Amino acid dipepetide frequency for Mycoplasma glycophilum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.395AlaAla: 3.395 ± 0.182
0.236AlaCys: 0.236 ± 0.031
2.788AlaAsp: 2.788 ± 0.132
3.614AlaGlu: 3.614 ± 0.142
2.861AlaPhe: 2.861 ± 0.115
2.597AlaGly: 2.597 ± 0.125
0.815AlaHis: 0.815 ± 0.063
5.656AlaIle: 5.656 ± 0.176
6.901AlaLys: 6.901 ± 0.329
6.384AlaLeu: 6.384 ± 0.209
0.971AlaMet: 0.971 ± 0.068
4.678AlaAsn: 4.678 ± 0.233
1.411AlaPro: 1.411 ± 0.084
2.66AlaGln: 2.66 ± 0.159
2.025AlaArg: 2.025 ± 0.092
3.548AlaSer: 3.548 ± 0.128
3.239AlaThr: 3.239 ± 0.126
2.317AlaVal: 2.317 ± 0.117
0.503AlaTrp: 0.503 ± 0.043
2.213AlaTyr: 2.213 ± 0.093
0.0AlaXaa: 0.0 ± 0.0
Cys
0.264CysAla: 0.264 ± 0.033
0.021CysCys: 0.021 ± 0.008
0.225CysAsp: 0.225 ± 0.03
0.25CysGlu: 0.25 ± 0.03
0.288CysPhe: 0.288 ± 0.033
0.243CysGly: 0.243 ± 0.027
0.076CysHis: 0.076 ± 0.02
0.291CysIle: 0.291 ± 0.037
0.291CysLys: 0.291 ± 0.036
0.42CysLeu: 0.42 ± 0.043
0.059CysMet: 0.059 ± 0.013
0.191CysAsn: 0.191 ± 0.026
0.146CysPro: 0.146 ± 0.023
0.114CysGln: 0.114 ± 0.021
0.111CysArg: 0.111 ± 0.017
0.284CysSer: 0.284 ± 0.033
0.121CysThr: 0.121 ± 0.023
0.201CysVal: 0.201 ± 0.029
0.031CysTrp: 0.031 ± 0.011
0.187CysTyr: 0.187 ± 0.024
0.0CysXaa: 0.0 ± 0.0
Asp
3.787AspAla: 3.787 ± 0.282
0.184AspCys: 0.184 ± 0.026
2.861AspAsp: 2.861 ± 0.138
4.48AspGlu: 4.48 ± 0.169
3.62AspPhe: 3.62 ± 0.136
2.577AspGly: 2.577 ± 0.114
0.728AspHis: 0.728 ± 0.052
4.161AspIle: 4.161 ± 0.115
5.847AspLys: 5.847 ± 0.245
6.287AspLeu: 6.287 ± 0.202
0.725AspMet: 0.725 ± 0.057
4.071AspAsn: 4.071 ± 0.185
1.758AspPro: 1.758 ± 0.087
2.559AspGln: 2.559 ± 0.175
1.526AspArg: 1.526 ± 0.073
3.562AspSer: 3.562 ± 0.177
2.448AspThr: 2.448 ± 0.131
3.218AspVal: 3.218 ± 0.115
0.565AspTrp: 0.565 ± 0.039
2.882AspTyr: 2.882 ± 0.096
0.0AspXaa: 0.0 ± 0.0
Glu
4.692GluAla: 4.692 ± 0.205
0.246GluCys: 0.246 ± 0.033
3.655GluAsp: 3.655 ± 0.147
5.739GluGlu: 5.739 ± 0.186
3.7GluPhe: 3.7 ± 0.128
2.49GluGly: 2.49 ± 0.11
0.825GluHis: 0.825 ± 0.05
8.073GluIle: 8.073 ± 0.212
8.129GluLys: 8.129 ± 0.198
7.99GluLeu: 7.99 ± 0.241
1.342GluMet: 1.342 ± 0.074
6.558GluAsn: 6.558 ± 0.19
1.387GluPro: 1.387 ± 0.09
3.173GluGln: 3.173 ± 0.124
2.31GluArg: 2.31 ± 0.093
3.444GluSer: 3.444 ± 0.102
4.089GluThr: 4.089 ± 0.137
3.849GluVal: 3.849 ± 0.114
0.593GluTrp: 0.593 ± 0.046
3.1GluTyr: 3.1 ± 0.102
0.0GluXaa: 0.0 ± 0.0
Phe
2.941PheAla: 2.941 ± 0.108
0.257PheCys: 0.257 ± 0.028
3.672PheAsp: 3.672 ± 0.121
3.908PheGlu: 3.908 ± 0.145
2.764PhePhe: 2.764 ± 0.162
2.532PheGly: 2.532 ± 0.131
0.624PheHis: 0.624 ± 0.053
4.265PheIle: 4.265 ± 0.192
4.855PheLys: 4.855 ± 0.148
5.056PheLeu: 5.056 ± 0.225
0.794PheMet: 0.794 ± 0.06
3.7PheAsn: 3.7 ± 0.122
1.196PhePro: 1.196 ± 0.073
1.557PheGln: 1.557 ± 0.088
1.3PheArg: 1.3 ± 0.075
3.326PheSer: 3.326 ± 0.14
2.549PheThr: 2.549 ± 0.114
3.336PheVal: 3.336 ± 0.141
0.659PheTrp: 0.659 ± 0.062
2.285PheTyr: 2.285 ± 0.126
0.0PheXaa: 0.0 ± 0.0
Gly
2.681GlyAla: 2.681 ± 0.126
0.156GlyCys: 0.156 ± 0.023
2.292GlyAsp: 2.292 ± 0.1
2.906GlyGlu: 2.906 ± 0.111
2.584GlyPhe: 2.584 ± 0.123
2.459GlyGly: 2.459 ± 0.167
0.697GlyHis: 0.697 ± 0.072
3.967GlyIle: 3.967 ± 0.163
4.096GlyLys: 4.096 ± 0.17
4.047GlyLeu: 4.047 ± 0.147
0.839GlyMet: 0.839 ± 0.062
2.285GlyAsn: 2.285 ± 0.102
0.811GlyPro: 0.811 ± 0.065
1.678GlyGln: 1.678 ± 0.073
1.346GlyArg: 1.346 ± 0.095
2.868GlySer: 2.868 ± 0.126
2.611GlyThr: 2.611 ± 0.124
2.674GlyVal: 2.674 ± 0.15
0.52GlyTrp: 0.52 ± 0.04
2.157GlyTyr: 2.157 ± 0.1
0.0GlyXaa: 0.0 ± 0.0
His
0.721HisAla: 0.721 ± 0.053
0.076HisCys: 0.076 ± 0.016
0.701HisAsp: 0.701 ± 0.046
0.922HisGlu: 0.922 ± 0.064
0.874HisPhe: 0.874 ± 0.059
0.673HisGly: 0.673 ± 0.06
0.215HisHis: 0.215 ± 0.03
1.075HisIle: 1.075 ± 0.068
1.29HisLys: 1.29 ± 0.088
1.352HisLeu: 1.352 ± 0.073
0.201HisMet: 0.201 ± 0.029
1.02HisAsn: 1.02 ± 0.072
0.513HisPro: 0.513 ± 0.046
0.489HisGln: 0.489 ± 0.041
0.336HisArg: 0.336 ± 0.038
0.843HisSer: 0.843 ± 0.055
0.593HisThr: 0.593 ± 0.051
0.621HisVal: 0.621 ± 0.056
0.125HisTrp: 0.125 ± 0.02
0.551HisTyr: 0.551 ± 0.052
0.0HisXaa: 0.0 ± 0.0
Ile
5.164IleAla: 5.164 ± 0.143
0.489IleCys: 0.489 ± 0.046
6.242IleAsp: 6.242 ± 0.181
6.443IleGlu: 6.443 ± 0.18
4.408IlePhe: 4.408 ± 0.207
3.61IleGly: 3.61 ± 0.196
1.155IleHis: 1.155 ± 0.076
6.61IleIle: 6.61 ± 0.234
8.514IleLys: 8.514 ± 0.212
8.073IleLeu: 8.073 ± 0.25
1.165IleMet: 1.165 ± 0.09
7.165IleAsn: 7.165 ± 0.239
2.466IlePro: 2.466 ± 0.124
3.246IleGln: 3.246 ± 0.137
2.348IleArg: 2.348 ± 0.087
6.107IleSer: 6.107 ± 0.193
4.678IleThr: 4.678 ± 0.151
4.754IleVal: 4.754 ± 0.154
0.718IleTrp: 0.718 ± 0.051
3.34IleTyr: 3.34 ± 0.128
0.0IleXaa: 0.0 ± 0.0
Lys
6.207LysAla: 6.207 ± 0.304
0.243LysCys: 0.243 ± 0.036
5.979LysAsp: 5.979 ± 0.272
9.367LysGlu: 9.367 ± 0.277
3.936LysPhe: 3.936 ± 0.136
3.562LysGly: 3.562 ± 0.144
1.439LysHis: 1.439 ± 0.087
9.412LysIle: 9.412 ± 0.245
8.888LysLys: 8.888 ± 0.233
9.308LysLeu: 9.308 ± 0.223
2.403LysMet: 2.403 ± 0.111
8.493LysAsn: 8.493 ± 0.221
2.181LysPro: 2.181 ± 0.097
4.307LysGln: 4.307 ± 0.169
3.118LysArg: 3.118 ± 0.128
5.521LysSer: 5.521 ± 0.143
5.809LysThr: 5.809 ± 0.17
5.06LysVal: 5.06 ± 0.133
1.03LysTrp: 1.03 ± 0.057
4.605LysTyr: 4.605 ± 0.154
0.0LysXaa: 0.0 ± 0.0
Leu
5.84LeuAla: 5.84 ± 0.171
0.475LeuCys: 0.475 ± 0.048
5.934LeuAsp: 5.934 ± 0.231
7.605LeuGlu: 7.605 ± 0.193
4.855LeuPhe: 4.855 ± 0.236
4.297LeuGly: 4.297 ± 0.181
1.162LeuHis: 1.162 ± 0.08
8.59LeuIle: 8.59 ± 0.272
9.655LeuLys: 9.655 ± 0.235
8.153LeuLeu: 8.153 ± 0.257
1.415LeuMet: 1.415 ± 0.088
8.576LeuAsn: 8.576 ± 0.364
2.816LeuPro: 2.816 ± 0.108
2.93LeuGln: 2.93 ± 0.116
2.695LeuArg: 2.695 ± 0.103
6.946LeuSer: 6.946 ± 0.163
5.604LeuThr: 5.604 ± 0.197
6.159LeuVal: 6.159 ± 0.153
0.635LeuTrp: 0.635 ± 0.052
3.01LeuTyr: 3.01 ± 0.129
0.0LeuXaa: 0.0 ± 0.0
Met
0.846MetAla: 0.846 ± 0.061
0.09MetCys: 0.09 ± 0.018
0.836MetAsp: 0.836 ± 0.069
0.929MetGlu: 0.929 ± 0.067
0.884MetPhe: 0.884 ± 0.062
0.614MetGly: 0.614 ± 0.054
0.291MetHis: 0.291 ± 0.039
1.415MetIle: 1.415 ± 0.093
1.744MetLys: 1.744 ± 0.081
1.47MetLeu: 1.47 ± 0.096
0.284MetMet: 0.284 ± 0.036
1.28MetAsn: 1.28 ± 0.072
0.555MetPro: 0.555 ± 0.05
0.572MetGln: 0.572 ± 0.047
0.544MetArg: 0.544 ± 0.046
1.162MetSer: 1.162 ± 0.081
0.801MetThr: 0.801 ± 0.068
0.895MetVal: 0.895 ± 0.068
0.118MetTrp: 0.118 ± 0.021
0.524MetTyr: 0.524 ± 0.048
0.0MetXaa: 0.0 ± 0.0
Asn
4.522AsnAla: 4.522 ± 0.264
0.191AsnCys: 0.191 ± 0.028
4.692AsnAsp: 4.692 ± 0.257
5.954AsnGlu: 5.954 ± 0.186
3.87AsnPhe: 3.87 ± 0.125
3.562AsnGly: 3.562 ± 0.134
0.985AsnHis: 0.985 ± 0.061
6.187AsnIle: 6.187 ± 0.176
8.479AsnLys: 8.479 ± 0.235
8.573AsnLeu: 8.573 ± 0.284
1.051AsnMet: 1.051 ± 0.063
6.832AsnAsn: 6.832 ± 0.315
2.819AsnPro: 2.819 ± 0.138
3.357AsnGln: 3.357 ± 0.191
1.932AsnArg: 1.932 ± 0.082
5.656AsnSer: 5.656 ± 0.216
3.783AsnThr: 3.783 ± 0.19
3.78AsnVal: 3.78 ± 0.113
0.874AsnTrp: 0.874 ± 0.067
3.444AsnTyr: 3.444 ± 0.132
0.0AsnXaa: 0.0 ± 0.0
Pro
1.359ProAla: 1.359 ± 0.094
0.09ProCys: 0.09 ± 0.017
1.352ProAsp: 1.352 ± 0.072
2.188ProGlu: 2.188 ± 0.095
1.515ProPhe: 1.515 ± 0.086
1.325ProGly: 1.325 ± 0.076
0.406ProHis: 0.406 ± 0.037
2.029ProIle: 2.029 ± 0.093
2.421ProLys: 2.421 ± 0.102
2.206ProLeu: 2.206 ± 0.098
0.34ProMet: 0.34 ± 0.032
2.417ProAsn: 2.417 ± 0.112
0.34ProPro: 0.34 ± 0.038
0.888ProGln: 0.888 ± 0.054
0.666ProArg: 0.666 ± 0.059
1.907ProSer: 1.907 ± 0.095
1.661ProThr: 1.661 ± 0.101
1.633ProVal: 1.633 ± 0.098
0.236ProTrp: 0.236 ± 0.027
1.169ProTyr: 1.169 ± 0.07
0.0ProXaa: 0.0 ± 0.0
Gln
2.459GlnAla: 2.459 ± 0.159
0.038GlnCys: 0.038 ± 0.012
2.195GlnAsp: 2.195 ± 0.128
3.027GlnGlu: 3.027 ± 0.111
1.505GlnPhe: 1.505 ± 0.078
1.418GlnGly: 1.418 ± 0.078
0.333GlnHis: 0.333 ± 0.034
3.995GlnIle: 3.995 ± 0.119
4.761GlnLys: 4.761 ± 0.173
3.187GlnLeu: 3.187 ± 0.12
0.631GlnMet: 0.631 ± 0.051
3.863GlnAsn: 3.863 ± 0.194
0.843GlnPro: 0.843 ± 0.059
1.068GlnGln: 1.068 ± 0.066
1.228GlnArg: 1.228 ± 0.069
1.928GlnSer: 1.928 ± 0.099
2.095GlnThr: 2.095 ± 0.102
1.696GlnVal: 1.696 ± 0.083
0.326GlnTrp: 0.326 ± 0.035
1.148GlnTyr: 1.148 ± 0.068
0.0GlnXaa: 0.0 ± 0.0
Arg
1.64ArgAla: 1.64 ± 0.078
0.094ArgCys: 0.094 ± 0.018
1.744ArgAsp: 1.744 ± 0.073
2.337ArgGlu: 2.337 ± 0.097
1.391ArgPhe: 1.391 ± 0.059
1.287ArgGly: 1.287 ± 0.087
0.423ArgHis: 0.423 ± 0.042
2.684ArgIle: 2.684 ± 0.094
2.864ArgLys: 2.864 ± 0.117
2.747ArgLeu: 2.747 ± 0.1
0.621ArgMet: 0.621 ± 0.048
2.226ArgAsn: 2.226 ± 0.084
0.822ArgPro: 0.822 ± 0.058
1.02ArgGln: 1.02 ± 0.06
1.099ArgArg: 1.099 ± 0.07
1.561ArgSer: 1.561 ± 0.08
1.554ArgThr: 1.554 ± 0.07
1.592ArgVal: 1.592 ± 0.094
0.246ArgTrp: 0.246 ± 0.029
1.245ArgTyr: 1.245 ± 0.075
0.0ArgXaa: 0.0 ± 0.0
Ser
3.145SerAla: 3.145 ± 0.128
0.274SerCys: 0.274 ± 0.029
3.478SerAsp: 3.478 ± 0.139
4.432SerGlu: 4.432 ± 0.157
3.801SerPhe: 3.801 ± 0.144
3.097SerGly: 3.097 ± 0.139
0.902SerHis: 0.902 ± 0.063
5.16SerIle: 5.16 ± 0.176
6.461SerLys: 6.461 ± 0.176
6.762SerLeu: 6.762 ± 0.177
0.905SerMet: 0.905 ± 0.064
5.074SerAsn: 5.074 ± 0.173
1.505SerPro: 1.505 ± 0.086
2.438SerGln: 2.438 ± 0.092
1.838SerArg: 1.838 ± 0.094
4.616SerSer: 4.616 ± 0.149
3.392SerThr: 3.392 ± 0.138
3.125SerVal: 3.125 ± 0.099
0.68SerTrp: 0.68 ± 0.055
2.806SerTyr: 2.806 ± 0.113
0.0SerXaa: 0.0 ± 0.0
Thr
2.708ThrAla: 2.708 ± 0.142
0.139ThrCys: 0.139 ± 0.025
2.764ThrAsp: 2.764 ± 0.164
3.527ThrGlu: 3.527 ± 0.114
2.944ThrPhe: 2.944 ± 0.112
2.545ThrGly: 2.545 ± 0.136
0.732ThrHis: 0.732 ± 0.059
4.897ThrIle: 4.897 ± 0.16
5.621ThrLys: 5.621 ± 0.172
5.164ThrLeu: 5.164 ± 0.146
0.642ThrMet: 0.642 ± 0.054
4.709ThrAsn: 4.709 ± 0.235
1.651ThrPro: 1.651 ± 0.082
1.876ThrGln: 1.876 ± 0.1
1.699ThrArg: 1.699 ± 0.074
3.575ThrSer: 3.575 ± 0.126
3.239ThrThr: 3.239 ± 0.146
2.58ThrVal: 2.58 ± 0.102
0.413ThrTrp: 0.413 ± 0.034
2.126ThrTyr: 2.126 ± 0.089
0.0ThrXaa: 0.0 ± 0.0
Val
3.846ValAla: 3.846 ± 0.129
0.274ValCys: 0.274 ± 0.034
3.329ValAsp: 3.329 ± 0.1
3.815ValGlu: 3.815 ± 0.152
2.788ValPhe: 2.788 ± 0.136
2.622ValGly: 2.622 ± 0.139
0.697ValHis: 0.697 ± 0.052
4.453ValIle: 4.453 ± 0.132
4.737ValLys: 4.737 ± 0.132
5.226ValLeu: 5.226 ± 0.145
0.746ValMet: 0.746 ± 0.063
3.555ValAsn: 3.555 ± 0.109
1.606ValPro: 1.606 ± 0.08
1.772ValGln: 1.772 ± 0.068
1.578ValArg: 1.578 ± 0.092
3.863ValSer: 3.863 ± 0.139
2.636ValThr: 2.636 ± 0.111
3.627ValVal: 3.627 ± 0.15
0.458ValTrp: 0.458 ± 0.041
2.015ValTyr: 2.015 ± 0.09
0.0ValXaa: 0.0 ± 0.0
Trp
0.503TrpAla: 0.503 ± 0.044
0.052TrpCys: 0.052 ± 0.015
0.499TrpAsp: 0.499 ± 0.043
0.843TrpGlu: 0.843 ± 0.057
0.544TrpPhe: 0.544 ± 0.046
0.409TrpGly: 0.409 ± 0.042
0.055TrpHis: 0.055 ± 0.013
0.891TrpIle: 0.891 ± 0.062
0.909TrpLys: 0.909 ± 0.063
0.766TrpLeu: 0.766 ± 0.049
0.17TrpMet: 0.17 ± 0.026
0.832TrpAsn: 0.832 ± 0.055
0.205TrpPro: 0.205 ± 0.027
0.25TrpGln: 0.25 ± 0.033
0.298TrpArg: 0.298 ± 0.035
0.531TrpSer: 0.531 ± 0.046
0.586TrpThr: 0.586 ± 0.05
0.416TrpVal: 0.416 ± 0.039
0.125TrpTrp: 0.125 ± 0.022
0.42TrpTyr: 0.42 ± 0.041
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.091TyrAla: 2.091 ± 0.092
0.191TyrCys: 0.191 ± 0.029
2.608TyrAsp: 2.608 ± 0.1
3.097TyrGlu: 3.097 ± 0.117
2.445TyrPhe: 2.445 ± 0.111
1.758TyrGly: 1.758 ± 0.095
0.631TyrHis: 0.631 ± 0.047
2.885TyrIle: 2.885 ± 0.14
4.404TyrLys: 4.404 ± 0.16
4.179TyrLeu: 4.179 ± 0.141
0.548TyrMet: 0.548 ± 0.046
3.017TyrAsn: 3.017 ± 0.115
1.117TyrPro: 1.117 ± 0.064
1.789TyrGln: 1.789 ± 0.09
1.2TyrArg: 1.2 ± 0.061
2.643TyrSer: 2.643 ± 0.092
2.063TyrThr: 2.063 ± 0.081
2.108TyrVal: 2.108 ± 0.1
0.451TyrTrp: 0.451 ± 0.041
1.692TyrTyr: 1.692 ± 0.096
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 692 proteins (288362 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski