Amino acid dipepetide frequency for Alistipes sp. CHKCI003

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.216AlaAla: 13.216 ± 0.25	1.317AlaCys: 1.317 ± 0.047	6.145AlaAsp: 6.145 ± 0.087	7.636AlaGlu: 7.636 ± 0.111	3.589AlaPhe: 3.589 ± 0.068	8.444AlaGly: 8.444 ± 0.136	1.537AlaHis: 1.537 ± 0.046	4.262AlaIle: 4.262 ± 0.087	3.755AlaLys: 3.755 ± 0.089	8.737AlaLeu: 8.737 ± 0.124	2.286AlaMet: 2.286 ± 0.058	2.596AlaAsn: 2.596 ± 0.059	3.937AlaPro: 3.937 ± 0.089	3.058AlaGln: 3.058 ± 0.071	6.344AlaArg: 6.344 ± 0.106	5.252AlaSer: 5.252 ± 0.092	4.346AlaThr: 4.346 ± 0.084	7.668AlaVal: 7.668 ± 0.122	1.046AlaTrp: 1.046 ± 0.042	2.929AlaTyr: 2.929 ± 0.07	0.0AlaXaa: 0.0 ± 0.0
Cys	1.298CysAla: 1.298 ± 0.043	0.332CysCys: 0.332 ± 0.024	0.834CysAsp: 0.834 ± 0.031	0.775CysGlu: 0.775 ± 0.031	0.592CysPhe: 0.592 ± 0.032	1.575CysGly: 1.575 ± 0.055	0.219CysHis: 0.219 ± 0.016	0.747CysIle: 0.747 ± 0.031	0.484CysLys: 0.484 ± 0.023	0.974CysLeu: 0.974 ± 0.037	0.293CysMet: 0.293 ± 0.017	0.479CysAsn: 0.479 ± 0.025	0.715CysPro: 0.715 ± 0.03	0.212CysGln: 0.212 ± 0.016	1.316CysArg: 1.316 ± 0.059	0.874CysSer: 0.874 ± 0.036	0.821CysThr: 0.821 ± 0.036	0.925CysVal: 0.925 ± 0.033	0.148CysTrp: 0.148 ± 0.013	0.484CysTyr: 0.484 ± 0.026	0.0CysXaa: 0.0 ± 0.0
Asp	5.399AspAla: 5.399 ± 0.082	0.731AspCys: 0.731 ± 0.034	3.225AspAsp: 3.225 ± 0.079	4.032AspGlu: 4.032 ± 0.079	2.753AspPhe: 2.753 ± 0.063	4.791AspGly: 4.791 ± 0.084	0.835AspHis: 0.835 ± 0.037	3.226AspIle: 3.226 ± 0.073	2.63AspLys: 2.63 ± 0.068	4.674AspLeu: 4.674 ± 0.084	1.352AspMet: 1.352 ± 0.043	1.974AspAsn: 1.974 ± 0.054	2.701AspPro: 2.701 ± 0.061	0.89AspGln: 0.89 ± 0.033	4.596AspArg: 4.596 ± 0.078	2.838AspSer: 2.838 ± 0.068	2.964AspThr: 2.964 ± 0.065	3.471AspVal: 3.471 ± 0.075	0.709AspTrp: 0.709 ± 0.034	2.656AspTyr: 2.656 ± 0.063	0.0AspXaa: 0.0 ± 0.0
Glu	6.659GluAla: 6.659 ± 0.1	0.761GluCys: 0.761 ± 0.033	2.612GluAsp: 2.612 ± 0.063	4.65GluGlu: 4.65 ± 0.092	2.453GluPhe: 2.453 ± 0.056	4.615GluGly: 4.615 ± 0.083	1.297GluHis: 1.297 ± 0.042	4.113GluIle: 4.113 ± 0.08	3.661GluLys: 3.661 ± 0.079	6.239GluLeu: 6.239 ± 0.107	1.829GluMet: 1.829 ± 0.048	2.565GluAsn: 2.565 ± 0.064	2.461GluPro: 2.461 ± 0.066	2.446GluGln: 2.446 ± 0.061	5.594GluArg: 5.594 ± 0.096	3.056GluSer: 3.056 ± 0.058	3.727GluThr: 3.727 ± 0.067	4.261GluVal: 4.261 ± 0.073	0.799GluTrp: 0.799 ± 0.029	2.61GluTyr: 2.61 ± 0.063	0.0GluXaa: 0.0 ± 0.0
Phe	4.15PheAla: 4.15 ± 0.075	0.593PheCys: 0.593 ± 0.028	3.047PheAsp: 3.047 ± 0.062	2.453PheGlu: 2.453 ± 0.053	1.888PhePhe: 1.888 ± 0.057	3.668PheGly: 3.668 ± 0.079	0.69PheHis: 0.69 ± 0.03	2.126PheIle: 2.126 ± 0.05	1.438PheLys: 1.438 ± 0.048	3.419PheLeu: 3.419 ± 0.076	0.974PheMet: 0.974 ± 0.038	1.437PheAsn: 1.437 ± 0.051	1.709PhePro: 1.709 ± 0.051	0.856PheGln: 0.856 ± 0.032	3.266PheArg: 3.266 ± 0.069	2.706PheSer: 2.706 ± 0.062	2.574PheThr: 2.574 ± 0.059	3.024PheVal: 3.024 ± 0.068	0.454PheTrp: 0.454 ± 0.026	1.615PheTyr: 1.615 ± 0.048	0.0PheXaa: 0.0 ± 0.0
Gly	6.83GlyAla: 6.83 ± 0.128	1.328GlyCys: 1.328 ± 0.048	4.026GlyAsp: 4.026 ± 0.086	4.782GlyGlu: 4.782 ± 0.072	3.302GlyPhe: 3.302 ± 0.069	6.331GlyGly: 6.331 ± 0.111	1.346GlyHis: 1.346 ± 0.039	4.902GlyIle: 4.902 ± 0.095	3.655GlyLys: 3.655 ± 0.079	6.261GlyLeu: 6.261 ± 0.089	2.052GlyMet: 2.052 ± 0.053	2.62GlyAsn: 2.62 ± 0.072	1.998GlyPro: 1.998 ± 0.057	1.923GlyGln: 1.923 ± 0.059	6.109GlyArg: 6.109 ± 0.125	4.46GlySer: 4.46 ± 0.073	4.752GlyThr: 4.752 ± 0.076	5.277GlyVal: 5.277 ± 0.086	1.024GlyTrp: 1.024 ± 0.036	3.093GlyTyr: 3.093 ± 0.073	0.0GlyXaa: 0.0 ± 0.0
His	1.602HisAla: 1.602 ± 0.047	0.302HisCys: 0.302 ± 0.02	1.023HisAsp: 1.023 ± 0.042	1.018HisGlu: 1.018 ± 0.036	0.867HisPhe: 0.867 ± 0.032	1.292HisGly: 1.292 ± 0.042	0.391HisHis: 0.391 ± 0.021	1.148HisIle: 1.148 ± 0.04	0.76HisLys: 0.76 ± 0.033	1.557HisLeu: 1.557 ± 0.039	0.362HisMet: 0.362 ± 0.02	0.682HisAsn: 0.682 ± 0.033	1.12HisPro: 1.12 ± 0.042	0.339HisGln: 0.339 ± 0.022	1.478HisArg: 1.478 ± 0.052	0.921HisSer: 0.921 ± 0.037	1.164HisThr: 1.164 ± 0.043	0.95HisVal: 0.95 ± 0.036	0.184HisTrp: 0.184 ± 0.014	0.744HisTyr: 0.744 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	5.897IleAla: 5.897 ± 0.091	0.726IleCys: 0.726 ± 0.034	3.814IleAsp: 3.814 ± 0.078	4.121IleGlu: 4.121 ± 0.08	2.209IlePhe: 2.209 ± 0.063	4.426IleGly: 4.426 ± 0.094	1.01IleHis: 1.01 ± 0.032	2.574IleIle: 2.574 ± 0.074	2.148IleLys: 2.148 ± 0.063	4.789IleLeu: 4.789 ± 0.103	0.99IleMet: 0.99 ± 0.033	1.789IleAsn: 1.789 ± 0.06	2.775IlePro: 2.775 ± 0.059	1.217IleGln: 1.217 ± 0.042	4.431IleArg: 4.431 ± 0.08	3.028IleSer: 3.028 ± 0.068	3.123IleThr: 3.123 ± 0.065	4.485IleVal: 4.485 ± 0.086	0.452IleTrp: 0.452 ± 0.024	2.009IleTyr: 2.009 ± 0.059	0.0IleXaa: 0.0 ± 0.0
Lys	3.867LysAla: 3.867 ± 0.09	0.467LysCys: 0.467 ± 0.025	2.131LysAsp: 2.131 ± 0.06	3.169LysGlu: 3.169 ± 0.083	1.615LysPhe: 1.615 ± 0.049	3.136LysGly: 3.136 ± 0.074	0.855LysHis: 0.855 ± 0.037	3.049LysIle: 3.049 ± 0.069	2.609LysLys: 2.609 ± 0.074	3.748LysLeu: 3.748 ± 0.082	1.466LysMet: 1.466 ± 0.048	1.945LysAsn: 1.945 ± 0.051	1.876LysPro: 1.876 ± 0.057	1.532LysGln: 1.532 ± 0.047	3.195LysArg: 3.195 ± 0.07	2.587LysSer: 2.587 ± 0.058	2.818LysThr: 2.818 ± 0.068	2.862LysVal: 2.862 ± 0.059	0.473LysTrp: 0.473 ± 0.027	1.905LysTyr: 1.905 ± 0.051	0.0LysXaa: 0.0 ± 0.0
Leu	8.633LeuAla: 8.633 ± 0.125	1.49LeuCys: 1.49 ± 0.046	4.876LeuAsp: 4.876 ± 0.093	4.961LeuGlu: 4.961 ± 0.092	4.321LeuPhe: 4.321 ± 0.088	6.244LeuGly: 6.244 ± 0.108	1.828LeuHis: 1.828 ± 0.054	4.259LeuIle: 4.259 ± 0.088	3.877LeuLys: 3.877 ± 0.081	8.886LeuLeu: 8.886 ± 0.16	2.166LeuMet: 2.166 ± 0.059	2.865LeuAsn: 2.865 ± 0.065	4.39LeuPro: 4.39 ± 0.083	2.517LeuGln: 2.517 ± 0.059	7.476LeuArg: 7.476 ± 0.127	6.045LeuSer: 6.045 ± 0.105	5.182LeuThr: 5.182 ± 0.083	5.394LeuVal: 5.394 ± 0.094	0.995LeuTrp: 0.995 ± 0.035	3.118LeuTyr: 3.118 ± 0.065	0.0LeuXaa: 0.0 ± 0.0
Met	2.114MetAla: 2.114 ± 0.062	0.269MetCys: 0.269 ± 0.019	1.256MetAsp: 1.256 ± 0.041	1.537MetGlu: 1.537 ± 0.043	0.866MetPhe: 0.866 ± 0.036	1.616MetGly: 1.616 ± 0.048	0.449MetHis: 0.449 ± 0.026	1.337MetIle: 1.337 ± 0.044	1.799MetLys: 1.799 ± 0.051	2.307MetLeu: 2.307 ± 0.054	0.66MetMet: 0.66 ± 0.026	1.073MetAsn: 1.073 ± 0.043	1.338MetPro: 1.338 ± 0.038	1.014MetGln: 1.014 ± 0.037	1.985MetArg: 1.985 ± 0.049	1.402MetSer: 1.402 ± 0.045	1.543MetThr: 1.543 ± 0.042	1.307MetVal: 1.307 ± 0.045	0.238MetTrp: 0.238 ± 0.018	0.648MetTyr: 0.648 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	3.079AsnAla: 3.079 ± 0.071	0.437AsnCys: 0.437 ± 0.027	1.921AsnAsp: 1.921 ± 0.053	2.023AsnGlu: 2.023 ± 0.055	1.457AsnPhe: 1.457 ± 0.044	2.833AsnGly: 2.833 ± 0.064	0.6AsnHis: 0.6 ± 0.028	2.456AsnIle: 2.456 ± 0.066	1.568AsnLys: 1.568 ± 0.053	3.169AsnLeu: 3.169 ± 0.073	0.859AsnMet: 0.859 ± 0.033	1.368AsnAsn: 1.368 ± 0.049	1.941AsnPro: 1.941 ± 0.057	0.782AsnGln: 0.782 ± 0.031	2.607AsnArg: 2.607 ± 0.057	1.727AsnSer: 1.727 ± 0.056	1.893AsnThr: 1.893 ± 0.054	2.307AsnVal: 2.307 ± 0.057	0.357AsnTrp: 0.357 ± 0.023	1.462AsnTyr: 1.462 ± 0.042	0.0AsnXaa: 0.0 ± 0.0
Pro	5.212ProAla: 5.212 ± 0.111	0.593ProCys: 0.593 ± 0.026	3.2ProAsp: 3.2 ± 0.07	3.877ProGlu: 3.877 ± 0.069	1.766ProPhe: 1.766 ± 0.041	2.466ProGly: 2.466 ± 0.061	0.958ProHis: 0.958 ± 0.04	1.933ProIle: 1.933 ± 0.058	1.795ProLys: 1.795 ± 0.051	3.755ProLeu: 3.755 ± 0.071	1.033ProMet: 1.033 ± 0.04	1.289ProAsn: 1.289 ± 0.042	1.74ProPro: 1.74 ± 0.064	1.57ProGln: 1.57 ± 0.048	2.676ProArg: 2.676 ± 0.076	2.659ProSer: 2.659 ± 0.066	2.058ProThr: 2.058 ± 0.049	3.588ProVal: 3.588 ± 0.077	0.411ProTrp: 0.411 ± 0.025	1.606ProTyr: 1.606 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	2.303GlnAla: 2.303 ± 0.057	0.302GlnCys: 0.302 ± 0.02	1.13GlnAsp: 1.13 ± 0.037	1.705GlnGlu: 1.705 ± 0.057	1.063GlnPhe: 1.063 ± 0.044	1.759GlnGly: 1.759 ± 0.057	0.556GlnHis: 0.556 ± 0.028	1.994GlnIle: 1.994 ± 0.059	1.614GlnLys: 1.614 ± 0.051	2.516GlnLeu: 2.516 ± 0.054	0.809GlnMet: 0.809 ± 0.033	1.23GlnAsn: 1.23 ± 0.047	1.307GlnPro: 1.307 ± 0.036	1.256GlnGln: 1.256 ± 0.057	2.069GlnArg: 2.069 ± 0.051	1.676GlnSer: 1.676 ± 0.045	1.925GlnThr: 1.925 ± 0.05	1.552GlnVal: 1.552 ± 0.047	0.318GlnTrp: 0.318 ± 0.021	1.153GlnTyr: 1.153 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	5.657ArgAla: 5.657 ± 0.112	1.034ArgCys: 1.034 ± 0.041	3.357ArgAsp: 3.357 ± 0.062	4.911ArgGlu: 4.911 ± 0.092	3.39ArgPhe: 3.39 ± 0.077	4.339ArgGly: 4.339 ± 0.087	1.495ArgHis: 1.495 ± 0.057	5.667ArgIle: 5.667 ± 0.096	3.639ArgLys: 3.639 ± 0.078	6.868ArgLeu: 6.868 ± 0.123	2.401ArgMet: 2.401 ± 0.053	2.978ArgAsn: 2.978 ± 0.06	3.485ArgPro: 3.485 ± 0.08	2.445ArgGln: 2.445 ± 0.072	6.961ArgArg: 6.961 ± 0.152	4.541ArgSer: 4.541 ± 0.104	4.96ArgThr: 4.96 ± 0.101	3.742ArgVal: 3.742 ± 0.076	0.884ArgTrp: 0.884 ± 0.039	2.934ArgTyr: 2.934 ± 0.061	0.001ArgXaa: 0.001 ± 0.001
Ser	5.659SerAla: 5.659 ± 0.099	0.874SerCys: 0.874 ± 0.036	3.475SerAsp: 3.475 ± 0.077	3.575SerGlu: 3.575 ± 0.07	2.616SerPhe: 2.616 ± 0.056	5.287SerGly: 5.287 ± 0.092	0.939SerHis: 0.939 ± 0.035	2.957SerIle: 2.957 ± 0.068	2.441SerLys: 2.441 ± 0.064	5.294SerLeu: 5.294 ± 0.084	1.318SerMet: 1.318 ± 0.04	1.861SerAsn: 1.861 ± 0.055	2.496SerPro: 2.496 ± 0.059	1.5SerGln: 1.5 ± 0.05	3.598SerArg: 3.598 ± 0.061	3.311SerSer: 3.311 ± 0.081	2.724SerThr: 2.724 ± 0.058	4.453SerVal: 4.453 ± 0.077	0.597SerTrp: 0.597 ± 0.029	2.253SerTyr: 2.253 ± 0.059	0.0SerXaa: 0.0 ± 0.0
Thr	5.733ThrAla: 5.733 ± 0.104	0.581ThrCys: 0.581 ± 0.027	3.505ThrAsp: 3.505 ± 0.08	3.595ThrGlu: 3.595 ± 0.073	2.31ThrPhe: 2.31 ± 0.055	4.654ThrGly: 4.654 ± 0.08	0.975ThrHis: 0.975 ± 0.037	3.218ThrIle: 3.218 ± 0.071	2.11ThrLys: 2.11 ± 0.06	5.572ThrLeu: 5.572 ± 0.095	1.133ThrMet: 1.133 ± 0.042	1.685ThrAsn: 1.685 ± 0.051	3.112ThrPro: 3.112 ± 0.065	1.55ThrGln: 1.55 ± 0.05	2.894ThrArg: 2.894 ± 0.065	2.91ThrSer: 2.91 ± 0.069	3.111ThrThr: 3.111 ± 0.072	4.607ThrVal: 4.607 ± 0.095	0.546ThrTrp: 0.546 ± 0.026	1.964ThrTyr: 1.964 ± 0.055	0.001ThrXaa: 0.001 ± 0.001
Val	6.618ValAla: 6.618 ± 0.11	1.237ValCys: 1.237 ± 0.042	3.643ValAsp: 3.643 ± 0.075	4.59ValGlu: 4.59 ± 0.077	2.789ValPhe: 2.789 ± 0.052	4.816ValGly: 4.816 ± 0.095	1.08ValHis: 1.08 ± 0.039	3.327ValIle: 3.327 ± 0.081	3.203ValLys: 3.203 ± 0.07	6.157ValLeu: 6.157 ± 0.098	1.612ValMet: 1.612 ± 0.048	2.321ValAsn: 2.321 ± 0.058	3.167ValPro: 3.167 ± 0.071	1.948ValGln: 1.948 ± 0.053	5.593ValArg: 5.593 ± 0.093	4.52ValSer: 4.52 ± 0.079	3.127ValThr: 3.127 ± 0.067	5.689ValVal: 5.689 ± 0.114	0.834ValTrp: 0.834 ± 0.03	2.373ValTyr: 2.373 ± 0.055	0.003ValXaa: 0.003 ± 0.002
Trp	0.799TrpAla: 0.799 ± 0.033	0.2TrpCys: 0.2 ± 0.016	0.565TrpAsp: 0.565 ± 0.026	0.657TrpGlu: 0.657 ± 0.027	0.532TrpPhe: 0.532 ± 0.027	0.866TrpGly: 0.866 ± 0.035	0.215TrpHis: 0.215 ± 0.018	0.736TrpIle: 0.736 ± 0.035	0.468TrpLys: 0.468 ± 0.028	1.135TrpLeu: 1.135 ± 0.041	0.334TrpMet: 0.334 ± 0.02	0.507TrpAsn: 0.507 ± 0.027	0.25TrpPro: 0.25 ± 0.015	0.401TrpGln: 0.401 ± 0.021	0.859TrpArg: 0.859 ± 0.033	0.665TrpSer: 0.665 ± 0.03	0.646TrpThr: 0.646 ± 0.03	0.628TrpVal: 0.628 ± 0.029	0.192TrpTrp: 0.192 ± 0.017	0.409TrpTyr: 0.409 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.376TyrAla: 3.376 ± 0.064	0.523TyrCys: 0.523 ± 0.023	2.664TyrAsp: 2.664 ± 0.062	2.342TyrGlu: 2.342 ± 0.058	1.707TyrPhe: 1.707 ± 0.055	2.913TyrGly: 2.913 ± 0.053	0.631TyrHis: 0.631 ± 0.029	1.984TyrIle: 1.984 ± 0.055	1.649TyrLys: 1.649 ± 0.046	3.461TyrLeu: 3.461 ± 0.071	0.831TyrMet: 0.831 ± 0.031	1.581TyrAsn: 1.581 ± 0.055	1.665TyrPro: 1.665 ± 0.053	0.782TyrGln: 0.782 ± 0.041	2.641TyrArg: 2.641 ± 0.065	2.048TyrSer: 2.048 ± 0.058	2.307TyrThr: 2.307 ± 0.063	2.456TyrVal: 2.456 ± 0.054	0.406TyrTrp: 0.406 ± 0.022	1.632TyrTyr: 1.632 ± 0.053	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.001	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.001XaaThr: 0.001 ± 0.001	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.025XaaXaa: 0.025 ± 0.016

Statistics based on 2504 proteins (798870 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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