Amino acid dipepetide frequency for Propionibacterium cyclohexanicum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.968AlaAla: 16.968 ± 0.203	1.168AlaCys: 1.168 ± 0.038	6.906AlaAsp: 6.906 ± 0.11	6.771AlaGlu: 6.771 ± 0.108	3.183AlaPhe: 3.183 ± 0.071	12.036AlaGly: 12.036 ± 0.136	2.851AlaHis: 2.851 ± 0.057	5.285AlaIle: 5.285 ± 0.091	2.742AlaLys: 2.742 ± 0.072	13.418AlaLeu: 13.418 ± 0.145	3.135AlaMet: 3.135 ± 0.06	2.349AlaAsn: 2.349 ± 0.057	5.98AlaPro: 5.98 ± 0.105	5.182AlaGln: 5.182 ± 0.092	9.616AlaArg: 9.616 ± 0.141	7.509AlaSer: 7.509 ± 0.11	6.79AlaThr: 6.79 ± 0.097	10.22AlaVal: 10.22 ± 0.128	1.77AlaTrp: 1.77 ± 0.051	2.002AlaTyr: 2.002 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	1.144CysAla: 1.144 ± 0.043	0.128CysCys: 0.128 ± 0.013	0.458CysAsp: 0.458 ± 0.024	0.526CysGlu: 0.526 ± 0.024	0.252CysPhe: 0.252 ± 0.018	0.988CysGly: 0.988 ± 0.035	0.249CysHis: 0.249 ± 0.018	0.272CysIle: 0.272 ± 0.018	0.098CysLys: 0.098 ± 0.012	0.908CysLeu: 0.908 ± 0.036	0.122CysMet: 0.122 ± 0.013	0.138CysAsn: 0.138 ± 0.013	0.573CysPro: 0.573 ± 0.029	0.259CysGln: 0.259 ± 0.018	0.639CysArg: 0.639 ± 0.031	0.542CysSer: 0.542 ± 0.028	0.58CysThr: 0.58 ± 0.028	0.687CysVal: 0.687 ± 0.028	0.15CysTrp: 0.15 ± 0.015	0.21CysTyr: 0.21 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	7.223AspAla: 7.223 ± 0.105	0.401AspCys: 0.401 ± 0.025	3.434AspAsp: 3.434 ± 0.08	4.461AspGlu: 4.461 ± 0.086	1.71AspPhe: 1.71 ± 0.055	4.563AspGly: 4.563 ± 0.081	1.349AspHis: 1.349 ± 0.041	2.28AspIle: 2.28 ± 0.053	1.256AspLys: 1.256 ± 0.042	5.706AspLeu: 5.706 ± 0.093	0.989AspMet: 0.989 ± 0.036	1.091AspAsn: 1.091 ± 0.038	4.38AspPro: 4.38 ± 0.073	1.918AspGln: 1.918 ± 0.045	4.016AspArg: 4.016 ± 0.079	2.959AspSer: 2.959 ± 0.062	2.719AspThr: 2.719 ± 0.065	4.425AspVal: 4.425 ± 0.07	0.832AspTrp: 0.832 ± 0.033	1.346AspTyr: 1.346 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	6.085GluAla: 6.085 ± 0.099	0.395GluCys: 0.395 ± 0.022	2.57GluAsp: 2.57 ± 0.06	2.656GluGlu: 2.656 ± 0.075	1.579GluPhe: 1.579 ± 0.043	3.762GluGly: 3.762 ± 0.069	1.577GluHis: 1.577 ± 0.042	2.545GluIle: 2.545 ± 0.056	1.301GluLys: 1.301 ± 0.047	6.927GluLeu: 6.927 ± 0.111	1.082GluMet: 1.082 ± 0.038	1.12GluAsn: 1.12 ± 0.034	3.157GluPro: 3.157 ± 0.075	2.854GluGln: 2.854 ± 0.061	4.43GluArg: 4.43 ± 0.086	2.816GluSer: 2.816 ± 0.059	2.394GluThr: 2.394 ± 0.052	4.24GluVal: 4.24 ± 0.077	0.697GluTrp: 0.697 ± 0.031	1.048GluTyr: 1.048 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	3.832PheAla: 3.832 ± 0.075	0.3PheCys: 0.3 ± 0.017	2.144PheAsp: 2.144 ± 0.051	1.515PheGlu: 1.515 ± 0.045	0.989PhePhe: 0.989 ± 0.041	3.201PheGly: 3.201 ± 0.076	0.615PheHis: 0.615 ± 0.024	1.179PheIle: 1.179 ± 0.044	0.552PheLys: 0.552 ± 0.031	2.586PheLeu: 2.586 ± 0.063	0.523PheMet: 0.523 ± 0.025	0.664PheAsn: 0.664 ± 0.032	1.284PhePro: 1.284 ± 0.039	0.7PheGln: 0.7 ± 0.029	1.672PheArg: 1.672 ± 0.048	1.853PheSer: 1.853 ± 0.049	2.012PheThr: 2.012 ± 0.052	2.612PheVal: 2.612 ± 0.064	0.438PheTrp: 0.438 ± 0.027	0.572PheTyr: 0.572 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	10.13GlyAla: 10.13 ± 0.136	0.895GlyCys: 0.895 ± 0.034	4.373GlyAsp: 4.373 ± 0.086	4.783GlyGlu: 4.783 ± 0.08	3.059GlyPhe: 3.059 ± 0.064	7.06GlyGly: 7.06 ± 0.12	2.333GlyHis: 2.333 ± 0.055	4.351GlyIle: 4.351 ± 0.079	2.21GlyLys: 2.21 ± 0.054	9.641GlyLeu: 9.641 ± 0.133	2.05GlyMet: 2.05 ± 0.052	1.801GlyAsn: 1.801 ± 0.05	4.293GlyPro: 4.293 ± 0.074	3.323GlyGln: 3.323 ± 0.064	6.626GlyArg: 6.626 ± 0.096	5.753GlySer: 5.753 ± 0.091	5.308GlyThr: 5.308 ± 0.08	7.306GlyVal: 7.306 ± 0.102	1.755GlyTrp: 1.755 ± 0.05	2.219GlyTyr: 2.219 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	2.491HisAla: 2.491 ± 0.057	0.234HisCys: 0.234 ± 0.016	1.601HisAsp: 1.601 ± 0.048	1.496HisGlu: 1.496 ± 0.046	0.667HisPhe: 0.667 ± 0.027	2.148HisGly: 2.148 ± 0.06	0.717HisHis: 0.717 ± 0.027	0.945HisIle: 0.945 ± 0.035	0.368HisLys: 0.368 ± 0.02	2.289HisLeu: 2.289 ± 0.056	0.397HisMet: 0.397 ± 0.022	0.456HisAsn: 0.456 ± 0.022	1.769HisPro: 1.769 ± 0.049	0.77HisGln: 0.77 ± 0.033	2.054HisArg: 2.054 ± 0.045	1.308HisSer: 1.308 ± 0.044	1.196HisThr: 1.196 ± 0.041	1.692HisVal: 1.692 ± 0.043	0.372HisTrp: 0.372 ± 0.022	0.585HisTyr: 0.585 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.253IleAla: 6.253 ± 0.091	0.53IleCys: 0.53 ± 0.024	3.345IleAsp: 3.345 ± 0.066	2.546IleGlu: 2.546 ± 0.07	1.174IlePhe: 1.174 ± 0.044	4.591IleGly: 4.591 ± 0.078	0.835IleHis: 0.835 ± 0.033	1.776IleIle: 1.776 ± 0.053	0.873IleLys: 0.873 ± 0.036	3.384IleLeu: 3.384 ± 0.066	0.74IleMet: 0.74 ± 0.032	1.084IleAsn: 1.084 ± 0.037	2.232IlePro: 2.232 ± 0.055	0.945IleGln: 0.945 ± 0.033	2.58IleArg: 2.58 ± 0.055	2.691IleSer: 2.691 ± 0.062	2.761IleThr: 2.761 ± 0.062	4.182IleVal: 4.182 ± 0.081	0.58IleTrp: 0.58 ± 0.026	0.826IleTyr: 0.826 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	2.696LysAla: 2.696 ± 0.074	0.11LysCys: 0.11 ± 0.011	1.202LysAsp: 1.202 ± 0.044	0.976LysGlu: 0.976 ± 0.044	0.479LysPhe: 0.479 ± 0.027	1.785LysGly: 1.785 ± 0.056	0.437LysHis: 0.437 ± 0.023	1.103LysIle: 1.103 ± 0.04	0.835LysLys: 0.835 ± 0.033	2.002LysLeu: 2.002 ± 0.057	0.434LysMet: 0.434 ± 0.024	0.606LysAsn: 0.606 ± 0.031	1.194LysPro: 1.194 ± 0.039	0.831LysGln: 0.831 ± 0.037	1.402LysArg: 1.402 ± 0.043	1.288LysSer: 1.288 ± 0.048	1.335LysThr: 1.335 ± 0.043	1.825LysVal: 1.825 ± 0.058	0.213LysTrp: 0.213 ± 0.017	0.522LysTyr: 0.522 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	14.539LeuAla: 14.539 ± 0.172	0.92LeuCys: 0.92 ± 0.03	6.846LeuAsp: 6.846 ± 0.114	4.47LeuGlu: 4.47 ± 0.077	2.947LeuPhe: 2.947 ± 0.07	9.677LeuGly: 9.677 ± 0.127	2.179LeuHis: 2.179 ± 0.056	4.28LeuIle: 4.28 ± 0.089	1.837LeuLys: 1.837 ± 0.057	10.252LeuLeu: 10.252 ± 0.166	1.934LeuMet: 1.934 ± 0.053	2.172LeuAsn: 2.172 ± 0.055	5.495LeuPro: 5.495 ± 0.087	2.384LeuGln: 2.384 ± 0.058	7.482LeuArg: 7.482 ± 0.113	6.455LeuSer: 6.455 ± 0.095	5.983LeuThr: 5.983 ± 0.082	9.779LeuVal: 9.779 ± 0.122	1.208LeuTrp: 1.208 ± 0.042	1.653LeuTyr: 1.653 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	2.775MetAla: 2.775 ± 0.066	0.183MetCys: 0.183 ± 0.015	1.037MetAsp: 1.037 ± 0.033	0.706MetGlu: 0.706 ± 0.026	0.491MetPhe: 0.491 ± 0.023	1.681MetGly: 1.681 ± 0.049	0.465MetHis: 0.465 ± 0.028	0.986MetIle: 0.986 ± 0.035	0.494MetLys: 0.494 ± 0.028	2.017MetLeu: 2.017 ± 0.047	0.407MetMet: 0.407 ± 0.024	0.609MetAsn: 0.609 ± 0.027	1.192MetPro: 1.192 ± 0.038	0.497MetGln: 0.497 ± 0.024	1.486MetArg: 1.486 ± 0.048	1.822MetSer: 1.822 ± 0.045	1.613MetThr: 1.613 ± 0.049	1.776MetVal: 1.776 ± 0.052	0.265MetTrp: 0.265 ± 0.018	0.331MetTyr: 0.331 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	2.436AsnAla: 2.436 ± 0.064	0.2AsnCys: 0.2 ± 0.016	1.191AsnAsp: 1.191 ± 0.042	1.034AsnGlu: 1.034 ± 0.035	0.63AsnPhe: 0.63 ± 0.026	1.975AsnGly: 1.975 ± 0.056	0.517AsnHis: 0.517 ± 0.024	0.851AsnIle: 0.851 ± 0.033	0.513AsnLys: 0.513 ± 0.029	2.021AsnLeu: 2.021 ± 0.044	0.366AsnMet: 0.366 ± 0.023	0.512AsnAsn: 0.512 ± 0.026	1.685AsnPro: 1.685 ± 0.05	0.698AsnGln: 0.698 ± 0.033	1.403AsnArg: 1.403 ± 0.041	1.312AsnSer: 1.312 ± 0.043	1.206AsnThr: 1.206 ± 0.036	1.506AsnVal: 1.506 ± 0.044	0.379AsnTrp: 0.379 ± 0.022	0.595AsnTyr: 0.595 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	7.22ProAla: 7.22 ± 0.126	0.339ProCys: 0.339 ± 0.021	3.802ProAsp: 3.802 ± 0.072	3.52ProGlu: 3.52 ± 0.069	1.419ProPhe: 1.419 ± 0.043	5.789ProGly: 5.789 ± 0.085	1.347ProHis: 1.347 ± 0.04	2.026ProIle: 2.026 ± 0.042	1.171ProLys: 1.171 ± 0.044	4.888ProLeu: 4.888 ± 0.078	1.034ProMet: 1.034 ± 0.031	1.077ProAsn: 1.077 ± 0.036	2.499ProPro: 2.499 ± 0.079	2.31ProGln: 2.31 ± 0.05	3.819ProArg: 3.819 ± 0.078	3.622ProSer: 3.622 ± 0.07	3.087ProThr: 3.087 ± 0.067	4.797ProVal: 4.797 ± 0.084	0.837ProTrp: 0.837 ± 0.03	1.039ProTyr: 1.039 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	4.684GlnAla: 4.684 ± 0.086	0.258GlnCys: 0.258 ± 0.019	1.407GlnAsp: 1.407 ± 0.043	1.606GlnGlu: 1.606 ± 0.049	0.956GlnPhe: 0.956 ± 0.037	2.559GlnGly: 2.559 ± 0.063	0.776GlnHis: 0.776 ± 0.033	1.83GlnIle: 1.83 ± 0.048	0.619GlnLys: 0.619 ± 0.027	4.272GlnLeu: 4.272 ± 0.084	0.828GlnMet: 0.828 ± 0.03	0.646GlnAsn: 0.646 ± 0.031	1.967GlnPro: 1.967 ± 0.049	1.497GlnGln: 1.497 ± 0.051	2.737GlnArg: 2.737 ± 0.058	1.618GlnSer: 1.618 ± 0.045	1.882GlnThr: 1.882 ± 0.054	3.218GlnVal: 3.218 ± 0.065	0.568GlnTrp: 0.568 ± 0.025	0.637GlnTyr: 0.637 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	8.832ArgAla: 8.832 ± 0.125	0.668ArgCys: 0.668 ± 0.034	3.721ArgAsp: 3.721 ± 0.078	4.46ArgGlu: 4.46 ± 0.08	2.201ArgPhe: 2.201 ± 0.054	5.388ArgGly: 5.388 ± 0.092	2.034ArgHis: 2.034 ± 0.049	3.562ArgIle: 3.562 ± 0.066	1.468ArgLys: 1.468 ± 0.051	7.634ArgLeu: 7.634 ± 0.119	1.686ArgMet: 1.686 ± 0.047	1.491ArgAsn: 1.491 ± 0.042	4.262ArgPro: 4.262 ± 0.079	2.691ArgGln: 2.691 ± 0.06	7.048ArgArg: 7.048 ± 0.12	4.255ArgSer: 4.255 ± 0.076	4.283ArgThr: 4.283 ± 0.075	5.548ArgVal: 5.548 ± 0.085	1.371ArgTrp: 1.371 ± 0.044	1.643ArgTyr: 1.643 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	7.636SerAla: 7.636 ± 0.119	0.535SerCys: 0.535 ± 0.029	3.015SerAsp: 3.015 ± 0.058	2.859SerGlu: 2.859 ± 0.065	2.006SerPhe: 2.006 ± 0.053	6.47SerGly: 6.47 ± 0.105	1.311SerHis: 1.311 ± 0.042	2.481SerIle: 2.481 ± 0.066	1.184SerLys: 1.184 ± 0.047	5.578SerLeu: 5.578 ± 0.09	1.43SerMet: 1.43 ± 0.043	1.266SerAsn: 1.266 ± 0.036	3.536SerPro: 3.536 ± 0.074	2.165SerGln: 2.165 ± 0.051	4.272SerArg: 4.272 ± 0.073	4.297SerSer: 4.297 ± 0.09	3.855SerThr: 3.855 ± 0.074	4.801SerVal: 4.801 ± 0.089	1.179SerTrp: 1.179 ± 0.039	1.385SerTyr: 1.385 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	7.023ThrAla: 7.023 ± 0.112	0.44ThrCys: 0.44 ± 0.023	3.035ThrAsp: 3.035 ± 0.065	2.739ThrGlu: 2.739 ± 0.058	1.57ThrPhe: 1.57 ± 0.049	5.728ThrGly: 5.728 ± 0.085	1.205ThrHis: 1.205 ± 0.039	2.818ThrIle: 2.818 ± 0.059	1.329ThrLys: 1.329 ± 0.046	5.601ThrLeu: 5.601 ± 0.08	1.215ThrMet: 1.215 ± 0.041	1.246ThrAsn: 1.246 ± 0.041	3.69ThrPro: 3.69 ± 0.076	1.782ThrGln: 1.782 ± 0.045	4.003ThrArg: 4.003 ± 0.073	3.601ThrSer: 3.601 ± 0.073	3.889ThrThr: 3.889 ± 0.082	5.227ThrVal: 5.227 ± 0.08	0.784ThrTrp: 0.784 ± 0.029	0.957ThrTyr: 0.957 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	10.224ValAla: 10.224 ± 0.12	0.844ValCys: 0.844 ± 0.033	5.117ValAsp: 5.117 ± 0.086	4.493ValGlu: 4.493 ± 0.093	2.643ValPhe: 2.643 ± 0.058	6.872ValGly: 6.872 ± 0.098	1.973ValHis: 1.973 ± 0.055	4.06ValIle: 4.06 ± 0.072	1.779ValLys: 1.779 ± 0.054	9.171ValLeu: 9.171 ± 0.116	1.825ValMet: 1.825 ± 0.048	1.846ValAsn: 1.846 ± 0.058	4.544ValPro: 4.544 ± 0.078	2.336ValGln: 2.336 ± 0.051	5.935ValArg: 5.935 ± 0.089	5.384ValSer: 5.384 ± 0.089	5.021ValThr: 5.021 ± 0.085	8.161ValVal: 8.161 ± 0.119	1.061ValTrp: 1.061 ± 0.037	1.431ValTyr: 1.431 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	1.608TrpAla: 1.608 ± 0.053	0.17TrpCys: 0.17 ± 0.017	0.691TrpAsp: 0.691 ± 0.031	0.505TrpGlu: 0.505 ± 0.025	0.578TrpPhe: 0.578 ± 0.027	1.119TrpGly: 1.119 ± 0.035	0.392TrpHis: 0.392 ± 0.023	0.646TrpIle: 0.646 ± 0.031	0.289TrpLys: 0.289 ± 0.02	1.886TrpLeu: 1.886 ± 0.058	0.335TrpMet: 0.335 ± 0.021	0.387TrpAsn: 0.387 ± 0.023	0.835TrpPro: 0.835 ± 0.034	0.71TrpGln: 0.71 ± 0.027	1.307TrpArg: 1.307 ± 0.039	0.999TrpSer: 0.999 ± 0.039	0.887TrpThr: 0.887 ± 0.033	1.155TrpVal: 1.155 ± 0.037	0.383TrpTrp: 0.383 ± 0.021	0.297TrpTyr: 0.297 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.081TyrAla: 2.081 ± 0.048	0.207TyrCys: 0.207 ± 0.015	1.165TyrAsp: 1.165 ± 0.043	1.113TyrGlu: 1.113 ± 0.038	0.711TyrPhe: 0.711 ± 0.03	1.876TyrGly: 1.876 ± 0.051	0.393TyrHis: 0.393 ± 0.023	0.651TyrIle: 0.651 ± 0.027	0.357TyrLys: 0.357 ± 0.025	2.311TyrLeu: 2.311 ± 0.058	0.302TyrMet: 0.302 ± 0.02	0.468TyrAsn: 0.468 ± 0.024	1.072TyrPro: 1.072 ± 0.036	0.711TyrGln: 0.711 ± 0.029	1.719TyrArg: 1.719 ± 0.047	1.177TyrSer: 1.177 ± 0.039	1.082TyrThr: 1.082 ± 0.04	1.563TyrVal: 1.563 ± 0.039	0.338TyrTrp: 0.338 ± 0.023	0.479TyrTyr: 0.479 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2509 proteins (833824 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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