Amino acid dipepetide frequency for Moraxella phage Mcat4

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.816AlaAla: 2.816 ± 0.582
0.704AlaCys: 0.704 ± 0.288
5.163AlaAsp: 5.163 ± 0.716
3.129AlaGlu: 3.129 ± 0.424
3.364AlaPhe: 3.364 ± 0.513
4.537AlaGly: 4.537 ± 0.728
1.799AlaHis: 1.799 ± 0.454
5.789AlaIle: 5.789 ± 0.638
7.745AlaLys: 7.745 ± 0.822
7.354AlaLeu: 7.354 ± 0.788
2.894AlaMet: 2.894 ± 0.574
4.616AlaAsn: 4.616 ± 0.772
2.582AlaPro: 2.582 ± 0.511
4.146AlaGln: 4.146 ± 0.621
3.442AlaArg: 3.442 ± 0.568
6.493AlaSer: 6.493 ± 0.961
5.945AlaThr: 5.945 ± 1.118
6.571AlaVal: 6.571 ± 0.676
1.956AlaTrp: 1.956 ± 0.38
3.051AlaTyr: 3.051 ± 0.42
0.0AlaXaa: 0.0 ± 0.0
Cys
0.548CysAla: 0.548 ± 0.235
0.235CysCys: 0.235 ± 0.13
0.626CysAsp: 0.626 ± 0.186
0.626CysGlu: 0.626 ± 0.243
0.391CysPhe: 0.391 ± 0.189
1.017CysGly: 1.017 ± 0.339
0.313CysHis: 0.313 ± 0.176
0.548CysIle: 0.548 ± 0.191
0.626CysLys: 0.626 ± 0.258
1.017CysLeu: 1.017 ± 0.342
0.235CysMet: 0.235 ± 0.151
0.235CysAsn: 0.235 ± 0.145
0.469CysPro: 0.469 ± 0.187
0.313CysGln: 0.313 ± 0.174
0.391CysArg: 0.391 ± 0.157
0.626CysSer: 0.626 ± 0.244
0.391CysThr: 0.391 ± 0.202
0.626CysVal: 0.626 ± 0.298
0.0CysTrp: 0.0 ± 0.0
0.704CysTyr: 0.704 ± 0.276
0.0CysXaa: 0.0 ± 0.0
Asp
3.52AspAla: 3.52 ± 0.619
0.626AspCys: 0.626 ± 0.332
6.571AspAsp: 6.571 ± 0.897
4.928AspGlu: 4.928 ± 0.697
2.582AspPhe: 2.582 ± 0.631
5.32AspGly: 5.32 ± 0.586
0.782AspHis: 0.782 ± 0.306
4.616AspIle: 4.616 ± 0.676
5.632AspLys: 5.632 ± 0.724
5.476AspLeu: 5.476 ± 0.664
1.486AspMet: 1.486 ± 0.435
3.599AspAsn: 3.599 ± 0.518
1.252AspPro: 1.252 ± 0.378
1.408AspGln: 1.408 ± 0.3
1.721AspArg: 1.721 ± 0.429
2.66AspSer: 2.66 ± 0.493
3.52AspThr: 3.52 ± 0.486
2.66AspVal: 2.66 ± 0.495
1.017AspTrp: 1.017 ± 0.289
2.582AspTyr: 2.582 ± 0.537
0.0AspXaa: 0.0 ± 0.0
Glu
3.129GluAla: 3.129 ± 0.636
0.939GluCys: 0.939 ± 0.374
1.33GluAsp: 1.33 ± 0.377
1.408GluGlu: 1.408 ± 0.422
2.973GluPhe: 2.973 ± 0.5
2.269GluGly: 2.269 ± 0.469
1.565GluHis: 1.565 ± 0.395
3.911GluIle: 3.911 ± 0.534
3.051GluLys: 3.051 ± 0.572
7.041GluLeu: 7.041 ± 0.667
1.721GluMet: 1.721 ± 0.414
2.503GluAsn: 2.503 ± 0.535
2.269GluPro: 2.269 ± 0.546
3.911GluGln: 3.911 ± 0.643
3.911GluArg: 3.911 ± 0.687
2.738GluSer: 2.738 ± 0.565
2.034GluThr: 2.034 ± 0.373
2.816GluVal: 2.816 ± 0.494
0.939GluTrp: 0.939 ± 0.245
1.565GluTyr: 1.565 ± 0.355
0.0GluXaa: 0.0 ± 0.0
Phe
4.146PheAla: 4.146 ± 0.481
0.861PheCys: 0.861 ± 0.256
2.66PheAsp: 2.66 ± 0.439
2.19PheGlu: 2.19 ± 0.35
1.408PhePhe: 1.408 ± 0.391
2.973PheGly: 2.973 ± 0.442
1.017PheHis: 1.017 ± 0.318
3.755PheIle: 3.755 ± 0.793
1.877PheLys: 1.877 ± 0.418
2.269PheLeu: 2.269 ± 0.641
0.939PheMet: 0.939 ± 0.271
1.721PheAsn: 1.721 ± 0.427
0.782PhePro: 0.782 ± 0.224
0.469PheGln: 0.469 ± 0.21
1.643PheArg: 1.643 ± 0.388
1.956PheSer: 1.956 ± 0.386
1.565PheThr: 1.565 ± 0.369
1.877PheVal: 1.877 ± 0.417
0.626PheTrp: 0.626 ± 0.216
1.721PheTyr: 1.721 ± 0.38
0.0PheXaa: 0.0 ± 0.0
Gly
4.224GlyAla: 4.224 ± 0.894
0.469GlyCys: 0.469 ± 0.221
4.616GlyAsp: 4.616 ± 0.66
4.381GlyGlu: 4.381 ± 0.679
2.582GlyPhe: 2.582 ± 0.571
5.241GlyGly: 5.241 ± 0.748
1.173GlyHis: 1.173 ± 0.293
5.085GlyIle: 5.085 ± 0.616
4.381GlyLys: 4.381 ± 0.663
5.32GlyLeu: 5.32 ± 0.674
1.956GlyMet: 1.956 ± 0.404
3.364GlyAsn: 3.364 ± 0.552
0.156GlyPro: 0.156 ± 0.116
3.051GlyGln: 3.051 ± 0.554
3.52GlyArg: 3.52 ± 0.569
3.677GlySer: 3.677 ± 0.466
3.677GlyThr: 3.677 ± 0.76
5.711GlyVal: 5.711 ± 0.593
1.486GlyTrp: 1.486 ± 0.33
2.269GlyTyr: 2.269 ± 0.36
0.0GlyXaa: 0.0 ± 0.0
His
2.269HisAla: 2.269 ± 0.433
0.0HisCys: 0.0 ± 0.0
1.252HisAsp: 1.252 ± 0.303
1.095HisGlu: 1.095 ± 0.275
0.782HisPhe: 0.782 ± 0.273
2.112HisGly: 2.112 ± 0.505
0.861HisHis: 0.861 ± 0.332
1.33HisIle: 1.33 ± 0.34
1.173HisLys: 1.173 ± 0.327
1.956HisLeu: 1.956 ± 0.351
0.391HisMet: 0.391 ± 0.169
1.017HisAsn: 1.017 ± 0.371
1.017HisPro: 1.017 ± 0.318
0.939HisGln: 0.939 ± 0.296
1.095HisArg: 1.095 ± 0.3
1.173HisSer: 1.173 ± 0.336
3.442HisThr: 3.442 ± 0.851
0.548HisVal: 0.548 ± 0.207
0.313HisTrp: 0.313 ± 0.218
1.173HisTyr: 1.173 ± 0.313
0.0HisXaa: 0.0 ± 0.0
Ile
7.275IleAla: 7.275 ± 0.843
0.861IleCys: 0.861 ± 0.34
5.32IleAsp: 5.32 ± 0.575
3.286IleGlu: 3.286 ± 0.598
1.877IlePhe: 1.877 ± 0.466
4.928IleGly: 4.928 ± 0.701
0.782IleHis: 0.782 ± 0.229
4.772IleIle: 4.772 ± 0.87
5.476IleLys: 5.476 ± 0.831
4.224IleLeu: 4.224 ± 0.711
1.408IleMet: 1.408 ± 0.267
5.476IleAsn: 5.476 ± 1.103
2.582IlePro: 2.582 ± 0.537
2.66IleGln: 2.66 ± 0.374
2.894IleArg: 2.894 ± 0.476
5.241IleSer: 5.241 ± 0.999
5.945IleThr: 5.945 ± 0.917
3.051IleVal: 3.051 ± 0.527
0.391IleTrp: 0.391 ± 0.173
2.347IleTyr: 2.347 ± 0.543
0.0IleXaa: 0.0 ± 0.0
Lys
6.337LysAla: 6.337 ± 0.603
0.313LysCys: 0.313 ± 0.17
3.364LysAsp: 3.364 ± 0.636
4.537LysGlu: 4.537 ± 0.598
2.112LysPhe: 2.112 ± 0.408
3.599LysGly: 3.599 ± 0.46
1.799LysHis: 1.799 ± 0.4
5.632LysIle: 5.632 ± 0.558
4.85LysLys: 4.85 ± 0.798
4.537LysLeu: 4.537 ± 0.503
2.269LysMet: 2.269 ± 0.58
3.051LysAsn: 3.051 ± 0.59
2.738LysPro: 2.738 ± 0.484
3.833LysGln: 3.833 ± 0.552
2.894LysArg: 2.894 ± 0.592
4.928LysSer: 4.928 ± 0.525
4.616LysThr: 4.616 ± 0.571
4.068LysVal: 4.068 ± 0.675
0.861LysTrp: 0.861 ± 0.238
2.112LysTyr: 2.112 ± 0.398
0.0LysXaa: 0.0 ± 0.0
Leu
7.979LeuAla: 7.979 ± 0.968
0.939LeuCys: 0.939 ± 0.339
6.024LeuAsp: 6.024 ± 0.654
3.286LeuGlu: 3.286 ± 0.463
2.347LeuPhe: 2.347 ± 0.413
6.18LeuGly: 6.18 ± 0.776
1.799LeuHis: 1.799 ± 0.541
6.102LeuIle: 6.102 ± 0.647
5.241LeuLys: 5.241 ± 0.808
5.007LeuLeu: 5.007 ± 0.695
2.112LeuMet: 2.112 ± 0.575
5.241LeuAsn: 5.241 ± 0.723
3.833LeuPro: 3.833 ± 0.662
3.99LeuGln: 3.99 ± 0.53
3.599LeuArg: 3.599 ± 0.577
7.432LeuSer: 7.432 ± 0.738
6.493LeuThr: 6.493 ± 0.643
3.911LeuVal: 3.911 ± 0.543
0.861LeuTrp: 0.861 ± 0.223
2.582LeuTyr: 2.582 ± 0.463
0.0LeuXaa: 0.0 ± 0.0
Met
2.66MetAla: 2.66 ± 0.609
0.156MetCys: 0.156 ± 0.11
1.252MetAsp: 1.252 ± 0.332
0.391MetGlu: 0.391 ± 0.211
0.704MetPhe: 0.704 ± 0.266
2.112MetGly: 2.112 ± 0.353
0.704MetHis: 0.704 ± 0.344
1.095MetIle: 1.095 ± 0.28
1.408MetLys: 1.408 ± 0.298
1.565MetLeu: 1.565 ± 0.543
0.548MetMet: 0.548 ± 0.258
1.799MetAsn: 1.799 ± 0.418
0.861MetPro: 0.861 ± 0.265
1.33MetGln: 1.33 ± 0.438
1.173MetArg: 1.173 ± 0.322
2.582MetSer: 2.582 ± 0.497
1.956MetThr: 1.956 ± 0.438
0.861MetVal: 0.861 ± 0.206
0.156MetTrp: 0.156 ± 0.144
0.313MetTyr: 0.313 ± 0.165
0.0MetXaa: 0.0 ± 0.0
Asn
4.381AsnAla: 4.381 ± 0.664
0.156AsnCys: 0.156 ± 0.125
2.503AsnAsp: 2.503 ± 0.536
3.52AsnGlu: 3.52 ± 0.593
2.503AsnPhe: 2.503 ± 0.428
3.599AsnGly: 3.599 ± 0.684
1.408AsnHis: 1.408 ± 0.281
2.112AsnIle: 2.112 ± 0.375
3.52AsnLys: 3.52 ± 0.661
5.711AsnLeu: 5.711 ± 0.73
0.704AsnMet: 0.704 ± 0.227
3.364AsnAsn: 3.364 ± 0.58
3.207AsnPro: 3.207 ± 0.749
3.051AsnGln: 3.051 ± 0.534
1.956AsnArg: 1.956 ± 0.39
3.99AsnSer: 3.99 ± 0.768
4.068AsnThr: 4.068 ± 0.977
2.425AsnVal: 2.425 ± 0.513
0.469AsnTrp: 0.469 ± 0.189
1.721AsnTyr: 1.721 ± 0.402
0.0AsnXaa: 0.0 ± 0.0
Pro
3.364ProAla: 3.364 ± 0.488
0.313ProCys: 0.313 ± 0.186
1.877ProAsp: 1.877 ± 0.348
1.486ProGlu: 1.486 ± 0.426
1.486ProPhe: 1.486 ± 0.334
0.078ProGly: 0.078 ± 0.103
0.861ProHis: 0.861 ± 0.278
2.816ProIle: 2.816 ± 0.427
2.582ProLys: 2.582 ± 0.519
2.973ProLeu: 2.973 ± 0.654
0.861ProMet: 0.861 ± 0.258
2.269ProAsn: 2.269 ± 0.416
1.173ProPro: 1.173 ± 0.308
1.486ProGln: 1.486 ± 0.311
1.565ProArg: 1.565 ± 0.346
2.347ProSer: 2.347 ± 0.605
3.442ProThr: 3.442 ± 0.482
2.19ProVal: 2.19 ± 0.492
0.313ProTrp: 0.313 ± 0.138
0.782ProTyr: 0.782 ± 0.244
0.0ProXaa: 0.0 ± 0.0
Gln
5.476GlnAla: 5.476 ± 0.638
0.469GlnCys: 0.469 ± 0.22
2.034GlnAsp: 2.034 ± 0.432
1.956GlnGlu: 1.956 ± 0.426
1.721GlnPhe: 1.721 ± 0.317
2.894GlnGly: 2.894 ± 0.558
0.861GlnHis: 0.861 ± 0.278
3.99GlnIle: 3.99 ± 0.599
3.911GlnLys: 3.911 ± 0.561
3.286GlnLeu: 3.286 ± 0.508
1.173GlnMet: 1.173 ± 0.327
3.051GlnAsn: 3.051 ± 0.637
1.33GlnPro: 1.33 ± 0.423
1.565GlnGln: 1.565 ± 0.421
1.643GlnArg: 1.643 ± 0.405
4.224GlnSer: 4.224 ± 0.969
3.286GlnThr: 3.286 ± 0.49
2.269GlnVal: 2.269 ± 0.481
0.313GlnTrp: 0.313 ± 0.148
1.33GlnTyr: 1.33 ± 0.348
0.0GlnXaa: 0.0 ± 0.0
Arg
4.616ArgAla: 4.616 ± 0.751
0.391ArgCys: 0.391 ± 0.182
1.799ArgAsp: 1.799 ± 0.441
2.582ArgGlu: 2.582 ± 0.43
1.877ArgPhe: 1.877 ± 0.435
1.956ArgGly: 1.956 ± 0.373
1.486ArgHis: 1.486 ± 0.342
3.051ArgIle: 3.051 ± 0.695
2.425ArgLys: 2.425 ± 0.475
4.459ArgLeu: 4.459 ± 0.729
0.782ArgMet: 0.782 ± 0.214
1.252ArgAsn: 1.252 ± 0.391
1.486ArgPro: 1.486 ± 0.432
3.051ArgGln: 3.051 ± 0.394
2.503ArgArg: 2.503 ± 0.391
2.816ArgSer: 2.816 ± 0.367
2.582ArgThr: 2.582 ± 0.497
2.738ArgVal: 2.738 ± 0.495
0.313ArgTrp: 0.313 ± 0.166
1.799ArgTyr: 1.799 ± 0.364
0.0ArgXaa: 0.0 ± 0.0
Ser
5.163SerAla: 5.163 ± 0.858
0.626SerCys: 0.626 ± 0.284
4.928SerAsp: 4.928 ± 0.71
4.146SerGlu: 4.146 ± 0.575
1.956SerPhe: 1.956 ± 0.425
5.241SerGly: 5.241 ± 0.897
2.738SerHis: 2.738 ± 0.761
4.85SerIle: 4.85 ± 1.004
4.224SerLys: 4.224 ± 0.576
6.258SerLeu: 6.258 ± 0.804
1.252SerMet: 1.252 ± 0.228
3.364SerAsn: 3.364 ± 0.721
1.486SerPro: 1.486 ± 0.425
3.833SerGln: 3.833 ± 0.617
2.347SerArg: 2.347 ± 0.499
3.599SerSer: 3.599 ± 1.01
3.207SerThr: 3.207 ± 0.447
5.789SerVal: 5.789 ± 0.991
1.173SerTrp: 1.173 ± 0.327
1.173SerTyr: 1.173 ± 0.316
0.0SerXaa: 0.0 ± 0.0
Thr
7.51ThrAla: 7.51 ± 1.123
0.313ThrCys: 0.313 ± 0.17
3.99ThrAsp: 3.99 ± 0.692
3.129ThrGlu: 3.129 ± 0.547
2.034ThrPhe: 2.034 ± 0.41
4.772ThrGly: 4.772 ± 0.842
2.034ThrHis: 2.034 ± 0.477
3.599ThrIle: 3.599 ± 0.529
5.241ThrLys: 5.241 ± 0.654
7.432ThrLeu: 7.432 ± 0.784
1.486ThrMet: 1.486 ± 0.354
3.286ThrAsn: 3.286 ± 0.558
3.442ThrPro: 3.442 ± 0.607
2.425ThrGln: 2.425 ± 0.58
1.799ThrArg: 1.799 ± 0.405
4.146ThrSer: 4.146 ± 0.793
4.146ThrThr: 4.146 ± 0.734
3.833ThrVal: 3.833 ± 0.798
0.548ThrTrp: 0.548 ± 0.187
1.643ThrTyr: 1.643 ± 0.407
0.0ThrXaa: 0.0 ± 0.0
Val
4.616ValAla: 4.616 ± 0.674
0.704ValCys: 0.704 ± 0.225
3.286ValAsp: 3.286 ± 0.474
2.816ValGlu: 2.816 ± 0.401
2.503ValPhe: 2.503 ± 0.474
4.772ValGly: 4.772 ± 0.641
0.704ValHis: 0.704 ± 0.198
5.085ValIle: 5.085 ± 0.762
2.973ValLys: 2.973 ± 0.636
4.928ValLeu: 4.928 ± 0.573
0.861ValMet: 0.861 ± 0.32
2.894ValAsn: 2.894 ± 0.419
2.112ValPro: 2.112 ± 0.453
2.347ValGln: 2.347 ± 0.44
3.207ValArg: 3.207 ± 0.502
4.303ValSer: 4.303 ± 0.475
3.599ValThr: 3.599 ± 0.628
2.66ValVal: 2.66 ± 0.586
1.095ValTrp: 1.095 ± 0.276
2.112ValTyr: 2.112 ± 0.356
0.0ValXaa: 0.0 ± 0.0
Trp
1.33TrpAla: 1.33 ± 0.272
0.391TrpCys: 0.391 ± 0.235
0.939TrpAsp: 0.939 ± 0.237
1.017TrpGlu: 1.017 ± 0.311
0.469TrpPhe: 0.469 ± 0.221
0.782TrpGly: 0.782 ± 0.228
0.235TrpHis: 0.235 ± 0.197
0.156TrpIle: 0.156 ± 0.117
0.548TrpLys: 0.548 ± 0.198
0.861TrpLeu: 0.861 ± 0.281
0.0TrpMet: 0.0 ± 0.0
0.626TrpAsn: 0.626 ± 0.172
0.0TrpPro: 0.0 ± 0.0
1.408TrpGln: 1.408 ± 0.506
0.861TrpArg: 0.861 ± 0.251
0.861TrpSer: 0.861 ± 0.343
0.861TrpThr: 0.861 ± 0.206
1.565TrpVal: 1.565 ± 0.375
0.313TrpTrp: 0.313 ± 0.182
0.391TrpTyr: 0.391 ± 0.15
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.738TyrAla: 2.738 ± 0.426
0.469TyrCys: 0.469 ± 0.245
2.425TyrAsp: 2.425 ± 0.47
2.112TyrGlu: 2.112 ± 0.408
0.782TyrPhe: 0.782 ± 0.24
2.034TyrGly: 2.034 ± 0.386
1.017TyrHis: 1.017 ± 0.288
2.503TyrIle: 2.503 ± 0.452
1.565TyrLys: 1.565 ± 0.364
3.286TyrLeu: 3.286 ± 0.693
0.469TyrMet: 0.469 ± 0.225
1.643TyrAsn: 1.643 ± 0.327
1.486TyrPro: 1.486 ± 0.348
1.565TyrGln: 1.565 ± 0.438
1.799TyrArg: 1.799 ± 0.479
1.565TyrSer: 1.565 ± 0.464
2.034TyrThr: 2.034 ± 0.429
1.408TyrVal: 1.408 ± 0.32
0.469TyrTrp: 0.469 ± 0.193
1.33TyrTyr: 1.33 ± 0.428
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 57 proteins (12784 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski