Amino acid dipepetide frequency for Simonsiella muelleri ATCC 29453

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.715AlaAla: 9.715 ± 0.178
1.066AlaCys: 1.066 ± 0.041
5.148AlaAsp: 5.148 ± 0.093
5.832AlaGlu: 5.832 ± 0.131
3.396AlaPhe: 3.396 ± 0.07
5.587AlaGly: 5.587 ± 0.124
1.91AlaHis: 1.91 ± 0.064
5.515AlaIle: 5.515 ± 0.107
5.699AlaLys: 5.699 ± 0.115
8.873AlaLeu: 8.873 ± 0.14
2.717AlaMet: 2.717 ± 0.063
4.321AlaAsn: 4.321 ± 0.089
3.234AlaPro: 3.234 ± 0.077
5.39AlaGln: 5.39 ± 0.124
4.041AlaArg: 4.041 ± 0.077
4.306AlaSer: 4.306 ± 0.091
4.669AlaThr: 4.669 ± 0.118
6.231AlaVal: 6.231 ± 0.119
1.192AlaTrp: 1.192 ± 0.047
2.538AlaTyr: 2.538 ± 0.063
0.0AlaXaa: 0.0 ± 0.0
Cys
0.887CysAla: 0.887 ± 0.042
0.156CysCys: 0.156 ± 0.018
0.529CysAsp: 0.529 ± 0.03
0.623CysGlu: 0.623 ± 0.03
0.375CysPhe: 0.375 ± 0.021
0.972CysGly: 0.972 ± 0.044
0.286CysHis: 0.286 ± 0.021
0.456CysIle: 0.456 ± 0.031
0.384CysLys: 0.384 ± 0.025
0.958CysLeu: 0.958 ± 0.043
0.201CysMet: 0.201 ± 0.016
0.332CysAsn: 0.332 ± 0.021
0.422CysPro: 0.422 ± 0.027
0.5CysGln: 0.5 ± 0.029
0.459CysArg: 0.459 ± 0.026
0.487CysSer: 0.487 ± 0.028
0.499CysThr: 0.499 ± 0.028
0.748CysVal: 0.748 ± 0.035
0.103CysTrp: 0.103 ± 0.012
0.328CysTyr: 0.328 ± 0.025
0.0CysXaa: 0.0 ± 0.0
Asp
4.709AspAla: 4.709 ± 0.086
0.52AspCys: 0.52 ± 0.027
3.113AspAsp: 3.113 ± 0.093
3.869AspGlu: 3.869 ± 0.083
2.743AspPhe: 2.743 ± 0.071
3.795AspGly: 3.795 ± 0.089
0.698AspHis: 0.698 ± 0.031
3.268AspIle: 3.268 ± 0.066
3.441AspLys: 3.441 ± 0.078
5.518AspLeu: 5.518 ± 0.123
1.27AspMet: 1.27 ± 0.049
2.793AspAsn: 2.793 ± 0.077
1.52AspPro: 1.52 ± 0.05
1.004AspGln: 1.004 ± 0.048
1.681AspArg: 1.681 ± 0.054
2.766AspSer: 2.766 ± 0.082
2.687AspThr: 2.687 ± 0.072
3.979AspVal: 3.979 ± 0.087
0.963AspTrp: 0.963 ± 0.039
2.075AspTyr: 2.075 ± 0.055
0.0AspXaa: 0.0 ± 0.0
Glu
4.226GluAla: 4.226 ± 0.12
0.567GluCys: 0.567 ± 0.031
2.373GluAsp: 2.373 ± 0.056
2.912GluGlu: 2.912 ± 0.083
2.627GluPhe: 2.627 ± 0.064
2.365GluGly: 2.365 ± 0.075
1.531GluHis: 1.531 ± 0.049
4.528GluIle: 4.528 ± 0.098
4.368GluLys: 4.368 ± 0.09
6.316GluLeu: 6.316 ± 0.128
1.879GluMet: 1.879 ± 0.051
3.957GluAsn: 3.957 ± 0.085
1.844GluPro: 1.844 ± 0.062
3.712GluGln: 3.712 ± 0.09
3.212GluArg: 3.212 ± 0.084
3.077GluSer: 3.077 ± 0.066
3.441GluThr: 3.441 ± 0.08
3.257GluVal: 3.257 ± 0.091
0.857GluTrp: 0.857 ± 0.039
1.817GluTyr: 1.817 ± 0.051
0.0GluXaa: 0.0 ± 0.0
Phe
3.913PheAla: 3.913 ± 0.084
0.505PheCys: 0.505 ± 0.027
2.658PheAsp: 2.658 ± 0.066
2.38PheGlu: 2.38 ± 0.07
1.744PhePhe: 1.744 ± 0.067
3.379PheGly: 3.379 ± 0.084
0.92PheHis: 0.92 ± 0.035
2.545PheIle: 2.545 ± 0.064
2.046PheLys: 2.046 ± 0.057
3.719PheLeu: 3.719 ± 0.084
0.969PheMet: 0.969 ± 0.038
2.092PheAsn: 2.092 ± 0.057
1.505PhePro: 1.505 ± 0.053
1.676PheGln: 1.676 ± 0.061
1.744PheArg: 1.744 ± 0.053
2.911PheSer: 2.911 ± 0.072
2.237PheThr: 2.237 ± 0.058
2.858PheVal: 2.858 ± 0.075
0.567PheTrp: 0.567 ± 0.033
1.362PheTyr: 1.362 ± 0.049
0.0PheXaa: 0.0 ± 0.0
Gly
5.361GlyAla: 5.361 ± 0.111
0.79GlyCys: 0.79 ± 0.036
3.258GlyAsp: 3.258 ± 0.093
3.789GlyGlu: 3.789 ± 0.093
3.145GlyPhe: 3.145 ± 0.079
4.785GlyGly: 4.785 ± 0.124
1.356GlyHis: 1.356 ± 0.051
4.073GlyIle: 4.073 ± 0.088
4.903GlyLys: 4.903 ± 0.096
6.577GlyLeu: 6.577 ± 0.126
1.956GlyMet: 1.956 ± 0.068
3.121GlyAsn: 3.121 ± 0.108
0.648GlyPro: 0.648 ± 0.038
2.509GlyGln: 2.509 ± 0.07
2.817GlyArg: 2.817 ± 0.084
4.412GlySer: 4.412 ± 0.095
3.41GlyThr: 3.41 ± 0.089
5.358GlyVal: 5.358 ± 0.105
0.916GlyTrp: 0.916 ± 0.047
2.247GlyTyr: 2.247 ± 0.056
0.0GlyXaa: 0.0 ± 0.0
His
2.012HisAla: 2.012 ± 0.058
0.255HisCys: 0.255 ± 0.018
1.315HisAsp: 1.315 ± 0.05
1.431HisGlu: 1.431 ± 0.05
1.15HisPhe: 1.15 ± 0.04
1.626HisGly: 1.626 ± 0.054
0.75HisHis: 0.75 ± 0.04
1.749HisIle: 1.749 ± 0.062
1.052HisLys: 1.052 ± 0.041
2.235HisLeu: 2.235 ± 0.065
0.449HisMet: 0.449 ± 0.026
1.102HisAsn: 1.102 ± 0.045
0.967HisPro: 0.967 ± 0.043
1.215HisGln: 1.215 ± 0.051
0.991HisArg: 0.991 ± 0.038
1.215HisSer: 1.215 ± 0.049
1.354HisThr: 1.354 ± 0.048
1.177HisVal: 1.177 ± 0.039
0.329HisTrp: 0.329 ± 0.025
0.852HisTyr: 0.852 ± 0.035
0.0HisXaa: 0.0 ± 0.0
Ile
6.127IleAla: 6.127 ± 0.115
0.689IleCys: 0.689 ± 0.035
3.727IleAsp: 3.727 ± 0.087
3.92IleGlu: 3.92 ± 0.082
2.453IlePhe: 2.453 ± 0.073
4.51IleGly: 4.51 ± 0.104
1.487IleHis: 1.487 ± 0.052
3.774IleIle: 3.774 ± 0.095
3.485IleLys: 3.485 ± 0.083
5.985IleLeu: 5.985 ± 0.116
1.433IleMet: 1.433 ± 0.053
3.252IleAsn: 3.252 ± 0.076
2.501IlePro: 2.501 ± 0.063
3.125IleGln: 3.125 ± 0.089
3.021IleArg: 3.021 ± 0.077
3.975IleSer: 3.975 ± 0.089
3.748IleThr: 3.748 ± 0.092
4.082IleVal: 4.082 ± 0.077
0.765IleTrp: 0.765 ± 0.038
1.918IleTyr: 1.918 ± 0.055
0.0IleXaa: 0.0 ± 0.0
Lys
4.558LysAla: 4.558 ± 0.112
0.292LysCys: 0.292 ± 0.02
2.757LysAsp: 2.757 ± 0.075
2.853LysGlu: 2.853 ± 0.077
2.045LysPhe: 2.045 ± 0.055
3.135LysGly: 3.135 ± 0.076
1.27LysHis: 1.27 ± 0.042
4.422LysIle: 4.422 ± 0.096
3.667LysLys: 3.667 ± 0.096
5.974LysLeu: 5.974 ± 0.11
1.977LysMet: 1.977 ± 0.054
3.68LysAsn: 3.68 ± 0.087
2.586LysPro: 2.586 ± 0.084
3.34LysGln: 3.34 ± 0.071
2.9LysArg: 2.9 ± 0.073
3.281LysSer: 3.281 ± 0.079
3.546LysThr: 3.546 ± 0.087
3.175LysVal: 3.175 ± 0.084
0.65LysTrp: 0.65 ± 0.031
1.703LysTyr: 1.703 ± 0.05
0.0LysXaa: 0.0 ± 0.0
Leu
10.108LeuAla: 10.108 ± 0.148
0.964LeuCys: 0.964 ± 0.034
5.332LeuAsp: 5.332 ± 0.103
4.809LeuGlu: 4.809 ± 0.094
3.996LeuPhe: 3.996 ± 0.086
6.491LeuGly: 6.491 ± 0.132
2.216LeuHis: 2.216 ± 0.059
6.135LeuIle: 6.135 ± 0.122
5.87LeuLys: 5.87 ± 0.106
9.786LeuLeu: 9.786 ± 0.168
2.749LeuMet: 2.749 ± 0.07
5.477LeuAsn: 5.477 ± 0.102
5.654LeuPro: 5.654 ± 0.107
4.46LeuGln: 4.46 ± 0.098
4.788LeuArg: 4.788 ± 0.093
6.682LeuSer: 6.682 ± 0.103
5.385LeuThr: 5.385 ± 0.094
5.751LeuVal: 5.751 ± 0.112
1.069LeuTrp: 1.069 ± 0.046
2.509LeuTyr: 2.509 ± 0.07
0.0LeuXaa: 0.0 ± 0.0
Met
2.524MetAla: 2.524 ± 0.071
0.221MetCys: 0.221 ± 0.02
1.061MetAsp: 1.061 ± 0.041
1.112MetGlu: 1.112 ± 0.041
0.889MetPhe: 0.889 ± 0.034
1.874MetGly: 1.874 ± 0.065
0.493MetHis: 0.493 ± 0.024
1.652MetIle: 1.652 ± 0.056
1.678MetLys: 1.678 ± 0.055
2.705MetLeu: 2.705 ± 0.072
0.913MetMet: 0.913 ± 0.042
1.514MetAsn: 1.514 ± 0.046
1.208MetPro: 1.208 ± 0.041
1.377MetGln: 1.377 ± 0.048
1.357MetArg: 1.357 ± 0.044
1.696MetSer: 1.696 ± 0.053
1.469MetThr: 1.469 ± 0.045
1.7MetVal: 1.7 ± 0.058
0.258MetTrp: 0.258 ± 0.02
0.541MetTyr: 0.541 ± 0.031
0.0MetXaa: 0.0 ± 0.0
Asn
4.295AsnAla: 4.295 ± 0.089
0.425AsnCys: 0.425 ± 0.026
2.565AsnAsp: 2.565 ± 0.074
2.914AsnGlu: 2.914 ± 0.078
1.786AsnPhe: 1.786 ± 0.063
3.662AsnGly: 3.662 ± 0.094
1.433AsnHis: 1.433 ± 0.05
3.42AsnIle: 3.42 ± 0.081
2.74AsnLys: 2.74 ± 0.083
4.65AsnLeu: 4.65 ± 0.098
1.233AsnMet: 1.233 ± 0.042
2.609AsnAsn: 2.609 ± 0.076
2.737AsnPro: 2.737 ± 0.073
3.369AsnGln: 3.369 ± 0.089
2.32AsnArg: 2.32 ± 0.055
2.637AsnSer: 2.637 ± 0.066
2.98AsnThr: 2.98 ± 0.072
3.18AsnVal: 3.18 ± 0.08
0.772AsnTrp: 0.772 ± 0.035
1.684AsnTyr: 1.684 ± 0.052
0.0AsnXaa: 0.0 ± 0.0
Pro
3.073ProAla: 3.073 ± 0.075
0.328ProCys: 0.328 ± 0.022
2.334ProAsp: 2.334 ± 0.064
4.04ProGlu: 4.04 ± 0.087
1.744ProPhe: 1.744 ± 0.053
0.887ProGly: 0.887 ± 0.044
1.052ProHis: 1.052 ± 0.042
2.733ProIle: 2.733 ± 0.069
2.424ProLys: 2.424 ± 0.072
3.472ProLeu: 3.472 ± 0.082
0.982ProMet: 0.982 ± 0.037
2.527ProAsn: 2.527 ± 0.061
1.374ProPro: 1.374 ± 0.053
1.88ProGln: 1.88 ± 0.047
1.554ProArg: 1.554 ± 0.046
2.03ProSer: 2.03 ± 0.06
2.562ProThr: 2.562 ± 0.074
2.698ProVal: 2.698 ± 0.075
0.299ProTrp: 0.299 ± 0.022
1.316ProTyr: 1.316 ± 0.05
0.0ProXaa: 0.0 ± 0.0
Gln
5.299GlnAla: 5.299 ± 0.107
0.325GlnCys: 0.325 ± 0.025
2.104GlnAsp: 2.104 ± 0.065
2.438GlnGlu: 2.438 ± 0.069
2.155GlnPhe: 2.155 ± 0.062
2.639GlnGly: 2.639 ± 0.067
1.338GlnHis: 1.338 ± 0.049
3.81GlnIle: 3.81 ± 0.072
2.905GlnLys: 2.905 ± 0.08
4.663GlnLeu: 4.663 ± 0.099
1.325GlnMet: 1.325 ± 0.048
3.074GlnAsn: 3.074 ± 0.073
2.355GlnPro: 2.355 ± 0.063
3.181GlnGln: 3.181 ± 0.109
2.331GlnArg: 2.331 ± 0.059
3.074GlnSer: 3.074 ± 0.069
3.233GlnThr: 3.233 ± 0.075
2.669GlnVal: 2.669 ± 0.069
0.626GlnTrp: 0.626 ± 0.033
1.691GlnTyr: 1.691 ± 0.047
0.0GlnXaa: 0.0 ± 0.0
Arg
3.76ArgAla: 3.76 ± 0.089
0.372ArgCys: 0.372 ± 0.024
2.568ArgAsp: 2.568 ± 0.066
3.357ArgGlu: 3.357 ± 0.079
2.12ArgPhe: 2.12 ± 0.057
2.843ArgGly: 2.843 ± 0.071
1.164ArgHis: 1.164 ± 0.039
2.89ArgIle: 2.89 ± 0.066
2.462ArgLys: 2.462 ± 0.065
4.986ArgLeu: 4.986 ± 0.102
1.203ArgMet: 1.203 ± 0.042
1.975ArgAsn: 1.975 ± 0.048
1.629ArgPro: 1.629 ± 0.051
2.725ArgGln: 2.725 ± 0.069
2.169ArgArg: 2.169 ± 0.062
2.149ArgSer: 2.149 ± 0.057
2.164ArgThr: 2.164 ± 0.069
3.322ArgVal: 3.322 ± 0.071
0.508ArgTrp: 0.508 ± 0.028
1.724ArgTyr: 1.724 ± 0.047
0.0ArgXaa: 0.0 ± 0.0
Ser
4.93SerAla: 4.93 ± 0.1
0.54SerCys: 0.54 ± 0.034
3.089SerAsp: 3.089 ± 0.075
3.342SerGlu: 3.342 ± 0.081
2.211SerPhe: 2.211 ± 0.06
5.451SerGly: 5.451 ± 0.107
1.393SerHis: 1.393 ± 0.046
3.275SerIle: 3.275 ± 0.08
2.819SerLys: 2.819 ± 0.07
6.082SerLeu: 6.082 ± 0.108
1.306SerMet: 1.306 ± 0.047
2.621SerAsn: 2.621 ± 0.069
2.305SerPro: 2.305 ± 0.062
2.773SerGln: 2.773 ± 0.074
2.616SerArg: 2.616 ± 0.073
3.249SerSer: 3.249 ± 0.082
2.813SerThr: 2.813 ± 0.067
3.993SerVal: 3.993 ± 0.078
0.641SerTrp: 0.641 ± 0.032
1.617SerTyr: 1.617 ± 0.053
0.0SerXaa: 0.0 ± 0.0
Thr
5.238ThrAla: 5.238 ± 0.129
0.435ThrCys: 0.435 ± 0.027
2.924ThrAsp: 2.924 ± 0.074
3.249ThrGlu: 3.249 ± 0.071
2.098ThrPhe: 2.098 ± 0.062
3.898ThrGly: 3.898 ± 0.094
1.413ThrHis: 1.413 ± 0.045
3.287ThrIle: 3.287 ± 0.07
2.518ThrLys: 2.518 ± 0.066
5.757ThrLeu: 5.757 ± 0.106
1.07ThrMet: 1.07 ± 0.043
2.259ThrAsn: 2.259 ± 0.066
2.983ThrPro: 2.983 ± 0.067
3.008ThrGln: 3.008 ± 0.08
2.482ThrArg: 2.482 ± 0.068
2.668ThrSer: 2.668 ± 0.075
3.116ThrThr: 3.116 ± 0.1
4.084ThrVal: 4.084 ± 0.09
0.597ThrTrp: 0.597 ± 0.032
1.452ThrTyr: 1.452 ± 0.057
0.0ThrXaa: 0.0 ± 0.0
Val
6.698ValAla: 6.698 ± 0.106
0.774ValCys: 0.774 ± 0.036
3.302ValAsp: 3.302 ± 0.074
3.795ValGlu: 3.795 ± 0.086
2.717ValPhe: 2.717 ± 0.069
4.682ValGly: 4.682 ± 0.093
1.335ValHis: 1.335 ± 0.046
4.061ValIle: 4.061 ± 0.087
3.543ValLys: 3.543 ± 0.099
6.809ValLeu: 6.809 ± 0.127
1.817ValMet: 1.817 ± 0.057
3.101ValAsn: 3.101 ± 0.087
2.352ValPro: 2.352 ± 0.053
2.971ValGln: 2.971 ± 0.063
3.044ValArg: 3.044 ± 0.071
4.279ValSer: 4.279 ± 0.097
2.896ValThr: 2.896 ± 0.096
4.876ValVal: 4.876 ± 0.109
0.842ValTrp: 0.842 ± 0.04
1.993ValTyr: 1.993 ± 0.063
0.0ValXaa: 0.0 ± 0.0
Trp
1.099TrpAla: 1.099 ± 0.04
0.142TrpCys: 0.142 ± 0.013
0.556TrpAsp: 0.556 ± 0.029
0.535TrpGlu: 0.535 ± 0.031
0.653TrpPhe: 0.653 ± 0.038
0.722TrpGly: 0.722 ± 0.038
0.375TrpHis: 0.375 ± 0.025
0.71TrpIle: 0.71 ± 0.033
0.562TrpLys: 0.562 ± 0.032
1.874TrpLeu: 1.874 ± 0.066
0.181TrpMet: 0.181 ± 0.017
0.408TrpAsn: 0.408 ± 0.027
0.08TrpPro: 0.08 ± 0.011
1.233TrpGln: 1.233 ± 0.052
0.803TrpArg: 0.803 ± 0.042
0.514TrpSer: 0.514 ± 0.033
0.577TrpThr: 0.577 ± 0.031
0.923TrpVal: 0.923 ± 0.044
0.199TrpTrp: 0.199 ± 0.016
0.438TrpTyr: 0.438 ± 0.035
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.85TyrAla: 2.85 ± 0.076
0.34TyrCys: 0.34 ± 0.022
1.699TyrAsp: 1.699 ± 0.053
1.662TyrGlu: 1.662 ± 0.048
1.684TyrPhe: 1.684 ± 0.056
2.126TyrGly: 2.126 ± 0.056
0.81TyrHis: 0.81 ± 0.034
1.676TyrIle: 1.676 ± 0.055
1.245TyrLys: 1.245 ± 0.044
3.29TyrLeu: 3.29 ± 0.079
0.611TyrMet: 0.611 ± 0.03
1.195TyrAsn: 1.195 ± 0.045
1.403TyrPro: 1.403 ± 0.046
1.785TyrGln: 1.785 ± 0.056
1.761TyrArg: 1.761 ± 0.058
1.659TyrSer: 1.659 ± 0.049
1.752TyrThr: 1.752 ± 0.053
1.824TyrVal: 1.824 ± 0.054
0.434TyrTrp: 0.434 ± 0.029
1.058TyrTyr: 1.058 ± 0.05
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2220 proteins (661657 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski