Amino acid dipepetide frequency for Xylella fastidiosa (strain 9a5c)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.279AlaAla: 12.279 ± 0.197	1.196AlaCys: 1.196 ± 0.041	5.181AlaAsp: 5.181 ± 0.086	5.32AlaGlu: 5.32 ± 0.106	3.379AlaPhe: 3.379 ± 0.077	7.494AlaGly: 7.494 ± 0.115	2.609AlaHis: 2.609 ± 0.063	5.313AlaIle: 5.313 ± 0.093	3.502AlaLys: 3.502 ± 0.081	12.704AlaLeu: 12.704 ± 0.153	2.676AlaMet: 2.676 ± 0.064	2.844AlaAsn: 2.844 ± 0.06	4.312AlaPro: 4.312 ± 0.089	4.546AlaGln: 4.546 ± 0.097	6.448AlaArg: 6.448 ± 0.111	5.674AlaSer: 5.674 ± 0.098	5.581AlaThr: 5.581 ± 0.149	7.358AlaVal: 7.358 ± 0.15	1.514AlaTrp: 1.514 ± 0.051	2.415AlaTyr: 2.415 ± 0.065	0.0AlaXaa: 0.0 ± 0.0
Cys	1.132CysAla: 1.132 ± 0.049	0.273CysCys: 0.273 ± 0.022	0.622CysAsp: 0.622 ± 0.03	0.562CysGlu: 0.562 ± 0.03	0.503CysPhe: 0.503 ± 0.029	1.079CysGly: 1.079 ± 0.039	0.312CysHis: 0.312 ± 0.023	0.634CysIle: 0.634 ± 0.034	0.358CysLys: 0.358 ± 0.022	1.185CysLeu: 1.185 ± 0.042	0.26CysMet: 0.26 ± 0.02	0.416CysAsn: 0.416 ± 0.022	0.534CysPro: 0.534 ± 0.03	0.369CysGln: 0.369 ± 0.025	0.747CysArg: 0.747 ± 0.034	0.776CysSer: 0.776 ± 0.04	0.661CysThr: 0.661 ± 0.035	0.942CysVal: 0.942 ± 0.047	0.198CysTrp: 0.198 ± 0.017	0.34CysTyr: 0.34 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	6.174AspAla: 6.174 ± 0.093	0.496AspCys: 0.496 ± 0.029	2.511AspAsp: 2.511 ± 0.073	2.752AspGlu: 2.752 ± 0.076	1.946AspPhe: 1.946 ± 0.051	4.452AspGly: 4.452 ± 0.109	1.262AspHis: 1.262 ± 0.044	2.882AspIle: 2.882 ± 0.079	1.802AspLys: 1.802 ± 0.06	5.329AspLeu: 5.329 ± 0.092	1.179AspMet: 1.179 ± 0.048	1.693AspAsn: 1.693 ± 0.07	2.883AspPro: 2.883 ± 0.066	1.771AspGln: 1.771 ± 0.047	3.026AspArg: 3.026 ± 0.059	2.598AspSer: 2.598 ± 0.061	3.305AspThr: 3.305 ± 0.101	4.373AspVal: 4.373 ± 0.093	1.0AspTrp: 1.0 ± 0.041	1.567AspTyr: 1.567 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	5.355GluAla: 5.355 ± 0.104	0.607GluCys: 0.607 ± 0.033	2.207GluAsp: 2.207 ± 0.066	2.546GluGlu: 2.546 ± 0.073	1.586GluPhe: 1.586 ± 0.048	3.356GluGly: 3.356 ± 0.084	1.545GluHis: 1.545 ± 0.045	3.065GluIle: 3.065 ± 0.074	1.985GluLys: 1.985 ± 0.055	5.243GluLeu: 5.243 ± 0.102	1.32GluMet: 1.32 ± 0.049	1.487GluAsn: 1.487 ± 0.049	1.923GluPro: 1.923 ± 0.049	2.792GluGln: 2.792 ± 0.066	4.409GluArg: 4.409 ± 0.085	2.749GluSer: 2.749 ± 0.064	2.815GluThr: 2.815 ± 0.069	3.711GluVal: 3.711 ± 0.084	0.681GluTrp: 0.681 ± 0.029	1.335GluTyr: 1.335 ± 0.047	0.0GluXaa: 0.0 ± 0.0
Phe	3.244PheAla: 3.244 ± 0.082	0.409PheCys: 0.409 ± 0.026	2.332PheAsp: 2.332 ± 0.056	1.807PheGlu: 1.807 ± 0.056	1.385PhePhe: 1.385 ± 0.06	3.043PheGly: 3.043 ± 0.074	0.856PheHis: 0.856 ± 0.035	1.839PheIle: 1.839 ± 0.05	1.253PheLys: 1.253 ± 0.039	3.198PheLeu: 3.198 ± 0.079	0.791PheMet: 0.791 ± 0.028	1.391PheAsn: 1.391 ± 0.045	1.518PhePro: 1.518 ± 0.044	1.21PheGln: 1.21 ± 0.039	1.979PheArg: 1.979 ± 0.046	2.466PheSer: 2.466 ± 0.072	1.966PheThr: 1.966 ± 0.055	2.484PheVal: 2.484 ± 0.052	0.509PheTrp: 0.509 ± 0.03	1.028PheTyr: 1.028 ± 0.042	0.0PheXaa: 0.0 ± 0.0
Gly	6.569GlyAla: 6.569 ± 0.102	1.09GlyCys: 1.09 ± 0.042	4.055GlyAsp: 4.055 ± 0.109	3.897GlyGlu: 3.897 ± 0.093	2.902GlyPhe: 2.902 ± 0.069	5.911GlyGly: 5.911 ± 0.149	2.176GlyHis: 2.176 ± 0.065	4.482GlyIle: 4.482 ± 0.08	3.295GlyLys: 3.295 ± 0.072	7.435GlyLeu: 7.435 ± 0.113	2.067GlyMet: 2.067 ± 0.061	2.711GlyAsn: 2.711 ± 0.093	2.415GlyPro: 2.415 ± 0.059	3.089GlyGln: 3.089 ± 0.07	4.976GlyArg: 4.976 ± 0.082	4.507GlySer: 4.507 ± 0.112	4.571GlyThr: 4.571 ± 0.138	6.086GlyVal: 6.086 ± 0.13	1.308GlyTrp: 1.308 ± 0.042	2.321GlyTyr: 2.321 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	2.725HisAla: 2.725 ± 0.072	0.47HisCys: 0.47 ± 0.029	1.387HisAsp: 1.387 ± 0.046	1.107HisGlu: 1.107 ± 0.042	1.037HisPhe: 1.037 ± 0.04	2.184HisGly: 2.184 ± 0.061	0.942HisHis: 0.942 ± 0.044	1.316HisIle: 1.316 ± 0.047	0.688HisLys: 0.688 ± 0.031	2.788HisLeu: 2.788 ± 0.081	0.603HisMet: 0.603 ± 0.03	0.795HisAsn: 0.795 ± 0.035	1.802HisPro: 1.802 ± 0.051	1.048HisGln: 1.048 ± 0.036	1.853HisArg: 1.853 ± 0.054	1.493HisSer: 1.493 ± 0.053	1.835HisThr: 1.835 ± 0.084	1.923HisVal: 1.923 ± 0.05	0.576HisTrp: 0.576 ± 0.034	0.862HisTyr: 0.862 ± 0.034	0.0HisXaa: 0.0 ± 0.0
Ile	6.316IleAla: 6.316 ± 0.095	0.577IleCys: 0.577 ± 0.025	3.704IleAsp: 3.704 ± 0.071	3.471IleGlu: 3.471 ± 0.077	1.573IlePhe: 1.573 ± 0.049	4.793IleGly: 4.793 ± 0.094	1.39IleHis: 1.39 ± 0.046	2.26IleIle: 2.26 ± 0.068	2.19IleLys: 2.19 ± 0.06	4.133IleLeu: 4.133 ± 0.087	0.846IleMet: 0.846 ± 0.034	2.131IleAsn: 2.131 ± 0.058	2.643IlePro: 2.643 ± 0.059	1.909IleGln: 1.909 ± 0.053	3.073IleArg: 3.073 ± 0.073	3.263IleSer: 3.263 ± 0.07	3.399IleThr: 3.399 ± 0.087	3.915IleVal: 3.915 ± 0.083	0.552IleTrp: 0.552 ± 0.032	1.22IleTyr: 1.22 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	3.353LysAla: 3.353 ± 0.092	0.277LysCys: 0.277 ± 0.019	1.795LysAsp: 1.795 ± 0.057	1.857LysGlu: 1.857 ± 0.053	0.974LysPhe: 0.974 ± 0.036	2.355LysGly: 2.355 ± 0.059	1.002LysHis: 1.002 ± 0.034	2.042LysIle: 2.042 ± 0.058	1.6LysLys: 1.6 ± 0.06	3.473LysLeu: 3.473 ± 0.075	0.869LysMet: 0.869 ± 0.035	1.387LysAsn: 1.387 ± 0.047	1.913LysPro: 1.913 ± 0.052	1.87LysGln: 1.87 ± 0.053	2.638LysArg: 2.638 ± 0.064	2.011LysSer: 2.011 ± 0.055	2.166LysThr: 2.166 ± 0.065	2.719LysVal: 2.719 ± 0.08	0.381LysTrp: 0.381 ± 0.022	0.932LysTyr: 0.932 ± 0.034	0.0LysXaa: 0.0 ± 0.0
Leu	10.985LeuAla: 10.985 ± 0.151	1.276LeuCys: 1.276 ± 0.037	6.013LeuAsp: 6.013 ± 0.118	5.498LeuGlu: 5.498 ± 0.103	3.638LeuPhe: 3.638 ± 0.081	7.78LeuGly: 7.78 ± 0.11	2.96LeuHis: 2.96 ± 0.076	5.593LeuIle: 5.593 ± 0.096	3.789LeuLys: 3.789 ± 0.088	11.807LeuLeu: 11.807 ± 0.208	2.357LeuMet: 2.357 ± 0.061	3.461LeuAsn: 3.461 ± 0.074	6.049LeuPro: 6.049 ± 0.119	4.358LeuGln: 4.358 ± 0.082	7.816LeuArg: 7.816 ± 0.119	7.001LeuSer: 7.001 ± 0.103	5.904LeuThr: 5.904 ± 0.189	6.925LeuVal: 6.925 ± 0.122	1.405LeuTrp: 1.405 ± 0.051	2.528LeuTyr: 2.528 ± 0.062	0.0LeuXaa: 0.0 ± 0.0
Met	2.254MetAla: 2.254 ± 0.049	0.262MetCys: 0.262 ± 0.017	1.123MetAsp: 1.123 ± 0.047	0.943MetGlu: 0.943 ± 0.034	0.755MetPhe: 0.755 ± 0.036	1.523MetGly: 1.523 ± 0.051	0.658MetHis: 0.658 ± 0.029	1.288MetIle: 1.288 ± 0.044	0.958MetLys: 0.958 ± 0.038	2.756MetLeu: 2.756 ± 0.065	0.688MetMet: 0.688 ± 0.036	0.914MetAsn: 0.914 ± 0.038	1.472MetPro: 1.472 ± 0.046	1.024MetGln: 1.024 ± 0.033	1.748MetArg: 1.748 ± 0.058	1.729MetSer: 1.729 ± 0.048	1.682MetThr: 1.682 ± 0.045	1.623MetVal: 1.623 ± 0.05	0.194MetTrp: 0.194 ± 0.017	0.44MetTyr: 0.44 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.664AsnAla: 3.664 ± 0.075	0.289AsnCys: 0.289 ± 0.018	1.943AsnAsp: 1.943 ± 0.067	1.545AsnGlu: 1.545 ± 0.047	1.035AsnPhe: 1.035 ± 0.041	2.873AsnGly: 2.873 ± 0.08	0.869AsnHis: 0.869 ± 0.035	1.843AsnIle: 1.843 ± 0.051	1.276AsnLys: 1.276 ± 0.044	2.839AsnLeu: 2.839 ± 0.07	0.65AsnMet: 0.65 ± 0.031	1.297AsnAsn: 1.297 ± 0.055	2.016AsnPro: 2.016 ± 0.059	1.271AsnGln: 1.271 ± 0.046	2.04AsnArg: 2.04 ± 0.06	1.859AsnSer: 1.859 ± 0.063	2.387AsnThr: 2.387 ± 0.078	2.515AsnVal: 2.515 ± 0.06	0.432AsnTrp: 0.432 ± 0.026	0.938AsnTyr: 0.938 ± 0.039	0.0AsnXaa: 0.0 ± 0.0
Pro	4.454ProAla: 4.454 ± 0.081	0.506ProCys: 0.506 ± 0.024	2.875ProAsp: 2.875 ± 0.054	2.886ProGlu: 2.886 ± 0.072	1.69ProPhe: 1.69 ± 0.046	3.7ProGly: 3.7 ± 0.084	1.414ProHis: 1.414 ± 0.055	2.395ProIle: 2.395 ± 0.052	1.656ProLys: 1.656 ± 0.047	5.308ProLeu: 5.308 ± 0.096	1.297ProMet: 1.297 ± 0.044	1.658ProAsn: 1.658 ± 0.049	2.643ProPro: 2.643 ± 0.069	2.26ProGln: 2.26 ± 0.062	2.706ProArg: 2.706 ± 0.058	3.126ProSer: 3.126 ± 0.065	2.847ProThr: 2.847 ± 0.075	3.773ProVal: 3.773 ± 0.082	0.729ProTrp: 0.729 ± 0.027	1.343ProTyr: 1.343 ± 0.045	0.0ProXaa: 0.0 ± 0.0
Gln	4.817GlnAla: 4.817 ± 0.096	0.478GlnCys: 0.478 ± 0.026	1.74GlnAsp: 1.74 ± 0.063	1.853GlnGlu: 1.853 ± 0.059	1.215GlnPhe: 1.215 ± 0.041	2.793GlnGly: 2.793 ± 0.071	1.38GlnHis: 1.38 ± 0.048	2.278GlnIle: 2.278 ± 0.059	1.331GlnLys: 1.331 ± 0.052	4.522GlnLeu: 4.522 ± 0.092	1.123GlnMet: 1.123 ± 0.037	0.998GlnAsn: 0.998 ± 0.038	2.114GlnPro: 2.114 ± 0.054	2.439GlnGln: 2.439 ± 0.078	3.779GlnArg: 3.779 ± 0.07	2.234GlnSer: 2.234 ± 0.06	2.268GlnThr: 2.268 ± 0.065	3.082GlnVal: 3.082 ± 0.064	0.7GlnTrp: 0.7 ± 0.033	1.005GlnTyr: 1.005 ± 0.04	0.0GlnXaa: 0.0 ± 0.0
Arg	6.039ArgAla: 6.039 ± 0.117	0.889ArgCys: 0.889 ± 0.039	3.555ArgAsp: 3.555 ± 0.073	3.665ArgGlu: 3.665 ± 0.075	2.725ArgPhe: 2.725 ± 0.07	4.315ArgGly: 4.315 ± 0.086	1.981ArgHis: 1.981 ± 0.053	4.028ArgIle: 4.028 ± 0.085	2.207ArgLys: 2.207 ± 0.059	7.562ArgLeu: 7.562 ± 0.115	1.812ArgMet: 1.812 ± 0.046	2.386ArgAsn: 2.386 ± 0.059	2.815ArgPro: 2.815 ± 0.075	2.939ArgGln: 2.939 ± 0.07	4.704ArgArg: 4.704 ± 0.103	3.715ArgSer: 3.715 ± 0.07	3.372ArgThr: 3.372 ± 0.074	4.723ArgVal: 4.723 ± 0.095	1.227ArgTrp: 1.227 ± 0.045	2.286ArgTyr: 2.286 ± 0.058	0.0ArgXaa: 0.0 ± 0.0
Ser	5.605SerAla: 5.605 ± 0.098	0.655SerCys: 0.655 ± 0.032	3.202SerAsp: 3.202 ± 0.07	2.926SerGlu: 2.926 ± 0.068	2.115SerPhe: 2.115 ± 0.065	5.601SerGly: 5.601 ± 0.118	1.576SerHis: 1.576 ± 0.066	3.139SerIle: 3.139 ± 0.071	2.351SerLys: 2.351 ± 0.061	5.892SerLeu: 5.892 ± 0.098	1.493SerMet: 1.493 ± 0.048	2.461SerAsn: 2.461 ± 0.07	2.851SerPro: 2.851 ± 0.059	2.301SerGln: 2.301 ± 0.064	3.549SerArg: 3.549 ± 0.066	4.004SerSer: 4.004 ± 0.117	3.411SerThr: 3.411 ± 0.086	4.416SerVal: 4.416 ± 0.09	0.801SerTrp: 0.801 ± 0.036	1.454SerTyr: 1.454 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	6.016ThrAla: 6.016 ± 0.166	0.63ThrCys: 0.63 ± 0.028	2.795ThrAsp: 2.795 ± 0.075	2.633ThrGlu: 2.633 ± 0.06	1.886ThrPhe: 1.886 ± 0.052	4.502ThrGly: 4.502 ± 0.128	1.741ThrHis: 1.741 ± 0.066	2.858ThrIle: 2.858 ± 0.085	1.685ThrLys: 1.685 ± 0.049	7.579ThrLeu: 7.579 ± 0.213	1.196ThrMet: 1.196 ± 0.039	1.648ThrAsn: 1.648 ± 0.064	3.892ThrPro: 3.892 ± 0.104	2.486ThrGln: 2.486 ± 0.06	3.31ThrArg: 3.31 ± 0.065	3.283ThrSer: 3.283 ± 0.088	3.561ThrThr: 3.561 ± 0.155	4.061ThrVal: 4.061 ± 0.085	0.815ThrTrp: 0.815 ± 0.031	1.387ThrTyr: 1.387 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	7.747ValAla: 7.747 ± 0.132	0.955ValCys: 0.955 ± 0.04	3.949ValAsp: 3.949 ± 0.087	3.63ValGlu: 3.63 ± 0.085	2.687ValPhe: 2.687 ± 0.063	5.013ValGly: 5.013 ± 0.117	1.705ValHis: 1.705 ± 0.045	4.206ValIle: 4.206 ± 0.095	2.324ValLys: 2.324 ± 0.065	8.614ValLeu: 8.614 ± 0.158	1.923ValMet: 1.923 ± 0.058	2.468ValAsn: 2.468 ± 0.07	3.543ValPro: 3.543 ± 0.084	2.624ValGln: 2.624 ± 0.066	4.838ValArg: 4.838 ± 0.101	4.729ValSer: 4.729 ± 0.099	4.026ValThr: 4.026 ± 0.085	5.825ValVal: 5.825 ± 0.13	0.94ValTrp: 0.94 ± 0.036	1.617ValTyr: 1.617 ± 0.053	0.0ValXaa: 0.0 ± 0.0
Trp	1.006TrpAla: 1.006 ± 0.035	0.253TrpCys: 0.253 ± 0.016	0.653TrpAsp: 0.653 ± 0.029	0.583TrpGlu: 0.583 ± 0.026	0.603TrpPhe: 0.603 ± 0.026	0.896TrpGly: 0.896 ± 0.036	0.392TrpHis: 0.392 ± 0.025	0.756TrpIle: 0.756 ± 0.03	0.534TrpLys: 0.534 ± 0.026	2.026TrpLeu: 2.026 ± 0.055	0.401TrpMet: 0.401 ± 0.025	0.604TrpAsn: 0.604 ± 0.031	0.647TrpPro: 0.647 ± 0.032	0.714TrpGln: 0.714 ± 0.035	1.238TrpArg: 1.238 ± 0.052	0.954TrpSer: 0.954 ± 0.039	0.706TrpThr: 0.706 ± 0.031	1.017TrpVal: 1.017 ± 0.043	0.264TrpTrp: 0.264 ± 0.02	0.396TrpTyr: 0.396 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.616TyrAla: 2.616 ± 0.051	0.313TyrCys: 0.313 ± 0.019	1.359TyrAsp: 1.359 ± 0.04	1.234TyrGlu: 1.234 ± 0.037	1.074TyrPhe: 1.074 ± 0.038	2.199TyrGly: 2.199 ± 0.065	0.665TyrHis: 0.665 ± 0.027	1.141TyrIle: 1.141 ± 0.042	0.836TyrLys: 0.836 ± 0.036	2.747TyrLeu: 2.747 ± 0.07	0.479TyrMet: 0.479 ± 0.029	0.83TyrAsn: 0.83 ± 0.038	1.281TyrPro: 1.281 ± 0.042	1.13TyrGln: 1.13 ± 0.037	2.065TyrArg: 2.065 ± 0.056	1.632TyrSer: 1.632 ± 0.048	1.503TyrThr: 1.503 ± 0.045	1.893TyrVal: 1.893 ± 0.052	0.42TyrTrp: 0.42 ± 0.025	0.763TyrTyr: 0.763 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2772 proteins (743229 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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