Amino acid dipepetide frequency for Thalassococcus sp. S3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.155AlaAla: 15.155 ± 0.153	1.123AlaCys: 1.123 ± 0.03	7.091AlaAsp: 7.091 ± 0.069	8.261AlaGlu: 8.261 ± 0.093	4.481AlaPhe: 4.481 ± 0.059	10.011AlaGly: 10.011 ± 0.088	2.344AlaHis: 2.344 ± 0.04	5.841AlaIle: 5.841 ± 0.071	3.539AlaLys: 3.539 ± 0.064	13.746AlaLeu: 13.746 ± 0.135	3.665AlaMet: 3.665 ± 0.049	2.62AlaAsn: 2.62 ± 0.047	5.727AlaPro: 5.727 ± 0.081	4.503AlaGln: 4.503 ± 0.057	8.697AlaArg: 8.697 ± 0.106	5.743AlaSer: 5.743 ± 0.077	5.686AlaThr: 5.686 ± 0.072	8.002AlaVal: 8.002 ± 0.081	1.496AlaTrp: 1.496 ± 0.035	2.588AlaTyr: 2.588 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	1.067CysAla: 1.067 ± 0.03	0.106CysCys: 0.106 ± 0.009	0.616CysAsp: 0.616 ± 0.021	0.441CysGlu: 0.441 ± 0.016	0.332CysPhe: 0.332 ± 0.015	0.922CysGly: 0.922 ± 0.028	0.265CysHis: 0.265 ± 0.015	0.4CysIle: 0.4 ± 0.018	0.219CysLys: 0.219 ± 0.012	0.887CysLeu: 0.887 ± 0.023	0.176CysMet: 0.176 ± 0.012	0.202CysAsn: 0.202 ± 0.011	0.525CysPro: 0.525 ± 0.02	0.263CysGln: 0.263 ± 0.015	0.552CysArg: 0.552 ± 0.02	0.446CysSer: 0.446 ± 0.018	0.448CysThr: 0.448 ± 0.018	0.606CysVal: 0.606 ± 0.024	0.12CysTrp: 0.12 ± 0.009	0.213CysTyr: 0.213 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.717AspAla: 7.717 ± 0.078	0.497AspCys: 0.497 ± 0.02	3.686AspAsp: 3.686 ± 0.088	3.502AspGlu: 3.502 ± 0.052	2.386AspPhe: 2.386 ± 0.038	5.868AspGly: 5.868 ± 0.094	1.456AspHis: 1.456 ± 0.035	3.359AspIle: 3.359 ± 0.051	1.562AspLys: 1.562 ± 0.039	7.058AspLeu: 7.058 ± 0.08	1.729AspMet: 1.729 ± 0.032	1.316AspAsn: 1.316 ± 0.038	3.878AspPro: 3.878 ± 0.053	2.16AspGln: 2.16 ± 0.036	4.576AspArg: 4.576 ± 0.063	1.986AspSer: 1.986 ± 0.049	3.288AspThr: 3.288 ± 0.085	4.72AspVal: 4.72 ± 0.063	1.191AspTrp: 1.191 ± 0.031	1.511AspTyr: 1.511 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	8.175GluAla: 8.175 ± 0.079	0.355GluCys: 0.355 ± 0.017	3.697GluAsp: 3.697 ± 0.056	3.674GluGlu: 3.674 ± 0.058	1.677GluPhe: 1.677 ± 0.034	4.641GluGly: 4.641 ± 0.065	1.19GluHis: 1.19 ± 0.025	3.666GluIle: 3.666 ± 0.053	2.036GluLys: 2.036 ± 0.043	4.921GluLeu: 4.921 ± 0.061	1.916GluMet: 1.916 ± 0.039	1.705GluAsn: 1.705 ± 0.035	2.647GluPro: 2.647 ± 0.052	1.92GluGln: 1.92 ± 0.041	4.413GluArg: 4.413 ± 0.06	2.02GluSer: 2.02 ± 0.036	4.235GluThr: 4.235 ± 0.047	4.297GluVal: 4.297 ± 0.057	0.686GluTrp: 0.686 ± 0.021	1.073GluTyr: 1.073 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.545PheAla: 4.545 ± 0.061	0.439PheCys: 0.439 ± 0.018	3.046PheAsp: 3.046 ± 0.051	2.428PheGlu: 2.428 ± 0.046	1.476PhePhe: 1.476 ± 0.036	3.848PheGly: 3.848 ± 0.075	0.778PheHis: 0.778 ± 0.026	1.596PheIle: 1.596 ± 0.037	0.916PheLys: 0.916 ± 0.024	3.52PheLeu: 3.52 ± 0.055	0.826PheMet: 0.826 ± 0.02	1.036PheAsn: 1.036 ± 0.03	1.537PhePro: 1.537 ± 0.032	1.113PheGln: 1.113 ± 0.025	2.185PheArg: 2.185 ± 0.039	2.216PheSer: 2.216 ± 0.038	2.001PheThr: 2.001 ± 0.039	2.804PheVal: 2.804 ± 0.054	0.616PheTrp: 0.616 ± 0.022	0.942PheTyr: 0.942 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	9.698GlyAla: 9.698 ± 0.101	0.852GlyCys: 0.852 ± 0.026	4.877GlyAsp: 4.877 ± 0.114	4.647GlyGlu: 4.647 ± 0.065	3.726GlyPhe: 3.726 ± 0.052	7.502GlyGly: 7.502 ± 0.176	1.896GlyHis: 1.896 ± 0.04	4.271GlyIle: 4.271 ± 0.055	2.774GlyLys: 2.774 ± 0.048	9.175GlyLeu: 9.175 ± 0.09	2.39GlyMet: 2.39 ± 0.04	2.241GlyAsn: 2.241 ± 0.103	3.752GlyPro: 3.752 ± 0.056	3.41GlyGln: 3.41 ± 0.047	5.588GlyArg: 5.588 ± 0.06	4.292GlySer: 4.292 ± 0.068	4.689GlyThr: 4.689 ± 0.066	6.175GlyVal: 6.175 ± 0.073	1.432GlyTrp: 1.432 ± 0.034	2.308GlyTyr: 2.308 ± 0.038	0.0GlyXaa: 0.0 ± 0.0
His	2.342HisAla: 2.342 ± 0.045	0.233HisCys: 0.233 ± 0.012	1.303HisAsp: 1.303 ± 0.031	1.037HisGlu: 1.037 ± 0.026	0.841HisPhe: 0.841 ± 0.027	1.825HisGly: 1.825 ± 0.034	0.561HisHis: 0.561 ± 0.021	1.066HisIle: 1.066 ± 0.025	0.519HisLys: 0.519 ± 0.019	2.271HisLeu: 2.271 ± 0.047	0.546HisMet: 0.546 ± 0.019	0.458HisAsn: 0.458 ± 0.016	1.404HisPro: 1.404 ± 0.033	0.647HisGln: 0.647 ± 0.019	1.362HisArg: 1.362 ± 0.035	0.881HisSer: 0.881 ± 0.027	0.839HisThr: 0.839 ± 0.024	1.67HisVal: 1.67 ± 0.032	0.388HisTrp: 0.388 ± 0.014	0.559HisTyr: 0.559 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	6.818IleAla: 6.818 ± 0.078	0.633IleCys: 0.633 ± 0.02	3.554IleAsp: 3.554 ± 0.048	3.552IleGlu: 3.552 ± 0.047	1.825IlePhe: 1.825 ± 0.04	4.91IleGly: 4.91 ± 0.071	0.896IleHis: 0.896 ± 0.023	2.091IleIle: 2.091 ± 0.044	1.377IleLys: 1.377 ± 0.029	4.865IleLeu: 4.865 ± 0.07	1.048IleMet: 1.048 ± 0.027	1.353IleAsn: 1.353 ± 0.031	2.392IlePro: 2.392 ± 0.039	1.282IleGln: 1.282 ± 0.028	3.234IleArg: 3.234 ± 0.045	3.086IleSer: 3.086 ± 0.045	2.917IleThr: 2.917 ± 0.047	3.872IleVal: 3.872 ± 0.052	0.798IleTrp: 0.798 ± 0.026	1.23IleTyr: 1.23 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	3.83LysAla: 3.83 ± 0.059	0.174LysCys: 0.174 ± 0.012	1.784LysAsp: 1.784 ± 0.035	1.531LysGlu: 1.531 ± 0.039	0.796LysPhe: 0.796 ± 0.021	2.475LysGly: 2.475 ± 0.044	0.576LysHis: 0.576 ± 0.02	1.538LysIle: 1.538 ± 0.034	1.042LysLys: 1.042 ± 0.031	2.79LysLeu: 2.79 ± 0.051	0.806LysMet: 0.806 ± 0.022	0.733LysAsn: 0.733 ± 0.022	1.705LysPro: 1.705 ± 0.037	0.851LysGln: 0.851 ± 0.024	2.12LysArg: 2.12 ± 0.045	1.72LysSer: 1.72 ± 0.039	1.988LysThr: 1.988 ± 0.039	2.116LysVal: 2.116 ± 0.046	0.348LysTrp: 0.348 ± 0.017	0.565LysTyr: 0.565 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	12.292LeuAla: 12.292 ± 0.126	0.98LeuCys: 0.98 ± 0.028	6.357LeuAsp: 6.357 ± 0.072	5.475LeuGlu: 5.475 ± 0.057	3.633LeuPhe: 3.633 ± 0.067	8.247LeuGly: 8.247 ± 0.088	1.961LeuHis: 1.961 ± 0.041	5.518LeuIle: 5.518 ± 0.07	3.147LeuLys: 3.147 ± 0.047	9.153LeuLeu: 9.153 ± 0.117	2.661LeuMet: 2.661 ± 0.043	2.822LeuAsn: 2.822 ± 0.039	5.533LeuPro: 5.533 ± 0.065	2.976LeuGln: 2.976 ± 0.05	7.119LeuArg: 7.119 ± 0.076	7.14LeuSer: 7.14 ± 0.083	6.275LeuThr: 6.275 ± 0.072	6.651LeuVal: 6.651 ± 0.071	1.315LeuTrp: 1.315 ± 0.034	2.116LeuTyr: 2.116 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	3.332MetAla: 3.332 ± 0.049	0.188MetCys: 0.188 ± 0.013	1.406MetAsp: 1.406 ± 0.031	1.427MetGlu: 1.427 ± 0.032	0.83MetPhe: 0.83 ± 0.029	2.201MetGly: 2.201 ± 0.04	0.496MetHis: 0.496 ± 0.019	1.555MetIle: 1.555 ± 0.032	1.008MetLys: 1.008 ± 0.024	2.628MetLeu: 2.628 ± 0.039	0.788MetMet: 0.788 ± 0.025	0.772MetAsn: 0.772 ± 0.023	1.489MetPro: 1.489 ± 0.032	1.024MetGln: 1.024 ± 0.026	1.996MetArg: 1.996 ± 0.043	1.878MetSer: 1.878 ± 0.035	2.098MetThr: 2.098 ± 0.038	1.763MetVal: 1.763 ± 0.035	0.255MetTrp: 0.255 ± 0.014	0.325MetTyr: 0.325 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.182AsnAla: 3.182 ± 0.049	0.251AsnCys: 0.251 ± 0.013	1.68AsnAsp: 1.68 ± 0.089	1.184AsnGlu: 1.184 ± 0.034	0.88AsnPhe: 0.88 ± 0.025	2.452AsnGly: 2.452 ± 0.053	0.475AsnHis: 0.475 ± 0.019	1.278AsnIle: 1.278 ± 0.031	0.619AsnLys: 0.619 ± 0.021	2.451AsnLeu: 2.451 ± 0.046	0.694AsnMet: 0.694 ± 0.026	0.657AsnAsn: 0.657 ± 0.024	1.777AsnPro: 1.777 ± 0.038	0.743AsnGln: 0.743 ± 0.024	1.747AsnArg: 1.747 ± 0.035	1.131AsnSer: 1.131 ± 0.031	1.338AsnThr: 1.338 ± 0.028	1.945AsnVal: 1.945 ± 0.042	0.455AsnTrp: 0.455 ± 0.017	0.593AsnTyr: 0.593 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	5.393ProAla: 5.393 ± 0.071	0.354ProCys: 0.354 ± 0.016	4.32ProAsp: 4.32 ± 0.058	4.001ProGlu: 4.001 ± 0.058	2.024ProPhe: 2.024 ± 0.04	4.375ProGly: 4.375 ± 0.053	1.105ProHis: 1.105 ± 0.026	2.35ProIle: 2.35 ± 0.036	1.697ProLys: 1.697 ± 0.036	4.722ProLeu: 4.722 ± 0.057	1.343ProMet: 1.343 ± 0.033	1.376ProAsn: 1.376 ± 0.032	2.362ProPro: 2.362 ± 0.048	1.701ProGln: 1.701 ± 0.038	2.825ProArg: 2.825 ± 0.045	2.694ProSer: 2.694 ± 0.048	2.503ProThr: 2.503 ± 0.045	4.174ProVal: 4.174 ± 0.06	0.661ProTrp: 0.661 ± 0.022	1.194ProTyr: 1.194 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	4.138GlnAla: 4.138 ± 0.063	0.202GlnCys: 0.202 ± 0.011	1.918GlnAsp: 1.918 ± 0.036	1.58GlnGlu: 1.58 ± 0.033	1.111GlnPhe: 1.111 ± 0.028	2.646GlnGly: 2.646 ± 0.052	0.639GlnHis: 0.639 ± 0.02	2.203GlnIle: 2.203 ± 0.035	1.087GlnLys: 1.087 ± 0.03	2.845GlnLeu: 2.845 ± 0.054	1.137GlnMet: 1.137 ± 0.028	0.978GlnAsn: 0.978 ± 0.027	1.712GlnPro: 1.712 ± 0.033	1.098GlnGln: 1.098 ± 0.029	2.303GlnArg: 2.303 ± 0.043	2.059GlnSer: 2.059 ± 0.04	2.067GlnThr: 2.067 ± 0.04	2.469GlnVal: 2.469 ± 0.045	0.376GlnTrp: 0.376 ± 0.015	0.617GlnTyr: 0.617 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	8.073ArgAla: 8.073 ± 0.096	0.512ArgCys: 0.512 ± 0.017	4.469ArgAsp: 4.469 ± 0.061	3.65ArgGlu: 3.65 ± 0.049	2.852ArgPhe: 2.852 ± 0.046	4.477ArgGly: 4.477 ± 0.058	1.606ArgHis: 1.606 ± 0.035	3.962ArgIle: 3.962 ± 0.057	2.18ArgLys: 2.18 ± 0.043	7.407ArgLeu: 7.407 ± 0.072	2.003ArgMet: 2.003 ± 0.038	1.747ArgAsn: 1.747 ± 0.041	3.373ArgPro: 3.373 ± 0.052	2.449ArgGln: 2.449 ± 0.044	4.984ArgArg: 4.984 ± 0.072	3.42ArgSer: 3.42 ± 0.049	3.214ArgThr: 3.214 ± 0.049	4.669ArgVal: 4.669 ± 0.058	0.978ArgTrp: 0.978 ± 0.026	1.671ArgTyr: 1.671 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	5.967SerAla: 5.967 ± 0.064	0.436SerCys: 0.436 ± 0.018	3.69SerAsp: 3.69 ± 0.045	2.997SerGlu: 2.997 ± 0.046	2.306SerPhe: 2.306 ± 0.035	5.444SerGly: 5.444 ± 0.085	1.123SerHis: 1.123 ± 0.029	2.506SerIle: 2.506 ± 0.049	1.478SerLys: 1.478 ± 0.035	5.108SerLeu: 5.108 ± 0.07	1.397SerMet: 1.397 ± 0.03	1.404SerAsn: 1.404 ± 0.029	2.519SerPro: 2.519 ± 0.045	1.701SerGln: 1.701 ± 0.037	3.225SerArg: 3.225 ± 0.047	2.657SerSer: 2.657 ± 0.05	2.61SerThr: 2.61 ± 0.047	3.979SerVal: 3.979 ± 0.06	0.748SerTrp: 0.748 ± 0.026	1.301SerTyr: 1.301 ± 0.028	0.0SerXaa: 0.0 ± 0.0
Thr	6.199ThrAla: 6.199 ± 0.071	0.503ThrCys: 0.503 ± 0.018	3.361ThrAsp: 3.361 ± 0.047	3.175ThrGlu: 3.175 ± 0.052	2.172ThrPhe: 2.172 ± 0.042	5.341ThrGly: 5.341 ± 0.077	1.164ThrHis: 1.164 ± 0.029	2.733ThrIle: 2.733 ± 0.044	1.443ThrLys: 1.443 ± 0.032	6.4ThrLeu: 6.4 ± 0.072	1.301ThrMet: 1.301 ± 0.033	1.293ThrAsn: 1.293 ± 0.034	3.398ThrPro: 3.398 ± 0.049	1.731ThrGln: 1.731 ± 0.038	3.611ThrArg: 3.611 ± 0.05	2.84ThrSer: 2.84 ± 0.05	2.79ThrThr: 2.79 ± 0.051	4.102ThrVal: 4.102 ± 0.062	0.782ThrTrp: 0.782 ± 0.026	1.301ThrTyr: 1.301 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	8.42ValAla: 8.42 ± 0.081	0.623ValCys: 0.623 ± 0.022	4.104ValAsp: 4.104 ± 0.044	4.471ValGlu: 4.471 ± 0.067	3.011ValPhe: 3.011 ± 0.044	5.325ValGly: 5.325 ± 0.077	1.326ValHis: 1.326 ± 0.033	4.15ValIle: 4.15 ± 0.058	1.914ValLys: 1.914 ± 0.041	7.447ValLeu: 7.447 ± 0.087	2.114ValMet: 2.114 ± 0.037	1.856ValAsn: 1.856 ± 0.044	3.623ValPro: 3.623 ± 0.052	2.246ValGln: 2.246 ± 0.044	4.419ValArg: 4.419 ± 0.052	4.354ValSer: 4.354 ± 0.054	4.682ValThr: 4.682 ± 0.062	5.234ValVal: 5.234 ± 0.076	0.941ValTrp: 0.941 ± 0.023	1.443ValTyr: 1.443 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.384TrpAla: 1.384 ± 0.036	0.124TrpCys: 0.124 ± 0.009	0.82TrpAsp: 0.82 ± 0.025	0.649TrpGlu: 0.649 ± 0.019	0.562TrpPhe: 0.562 ± 0.021	1.022TrpGly: 1.022 ± 0.029	0.366TrpHis: 0.366 ± 0.017	0.726TrpIle: 0.726 ± 0.023	0.389TrpLys: 0.389 ± 0.014	1.682TrpLeu: 1.682 ± 0.037	0.421TrpMet: 0.421 ± 0.017	0.415TrpAsn: 0.415 ± 0.016	0.748TrpPro: 0.748 ± 0.022	0.619TrpGln: 0.619 ± 0.021	1.127TrpArg: 1.127 ± 0.031	0.884TrpSer: 0.884 ± 0.024	0.862TrpThr: 0.862 ± 0.023	0.875TrpVal: 0.875 ± 0.026	0.228TrpTrp: 0.228 ± 0.012	0.292TrpTyr: 0.292 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.592TyrAla: 2.592 ± 0.04	0.219TyrCys: 0.219 ± 0.012	1.666TyrAsp: 1.666 ± 0.039	1.266TyrGlu: 1.266 ± 0.033	0.943TyrPhe: 0.943 ± 0.024	2.163TyrGly: 2.163 ± 0.049	0.532TyrHis: 0.532 ± 0.019	0.924TyrIle: 0.924 ± 0.026	0.542TyrLys: 0.542 ± 0.018	2.294TyrLeu: 2.294 ± 0.042	0.499TyrMet: 0.499 ± 0.017	0.55TyrAsn: 0.55 ± 0.02	1.074TyrPro: 1.074 ± 0.027	0.747TyrGln: 0.747 ± 0.025	1.611TyrArg: 1.611 ± 0.036	1.148TyrSer: 1.148 ± 0.029	1.11TyrThr: 1.11 ± 0.03	1.579TyrVal: 1.579 ± 0.035	0.383TyrTrp: 0.383 ± 0.018	0.567TyrTyr: 0.567 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4726 proteins (1495523 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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