Amino acid dipepetide frequency for Anatid alphaherpesvirus 1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.129AlaAla: 8.129 ± 0.645
1.606AlaCys: 1.606 ± 0.221
4.596AlaAsp: 4.596 ± 0.422
4.151AlaGlu: 4.151 ± 0.323
3.113AlaPhe: 3.113 ± 0.252
4.423AlaGly: 4.423 ± 0.331
1.631AlaHis: 1.631 ± 0.203
5.337AlaIle: 5.337 ± 0.3
2.891AlaLys: 2.891 ± 0.293
8.253AlaLeu: 8.253 ± 0.425
2.397AlaMet: 2.397 ± 0.251
2.94AlaAsn: 2.94 ± 0.215
3.632AlaPro: 3.632 ± 0.31
2.1AlaGln: 2.1 ± 0.245
4.942AlaArg: 4.942 ± 0.363
6.721AlaSer: 6.721 ± 0.44
5.782AlaThr: 5.782 ± 0.39
5.337AlaVal: 5.337 ± 0.382
0.692AlaTrp: 0.692 ± 0.126
2.817AlaTyr: 2.817 ± 0.269
0.0AlaXaa: 0.0 ± 0.0
Cys
1.73CysAla: 1.73 ± 0.225
0.568CysCys: 0.568 ± 0.127
1.507CysAsp: 1.507 ± 0.221
1.161CysGlu: 1.161 ± 0.166
0.939CysPhe: 0.939 ± 0.157
1.483CysGly: 1.483 ± 0.18
0.741CysHis: 0.741 ± 0.127
1.507CysIle: 1.507 ± 0.207
0.988CysLys: 0.988 ± 0.15
2.001CysLeu: 2.001 ± 0.245
0.667CysMet: 0.667 ± 0.114
1.186CysAsn: 1.186 ± 0.173
0.865CysPro: 0.865 ± 0.142
0.667CysGln: 0.667 ± 0.136
1.408CysArg: 1.408 ± 0.196
1.656CysSer: 1.656 ± 0.24
0.964CysThr: 0.964 ± 0.155
1.433CysVal: 1.433 ± 0.167
0.148CysTrp: 0.148 ± 0.061
0.667CysTyr: 0.667 ± 0.112
0.0CysXaa: 0.0 ± 0.0
Asp
4.645AspAla: 4.645 ± 0.346
0.964AspCys: 0.964 ± 0.167
4.522AspAsp: 4.522 ± 0.387
3.83AspGlu: 3.83 ± 0.325
1.507AspPhe: 1.507 ± 0.183
4.695AspGly: 4.695 ± 0.318
1.31AspHis: 1.31 ± 0.158
3.682AspIle: 3.682 ± 0.304
2.249AspLys: 2.249 ± 0.206
5.016AspLeu: 5.016 ± 0.337
1.878AspMet: 1.878 ± 0.192
2.298AspAsn: 2.298 ± 0.216
2.99AspPro: 2.99 ± 0.267
1.334AspGln: 1.334 ± 0.218
3.805AspArg: 3.805 ± 0.34
4.398AspSer: 4.398 ± 0.312
4.374AspThr: 4.374 ± 0.325
3.706AspVal: 3.706 ± 0.318
0.692AspTrp: 0.692 ± 0.125
2.125AspTyr: 2.125 ± 0.195
0.0AspXaa: 0.0 ± 0.0
Glu
4.645GluAla: 4.645 ± 0.297
1.161GluCys: 1.161 ± 0.193
3.435GluAsp: 3.435 ± 0.315
3.929GluGlu: 3.929 ± 0.32
1.483GluPhe: 1.483 ± 0.209
2.496GluGly: 2.496 ± 0.243
1.483GluHis: 1.483 ± 0.193
2.595GluIle: 2.595 ± 0.193
1.804GluLys: 1.804 ± 0.227
5.584GluLeu: 5.584 ± 0.385
1.334GluMet: 1.334 ± 0.229
2.496GluAsn: 2.496 ± 0.283
2.471GluPro: 2.471 ± 0.229
2.15GluGln: 2.15 ± 0.234
3.41GluArg: 3.41 ± 0.268
3.756GluSer: 3.756 ± 0.275
4.003GluThr: 4.003 ± 0.254
2.94GluVal: 2.94 ± 0.279
0.717GluTrp: 0.717 ± 0.139
1.903GluTyr: 1.903 ± 0.173
0.0GluXaa: 0.0 ± 0.0
Phe
2.743PheAla: 2.743 ± 0.282
0.939PheCys: 0.939 ± 0.164
2.94PheAsp: 2.94 ± 0.302
2.15PheGlu: 2.15 ± 0.22
1.853PhePhe: 1.853 ± 0.284
2.767PheGly: 2.767 ± 0.285
0.741PheHis: 0.741 ± 0.121
2.224PheIle: 2.224 ± 0.186
1.68PheLys: 1.68 ± 0.193
3.385PheLeu: 3.385 ± 0.334
1.211PheMet: 1.211 ± 0.178
1.433PheAsn: 1.433 ± 0.17
1.334PhePro: 1.334 ± 0.134
0.766PheGln: 0.766 ± 0.156
1.483PheArg: 1.483 ± 0.207
3.163PheSer: 3.163 ± 0.303
2.125PheThr: 2.125 ± 0.277
2.669PheVal: 2.669 ± 0.24
0.42PheTrp: 0.42 ± 0.1
1.359PheTyr: 1.359 ± 0.185
0.0PheXaa: 0.0 ± 0.0
Gly
4.818GlyAla: 4.818 ± 0.276
1.087GlyCys: 1.087 ± 0.194
3.756GlyAsp: 3.756 ± 0.32
3.632GlyGlu: 3.632 ± 0.36
2.076GlyPhe: 2.076 ± 0.264
4.522GlyGly: 4.522 ± 0.309
1.31GlyHis: 1.31 ± 0.198
3.632GlyIle: 3.632 ± 0.285
2.347GlyLys: 2.347 ± 0.213
5.609GlyLeu: 5.609 ± 0.426
1.285GlyMet: 1.285 ± 0.191
2.718GlyAsn: 2.718 ± 0.209
3.262GlyPro: 3.262 ± 0.346
2.125GlyGln: 2.125 ± 0.357
4.769GlyArg: 4.769 ± 0.39
4.967GlySer: 4.967 ± 0.332
4.225GlyThr: 4.225 ± 0.365
3.657GlyVal: 3.657 ± 0.298
0.766GlyTrp: 0.766 ± 0.123
1.829GlyTyr: 1.829 ± 0.222
0.0GlyXaa: 0.0 ± 0.0
His
2.001HisAla: 2.001 ± 0.205
0.642HisCys: 0.642 ± 0.145
1.112HisAsp: 1.112 ± 0.202
1.013HisGlu: 1.013 ± 0.16
0.791HisPhe: 0.791 ± 0.165
1.903HisGly: 1.903 ± 0.261
0.84HisHis: 0.84 ± 0.116
1.31HisIle: 1.31 ± 0.15
1.235HisLys: 1.235 ± 0.13
2.199HisLeu: 2.199 ± 0.195
0.371HisMet: 0.371 ± 0.088
0.667HisAsn: 0.667 ± 0.134
1.038HisPro: 1.038 ± 0.181
0.667HisGln: 0.667 ± 0.135
1.483HisArg: 1.483 ± 0.205
1.606HisSer: 1.606 ± 0.206
1.532HisThr: 1.532 ± 0.169
1.458HisVal: 1.458 ± 0.244
0.198HisTrp: 0.198 ± 0.068
0.791HisTyr: 0.791 ± 0.118
0.0HisXaa: 0.0 ± 0.0
Ile
4.151IleAla: 4.151 ± 0.365
1.557IleCys: 1.557 ± 0.225
3.855IleAsp: 3.855 ± 0.31
3.262IleGlu: 3.262 ± 0.324
1.927IlePhe: 1.927 ± 0.228
3.781IleGly: 3.781 ± 0.304
0.914IleHis: 0.914 ± 0.169
3.509IleIle: 3.509 ± 0.346
2.125IleLys: 2.125 ± 0.248
4.893IleLeu: 4.893 ± 0.437
1.606IleMet: 1.606 ± 0.217
2.743IleAsn: 2.743 ± 0.274
3.015IlePro: 3.015 ± 0.272
1.952IleGln: 1.952 ± 0.192
3.657IleArg: 3.657 ± 0.295
4.769IleSer: 4.769 ± 0.402
4.127IleThr: 4.127 ± 0.312
3.533IleVal: 3.533 ± 0.319
0.692IleTrp: 0.692 ± 0.121
2.422IleTyr: 2.422 ± 0.273
0.0IleXaa: 0.0 ± 0.0
Lys
3.089LysAla: 3.089 ± 0.286
0.692LysCys: 0.692 ± 0.15
2.224LysAsp: 2.224 ± 0.202
1.631LysGlu: 1.631 ± 0.222
1.334LysPhe: 1.334 ± 0.224
1.705LysGly: 1.705 ± 0.211
1.161LysHis: 1.161 ± 0.204
2.076LysIle: 2.076 ± 0.247
1.606LysLys: 1.606 ± 0.21
3.336LysLeu: 3.336 ± 0.351
1.137LysMet: 1.137 ± 0.133
1.31LysAsn: 1.31 ± 0.175
2.1LysPro: 2.1 ± 0.239
1.804LysGln: 1.804 ± 0.226
3.855LysArg: 3.855 ± 0.358
2.743LysSer: 2.743 ± 0.251
3.682LysThr: 3.682 ± 0.335
1.952LysVal: 1.952 ± 0.219
0.395LysTrp: 0.395 ± 0.085
1.458LysTyr: 1.458 ± 0.173
0.0LysXaa: 0.0 ± 0.0
Leu
7.092LeuAla: 7.092 ± 0.547
2.249LeuCys: 2.249 ± 0.258
4.967LeuAsp: 4.967 ± 0.359
4.176LeuGlu: 4.176 ± 0.259
4.077LeuPhe: 4.077 ± 0.357
5.313LeuGly: 5.313 ± 0.344
2.15LeuHis: 2.15 ± 0.233
4.547LeuIle: 4.547 ± 0.331
3.682LeuLys: 3.682 ± 0.3
8.475LeuLeu: 8.475 ± 0.565
2.174LeuMet: 2.174 ± 0.263
3.954LeuAsn: 3.954 ± 0.348
4.201LeuPro: 4.201 ± 0.369
2.496LeuGln: 2.496 ± 0.268
6.177LeuArg: 6.177 ± 0.466
7.734LeuSer: 7.734 ± 0.449
5.14LeuThr: 5.14 ± 0.418
5.189LeuVal: 5.189 ± 0.287
1.038LeuTrp: 1.038 ± 0.171
3.138LeuTyr: 3.138 ± 0.303
0.0LeuXaa: 0.0 ± 0.0
Met
3.212MetAla: 3.212 ± 0.2
0.642MetCys: 0.642 ± 0.117
1.507MetAsp: 1.507 ± 0.168
1.063MetGlu: 1.063 ± 0.18
1.211MetPhe: 1.211 ± 0.182
1.334MetGly: 1.334 ± 0.215
0.568MetHis: 0.568 ± 0.111
1.384MetIle: 1.384 ± 0.175
0.89MetLys: 0.89 ± 0.146
2.249MetLeu: 2.249 ± 0.228
0.741MetMet: 0.741 ± 0.155
1.112MetAsn: 1.112 ± 0.164
1.458MetPro: 1.458 ± 0.22
0.741MetGln: 0.741 ± 0.111
1.829MetArg: 1.829 ± 0.192
1.977MetSer: 1.977 ± 0.208
1.804MetThr: 1.804 ± 0.166
1.384MetVal: 1.384 ± 0.198
0.395MetTrp: 0.395 ± 0.111
0.865MetTyr: 0.865 ± 0.124
0.0MetXaa: 0.0 ± 0.0
Asn
3.682AsnAla: 3.682 ± 0.3
1.112AsnCys: 1.112 ± 0.178
2.52AsnAsp: 2.52 ± 0.329
2.298AsnGlu: 2.298 ± 0.261
1.384AsnPhe: 1.384 ± 0.222
3.435AsnGly: 3.435 ± 0.233
0.914AsnHis: 0.914 ± 0.155
2.817AsnIle: 2.817 ± 0.205
1.581AsnLys: 1.581 ± 0.163
2.817AsnLeu: 2.817 ± 0.271
0.865AsnMet: 0.865 ± 0.129
1.853AsnAsn: 1.853 ± 0.192
1.631AsnPro: 1.631 ± 0.235
1.26AsnGln: 1.26 ± 0.19
2.347AsnArg: 2.347 ± 0.249
3.113AsnSer: 3.113 ± 0.255
3.039AsnThr: 3.039 ± 0.251
3.039AsnVal: 3.039 ± 0.285
0.642AsnTrp: 0.642 ± 0.11
1.359AsnTyr: 1.359 ± 0.182
0.0AsnXaa: 0.0 ± 0.0
Pro
2.916ProAla: 2.916 ± 0.311
1.063ProCys: 1.063 ± 0.178
2.669ProAsp: 2.669 ± 0.29
2.718ProGlu: 2.718 ± 0.326
1.606ProPhe: 1.606 ± 0.219
3.064ProGly: 3.064 ± 0.264
1.087ProHis: 1.087 ± 0.178
3.336ProIle: 3.336 ± 0.297
2.298ProLys: 2.298 ± 0.329
4.151ProLeu: 4.151 ± 0.365
1.285ProMet: 1.285 ± 0.191
2.076ProAsn: 2.076 ± 0.179
4.102ProPro: 4.102 ± 0.505
1.656ProGln: 1.656 ± 0.284
3.336ProArg: 3.336 ± 0.375
4.744ProSer: 4.744 ± 0.426
3.015ProThr: 3.015 ± 0.296
3.188ProVal: 3.188 ± 0.268
0.618ProTrp: 0.618 ± 0.144
1.631ProTyr: 1.631 ± 0.222
0.0ProXaa: 0.0 ± 0.0
Gln
2.644GlnAla: 2.644 ± 0.284
0.692GlnCys: 0.692 ± 0.134
1.458GlnAsp: 1.458 ± 0.173
1.458GlnGlu: 1.458 ± 0.217
1.112GlnPhe: 1.112 ± 0.154
1.235GlnGly: 1.235 ± 0.163
0.593GlnHis: 0.593 ± 0.104
1.483GlnIle: 1.483 ± 0.164
1.112GlnLys: 1.112 ± 0.161
2.743GlnLeu: 2.743 ± 0.238
0.815GlnMet: 0.815 ± 0.137
1.137GlnAsn: 1.137 ± 0.141
2.051GlnPro: 2.051 ± 0.309
1.68GlnGln: 1.68 ± 0.342
2.792GlnArg: 2.792 ± 0.26
2.026GlnSer: 2.026 ± 0.236
2.545GlnThr: 2.545 ± 0.391
1.507GlnVal: 1.507 ± 0.173
0.222GlnTrp: 0.222 ± 0.068
1.285GlnTyr: 1.285 ± 0.181
0.0GlnXaa: 0.0 ± 0.0
Arg
5.041ArgAla: 5.041 ± 0.362
1.631ArgCys: 1.631 ± 0.158
3.781ArgAsp: 3.781 ± 0.295
3.459ArgGlu: 3.459 ± 0.309
2.916ArgPhe: 2.916 ± 0.33
4.25ArgGly: 4.25 ± 0.488
2.199ArgHis: 2.199 ± 0.24
3.509ArgIle: 3.509 ± 0.275
2.817ArgLys: 2.817 ± 0.281
6.227ArgLeu: 6.227 ± 0.482
1.458ArgMet: 1.458 ± 0.181
2.817ArgAsn: 2.817 ± 0.333
3.558ArgPro: 3.558 ± 0.369
2.001ArgGln: 2.001 ± 0.211
6.82ArgArg: 6.82 ± 0.638
5.362ArgSer: 5.362 ± 0.401
3.311ArgThr: 3.311 ± 0.309
3.929ArgVal: 3.929 ± 0.28
0.469ArgTrp: 0.469 ± 0.099
2.174ArgTyr: 2.174 ± 0.31
0.0ArgXaa: 0.0 ± 0.0
Ser
6.696SerAla: 6.696 ± 0.546
1.878SerCys: 1.878 ± 0.232
4.547SerAsp: 4.547 ± 0.446
4.497SerGlu: 4.497 ± 0.395
3.113SerPhe: 3.113 ± 0.288
5.634SerGly: 5.634 ± 0.309
1.631SerHis: 1.631 ± 0.219
4.25SerIle: 4.25 ± 0.387
3.039SerLys: 3.039 ± 0.312
6.202SerLeu: 6.202 ± 0.374
2.199SerMet: 2.199 ± 0.213
3.583SerAsn: 3.583 ± 0.266
3.978SerPro: 3.978 ± 0.417
2.125SerGln: 2.125 ± 0.253
4.794SerArg: 4.794 ± 0.329
8.475SerSer: 8.475 ± 0.632
5.708SerThr: 5.708 ± 0.384
6.054SerVal: 6.054 ± 0.343
0.815SerTrp: 0.815 ± 0.182
2.199SerTyr: 2.199 ± 0.249
0.0SerXaa: 0.0 ± 0.0
Thr
5.461ThrAla: 5.461 ± 0.352
1.31ThrCys: 1.31 ± 0.176
3.509ThrAsp: 3.509 ± 0.29
4.275ThrGlu: 4.275 ± 0.311
2.619ThrPhe: 2.619 ± 0.264
4.052ThrGly: 4.052 ± 0.259
1.408ThrHis: 1.408 ± 0.164
4.645ThrIle: 4.645 ± 0.398
2.496ThrLys: 2.496 ± 0.269
5.56ThrLeu: 5.56 ± 0.401
1.68ThrMet: 1.68 ± 0.196
2.644ThrAsn: 2.644 ± 0.297
3.089ThrPro: 3.089 ± 0.328
2.1ThrGln: 2.1 ± 0.264
3.954ThrArg: 3.954 ± 0.303
5.906ThrSer: 5.906 ± 0.336
5.634ThrThr: 5.634 ± 0.45
4.67ThrVal: 4.67 ± 0.462
0.84ThrTrp: 0.84 ± 0.14
2.471ThrTyr: 2.471 ± 0.241
0.0ThrXaa: 0.0 ± 0.0
Val
5.411ValAla: 5.411 ± 0.367
1.507ValCys: 1.507 ± 0.214
4.201ValAsp: 4.201 ± 0.316
2.57ValGlu: 2.57 ± 0.209
2.52ValPhe: 2.52 ± 0.296
3.311ValGly: 3.311 ± 0.267
1.285ValHis: 1.285 ± 0.186
3.311ValIle: 3.311 ± 0.262
2.545ValLys: 2.545 ± 0.289
6.252ValLeu: 6.252 ± 0.37
1.977ValMet: 1.977 ± 0.244
2.866ValAsn: 2.866 ± 0.246
3.632ValPro: 3.632 ± 0.335
2.026ValGln: 2.026 ± 0.191
4.077ValArg: 4.077 ± 0.282
4.398ValSer: 4.398 ± 0.323
4.127ValThr: 4.127 ± 0.364
3.731ValVal: 3.731 ± 0.314
0.445ValTrp: 0.445 ± 0.076
2.076ValTyr: 2.076 ± 0.275
0.0ValXaa: 0.0 ± 0.0
Trp
0.692TrpAla: 0.692 ± 0.141
0.247TrpCys: 0.247 ± 0.076
0.741TrpAsp: 0.741 ± 0.14
0.568TrpGlu: 0.568 ± 0.137
0.519TrpPhe: 0.519 ± 0.148
0.445TrpGly: 0.445 ± 0.113
0.247TrpHis: 0.247 ± 0.076
0.667TrpIle: 0.667 ± 0.119
0.568TrpLys: 0.568 ± 0.114
0.865TrpLeu: 0.865 ± 0.125
0.222TrpMet: 0.222 ± 0.062
0.494TrpAsn: 0.494 ± 0.128
0.692TrpPro: 0.692 ± 0.184
0.321TrpGln: 0.321 ± 0.101
0.667TrpArg: 0.667 ± 0.116
0.914TrpSer: 0.914 ± 0.139
1.013TrpThr: 1.013 ± 0.14
0.519TrpVal: 0.519 ± 0.129
0.173TrpTrp: 0.173 ± 0.06
0.321TrpTyr: 0.321 ± 0.081
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.693TyrAla: 2.693 ± 0.24
0.741TyrCys: 0.741 ± 0.129
2.174TyrAsp: 2.174 ± 0.224
1.952TyrGlu: 1.952 ± 0.209
1.285TyrPhe: 1.285 ± 0.152
2.545TyrGly: 2.545 ± 0.271
0.667TyrHis: 0.667 ± 0.14
2.669TyrIle: 2.669 ± 0.227
1.334TyrLys: 1.334 ± 0.224
2.15TyrLeu: 2.15 ± 0.225
1.038TyrMet: 1.038 ± 0.14
1.384TyrAsn: 1.384 ± 0.183
1.458TyrPro: 1.458 ± 0.186
0.618TyrGln: 0.618 ± 0.132
2.125TyrArg: 2.125 ± 0.248
2.99TyrSer: 2.99 ± 0.249
2.174TyrThr: 2.174 ± 0.254
2.372TyrVal: 2.372 ± 0.267
0.519TyrTrp: 0.519 ± 0.132
1.285TyrTyr: 1.285 ± 0.191
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 74 proteins (40471 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski