Amino acid dipepetide frequency for Heliophilum fasciatum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.877AlaAla: 9.877 ± 0.156	1.083AlaCys: 1.083 ± 0.04	4.753AlaAsp: 4.753 ± 0.077	6.141AlaGlu: 6.141 ± 0.081	3.204AlaPhe: 3.204 ± 0.064	7.496AlaGly: 7.496 ± 0.109	1.809AlaHis: 1.809 ± 0.042	5.993AlaIle: 5.993 ± 0.092	4.562AlaLys: 4.562 ± 0.073	10.315AlaLeu: 10.315 ± 0.134	3.09AlaMet: 3.09 ± 0.055	2.835AlaAsn: 2.835 ± 0.06	3.77AlaPro: 3.77 ± 0.098	4.395AlaGln: 4.395 ± 0.084	5.034AlaArg: 5.034 ± 0.084	4.682AlaSer: 4.682 ± 0.079	5.176AlaThr: 5.176 ± 0.077	7.334AlaVal: 7.334 ± 0.118	1.144AlaTrp: 1.144 ± 0.035	2.623AlaTyr: 2.623 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	0.912CysAla: 0.912 ± 0.037	0.21CysCys: 0.21 ± 0.017	0.521CysAsp: 0.521 ± 0.025	0.518CysGlu: 0.518 ± 0.024	0.403CysPhe: 0.403 ± 0.02	1.037CysGly: 1.037 ± 0.034	0.321CysHis: 0.321 ± 0.024	0.541CysIle: 0.541 ± 0.021	0.38CysLys: 0.38 ± 0.02	1.021CysLeu: 1.021 ± 0.034	0.242CysMet: 0.242 ± 0.016	0.356CysAsn: 0.356 ± 0.021	0.651CysPro: 0.651 ± 0.034	0.462CysGln: 0.462 ± 0.025	0.708CysArg: 0.708 ± 0.03	0.626CysSer: 0.626 ± 0.025	0.6CysThr: 0.6 ± 0.03	0.642CysVal: 0.642 ± 0.029	0.117CysTrp: 0.117 ± 0.011	0.347CysTyr: 0.347 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	4.279AspAla: 4.279 ± 0.068	0.587AspCys: 0.587 ± 0.028	2.977AspAsp: 2.977 ± 0.063	3.625AspGlu: 3.625 ± 0.065	2.147AspPhe: 2.147 ± 0.047	3.984AspGly: 3.984 ± 0.077	1.152AspHis: 1.152 ± 0.04	3.209AspIle: 3.209 ± 0.06	2.318AspLys: 2.318 ± 0.062	5.188AspLeu: 5.188 ± 0.08	1.295AspMet: 1.295 ± 0.04	1.539AspAsn: 1.539 ± 0.048	2.544AspPro: 2.544 ± 0.053	2.39AspGln: 2.39 ± 0.059	3.204AspArg: 3.204 ± 0.068	2.1AspSer: 2.1 ± 0.047	2.406AspThr: 2.406 ± 0.061	3.99AspVal: 3.99 ± 0.07	0.662AspTrp: 0.662 ± 0.03	1.706AspTyr: 1.706 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	6.994GluAla: 6.994 ± 0.105	0.523GluCys: 0.523 ± 0.027	2.514GluAsp: 2.514 ± 0.06	4.874GluGlu: 4.874 ± 0.091	1.893GluPhe: 1.893 ± 0.045	4.082GluGly: 4.082 ± 0.071	1.254GluHis: 1.254 ± 0.044	4.154GluIle: 4.154 ± 0.074	4.359GluLys: 4.359 ± 0.085	6.436GluLeu: 6.436 ± 0.097	1.928GluMet: 1.928 ± 0.044	2.221GluAsn: 2.221 ± 0.046	2.407GluPro: 2.407 ± 0.057	3.695GluGln: 3.695 ± 0.085	4.701GluArg: 4.701 ± 0.084	2.841GluSer: 2.841 ± 0.057	3.249GluThr: 3.249 ± 0.064	4.701GluVal: 4.701 ± 0.08	0.771GluTrp: 0.771 ± 0.029	1.702GluTyr: 1.702 ± 0.05	0.0GluXaa: 0.0 ± 0.0
Phe	3.228PheAla: 3.228 ± 0.065	0.476PheCys: 0.476 ± 0.021	2.137PheAsp: 2.137 ± 0.046	1.987PheGlu: 1.987 ± 0.049	1.807PhePhe: 1.807 ± 0.051	2.831PheGly: 2.831 ± 0.062	0.787PheHis: 0.787 ± 0.027	2.168PheIle: 2.168 ± 0.053	1.222PheLys: 1.222 ± 0.041	3.487PheLeu: 3.487 ± 0.074	0.825PheMet: 0.825 ± 0.031	1.259PheAsn: 1.259 ± 0.041	1.601PhePro: 1.601 ± 0.045	1.405PheGln: 1.405 ± 0.043	1.925PheArg: 1.925 ± 0.042	2.258PheSer: 2.258 ± 0.051	2.121PheThr: 2.121 ± 0.056	2.495PheVal: 2.495 ± 0.054	0.5PheTrp: 0.5 ± 0.023	1.231PheTyr: 1.231 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	6.452GlyAla: 6.452 ± 0.102	0.993GlyCys: 0.993 ± 0.036	3.706GlyAsp: 3.706 ± 0.073	4.599GlyGlu: 4.599 ± 0.075	2.869GlyPhe: 2.869 ± 0.064	5.465GlyGly: 5.465 ± 0.107	1.628GlyHis: 1.628 ± 0.045	5.166GlyIle: 5.166 ± 0.084	4.103GlyLys: 4.103 ± 0.067	7.326GlyLeu: 7.326 ± 0.112	2.333GlyMet: 2.333 ± 0.048	2.516GlyAsn: 2.516 ± 0.064	2.432GlyPro: 2.432 ± 0.08	3.522GlyGln: 3.522 ± 0.068	4.373GlyArg: 4.373 ± 0.075	4.091GlySer: 4.091 ± 0.075	4.662GlyThr: 4.662 ± 0.085	5.484GlyVal: 5.484 ± 0.095	1.013GlyTrp: 1.013 ± 0.037	2.572GlyTyr: 2.572 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	1.499HisAla: 1.499 ± 0.042	0.32HisCys: 0.32 ± 0.016	1.138HisAsp: 1.138 ± 0.036	1.181HisGlu: 1.181 ± 0.032	0.847HisPhe: 0.847 ± 0.031	1.639HisGly: 1.639 ± 0.038	0.706HisHis: 0.706 ± 0.03	1.177HisIle: 1.177 ± 0.036	0.768HisLys: 0.768 ± 0.027	2.304HisLeu: 2.304 ± 0.055	0.448HisMet: 0.448 ± 0.023	0.639HisAsn: 0.639 ± 0.031	1.313HisPro: 1.313 ± 0.045	0.959HisGln: 0.959 ± 0.032	1.422HisArg: 1.422 ± 0.042	1.068HisSer: 1.068 ± 0.035	0.997HisThr: 0.997 ± 0.033	1.444HisVal: 1.444 ± 0.037	0.329HisTrp: 0.329 ± 0.019	0.728HisTyr: 0.728 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	6.37IleAla: 6.37 ± 0.09	0.696IleCys: 0.696 ± 0.029	4.092IleAsp: 4.092 ± 0.07	4.154IleGlu: 4.154 ± 0.076	2.104IlePhe: 2.104 ± 0.044	5.006IleGly: 5.006 ± 0.076	1.358IleHis: 1.358 ± 0.042	3.798IleIle: 3.798 ± 0.084	2.912IleLys: 2.912 ± 0.064	5.376IleLeu: 5.376 ± 0.078	1.335IleMet: 1.335 ± 0.036	2.47IleAsn: 2.47 ± 0.068	3.03IlePro: 3.03 ± 0.059	2.367IleGln: 2.367 ± 0.059	3.504IleArg: 3.504 ± 0.068	3.285IleSer: 3.285 ± 0.07	3.845IleThr: 3.845 ± 0.084	4.589IleVal: 4.589 ± 0.083	0.577IleTrp: 0.577 ± 0.026	1.8IleTyr: 1.8 ± 0.05	0.0IleXaa: 0.0 ± 0.0
Lys	4.508LysAla: 4.508 ± 0.075	0.324LysCys: 0.324 ± 0.021	2.395LysAsp: 2.395 ± 0.056	3.703LysGlu: 3.703 ± 0.071	1.306LysPhe: 1.306 ± 0.036	3.152LysGly: 3.152 ± 0.063	0.83LysHis: 0.83 ± 0.028	3.151LysIle: 3.151 ± 0.07	3.224LysLys: 3.224 ± 0.076	4.018LysLeu: 4.018 ± 0.077	1.355LysMet: 1.355 ± 0.037	1.975LysAsn: 1.975 ± 0.052	2.165LysPro: 2.165 ± 0.054	2.083LysGln: 2.083 ± 0.052	2.727LysArg: 2.727 ± 0.059	2.396LysSer: 2.396 ± 0.061	2.855LysThr: 2.855 ± 0.054	3.565LysVal: 3.565 ± 0.065	0.497LysTrp: 0.497 ± 0.024	1.36LysTyr: 1.36 ± 0.045	0.0LysXaa: 0.0 ± 0.0
Leu	10.442LeuAla: 10.442 ± 0.126	1.023LeuCys: 1.023 ± 0.038	4.875LeuAsp: 4.875 ± 0.078	6.016LeuGlu: 6.016 ± 0.082	3.575LeuPhe: 3.575 ± 0.082	7.162LeuGly: 7.162 ± 0.112	2.144LeuHis: 2.144 ± 0.051	5.991LeuIle: 5.991 ± 0.099	4.193LeuLys: 4.193 ± 0.072	10.678LeuLeu: 10.678 ± 0.156	2.546LeuMet: 2.546 ± 0.059	3.162LeuAsn: 3.162 ± 0.059	5.165LeuPro: 5.165 ± 0.078	4.581LeuGln: 4.581 ± 0.087	6.388LeuArg: 6.388 ± 0.104	5.761LeuSer: 5.761 ± 0.087	6.019LeuThr: 6.019 ± 0.089	6.696LeuVal: 6.696 ± 0.087	1.165LeuTrp: 1.165 ± 0.042	2.55LeuTyr: 2.55 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	2.997MetAla: 2.997 ± 0.064	0.175MetCys: 0.175 ± 0.014	1.553MetAsp: 1.553 ± 0.042	1.95MetGlu: 1.95 ± 0.053	0.739MetPhe: 0.739 ± 0.029	1.993MetGly: 1.993 ± 0.053	0.469MetHis: 0.469 ± 0.024	1.881MetIle: 1.881 ± 0.046	1.326MetLys: 1.326 ± 0.04	2.405MetLeu: 2.405 ± 0.056	0.839MetMet: 0.839 ± 0.039	1.227MetAsn: 1.227 ± 0.039	1.293MetPro: 1.293 ± 0.053	1.152MetGln: 1.152 ± 0.039	1.493MetArg: 1.493 ± 0.037	1.4MetSer: 1.4 ± 0.039	1.726MetThr: 1.726 ± 0.042	2.009MetVal: 2.009 ± 0.059	0.165MetTrp: 0.165 ± 0.014	0.554MetTyr: 0.554 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	2.714AsnAla: 2.714 ± 0.057	0.356AsnCys: 0.356 ± 0.024	1.762AsnAsp: 1.762 ± 0.047	2.001AsnGlu: 2.001 ± 0.048	1.178AsnPhe: 1.178 ± 0.043	2.702AsnGly: 2.702 ± 0.077	0.781AsnHis: 0.781 ± 0.029	2.116AsnIle: 2.116 ± 0.056	1.549AsnLys: 1.549 ± 0.047	3.373AsnLeu: 3.373 ± 0.066	0.799AsnMet: 0.799 ± 0.031	1.284AsnAsn: 1.284 ± 0.052	1.957AsnPro: 1.957 ± 0.052	1.647AsnGln: 1.647 ± 0.049	2.121AsnArg: 2.121 ± 0.046	1.671AsnSer: 1.671 ± 0.049	1.617AsnThr: 1.617 ± 0.052	2.271AsnVal: 2.271 ± 0.058	0.433AsnTrp: 0.433 ± 0.026	1.145AsnTyr: 1.145 ± 0.043	0.0AsnXaa: 0.0 ± 0.0
Pro	4.525ProAla: 4.525 ± 0.088	0.418ProCys: 0.418 ± 0.022	2.493ProAsp: 2.493 ± 0.053	3.673ProGlu: 3.673 ± 0.074	1.67ProPhe: 1.67 ± 0.045	3.731ProGly: 3.731 ± 0.09	0.86ProHis: 0.86 ± 0.032	2.46ProIle: 2.46 ± 0.055	1.895ProLys: 1.895 ± 0.052	4.56ProLeu: 4.56 ± 0.09	1.136ProMet: 1.136 ± 0.039	1.36ProAsn: 1.36 ± 0.044	2.145ProPro: 2.145 ± 0.075	1.845ProGln: 1.845 ± 0.047	2.035ProArg: 2.035 ± 0.068	2.547ProSer: 2.547 ± 0.058	2.463ProThr: 2.463 ± 0.065	4.143ProVal: 4.143 ± 0.076	0.735ProTrp: 0.735 ± 0.032	1.392ProTyr: 1.392 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	5.198GlnAla: 5.198 ± 0.098	0.344GlnCys: 0.344 ± 0.021	1.837GlnAsp: 1.837 ± 0.044	3.189GlnGlu: 3.189 ± 0.075	1.321GlnPhe: 1.321 ± 0.041	3.517GlnGly: 3.517 ± 0.074	0.858GlnHis: 0.858 ± 0.031	2.749GlnIle: 2.749 ± 0.058	2.448GlnLys: 2.448 ± 0.056	4.53GlnLeu: 4.53 ± 0.091	1.321GlnMet: 1.321 ± 0.037	1.281GlnAsn: 1.281 ± 0.037	2.024GlnPro: 2.024 ± 0.052	2.431GlnGln: 2.431 ± 0.065	2.95GlnArg: 2.95 ± 0.059	2.118GlnSer: 2.118 ± 0.054	2.213GlnThr: 2.213 ± 0.05	3.594GlnVal: 3.594 ± 0.061	0.582GlnTrp: 0.582 ± 0.026	1.094GlnTyr: 1.094 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	4.493ArgAla: 4.493 ± 0.081	0.731ArgCys: 0.731 ± 0.029	2.873ArgAsp: 2.873 ± 0.062	4.163ArgGlu: 4.163 ± 0.081	2.46ArgPhe: 2.46 ± 0.055	3.62ArgGly: 3.62 ± 0.081	1.393ArgHis: 1.393 ± 0.043	3.883ArgIle: 3.883 ± 0.064	2.707ArgLys: 2.707 ± 0.061	6.374ArgLeu: 6.374 ± 0.096	1.837ArgMet: 1.837 ± 0.038	1.864ArgAsn: 1.864 ± 0.047	2.533ArgPro: 2.533 ± 0.071	3.32ArgGln: 3.32 ± 0.066	4.029ArgArg: 4.029 ± 0.073	3.008ArgSer: 3.008 ± 0.061	2.849ArgThr: 2.849 ± 0.051	3.885ArgVal: 3.885 ± 0.064	1.051ArgTrp: 1.051 ± 0.039	2.021ArgTyr: 2.021 ± 0.051	0.0ArgXaa: 0.0 ± 0.0
Ser	4.488SerAla: 4.488 ± 0.076	0.51SerCys: 0.51 ± 0.025	2.484SerAsp: 2.484 ± 0.064	2.867SerGlu: 2.867 ± 0.054	2.111SerPhe: 2.111 ± 0.047	4.515SerGly: 4.515 ± 0.086	1.078SerHis: 1.078 ± 0.037	3.175SerIle: 3.175 ± 0.076	2.37SerLys: 2.37 ± 0.056	5.509SerLeu: 5.509 ± 0.081	1.471SerMet: 1.471 ± 0.042	1.773SerAsn: 1.773 ± 0.052	2.599SerPro: 2.599 ± 0.057	2.052SerGln: 2.052 ± 0.05	2.85SerArg: 2.85 ± 0.053	3.25SerSer: 3.25 ± 0.072	3.092SerThr: 3.092 ± 0.058	3.596SerVal: 3.596 ± 0.067	0.663SerTrp: 0.663 ± 0.029	1.499SerTyr: 1.499 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	5.478ThrAla: 5.478 ± 0.093	0.518ThrCys: 0.518 ± 0.023	2.761ThrAsp: 2.761 ± 0.066	3.453ThrGlu: 3.453 ± 0.066	2.015ThrPhe: 2.015 ± 0.051	5.04ThrGly: 5.04 ± 0.083	1.052ThrHis: 1.052 ± 0.033	3.71ThrIle: 3.71 ± 0.072	2.331ThrLys: 2.331 ± 0.059	5.503ThrLeu: 5.503 ± 0.082	1.604ThrMet: 1.604 ± 0.038	1.796ThrAsn: 1.796 ± 0.048	2.875ThrPro: 2.875 ± 0.066	1.875ThrGln: 1.875 ± 0.047	2.482ThrArg: 2.482 ± 0.055	2.841ThrSer: 2.841 ± 0.061	3.39ThrThr: 3.39 ± 0.092	5.019ThrVal: 5.019 ± 0.083	0.685ThrTrp: 0.685 ± 0.028	1.628ThrTyr: 1.628 ± 0.049	0.0ThrXaa: 0.0 ± 0.0
Val	7.588ValAla: 7.588 ± 0.11	0.785ValCys: 0.785 ± 0.029	4.197ValAsp: 4.197 ± 0.074	4.857ValGlu: 4.857 ± 0.081	2.529ValPhe: 2.529 ± 0.054	5.011ValGly: 5.011 ± 0.085	1.46ValHis: 1.46 ± 0.039	5.026ValIle: 5.026 ± 0.09	3.298ValLys: 3.298 ± 0.064	7.114ValLeu: 7.114 ± 0.101	1.95ValMet: 1.95 ± 0.049	2.544ValAsn: 2.544 ± 0.054	3.653ValPro: 3.653 ± 0.067	3.073ValGln: 3.073 ± 0.058	4.145ValArg: 4.145 ± 0.068	3.767ValSer: 3.767 ± 0.076	4.698ValThr: 4.698 ± 0.086	5.633ValVal: 5.633 ± 0.106	0.694ValTrp: 0.694 ± 0.031	1.897ValTyr: 1.897 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	1.009TrpAla: 1.009 ± 0.039	0.118TrpCys: 0.118 ± 0.011	0.625TrpAsp: 0.625 ± 0.03	0.7TrpGlu: 0.7 ± 0.025	0.456TrpPhe: 0.456 ± 0.023	0.825TrpGly: 0.825 ± 0.031	0.278TrpHis: 0.278 ± 0.016	0.679TrpIle: 0.679 ± 0.029	0.534TrpLys: 0.534 ± 0.022	1.48TrpLeu: 1.48 ± 0.043	0.367TrpMet: 0.367 ± 0.021	0.434TrpAsn: 0.434 ± 0.023	0.544TrpPro: 0.544 ± 0.026	0.857TrpGln: 0.857 ± 0.04	0.784TrpArg: 0.784 ± 0.03	0.718TrpSer: 0.718 ± 0.027	0.602TrpThr: 0.602 ± 0.025	0.83TrpVal: 0.83 ± 0.033	0.176TrpTrp: 0.176 ± 0.014	0.338TrpTyr: 0.338 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.265TyrAla: 2.265 ± 0.052	0.424TyrCys: 0.424 ± 0.023	1.607TyrAsp: 1.607 ± 0.046	1.649TyrGlu: 1.649 ± 0.044	1.117TyrPhe: 1.117 ± 0.037	2.496TyrGly: 2.496 ± 0.056	0.707TyrHis: 0.707 ± 0.029	1.642TyrIle: 1.642 ± 0.047	1.089TyrLys: 1.089 ± 0.039	3.136TyrLeu: 3.136 ± 0.06	0.623TyrMet: 0.623 ± 0.028	0.944TyrAsn: 0.944 ± 0.035	1.385TyrPro: 1.385 ± 0.039	1.49TyrGln: 1.49 ± 0.041	2.218TyrArg: 2.218 ± 0.061	1.523TyrSer: 1.523 ± 0.044	1.479TyrThr: 1.479 ± 0.041	2.0TyrVal: 2.0 ± 0.043	0.394TyrTrp: 0.394 ± 0.022	1.035TyrTyr: 1.035 ± 0.04	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2911 proteins (922013 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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