 ± 0.159
0.733ThrTrp: 0.733 ± 0.025
0.92ThrTyr: 0.92 ± 0.032
0.0ThrXaa: 0.0 ± 0.0
Val
9.619ValAla: 9.619 ± 0.092
0.74ValCys: 0.74 ± 0.024
4.295ValAsp: 4.295 ± 0.062
4.207ValGlu: 4.207 ± 0.07
2.43ValPhe: 2.43 ± 0.047
5.506ValGly: 5.506 ± 0.071
1.925ValHis: 1.925 ± 0.04
3.343ValIle: 3.343 ± 0.059
1.931ValLys: 1.931 ± 0.046
9.242ValLeu: 9.242 ± 0.084
1.946ValMet: 1.946 ± 0.039
1.751ValAsn: 1.751 ± 0.038
4.135ValPro: 4.135 ± 0.055
3.119ValGln: 3.119 ± 0.046
5.854ValArg: 5.854 ± 0.065
4.374ValSer: 4.374 ± 0.09
4.149ValThr: 4.149 ± 0.109
6.51ValVal: 6.51 ± 0.093
1.039ValTrp: 1.039 ± 0.026
1.35ValTyr: 1.35 ± 0.029
0.0ValXaa: 0.0 ± 0.0
Trp
1.576TrpAla: 1.576 ± 0.038
0.192TrpCys: 0.192 ± 0.013
0.624TrpAsp: 0.624 ± 0.023
0.486TrpGlu: 0.486 ± 0.021
0.521TrpPhe: 0.521 ± 0.021
0.919TrpGly: 0.919 ± 0.024
0.421TrpHis: 0.421 ± 0.019
0.628TrpIle: 0.628 ± 0.021
0.38TrpLys: 0.38 ± 0.019
2.258TrpLeu: 2.258 ± 0.052
0.442TrpMet: 0.442 ± 0.017
0.381TrpAsn: 0.381 ± 0.016
0.88TrpPro: 0.88 ± 0.031
0.894TrpGln: 0.894 ± 0.027
1.461TrpArg: 1.461 ± 0.044
0.968TrpSer: 0.968 ± 0.026
0.798TrpThr: 0.798 ± 0.023
1.098TrpVal: 1.098 ± 0.03
0.302TrpTrp: 0.302 ± 0.017
0.265TrpTyr: 0.265 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.19TyrAla: 2.19 ± 0.039
0.203TyrCys: 0.203 ± 0.013
1.032TyrAsp: 1.032 ± 0.028
0.985TyrGlu: 0.985 ± 0.028
0.736TyrPhe: 0.736 ± 0.025
1.726TyrGly: 1.726 ± 0.037
0.428TyrHis: 0.428 ± 0.017
0.616TyrIle: 0.616 ± 0.02
0.446TyrLys: 0.446 ± 0.019
2.154TyrLeu: 2.154 ± 0.047
0.305TyrMet: 0.305 ± 0.015
0.466TyrAsn: 0.466 ± 0.019
0.924TyrPro: 0.924 ± 0.029
0.755TyrGln: 0.755 ± 0.023
1.526TyrArg: 1.526 ± 0.037
1.017TyrSer: 1.017 ± 0.03
1.116TyrThr: 1.116 ± 0.041
1.374TyrVal: 1.374 ± 0.034
0.331TyrTrp: 0.331 ± 0.015
0.424TyrTyr: 0.424 ± 0.019
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3942 proteins (1352833 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski