Amino acid dipepetide frequency for Euphorbia yellow leaf curl virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.495AlaAla: 5.495 ± 2.386
0.916AlaCys: 0.916 ± 0.815
1.832AlaAsp: 1.832 ± 0.998
0.916AlaGlu: 0.916 ± 0.826
1.832AlaPhe: 1.832 ± 1.093
0.916AlaGly: 0.916 ± 0.815
1.832AlaHis: 1.832 ± 0.86
1.832AlaIle: 1.832 ± 1.73
2.747AlaLys: 2.747 ± 1.266
7.326AlaLeu: 7.326 ± 2.765
0.0AlaMet: 0.0 ± 0.0
2.747AlaAsn: 2.747 ± 1.227
1.832AlaPro: 1.832 ± 0.86
3.663AlaGln: 3.663 ± 1.677
4.579AlaArg: 4.579 ± 2.44
3.663AlaSer: 3.663 ± 1.433
3.663AlaThr: 3.663 ± 2.25
3.663AlaVal: 3.663 ± 2.448
0.916AlaTrp: 0.916 ± 0.66
1.832AlaTyr: 1.832 ± 0.806
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.916CysGlu: 0.916 ± 0.815
0.916CysPhe: 0.916 ± 1.025
1.832CysGly: 1.832 ± 0.86
0.916CysHis: 0.916 ± 0.865
0.916CysIle: 0.916 ± 0.826
0.916CysLys: 0.916 ± 0.815
0.916CysLeu: 0.916 ± 0.826
1.832CysMet: 1.832 ± 0.892
0.916CysAsn: 0.916 ± 0.66
2.747CysPro: 2.747 ± 2.478
0.0CysGln: 0.0 ± 0.0
0.916CysArg: 0.916 ± 0.66
3.663CysSer: 3.663 ± 1.835
1.832CysThr: 1.832 ± 0.806
1.832CysVal: 1.832 ± 1.63
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
0.916AspAla: 0.916 ± 0.66
0.0AspCys: 0.0 ± 0.0
2.747AspAsp: 2.747 ± 1.243
1.832AspGlu: 1.832 ± 0.806
0.916AspPhe: 0.916 ± 0.815
1.832AspGly: 1.832 ± 1.32
0.916AspHis: 0.916 ± 1.025
2.747AspIle: 2.747 ± 1.65
0.916AspLys: 0.916 ± 0.815
7.326AspLeu: 7.326 ± 3.118
0.0AspMet: 0.0 ± 0.0
1.832AspAsn: 1.832 ± 1.106
1.832AspPro: 1.832 ± 0.903
0.916AspGln: 0.916 ± 0.66
2.747AspArg: 2.747 ± 1.48
6.41AspSer: 6.41 ± 1.67
3.663AspThr: 3.663 ± 1.816
6.41AspVal: 6.41 ± 1.299
1.832AspTrp: 1.832 ± 0.86
0.916AspTyr: 0.916 ± 0.66
0.0AspXaa: 0.0 ± 0.0
Glu
5.495GluAla: 5.495 ± 1.856
0.0GluCys: 0.0 ± 0.0
0.916GluAsp: 0.916 ± 0.865
4.579GluGlu: 4.579 ± 1.743
3.663GluPhe: 3.663 ± 1.922
3.663GluGly: 3.663 ± 1.11
0.916GluHis: 0.916 ± 1.025
0.916GluIle: 0.916 ± 1.155
1.832GluLys: 1.832 ± 1.32
3.663GluLeu: 3.663 ± 1.565
0.0GluMet: 0.0 ± 0.0
5.495GluAsn: 5.495 ± 2.417
4.579GluPro: 4.579 ± 0.927
2.747GluGln: 2.747 ± 1.14
0.0GluArg: 0.0 ± 0.0
4.579GluSer: 4.579 ± 2.027
0.916GluThr: 0.916 ± 0.826
2.747GluVal: 2.747 ± 0.991
2.747GluTrp: 2.747 ± 1.266
0.0GluTyr: 0.0 ± 0.0
0.0GluXaa: 0.0 ± 0.0
Phe
0.0PheAla: 0.0 ± 0.0
0.916PheCys: 0.916 ± 0.815
3.663PheAsp: 3.663 ± 1.611
1.832PheGlu: 1.832 ± 0.806
1.832PhePhe: 1.832 ± 0.806
0.916PheGly: 0.916 ± 0.815
2.747PheHis: 2.747 ± 1.349
1.832PheIle: 1.832 ± 0.806
2.747PheLys: 2.747 ± 2.014
7.326PheLeu: 7.326 ± 2.718
0.916PheMet: 0.916 ± 0.66
2.747PheAsn: 2.747 ± 1.97
1.832PhePro: 1.832 ± 1.283
1.832PheGln: 1.832 ± 0.86
4.579PheArg: 4.579 ± 2.496
0.0PheSer: 0.0 ± 0.0
3.663PheThr: 3.663 ± 1.363
0.0PheVal: 0.0 ± 0.0
0.0PheTrp: 0.0 ± 0.0
0.916PheTyr: 0.916 ± 0.815
0.0PheXaa: 0.0 ± 0.0
Gly
2.747GlyAla: 2.747 ± 1.979
1.832GlyCys: 1.832 ± 1.091
2.747GlyAsp: 2.747 ± 1.266
4.579GlyGlu: 4.579 ± 1.097
1.832GlyPhe: 1.832 ± 1.283
2.747GlyGly: 2.747 ± 1.227
1.832GlyHis: 1.832 ± 1.093
1.832GlyIle: 1.832 ± 1.093
6.41GlyLys: 6.41 ± 3.023
1.832GlyLeu: 1.832 ± 1.091
0.0GlyMet: 0.0 ± 0.0
0.916GlyAsn: 0.916 ± 1.155
3.663GlyPro: 3.663 ± 1.797
3.663GlyGln: 3.663 ± 1.186
0.916GlyArg: 0.916 ± 0.66
4.579GlySer: 4.579 ± 1.465
2.747GlyThr: 2.747 ± 0.856
1.832GlyVal: 1.832 ± 2.05
0.0GlyTrp: 0.0 ± 0.0
0.916GlyTyr: 0.916 ± 0.826
0.0GlyXaa: 0.0 ± 0.0
His
1.832HisAla: 1.832 ± 1.63
0.916HisCys: 0.916 ± 0.865
0.916HisAsp: 0.916 ± 0.815
2.747HisGlu: 2.747 ± 1.156
3.663HisPhe: 3.663 ± 1.426
1.832HisGly: 1.832 ± 1.283
4.579HisHis: 4.579 ± 3.186
2.747HisIle: 2.747 ± 1.447
0.916HisLys: 0.916 ± 1.025
1.832HisLeu: 1.832 ± 1.32
0.0HisMet: 0.0 ± 0.0
4.579HisAsn: 4.579 ± 2.092
1.832HisPro: 1.832 ± 0.903
0.916HisGln: 0.916 ± 0.826
4.579HisArg: 4.579 ± 2.84
2.747HisSer: 2.747 ± 1.793
0.916HisThr: 0.916 ± 0.815
2.747HisVal: 2.747 ± 2.014
0.0HisTrp: 0.0 ± 0.0
0.916HisTyr: 0.916 ± 0.66
0.0HisXaa: 0.0 ± 0.0
Ile
0.0IleAla: 0.0 ± 0.0
1.832IleCys: 1.832 ± 0.903
1.832IleAsp: 1.832 ± 1.32
2.747IleGlu: 2.747 ± 1.349
2.747IlePhe: 2.747 ± 1.405
0.916IleGly: 0.916 ± 0.815
0.916IleHis: 0.916 ± 1.025
2.747IleIle: 2.747 ± 1.65
7.326IleLys: 7.326 ± 1.664
1.832IleLeu: 1.832 ± 1.216
0.0IleMet: 0.0 ± 0.0
1.832IleAsn: 1.832 ± 1.292
1.832IlePro: 1.832 ± 1.104
4.579IleGln: 4.579 ± 1.886
5.495IleArg: 5.495 ± 1.905
3.663IleSer: 3.663 ± 1.57
3.663IleThr: 3.663 ± 2.173
0.916IleVal: 0.916 ± 0.66
3.663IleTrp: 3.663 ± 2.156
0.916IleTyr: 0.916 ± 0.815
0.0IleXaa: 0.0 ± 0.0
Lys
2.747LysAla: 2.747 ± 1.14
1.832LysCys: 1.832 ± 1.093
1.832LysAsp: 1.832 ± 1.32
4.579LysGlu: 4.579 ± 2.414
1.832LysPhe: 1.832 ± 1.106
2.747LysGly: 2.747 ± 1.243
0.916LysHis: 0.916 ± 0.66
4.579LysIle: 4.579 ± 1.96
1.832LysLys: 1.832 ± 0.806
0.0LysLeu: 0.0 ± 0.0
0.0LysMet: 0.0 ± 0.0
5.495LysAsn: 5.495 ± 2.453
2.747LysPro: 2.747 ± 1.48
0.0LysGln: 0.0 ± 0.0
3.663LysArg: 3.663 ± 2.183
8.242LysSer: 8.242 ± 1.972
2.747LysThr: 2.747 ± 0.957
4.579LysVal: 4.579 ± 2.168
0.916LysTrp: 0.916 ± 0.815
5.495LysTyr: 5.495 ± 1.445
0.0LysXaa: 0.0 ± 0.0
Leu
2.747LeuAla: 2.747 ± 1.15
2.747LeuCys: 2.747 ± 1.349
4.579LeuAsp: 4.579 ± 1.839
8.242LeuGlu: 8.242 ± 2.637
0.916LeuPhe: 0.916 ± 0.865
3.663LeuGly: 3.663 ± 1.812
2.747LeuHis: 2.747 ± 1.486
3.663LeuIle: 3.663 ± 2.033
4.579LeuLys: 4.579 ± 1.558
0.916LeuLeu: 0.916 ± 1.155
1.832LeuMet: 1.832 ± 1.215
5.495LeuAsn: 5.495 ± 1.296
0.916LeuPro: 0.916 ± 0.865
2.747LeuGln: 2.747 ± 1.349
8.242LeuArg: 8.242 ± 1.91
2.747LeuSer: 2.747 ± 1.405
5.495LeuThr: 5.495 ± 1.849
4.579LeuVal: 4.579 ± 1.706
1.832LeuTrp: 1.832 ± 1.106
3.663LeuTyr: 3.663 ± 1.812
0.0LeuXaa: 0.0 ± 0.0
Met
0.916MetAla: 0.916 ± 0.815
0.916MetCys: 0.916 ± 0.815
1.832MetAsp: 1.832 ± 1.106
0.0MetGlu: 0.0 ± 0.0
2.747MetPhe: 2.747 ± 1.721
3.663MetGly: 3.663 ± 1.565
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
0.0MetLys: 0.0 ± 0.0
1.832MetLeu: 1.832 ± 0.998
0.0MetMet: 0.0 ± 0.0
1.832MetAsn: 1.832 ± 1.106
0.916MetPro: 0.916 ± 0.66
0.0MetGln: 0.0 ± 0.0
0.916MetArg: 0.916 ± 0.865
0.916MetSer: 0.916 ± 0.815
0.0MetThr: 0.0 ± 0.0
0.0MetVal: 0.0 ± 0.0
1.832MetTrp: 1.832 ± 0.903
1.832MetTyr: 1.832 ± 1.63
0.0MetXaa: 0.0 ± 0.0
Asn
3.663AsnAla: 3.663 ± 1.797
1.832AsnCys: 1.832 ± 1.73
0.916AsnAsp: 0.916 ± 0.66
2.747AsnGlu: 2.747 ± 0.823
0.916AsnPhe: 0.916 ± 0.815
2.747AsnGly: 2.747 ± 1.386
4.579AsnHis: 4.579 ± 1.685
1.832AsnIle: 1.832 ± 0.806
0.916AsnLys: 0.916 ± 0.66
7.326AsnLeu: 7.326 ± 3.051
1.832AsnMet: 1.832 ± 1.577
2.747AsnAsn: 2.747 ± 0.957
2.747AsnPro: 2.747 ± 0.957
3.663AsnGln: 3.663 ± 1.091
4.579AsnArg: 4.579 ± 1.337
2.747AsnSer: 2.747 ± 1.227
1.832AsnThr: 1.832 ± 1.32
3.663AsnVal: 3.663 ± 1.217
0.916AsnTrp: 0.916 ± 0.66
3.663AsnTyr: 3.663 ± 1.11
0.0AsnXaa: 0.0 ± 0.0
Pro
0.916ProAla: 0.916 ± 0.865
1.832ProCys: 1.832 ± 0.998
2.747ProAsp: 2.747 ± 1.319
1.832ProGlu: 1.832 ± 1.283
1.832ProPhe: 1.832 ± 1.093
3.663ProGly: 3.663 ± 1.439
2.747ProHis: 2.747 ± 1.979
3.663ProIle: 3.663 ± 1.454
3.663ProLys: 3.663 ± 2.639
5.495ProLeu: 5.495 ± 1.766
1.832ProMet: 1.832 ± 1.023
2.747ProAsn: 2.747 ± 1.266
1.832ProPro: 1.832 ± 1.093
4.579ProGln: 4.579 ± 2.027
5.495ProArg: 5.495 ± 1.79
3.663ProSer: 3.663 ± 2.035
5.495ProThr: 5.495 ± 1.445
3.663ProVal: 3.663 ± 1.611
0.0ProTrp: 0.0 ± 0.0
0.916ProTyr: 0.916 ± 0.826
0.0ProXaa: 0.0 ± 0.0
Gln
3.663GlnAla: 3.663 ± 2.354
0.916GlnCys: 0.916 ± 0.66
4.579GlnAsp: 4.579 ± 1.89
0.916GlnGlu: 0.916 ± 0.815
2.747GlnPhe: 2.747 ± 1.486
1.832GlnGly: 1.832 ± 1.32
2.747GlnHis: 2.747 ± 1.447
3.663GlnIle: 3.663 ± 1.426
1.832GlnLys: 1.832 ± 1.652
1.832GlnLeu: 1.832 ± 0.903
0.916GlnMet: 0.916 ± 0.865
0.916GlnAsn: 0.916 ± 1.025
4.579GlnPro: 4.579 ± 1.951
2.747GlnGln: 2.747 ± 0.823
2.747GlnArg: 2.747 ± 2.161
6.41GlnSer: 6.41 ± 1.316
2.747GlnThr: 2.747 ± 1.349
3.663GlnVal: 3.663 ± 0.932
0.0GlnTrp: 0.0 ± 0.0
0.916GlnTyr: 0.916 ± 0.815
0.0GlnXaa: 0.0 ± 0.0
Arg
6.41ArgAla: 6.41 ± 3.116
1.832ArgCys: 1.832 ± 1.652
3.663ArgAsp: 3.663 ± 1.367
1.832ArgGlu: 1.832 ± 1.104
1.832ArgPhe: 1.832 ± 0.806
3.663ArgGly: 3.663 ± 1.433
3.663ArgHis: 3.663 ± 1.995
4.579ArgIle: 4.579 ± 1.167
4.579ArgLys: 4.579 ± 2.346
4.579ArgLeu: 4.579 ± 2.191
1.832ArgMet: 1.832 ± 1.63
0.916ArgAsn: 0.916 ± 0.826
6.41ArgPro: 6.41 ± 0.812
0.916ArgGln: 0.916 ± 0.826
6.41ArgArg: 6.41 ± 3.218
6.41ArgSer: 6.41 ± 2.14
4.579ArgThr: 4.579 ± 3.373
6.41ArgVal: 6.41 ± 2.204
0.0ArgTrp: 0.0 ± 0.0
1.832ArgTyr: 1.832 ± 0.998
0.0ArgXaa: 0.0 ± 0.0
Ser
3.663SerAla: 3.663 ± 1.898
0.916SerCys: 0.916 ± 0.66
2.747SerAsp: 2.747 ± 0.856
4.579SerGlu: 4.579 ± 0.973
3.663SerPhe: 3.663 ± 1.042
0.916SerGly: 0.916 ± 0.66
0.916SerHis: 0.916 ± 0.865
3.663SerIle: 3.663 ± 2.173
5.495SerLys: 5.495 ± 2.038
4.579SerLeu: 4.579 ± 0.973
1.832SerMet: 1.832 ± 1.423
4.579SerAsn: 4.579 ± 1.388
9.158SerPro: 9.158 ± 1.565
4.579SerGln: 4.579 ± 1.951
8.242SerArg: 8.242 ± 2.906
16.484SerSer: 16.484 ± 4.854
7.326SerThr: 7.326 ± 3.973
2.747SerVal: 2.747 ± 2.445
0.0SerTrp: 0.0 ± 0.0
2.747SerTyr: 2.747 ± 1.266
0.0SerXaa: 0.0 ± 0.0
Thr
3.663ThrAla: 3.663 ± 0.932
0.916ThrCys: 0.916 ± 1.155
1.832ThrAsp: 1.832 ± 2.31
1.832ThrGlu: 1.832 ± 1.553
1.832ThrPhe: 1.832 ± 1.104
6.41ThrGly: 6.41 ± 1.679
4.579ThrHis: 4.579 ± 2.275
0.916ThrIle: 0.916 ± 0.66
3.663ThrLys: 3.663 ± 1.611
3.663ThrLeu: 3.663 ± 1.134
0.916ThrMet: 0.916 ± 0.66
2.747ThrAsn: 2.747 ± 1.227
3.663ThrPro: 3.663 ± 1.134
3.663ThrGln: 3.663 ± 1.454
1.832ThrArg: 1.832 ± 0.806
3.663ThrSer: 3.663 ± 2.305
1.832ThrThr: 1.832 ± 1.525
6.41ThrVal: 6.41 ± 2.46
0.916ThrTrp: 0.916 ± 1.155
1.832ThrTyr: 1.832 ± 0.903
0.0ThrXaa: 0.0 ± 0.0
Val
0.916ValAla: 0.916 ± 0.826
0.0ValCys: 0.0 ± 0.0
3.663ValAsp: 3.663 ± 0.932
1.832ValGlu: 1.832 ± 1.216
1.832ValPhe: 1.832 ± 1.106
1.832ValGly: 1.832 ± 0.998
2.747ValHis: 2.747 ± 1.319
5.495ValIle: 5.495 ± 3.279
4.579ValLys: 4.579 ± 2.095
5.495ValLeu: 5.495 ± 1.914
2.747ValMet: 2.747 ± 1.48
4.579ValAsn: 4.579 ± 1.167
3.663ValPro: 3.663 ± 1.433
6.41ValGln: 6.41 ± 2.024
2.747ValArg: 2.747 ± 2.445
4.579ValSer: 4.579 ± 1.388
2.747ValThr: 2.747 ± 2.445
1.832ValVal: 1.832 ± 1.106
0.0ValTrp: 0.0 ± 0.0
7.326ValTyr: 7.326 ± 2.008
0.0ValXaa: 0.0 ± 0.0
Trp
3.663TrpAla: 3.663 ± 1.797
0.0TrpCys: 0.0 ± 0.0
1.832TrpAsp: 1.832 ± 1.216
0.0TrpGlu: 0.0 ± 0.0
0.0TrpPhe: 0.0 ± 0.0
0.916TrpGly: 0.916 ± 0.66
0.916TrpHis: 0.916 ± 0.815
0.0TrpIle: 0.0 ± 0.0
0.916TrpLys: 0.916 ± 1.025
0.0TrpLeu: 0.0 ± 0.0
0.916TrpMet: 0.916 ± 0.815
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.916TrpGln: 0.916 ± 0.66
1.832TrpArg: 1.832 ± 1.45
0.916TrpSer: 0.916 ± 0.865
0.916TrpThr: 0.916 ± 1.025
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
1.832TrpTyr: 1.832 ± 1.104
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.747TyrAla: 2.747 ± 1.48
0.916TyrCys: 0.916 ± 0.826
1.832TyrAsp: 1.832 ± 0.998
0.916TyrGlu: 0.916 ± 0.815
2.747TyrPhe: 2.747 ± 0.957
0.916TyrGly: 0.916 ± 0.66
0.0TyrHis: 0.0 ± 0.0
1.832TyrIle: 1.832 ± 1.093
0.916TyrLys: 0.916 ± 0.66
5.495TyrLeu: 5.495 ± 1.766
1.832TyrMet: 1.832 ± 1.023
2.747TyrAsn: 2.747 ± 0.823
1.832TyrPro: 1.832 ± 1.104
1.832TyrGln: 1.832 ± 0.806
1.832TyrArg: 1.832 ± 1.63
2.747TyrSer: 2.747 ± 1.349
0.0TyrThr: 0.0 ± 0.0
7.326TyrVal: 7.326 ± 1.435
0.0TyrTrp: 0.0 ± 0.0
0.916TyrTyr: 0.916 ± 0.865
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (1093 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski